clioquinol has been researched along with Body Weight in 8 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When clioquinol was administered to Beagle dogs, disturbances in gait which were associated with abnormal reflexes and reactions, were seen in animals receiving 250 and 400 mg/kg body weight per day." | 3.65 | The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. ( Chesterman, H; Heywood, R; Worden, AN, 1976) |
| "Clioquinol (CQ) is a "metal protein attenuating compound" that crosses the blood-brain barrier and binds, with high affinity, copper(II) and zinc(II), two metal ions critically involved in amyloid-beta aggregation and toxicity." | 1.35 | Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease. ( Casamenti, F; Casini, A; Fiorentini, A; Francese, S; Gabbiani, C; Grossi, C; Luccarini, I; Messori, L; Moneti, G; Rosi, MC, 2009) |
| "Clioquinol treatment of transgenic Huntington's mice (R6/2) improved behavioral and pathologic phenotypes, including decreased huntingtin aggregate accumulation, decreased striatal atrophy, improved rotarod performance, reduction of weight loss, normalization of blood glucose and insulin levels, and extension of lifespan." | 1.33 | Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model. ( Hamby, A; Massa, SM; Nguyen, T, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Grossi, C | 1 |
| Francese, S | 1 |
| Casini, A | 1 |
| Rosi, MC | 1 |
| Luccarini, I | 1 |
| Fiorentini, A | 1 |
| Gabbiani, C | 1 |
| Messori, L | 1 |
| Moneti, G | 1 |
| Casamenti, F | 1 |
| Nguyen, T | 1 |
| Hamby, A | 1 |
| Massa, SM | 1 |
| Schäfer, S | 1 |
| Pajonk, FG | 1 |
| Multhaup, G | 1 |
| Bayer, TA | 1 |
| Ezzedeen, FW | 1 |
| Stohs, SJ | 1 |
| Kilzer, KL | 1 |
| Makoid, MC | 1 |
| Ezzedeen, NW | 1 |
| Heywood, R | 2 |
| Chesterman, H | 2 |
| Worden, AN | 2 |
| Prentice, DE | 1 |
| Skerrett, K | 1 |
| Thomann, PE | 1 |
| Ohshima, N | 1 |
| Kotaki, H | 1 |
| Hori, S | 1 |
| Saitoh, Y | 1 |
| Nakagawa, F | 1 |
| Tamura, Z | 1 |
| Garcia-Perez, A | 1 |
| Castro, C | 1 |
| Franco, A | 1 |
| Escribano, R | 1 |
8 other studies available for clioquinol and Body Weight
| Article | Year |
|---|---|
Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2009 |
Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.
Topics: Animals; Behavior, Animal; Blood Glucose; Body Weight; Cell Death; Cell Line; Clioquinol; Disease Mo | 2005 |
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Genetica | 2007 |
Percutaneous absorption and disposition of iodochlorhydroxyquin in dogs.
Topics: Adipose Tissue; Animals; Body Weight; Clioquinol; Dogs; Half-Life; Hydroxyquinolines; Kidney; Kineti | 1984 |
The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs.
Topics: Animals; Behavior, Animal; Body Weight; Chemical and Drug Induced Liver Injury; Clioquinol; Dogs; Fe | 1976 |
Clioquinol toxicity in the dog.
Topics: Animals; Body Weight; Clioquinol; Dogs; Female; Male; Motor Activity; Muscles; Nervous System | 1978 |
Changes in lipid peroxide concentrations in plasma and tissues by repeated administration of clioquinol to neonatal rats.
Topics: Animals; Animals, Newborn; Ataxia; Body Weight; Central Nervous System; Clioquinol; Drug Resistance; | 1988 |
A case of optic atrophy possibly induced by quinoline in acrodermatitis enteropathica.
Topics: Acrodermatitis; Alopecia; Blindness; Body Height; Body Weight; Child, Preschool; Clioquinol; Diarrhe | 1974 |