clioquinol has been researched along with Optic Atrophy in 23 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Optic Atrophy: Atrophy of the optic disk which may be congenital or acquired. This condition indicates a deficiency in the number of nerve fibers which arise in the RETINA and converge to form the OPTIC DISK; OPTIC NERVE; OPTIC CHIASM; and optic tracts. GLAUCOMA; ISCHEMIA; inflammation, a chronic elevation of intracranial pressure, toxins, optic nerve compression, and inherited conditions (see OPTIC ATROPHIES, HEREDITARY) are relatively common causes of this condition.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 72-year-old Caucasian woman developed degeneration of the spinal cord long tracts, polyneuropathy, and optic atrophy after chronic ingestion of clioquinol (200 mg/day) since she was 45." | 3.66 | Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan. ( Cabello, A; Ortega, A; Ricoy, JR, 1982) |
| "Subacute myelopathy was seen in six patients, optico-myelopathy in two, and myeloneuropathy only once." | 1.27 | SMON as seen from Bombay. ( Wadia, NH, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 23 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Thomas, PK | 2 |
| Wadia, NH | 1 |
| Gilland, O | 1 |
| Hanson, O | 1 |
| Herxheimer, O | 1 |
| Massons Cirera, J | 1 |
| Zunzunegui Costas, J | 1 |
| Titus Alvareda, F | 1 |
| Clifford Rose, F | 1 |
| Gawel, M | 1 |
| Pallis, C | 1 |
| Sturtevant, FM | 1 |
| Ricoy, JR | 1 |
| Ortega, A | 1 |
| Cabello, A | 1 |
| Smith, DL | 1 |
| Carr, WG | 1 |
| Bowen, RA | 1 |
| Horner, FA | 1 |
| Chevaleraud, JP | 1 |
| Hamard, H | 1 |
| Billson, FH | 1 |
| Reich, J | 1 |
| Hopkins, IJ | 1 |
| van Balen, AT | 1 |
| Schultz, MG | 1 |
| Wolfe, MS | 1 |
| Mishtowt, GI | 1 |
| Drukker, J | 1 |
| Lindenburg, PA | 1 |
| Selby, G | 1 |
| Garcia-Perez, A | 1 |
| Castro, C | 1 |
| Franco, A | 1 |
| Escribano, R | 1 |
2 reviews available for clioquinol and Optic Atrophy
| Article | Year |
|---|---|
Selective vulnerability of the centrifugal and centripetal axons of primary sensory neurons.
Topics: Acrylamides; Animals; Axons; Clioquinol; Dogs; Ganglia, Spinal; Haplorhini; Humans; Nerve Degenerati | 1982 |
Clioquinol neurotoxicity: an overview.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Kinetics; Nervous System; Nervous System Diseases; Opt | 1984 |
1 trial available for clioquinol and Optic Atrophy
| Article | Year |
|---|---|
Entero-Vioform in travelers' diarrhea.
Topics: Clioquinol; Diarrhea; Humans; Neuromuscular Diseases; Optic Atrophy; Placebos; Travel; Vision Disord | 1972 |
20 other studies available for clioquinol and Optic Atrophy
| Article | Year |
|---|---|
Neurotoxicity of halogenated hydroxyquinolines: non-Japanese cases.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Peripheral Nervous System Diseases; Spi | 1984 |
SMON as seen from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; Hydroxyquinolines; India; Japan; Male; Middle Aged; | 1984 |
A neurological evaluation of purported cases of SMON in Sweden.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Mal | 1984 |
Neuropathy and optic atrophy associted with halquinol.
Topics: Adult; Chloroquinolinols; Clioquinol; Diarrhea; Drug Labeling; Female; Humans; Hydroxyquinolines; Ju | 1981 |
[A case of myelo-optic neuropathy preceded by abdominal symptoms].
Topics: Abdomen; Clioquinol; Humans; Hydroxyquinolines; Male; Middle Aged; Optic Atrophy; Pain; Spinal Cord | 1983 |
Some thoughts on 'SMON'.
Topics: Clioquinol; Diagnosis, Differential; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Spinal Cord Di | 1984 |
Zinc deficiency, acrodermatitis enteropathica, optic atrophy, subacute myelo-optic neuropathy, and 5,7-dihalo-8-quinolinols.
Topics: Acrodermatitis; Clioquinol; Humans; Hydroxyquinolines; Myelitis; Optic Atrophy; Optic Neuritis; Oxyq | 1980 |
Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan.
Topics: Aged; Brain; Clioquinol; Demyelinating Diseases; Female; Humans; Nerve Degeneration; Nerve Fibers, M | 1982 |
Letter: Watch out for combinations.
Topics: Clioquinol; Drug Combinations; Humans; Hydrocortisone; Optic Atrophy | 1976 |
Iodochlorhydroxyquin and optic nerve damage.
Topics: Child, Preschool; Clioquinol; Humans; Male; Optic Atrophy | 1977 |
[Optic neuropathies].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Central Nervous System Agents; | 1985 |
Visual failure in a patient with ulcerative colitis treated by clioquinol.
Topics: Adolescent; Child; Clioquinol; Colitis, Ulcerative; Female; Humans; Optic Atrophy; Optic Nerve; Opti | 1972 |
Clioquinol and neurological disease.
Topics: Anti-Infective Agents, Local; Clioquinol; Ethnicity; Gastrointestinal Diseases; Humans; Japan; Neuro | 1971 |
Toxic damage to the optic nerve caused by iodochlorhydroxyquinoline (enterovioform).
Topics: Acrodermatitis; Child, Preschool; Clioquinol; Humans; Male; Nystagmus, Pathologic; Optic Atrophy; Qu | 1971 |
Entero-Vioform for preventing travelers' diarrhea.
Topics: Clioquinol; Diarrhea; Humans; Japan; Neuromuscular Diseases; Optic Atrophy; Travel; Vision Disorders | 1972 |
[Bilateral optic atrophy in a one and one-half-year-old child possibly a result of administration of iodochlorhydroxyquinoline (Enterovioform)].
Topics: Clioquinol; Diarrhea, Infantile; Female; Humans; Infant; Myelitis; Optic Atrophy | 1972 |
Subacute myelo-optico-neuropathy (SMON)--neurotoxicity of clioquinols.
Topics: Abdomen; Aged; Clioquinol; Diarrhea; Enteritis; Female; Humans; Intestinal Absorption; Male; Middle | 1973 |
A case of optic atrophy possibly induced by quinoline in acrodermatitis enteropathica.
Topics: Acrodermatitis; Alopecia; Blindness; Body Height; Body Weight; Child, Preschool; Clioquinol; Diarrhe | 1974 |
Warning on diiodohydroxyquin.
Topics: Abdomen; Acrodermatitis; Adult; Age Factors; Amebiasis; Child, Preschool; Chronic Disease; Clioquino | 1974 |
Entero-Vioform and organic neurologic disease.
Topics: Arthritis, Rheumatoid; Chloroquine; Clioquinol; Diarrhea; Humans; Malaria; Optic Atrophy; Peripheral | 1971 |