clioquinol has been researched along with Nerve Degeneration in 4 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 72-year-old Caucasian woman developed degeneration of the spinal cord long tracts, polyneuropathy, and optic atrophy after chronic ingestion of clioquinol (200 mg/day) since she was 45." | 3.66 | Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan. ( Cabello, A; Ortega, A; Ricoy, JR, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kaur, D | 1 |
| Rajagopalan, S | 1 |
| Andersen, JK | 1 |
| Thomas, PK | 2 |
| Schaumburg, HH | 1 |
| Spencer, PS | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 1 |
| Wadia, NH | 1 |
| Ricoy, JR | 1 |
| Ortega, A | 1 |
| Cabello, A | 1 |
1 review available for clioquinol and Nerve Degeneration
| Article | Year |
|---|---|
Selective vulnerability of the centrifugal and centripetal axons of primary sensory neurons.
Topics: Acrylamides; Animals; Axons; Clioquinol; Dogs; Ganglia, Spinal; Haplorhini; Humans; Nerve Degenerati | 1982 |
3 other studies available for clioquinol and Nerve Degeneration
| Article | Year |
|---|---|
Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease.
Topics: Aging; Animals; Apoferritins; Chelating Agents; Clioquinol; Dopamine; Gene Expression Regulation; Ir | 2009 |
Central distal axonopathy syndromes: newly recognized models of naturally occurring human degenerative disease.
Topics: Animals; Axons; Central Nervous System Diseases; Clioquinol; Disease Models, Animal; Dogs; Humans; L | 1984 |
Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan.
Topics: Aged; Brain; Clioquinol; Demyelinating Diseases; Female; Humans; Nerve Degeneration; Nerve Fibers, M | 1982 |