clioquinol has been researched along with Nervous System Diseases in 25 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Nervous System Diseases: Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol was administered to cats for more than 200 days, in order to investigate the neural mechanisms underlying the sensory disturbances of subacute myelo-opticoneuropathy (SMON)." | 1.28 | Electrophysiological changes in the fasciculus gracilis of the cat following chronic clioquinol administration. ( Koyama, N; Terada, M; Yokota, T, 1989) |
| "When clioquinol was given intraperitoneally and 63Ni2+ was given intravenously there were also very markedly increased tissue levels of the metal, compared with intravenous injections of 63Ni2+ only." | 1.27 | Effect of 5-chloro-7-iodo-8-hydroxy-quinoline (clioquinol) on the uptake and distribution of nickel, zinc and mercury in mice. ( Ståhl, K; Tjälve, H, 1984) |
| "Pyridoxine-treated dogs had proprioceptive loss involving both fore- and hindquarters, characterized by stiff, spastic, dysmetric leg movements." | 1.26 | The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. I. Clinical disease. ( Carlton, WW; Hoover, DM, 1981) |
| "Pyridoxine-treated dogs had lesions limited to tracts and nerves with neuronal bodies of their nerve fibers in the spinal and trigeminal ganglia." | 1.26 | The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. II. Pathology. ( Carlton, WW; Hoover, DM, 1981) |
| " The onset of all manifestations (except toxic encephalopathy) was usually subacute, with subsequent partial recovery." | 1.26 | Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. ( Baumgartner, G; Gawel, MJ; Kaeser, HE; Pallis, CA; Rose, FC; Schaumburg, HH; Thomas, PK; Wadia, NH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kumar, R | 1 |
| Pavlov, PF | 1 |
| Winblad, B | 1 |
| Thomas, PK | 2 |
| Kotaki, H | 1 |
| Nakajima, K | 1 |
| Tanimura, Y | 1 |
| Saitoh, Y | 1 |
| Nakagawa, F | 1 |
| Tamura, Z | 1 |
| Nagashima, K | 1 |
| Tjälve, H | 1 |
| Ståhl, K | 1 |
| Clifford Rose, F | 1 |
| Gawel, M | 1 |
| Hoover, DM | 2 |
| Carlton, WW | 2 |
| Sobue, I | 1 |
| Amson, K | 1 |
| de S Pinto, O | 1 |
| Scott, R | 1 |
| Sobotkiewicz, J | 1 |
| Hansson, O | 1 |
| Le Quesne, PM | 1 |
| Thomann, P | 1 |
| Krinke, G | 1 |
| Hess, R | 1 |
| Baumgartner, G | 1 |
| Gawel, MJ | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 2 |
| Schaumburg, HH | 1 |
| Wadia, NH | 1 |
| Matsuda, M | 1 |
| Yanagisawa, N | 1 |
| Tsukada, N | 1 |
| Yanagimoto, T | 1 |
| Kashiwagi, N | 1 |
| Koyama, N | 1 |
| Terada, M | 1 |
| Yokota, T | 1 |
| Tsubaki, T | 1 |
| Honma, Y | 1 |
| Hoshi, M | 1 |
| Inoue, YK | 1 |
| Nishibe, Y | 1 |
| Nakamura, Y | 1 |
| Marsden, PD | 1 |
| Knight, R | 1 |
| Osterman, PO | 1 |
| Tateishi, J | 1 |
| Bezjak, B | 1 |
| Breintenfeld, V | 1 |
| Schönwald, S | 1 |
| Car, V | 1 |
| Puskarić-Hamel, N | 1 |
| Vrancić, J | 1 |
| Hotujac, L | 1 |
5 reviews available for clioquinol and Nervous System Diseases
| Article | Year |
|---|---|
Selective vulnerability of the centrifugal and centripetal axons of primary sensory neurons.
Topics: Acrylamides; Animals; Axons; Clioquinol; Dogs; Ganglia, Spinal; Haplorhini; Humans; Nerve Degenerati | 1982 |
Clioquinol neurotoxicity: an overview.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Kinetics; Nervous System; Nervous System Diseases; Opt | 1984 |
[Exogenous toxic neuropathy (author's transl)].
Topics: Acrylamides; Adolescent; Adult; Aged; Aldrin; Carbon Disulfide; Chloramphenicol; Clioquinol; DDT; Di | 1976 |
Neurotoxic substances.
Topics: Acrylamides; Animals; Cats; Central Nervous System Diseases; Clioquinol; Environmental Exposure; Hex | 1975 |
[Toxicity studies on clioquinol in laboratory animals].
