clioquinol has been researched along with Myelopathy in 20 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 72-year-old Caucasian woman developed degeneration of the spinal cord long tracts, polyneuropathy, and optic atrophy after chronic ingestion of clioquinol (200 mg/day) since she was 45." | 3.66 | Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan. ( Cabello, A; Ortega, A; Ricoy, JR, 1982) |
| "Recently, dysphagia has attracted attention as a complication of SMON." | 1.48 | Tongue strength in patients with subacute myelo-optico-neuropathy. ( Ando, Y; Honda, S; Kimura, E; Konagaya, M; Nakama, T; Ueda, M; Yamashita, S, 2018) |
| "The prevalence of major depressive disorder in SMON patients was estimated by structured interview and using Beck's depression inventory (BDI) questionnaires." | 1.35 | Depression in patients with subacute myelo-optico-neuropathy (SMON). ( Fujimura, H; Funakawa, I; Hayashi, K; Hayashi, M; Kaido, M; Konishi, T; Ueno, S; Yoshida, S, 2008) |
| "Subacute myelopathy was seen in six patients, optico-myelopathy in two, and myeloneuropathy only once." | 1.27 | SMON as seen from Bombay. ( Wadia, NH, 1984) |
| " The onset of all manifestations (except toxic encephalopathy) was usually subacute, with subsequent partial recovery." | 1.26 | Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. ( Baumgartner, G; Gawel, MJ; Kaeser, HE; Pallis, CA; Rose, FC; Schaumburg, HH; Thomas, PK; Wadia, NH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 2 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, S | 2 |
| Nakama, T | 1 |
| Ueda, M | 1 |
| Honda, S | 1 |
| Kimura, E | 2 |
| Konagaya, M | 1 |
| Ando, Y | 1 |
| Schaumburg, H | 1 |
| Herskovitz, S | 1 |
| Mao, X | 1 |
| Li, X | 1 |
| Sprangers, R | 1 |
| Wang, X | 1 |
| Venugopal, A | 1 |
| Wood, T | 1 |
| Zhang, Y | 1 |
| Kuntz, DA | 1 |
| Coe, E | 1 |
| Trudel, S | 1 |
| Rose, D | 1 |
| Batey, RA | 1 |
| Kay, LE | 1 |
| Schimmer, AD | 1 |
| Konishi, T | 1 |
| Hayashi, K | 1 |
| Hayashi, M | 1 |
| Ueno, S | 1 |
| Yoshida, S | 1 |
| Fujimura, H | 1 |
| Funakawa, I | 1 |
| Kaido, M | 1 |
| Hirano, T | 1 |
| Hirai, T | 1 |
| Uchida, Y | 1 |
| Maeda, Y | 1 |
| Uchino, M | 1 |
| Yamanaka, Y | 1 |
| Asahina, M | 1 |
| Akaogi, Y | 1 |
| Koyama, Y | 1 |
| Hattori, T | 1 |
| Thomas, PK | 3 |
| Wadia, NH | 2 |
| Gilland, O | 1 |
| Massons Cirera, J | 1 |
| Zunzunegui Costas, J | 1 |
| Titus Alvareda, F | 1 |
| Clifford Rose, F | 1 |
| Gawel, M | 1 |
| Pallis, C | 1 |
| Ricoy, JR | 1 |
| Ortega, A | 1 |
| Cabello, A | 1 |
| Tateishi, J | 2 |
| Korczyn, AD | 1 |
| Kuritzky, A | 1 |
| Bechar, M | 1 |
| Baumgartner, G | 1 |
| Gawel, MJ | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 1 |
| Schaumburg, HH | 1 |
| Kuroda, S | 1 |
| Saito, A | 1 |
| Otsuki, S | 1 |
| Bezjak, B | 1 |
| Breintenfeld, V | 1 |
| Schönwald, S | 1 |
| Car, V | 1 |
| Puskarić-Hamel, N | 1 |
| Vrancić, J | 1 |
| Hotujac, L | 1 |
3 reviews available for clioquinol and Myelopathy
| Article | Year |
|---|---|
Selective vulnerability of the centrifugal and centripetal axons of primary sensory neurons.
Topics: Acrylamides; Animals; Axons; Clioquinol; Dogs; Ganglia, Spinal; Haplorhini; Humans; Nerve Degenerati | 1982 |
Clioquinol neurotoxicity: an overview.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Kinetics; Nervous System; Nervous System Diseases; Opt | 1984 |
Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals.
Topics: Animals; Brain Injuries; Clioquinol; Diagnosis, Differential; Disease Models, Animal; Humans; Japan; | 2000 |
17 other studies available for clioquinol and Myelopathy
| Article | Year |
|---|---|
Tongue strength in patients with subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Clioquinol; Deglutition Disorders; Female; H | 2018 |
Copper deficiency myeloneuropathy: a clue to clioquinol-induced subacute myelo-optic neuropathy?
Topics: Animals; Chelating Agents; Clioquinol; Copper; Humans; Nerve Fibers, Myelinated; Optic Nerve; Optic | 2008 |
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.
Topics: Animals; Antineoplastic Agents; Archaeal Proteins; Asian People; Cell Line, Tumor; Clioquinol; Coppe | 2009 |
Depression in patients with subacute myelo-optico-neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Clioquinol; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; | 2008 |
Cervical MRI of subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anthelmintics; Chelating Agents; Clioquinol; Copper; Female; Humans; Magnet | 2011 |
Diminished skin vasodilator response to local heating in patients with long-standingsubacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Autonomic Dysreflexia; Autonomic Nervous System Dise | 2007 |
Neurotoxicity of halogenated hydroxyquinolines: non-Japanese cases.
Topics: Clioquinol; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Peripheral Nervous System Diseases; Spi | 1984 |
SMON as seen from Bombay.
Topics: Adult; Aged; Child; Clioquinol; Female; Humans; Hydroxyquinolines; India; Japan; Male; Middle Aged; | 1984 |
A neurological evaluation of purported cases of SMON in Sweden.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Clioquinol; Female; Humans; Hydroxyquinolines; Mal | 1984 |
[A case of myelo-optic neuropathy preceded by abdominal symptoms].
Topics: Abdomen; Clioquinol; Humans; Hydroxyquinolines; Male; Middle Aged; Optic Atrophy; Pain; Spinal Cord | 1983 |
Some thoughts on 'SMON'.
Topics: Clioquinol; Diagnosis, Differential; Humans; Hydroxyquinolines; Japan; Optic Atrophy; Spinal Cord Di | 1984 |
Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan.
Topics: Aged; Brain; Clioquinol; Demyelinating Diseases; Female; Humans; Nerve Degeneration; Nerve Fibers, M | 1982 |
[Myelopathy following clioquinol].
Topics: Clioquinol; Humans; Male; Middle Aged; Spinal Cord Diseases | 1977 |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Clioquinol; Dose-Response Relation | 1979 |
More on S.M.O.N.
Topics: Clioquinol; Humans; Hydroxyquinolines; Optic Neuritis; Oxyquinoline; Spinal Cord Diseases | 1971 |
Myelo-optic neuropathy induced by clioquinol in animals.
Topics: Animals; Cats; Clioquinol; Disease Models, Animal; Dogs; Hydroxyquinolines; Macaca; Optic Neuritis; | 1971 |
[Prospective study on the side-effects of the clioquinol preparation mexaform with special reference to subacute myelo-optic neuropathy].
Topics: Clioquinol; Colitis; Eye Diseases; Gastroenteritis; Humans; Ketones; Nervous System Diseases; Phenan | 1974 |