Page last updated: 2024-10-25

clioquinol and Neuroblastoma

clioquinol has been researched along with Neuroblastoma in 7 studies

Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"Clioquinol was used extensively in the mid-1900s as an amebicide to treat indigestion and diarrhea."1.40Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression. ( Ibi, M; Iwata, K; Katsuyama, M; Matsumoto, M; Ohshima, Y; Yabe-Nishimura, C, 2014)
"As a disease-modifying approach for Alzheimer's disease (AD), clioquinol (CQ) targets beta-amyloid (Abeta) reactions with synaptic Zn and Cu yet promotes metal uptake."1.35Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. ( Adlard, PA; Barnham, KJ; Bush, AI; Cappai, R; Charman, SA; Cherny, RA; Cortes, M; Deleva, K; Finkelstein, DI; Gautier, E; Kok, G; Laughton, K; Li, QX; Liu, X; Lynch, T; Masters, CL; Nicolazzo, JA; Perez, K; Ritchie, CW; Robb, E; Smith, JP; Tanzi, RE; Volitakis, I; Wilkins, S, 2008)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's2 (28.57)24.3611
2020's1 (14.29)2.80

Authors

AuthorsStudies
Lv, X3
Fan, Z3
Cao, F3
Liu, W3
Huang, Z3
Shi, P3
Katsuyama, M2
Ibi, M2
Matsumoto, M2
Iwata, K2
Ohshima, Y1
Yabe-Nishimura, C2
Adlard, PA1
Cherny, RA2
Finkelstein, DI1
Gautier, E1
Robb, E1
Cortes, M1
Volitakis, I2
Liu, X1
Smith, JP1
Perez, K1
Laughton, K1
Li, QX2
Charman, SA1
Nicolazzo, JA1
Wilkins, S1
Deleva, K1
Lynch, T1
Kok, G1
Ritchie, CW1
Tanzi, RE1
Cappai, R1
Masters, CL2
Barnham, KJ2
Bush, AI2
Matsuno, K1
White, AR1
Du, T1
Laughton, KM1
Sharples, RA1
Xilinas, ME1
Hoke, DE1
Holsinger, RM1
Evin, G1
Hill, AF1
Choi, SM1
Choi, KO1
Park, YK1
Cho, H2
Yang, EG1
Park, H1
Bandyopadhyay, S1
Huang, X1
Greig, NH1
Youdim, MB1
Rogers, JT1

Other Studies

7 other studies available for clioquinol and Neuroblastoma

ArticleYear
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol induces autophagy by down-regulation of calreticulin in human neurotypic SH-SY5Y cells.
    Chemico-biological interactions, 2023, Jan-05, Volume: 369

    Topics: Apoptosis; Autophagy; Calcium; Calreticulin; Cell Line, Tumor; Clioquinol; Down-Regulation; Endoplas

2023
Clioquinol increases the expression of VGF, a neuropeptide precursor, through induction of c-Fos expression.
    Journal of pharmacological sciences, 2014, Volume: 124, Issue:4

    Topics: Amebicides; Clioquinol; Gene Expression; Humans; Myelitis; Nerve Growth Factors; Neuroblastoma; Neur

2014
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta.
    Neuron, 2008, Jul-10, Volume: 59, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim

2008
Clioquinol induces DNA double-strand breaks, activation of ATM, and subsequent activation of p53 signaling.
    Toxicology, 2012, Sep-04, Volume: 299, Issue:1

    Topics: Ataxia Telangiectasia Mutated Proteins; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Ch

2012
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity.
    The Journal of biological chemistry, 2006, Jun-30, Volume: 281, Issue:26

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Infective Agents, Local; Cell Line, Tumor; C

2006
Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
    The Journal of biological chemistry, 2006, Nov-10, Volume: 281, Issue:45

    Topics: Asparagine; Carcinoma, Hepatocellular; Cell Hypoxia; Chelating Agents; Clioquinol; Copper; Cyclic AM

2006
Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator.
    Journal of neural transmission. Supplementum, 2006, Issue:71

    Topics: Amyloid beta-Protein Precursor; Cell Line, Tumor; Clioquinol; Deferoxamine; Dose-Response Relationsh

2006