clioquinol has been researched along with Kahler Disease in 4 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recently it was reported clioquinol can inhibit the proteasomal chymotrypsin-like activity and induce apoptotic cell death in leukemia and myeloma." | 7.77 | Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus-host disease. ( Liang, Y; Liu, H; Mao, X, 2011) |
| "Clioquinol is an anti-microbial drug, and it was recently found to induce cancer cell death." | 5.40 | Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. ( Cao, B; Han, K; Juan, J; Kong, Y; Li, J; Mao, X; Wang, J; Zhang, Z; Zhou, X, 2014) |
| " Recently it was reported clioquinol can inhibit the proteasomal chymotrypsin-like activity and induce apoptotic cell death in leukemia and myeloma." | 3.77 | Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus-host disease. ( Liang, Y; Liu, H; Mao, X, 2011) |
| "Clioquinol is an anti-microbial drug, and it was recently found to induce cancer cell death." | 1.40 | Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway. ( Cao, B; Han, K; Juan, J; Kong, Y; Li, J; Mao, X; Wang, J; Zhang, Z; Zhou, X, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 3 (75.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cao, B | 2 |
| Li, J | 2 |
| Zhu, J | 1 |
| Shen, M | 1 |
| Han, K | 2 |
| Zhang, Z | 2 |
| Yu, Y | 1 |
| Wang, Y | 1 |
| Wu, D | 1 |
| Chen, S | 1 |
| Sun, A | 1 |
| Tang, X | 1 |
| Zhao, Y | 1 |
| Qiao, C | 1 |
| Hou, T | 1 |
| Mao, X | 4 |
| Zhou, X | 1 |
| Juan, J | 1 |
| Kong, Y | 1 |
| Wang, J | 1 |
| Li, X | 1 |
| Sprangers, R | 1 |
| Wang, X | 1 |
| Venugopal, A | 1 |
| Wood, T | 1 |
| Zhang, Y | 1 |
| Kuntz, DA | 1 |
| Coe, E | 1 |
| Trudel, S | 1 |
| Rose, D | 1 |
| Batey, RA | 1 |
| Kay, LE | 1 |
| Schimmer, AD | 1 |
| Liang, Y | 1 |
| Liu, H | 1 |
1 trial available for clioquinol and Kahler Disease
| Article | Year |
|---|---|
The antiparasitic clioquinol induces apoptosis in leukemia and myeloma cells by inhibiting histone deacetylase activity.
Topics: Antipruritics; Apoptosis; Chlorides; Clioquinol; Down-Regulation; Female; G1 Phase Cell Cycle Checkp | 2013 |
3 other studies available for clioquinol and Kahler Disease
| Article | Year |
|---|---|
Clioquinol induces pro-death autophagy in leukemia and myeloma cells by disrupting the mTOR signaling pathway.
Topics: Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Line, Tumor; Class I | 2014 |
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.
Topics: Animals; Antineoplastic Agents; Archaeal Proteins; Asian People; Cell Line, Tumor; Clioquinol; Coppe | 2009 |
Proteasome inhibitor clioquinol as a candidate drug in prophylaxis and treatment of acute graft-versus-host disease.
Topics: Bone Marrow Transplantation; Clioquinol; Enzyme Inhibitors; Graft vs Host Disease; Hematopoietic Ste | 2011 |