clioquinol has been researched along with Hepatocellular Carcinoma in 2 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol has been shown to have anticancer activity in several carcinoma cells." | 1.42 | Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol. ( Chen, L; Huang, Z; Shi, P; Wang, L; Zhang, Y, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Z | 1 |
| Wang, L | 1 |
| Chen, L | 1 |
| Zhang, Y | 1 |
| Shi, P | 1 |
| Choi, SM | 1 |
| Choi, KO | 1 |
| Park, YK | 1 |
| Cho, H | 1 |
| Yang, EG | 1 |
| Park, H | 1 |
2 other studies available for clioquinol and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Induction of cell cycle arrest via the p21, p27-cyclin E,A/Cdk2 pathway in SMMC-7721 hepatoma cells by clioquinol.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Clioquinol; Cycli | 2015 |
Clioquinol, a Cu(II)/Zn(II) chelator, inhibits both ubiquitination and asparagine hydroxylation of hypoxia-inducible factor-1alpha, leading to expression of vascular endothelial growth factor and erythropoietin in normoxic cells.
Topics: Asparagine; Carcinoma, Hepatocellular; Cell Hypoxia; Chelating Agents; Clioquinol; Copper; Cyclic AM | 2006 |