Topics: Animals; Clioquinol; Dogs; Nervous System Diseases; Peripheral Nerves; Peripheral Nervous System Dis | 1977 |
20 other studies available for clioquinol and Nervous System Diseases
| Article | Year |
|---|---|
Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity.
Topics: Amyloid beta-Peptides; Benzimidazoles; Cell Death; Cell Line; Chelating Agents; Clioquinol; Copper; | 2020 |
Appearance of intoxication in rats by intraperitoneal administration of clioquinol.
Topics: Animals; Ataxia; Clioquinol; Hydroxyquinolines; Injections, Intraperitoneal; Male; Nervous System Di | 1983 |
Effect of 5-chloro-7-iodo-8-hydroxy-quinoline (clioquinol) on the uptake and distribution of nickel, zinc and mercury in mice.
Topics: Animals; Clioquinol; Female; Hydroxyquinolines; Mercury; Mice; Mice, Inbred C57BL; Nervous System Di | 1984 |
The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. I. Clinical disease.
Topics: Animals; Ataxia; Blood Cell Count; Blood Proteins; Clioquinol; Diarrhea; Dogs; Eating; Female; Male; | 1981 |
The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. II. Pathology.
Topics: Animals; Brain; Clioquinol; Diarrhea; Dogs; Female; Male; Myocardium; Nervous System; Nervous System | 1981 |
[The effect and reported side effects of clioquinol].
Topics: Amebiasis; Clioquinol; Diarrhea; Dysentery, Bacillary; Giardiasis; Humans; Nervous System Diseases; | 1977 |
[Welcome clarifications from CIBA-GEIGY].
Topics: Animals; Clioquinol; Drug Evaluation, Preclinical; Drug Industry; Humans; Nervous System Diseases | 1977 |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Clioquinol; Dose-Response Relation | 1979 |
[Subsets of peripheral blood lymphocytes and ageing in patients with SMON].
Topics: Aged; Aging; Clioquinol; Humans; Leukocyte Count; Lymphocyte Subsets; Middle Aged; Myelitis; Nervous | 1991 |
American Academy of Pediatrics Committee on Drugs: Clioquinol (iodochlorhydroxyquin, vioform) and iodoquinol (diiodohydroxyquin): blindness and neuropathy.
Topics: Blindness; Child, Preschool; Clioquinol; Diaper Rash; Humans; Infant; Infant, Newborn; Iodoquinol; N | 1990 |
Empirical Bayes methods for smoothing data and for simultaneous estimation of many parameters.
Topics: Bayes Theorem; Clioquinol; Cohort Studies; Female; Humans; Japan; Likelihood Functions; Male; Neopla | 1990 |
Electrophysiological changes in the fasciculus gracilis of the cat following chronic clioquinol administration.
Topics: Action Potentials; Animals; Cats; Clioquinol; Electric Stimulation; Hydroxyquinolines; Medulla Oblon | 1989 |
Only in Japan?
Topics: Clioquinol; Diarrhea; Gastrointestinal Agents; Humans; Nervous System Diseases | 1971 |
Neurological syndrome associated with clioquinol.
Topics: Clioquinol; Diarrhea; Gastrointestinal Agents; Humans; Nervous System Diseases; Optic Nerve | 1971 |
Virus associated with S.M.O.N. in Japan.
Topics: Cerebrospinal Fluid; Clioquinol; Feces; Gastrointestinal Diseases; Humans; Japan; Nervous System Dis | 1971 |
Halogenated oxyquinoline derivatives.
Topics: Clioquinol; Cyanides; Dysentery, Amebic; Humans; Japan; Nervous System Diseases; Nigeria | 1971 |
Myelopathy after clioquinol treatment.
Topics: Abdomen; Adult; Clioquinol; Humans; Male; Myelitis; Nervous System Diseases; Neurologic Manifestatio | 1971 |
Non-S.M.O.N.
Topics: Clioquinol; Eye Diseases; Humans; Male; Middle Aged; Nervous System Diseases | 1972 |
Comparative study of neurotoxicity of clioquinol, ethambutol, isoniazid and chloramphenicol in dogs.
Topics: Abdomen; Administration, Oral; Animals; Axons; Chloramphenicol; Clioquinol; Dogs; Ethambutol; Isonia | 1974 |
[Prospective study on the side-effects of the clioquinol preparation mexaform with special reference to subacute myelo-optic neuropathy].
Topics: Clioquinol; Colitis; Eye Diseases; Gastroenteritis; Humans; Ketones; Nervous System Diseases; Phenan | 1974 |