clioquinol has been researched along with Cranial Nerve II Diseases in 13 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, dysphagia has attracted attention as a complication of SMON." | 1.48 | Tongue strength in patients with subacute myelo-optico-neuropathy. ( Ando, Y; Honda, S; Kimura, E; Konagaya, M; Nakama, T; Ueda, M; Yamashita, S, 2018) |
| "The prevalence of major depressive disorder in SMON patients was estimated by structured interview and using Beck's depression inventory (BDI) questionnaires." | 1.35 | Depression in patients with subacute myelo-optico-neuropathy (SMON). ( Fujimura, H; Funakawa, I; Hayashi, K; Hayashi, M; Kaido, M; Konishi, T; Ueno, S; Yoshida, S, 2008) |
| "Clioquinol is a hydroxyquinoline antibiotic that has been associated with severe side-effects in the CNS." | 1.31 | Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol. ( Ekblom, J; Gottfries, CG; Oreland, L; Xilinas, M; Yassin, MS, 2000) |
| " The onset of all manifestations (except toxic encephalopathy) was usually subacute, with subsequent partial recovery." | 1.26 | Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan. ( Baumgartner, G; Gawel, MJ; Kaeser, HE; Pallis, CA; Rose, FC; Schaumburg, HH; Thomas, PK; Wadia, NH, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (53.85) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, S | 2 |
| Nakama, T | 1 |
| Ueda, M | 1 |
| Honda, S | 1 |
| Kimura, E | 2 |
| Konagaya, M | 3 |
| Ando, Y | 1 |
| Konishi, T | 3 |
| Schaumburg, H | 1 |
| Herskovitz, S | 1 |
| Mao, X | 1 |
| Li, X | 1 |
| Sprangers, R | 1 |
| Wang, X | 1 |
| Venugopal, A | 1 |
| Wood, T | 1 |
| Zhang, Y | 1 |
| Kuntz, DA | 1 |
| Coe, E | 1 |
| Trudel, S | 1 |
| Rose, D | 1 |
| Batey, RA | 1 |
| Kay, LE | 1 |
| Schimmer, AD | 1 |
| Hayashi, K | 1 |
| Hayashi, M | 1 |
| Ueno, S | 1 |
| Yoshida, S | 1 |
| Fujimura, H | 1 |
| Funakawa, I | 1 |
| Kaido, M | 1 |
| Hirano, T | 1 |
| Hirai, T | 1 |
| Uchida, Y | 1 |
| Maeda, Y | 1 |
| Uchino, M | 1 |
| Kuru, S | 1 |
| Konagaya, Y | 1 |
| Matsumoto, A | 1 |
| Takase, S | 1 |
| Mizutani, T | 1 |
| Sobue, G | 1 |
| Hayabara, T | 1 |
| Iwashita, H | 1 |
| Ujihira, T | 1 |
| Miyata, K | 1 |
| Matsuoka, Y | 1 |
| Yamanaka, Y | 1 |
| Asahina, M | 1 |
| Akaogi, Y | 1 |
| Koyama, Y | 1 |
| Hattori, T | 1 |
| Yassin, MS | 1 |
| Ekblom, J | 1 |
| Xilinas, M | 1 |
| Gottfries, CG | 1 |
| Oreland, L | 1 |
| Tateishi, J | 1 |
| Baumgartner, G | 1 |
| Gawel, MJ | 1 |
| Kaeser, HE | 1 |
| Pallis, CA | 1 |
| Rose, FC | 1 |
| Schaumburg, HH | 1 |
| Thomas, PK | 1 |
| Wadia, NH | 1 |
| Chevaleraud, JP | 1 |
| Hamard, H | 1 |
1 review available for clioquinol and Cranial Nerve II Diseases
| Article | Year |
|---|---|
Subacute myelo-optico-neuropathy: clioquinol intoxication in humans and animals.
Topics: Animals; Brain Injuries; Clioquinol; Diagnosis, Differential; Disease Models, Animal; Humans; Japan; | 2000 |
12 other studies available for clioquinol and Cranial Nerve II Diseases
| Article | Year |
|---|---|
Tongue strength in patients with subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Clioquinol; Deglutition Disorders; Female; H | 2018 |
Physical Disabilities Related to the Depressive Mental States of Japanese Patients with Subacute Myelo-optico-neuropathy.
Topics: Age Factors; Aged; Aged, 80 and over; Clioquinol; Depressive Disorder; Disability Evaluation; Female | 2018 |
Copper deficiency myeloneuropathy: a clue to clioquinol-induced subacute myelo-optic neuropathy?
Topics: Animals; Chelating Agents; Clioquinol; Copper; Humans; Nerve Fibers, Myelinated; Optic Nerve; Optic | 2008 |
Clioquinol inhibits the proteasome and displays preclinical activity in leukemia and myeloma.
Topics: Animals; Antineoplastic Agents; Archaeal Proteins; Asian People; Cell Line, Tumor; Clioquinol; Coppe | 2009 |
Depression in patients with subacute myelo-optico-neuropathy (SMON).
Topics: Aged; Aged, 80 and over; Clioquinol; Depressive Disorder, Major; Female; Humans; Male; Middle Aged; | 2008 |
Cervical MRI of subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anthelmintics; Chelating Agents; Clioquinol; Copper; Female; Humans; Magnet | 2011 |
[Evaluation of neurological symptoms related to hip fracture in a 29-year longitudinal study of subacute myelo-optic-neuropathy (SMON)].
Topics: Aged; Clioquinol; Female; Femoral Neck Fractures; Humans; Longitudinal Studies; Male; Middle Aged; M | 2010 |
Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban.
Topics: Aged; Aged, 80 and over; Amebicides; Autonomic Nervous System Diseases; Blindness; Clioquinol; Cohor | 2004 |
Diminished skin vasodilator response to local heating in patients with long-standingsubacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Autonomic Dysreflexia; Autonomic Nervous System Dise | 2007 |
Changes in uptake of vitamin B(12) and trace metals in brains of mice treated with clioquinol.
Topics: Amebicides; Animals; Brain; Clioquinol; Male; Metals; Mice; Mice, Inbred Strains; Optic Nerve Diseas | 2000 |
Neurotoxicity of halogenated hydroxyquinolines: clinical analysis of cases reported outside Japan.
Topics: Adolescent; Adult; Aged; Brain Diseases; Child; Child, Preschool; Clioquinol; Dose-Response Relation | 1979 |
[Optic neuropathies].
Topics: Anti-Bacterial Agents; Antineoplastic Agents; Antitubercular Agents; Central Nervous System Agents; | 1985 |