clioquinol has been researched along with Neuroblastoma in 7 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol was used extensively in the mid-1900s as an amebicide to treat indigestion and diarrhea." | 1.40 | Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. ( Ibi, M; Iwata, K; Katsuyama, M; Matsumoto, M; Ohshima, Y; Yabe-Nishimura, C, 2014) |
| "As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets beta-amyloid (Abeta) reactions with synaptic Zn and Cu yet promotes metal uptake." | 1.35 | Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. ( Adlard, PA; Barnham, KJ; Bush, AI; Cappai, R; Charman, SA; Cherny, RA; Cortes, M; Deleva, K; Finkelstein, DI; Gautier, E; Kok, G; Laughton, K; Li, QX; Liu, X; Lynch, T; Masters, CL; Nicolazzo, JA; Perez, K; Ritchie, CW; Robb, E; Smith, JP; Tanzi, RE; Volitakis, I; Wilkins, S, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, X | 3 |
| Fan, Z | 3 |
| Cao, F | 3 |
| Liu, W | 3 |
| Huang, Z | 3 |
| Shi, P | 3 |
| Katsuyama, M | 2 |
| Ibi, M | 2 |
| Matsumoto, M | 2 |
| Iwata, K | 2 |
| Ohshima, Y | 1 |
| Yabe-Nishimura, C | 2 |
| Adlard, PA | 1 |
| Cherny, RA | 2 |
| Finkelstein, DI | 1 |
| Gautier, E | 1 |
| Robb, E | 1 |
| Cortes, M | 1 |
| Volitakis, I | 2 |
| Liu, X | 1 |
| Smith, JP | 1 |
| Perez, K | 1 |
| Laughton, K | 1 |
| Li, QX | 2 |
| Charman, SA | 1 |
| Nicolazzo, JA | 1 |
| Wilkins, S | 1 |
| Deleva, K | 1 |
| Lynch, T | 1 |
| Kok, G | 1 |
| Ritchie, CW | 1 |
| Tanzi, RE | 1 |
| Cappai, R | 1 |
| Masters, CL | 2 |
| Barnham, KJ | 2 |
| Bush, AI | 2 |
| Matsuno, K | 1 |
| White, AR | 1 |
| Du, T | 1 |
| Laughton, KM | 1 |
| Sharples, RA | 1 |
| Xilinas, ME | 1 |
| Hoke, DE | 1 |
| Holsinger, RM | 1 |
| Evin, G | 1 |
| Hill, AF | 1 |
| Choi, SM | 1 |
| Choi, KO | 1 |
| Park, YK | 1 |
| Cho, H | 2 |
| Yang, EG | 1 |
| Park, H | 1 |
| Bandyopadhyay, S | 1 |
| Huang, X | 1 |
| Greig, NH | 1 |
| Youdim, MB | 1 |
| Rogers, JT | 1 |
7 other studies available for clioquinol and Neuroblastoma
| Article | Year |
|---|---|
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas | 2023 |
Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression.
Topics: Amebicides; Clioquinol; Gene Expression; Humans; Myelitis; Nerve Growth Factors; Neuroblastoma; Neur | 2014 |
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2008 |
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
Topics: Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Ch | 2012 |
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Infective Agents, Local; Cell Line, Tumor; C | 2006 |
Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
Topics: Asparagine; Carcinoma, Hepatocellular; Cell Hypoxia; Chelating Agents; Clioquinol; Copper; Cyclic AM | 2006 |
Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator.
Topics: Amyloid beta-Protein Precursor; Cell Line, Tumor; Clioquinol; Deferoxamine; Dose-Response Relationsh | 2006 |