clioquinol has been researched along with Hematologic Malignancies in 1 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol is a small-molecule metal ionophore that inhibits the enzymatic activity of the proteasome and displays preclinical efficacy in hematologic malignancies in vitro and in vivo." | 9.16 | A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies. ( Ackloo, S; Booth, T; Brandwein, J; Chen, C; Chen, J; Gronda, M; Gupta, V; Jitkova, Y; Keays, S; Minden, MD; Schimmer, AD; Schuh, A; Wang, Z; Yee, K, 2012) |
| "Clioquinol is a small-molecule metal ionophore that inhibits the enzymatic activity of the proteasome and displays preclinical efficacy in hematologic malignancies in vitro and in vivo." | 5.16 | A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies. ( Ackloo, S; Booth, T; Brandwein, J; Chen, C; Chen, J; Gronda, M; Gupta, V; Jitkova, Y; Keays, S; Minden, MD; Schimmer, AD; Schuh, A; Wang, Z; Yee, K, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schimmer, AD | 1 |
| Jitkova, Y | 1 |
| Gronda, M | 1 |
| Wang, Z | 1 |
| Brandwein, J | 1 |
| Chen, C | 1 |
| Gupta, V | 1 |
| Schuh, A | 1 |
| Yee, K | 1 |
| Chen, J | 1 |
| Ackloo, S | 1 |
| Booth, T | 1 |
| Keays, S | 1 |
| Minden, MD | 1 |
1 trial available for clioquinol and Hematologic Malignancies
| Article | Year |
|---|---|
A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies.
Topics: Adult; Aged; Aged, 80 and over; Clioquinol; Drug Administration Schedule; Female; Follow-Up Studies; | 2012 |