clioquinol has been researched along with Clinically Isolated CNS Demyelinating Syndrome in 5 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 72-year-old Caucasian woman developed degeneration of the spinal cord long tracts, polyneuropathy, and optic atrophy after chronic ingestion of clioquinol (200 mg/day) since she was 45." | 3.66 | Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan. ( Cabello, A; Ortega, A; Ricoy, JR, 1982) |
| " Although clioquinol may show activity against Alzheimer's disease or malignancy, its toxic effects cause severe irreversible neurological sequelae." | 2.52 | [SMON: toxicity of clioquinol and the status quo]. ( Konagaya, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Konagaya, M | 1 |
| Ricoy, JR | 1 |
| Ortega, A | 1 |
| Cabello, A | 1 |
| Tateishi, J | 1 |
| Kuroda, S | 1 |
| Saito, A | 1 |
| Otsuki, S | 1 |
| Gendre, JP | 1 |
| Barbanel, C | 1 |
| Degos, JD | 1 |
| Le Quintrec, Y | 1 |
| Jones, EL | 1 |
| Searle, CE | 1 |
| Smith, WT | 1 |
1 review available for clioquinol and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
[SMON: toxicity of clioquinol and the status quo].
Topics: Clioquinol; Cognition; Demyelinating Diseases; Humans; Japan; Peripheral Nervous System Diseases; Sp | 2015 |
4 other studies available for clioquinol and Clinically Isolated CNS Demyelinating Syndrome
| Article | Year |
|---|---|
Subacute myelo-optic neuropathy (SMON). First neuro-pathological report outside Japan.
Topics: Aged; Brain; Clioquinol; Demyelinating Diseases; Female; Humans; Nerve Degeneration; Nerve Fibers, M | 1982 |
Experimental myelo-optic neuropathy induced by clioquinol.
Topics: Animals; Ataxia; Autopsy; Axons; Brain; Cats; Central Nervous System Diseases; Clioquinol; Demyelina | 1973 |
[Serious sensory-motor neuropathy. A case of renal failure following clioquinol absorption].
Topics: Abdomen; Autopsy; Clioquinol; Demyelinating Diseases; Drug Tolerance; Electromyography; Humans; Kidn | 1974 |
Peripheral neuropathy in ageing rats fed clioquinol and a maize diet.
Topics: Age Factors; Animals; Clioquinol; Demyelinating Diseases; Diet; Male; Peripheral Nervous System Dise | 1973 |