Page last updated: 2024-10-25

clioquinol and Atrophy

clioquinol has been researched along with Atrophy in 1 studies

Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cherny, RA1
Ayton, S1
Finkelstein, DI1
Bush, AI1
McColl, G1
Massa, SM1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Tolerability, and Efficacy of PBT2 in Patients With Early to Mid-stage Huntington Disease[NCT01590888]Phase 2109 participants (Actual)Interventional2012-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in Behaviour

Total Behavioural score from the Unified Huntington Disease Rating Scale. The behavioural assessment measures the frequency and severity of symptoms related to affect, thought content and coping styles. The total behaviour score is the sum of all responses, with scale range of 0 to 8. Higher scores on the behaviour assessments indicate more severe disturbance than lower scores. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionunits on a scale (Mean)
PBT2 250mg-2.3
PBT2 100mg3.0
Sugar Pill0.7

Change From Baseline in Blood Biomarkers

Biomarkers assessed primarily with mutant huntingtin protein, normalised to lysate protein concentrations, as a change from baseline. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionratio (Mean)
PBT2 250mg1.97
PBT2 100mg0.14
Sugar Pill-1.72

Change From Baseline in Blood Biomarkers

Biomarkers assessed primarily with soluble huntingtin protein, normalised to lysate protein concentrations, as a change from baseline. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionmg/mL (Mean)
PBT2 250mg-3.18
PBT2 100mg-2.09
Sugar Pill-3.07

Change From Baseline in Blood Biomarkers - Selenium

Biomarkers assessed primarily with plasma selenium as a change from baseline. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionug/L (Mean)
PBT2 250mg1.3
PBT2 100mg-6.3
Sugar Pill2.0

Change From Baseline in Brain Function (MRI)

Measure of the structural brain volume as assessed by the left caudate volume. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionmm^3 (Mean)
PBT2 250mg50.0
PBT2 100mg27.5
Sugar Pill-170.5

Change From Baseline in Brain Function (MRI)

Measure of whole brain iron concentrations. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionmm^3 (Mean)
PBT2 250mg0.0029
PBT2 100mg0.0067
Sugar Pill0.0098

Change From Baseline in Cognitive Test Battery - TMT Part B

"Trail Making Test Part B was assessed by the number of seconds to complete the test (from 0 to 240 seconds).~The Trails Making Test Part B actual change from baseline at Week 26 was analysed." (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionseconds (Mean)
PBT2 250mg-6.3
PBT2 100mg12.8
Sugar Pill8.9

Change From Baseline in Functional Abilities

"Total Functional Capacity (TFC) assessment was based on an individual's ability to perform common daily tasks. TFC score range was 0 to 13.~Higher scores on the function scales indicate better functioning than lower scores." (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionunits on a scale (Mean)
PBT2 250mg1.1
PBT2 100mg1.3
Sugar Pill1.3

Change From Baseline in Investigator Global Assessments by Efficacy Index

Global function was assessed by the Investigator using the clinical global impression (CGI) scale which included assessing the severity of illness and global improvement and calculating the efficacy index for each participant. The efficacy index aims to relate therapeutic effects to reported side effects as assessed by the Investigator (range from 0 [marked improvement and no side effects] to 4 [unchanged or worse] and side effects outweigh therapeutic effects) and is calculated for each participant by dividing the therapeutic effect score by the side effects score. An improvement is reflected by CGI scale Efficacy Index values >1. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionratio (Mean)
PBT2 250mg1.313
PBT2 100mg1.276
Sugar Pill1.176

Change From Baseline in Motor Function

Total motor score calculated from the Unified Huntington Disease Rating Scale - Motor Function. The motor section of the UHDRS assesses motor features of HD with standardized ratings of oculomotor function, dysarthria, chorea, dystonia, gait, and postural stability. The total motor impairment scores is the sum of all the individual motor ratings, with higher scores indicating more severe motor impairment than lower scores. A maximum score of 60 is possible (range 0-60). (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionunits on a scale (Mean)
PBT2 250mg-0.7
PBT2 100mg1.3
Sugar Pill-1.3

Change From Baseline in Urine Biomarkers

Biomarkers assessed primarily with 8-hydroxy-2'-deoxyguanosine, normalised to creatinine concentrations, as a change from baseline. (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionng/mL (Mean)
PBT2 250mg-0.4258
PBT2 100mg0.0832
Sugar Pill35.5302

Safety and Tolerability of PBT2 in Patients With HD

As measured by the total number of participants in each dose group who reported at least one adverse events during the study, (NCT01590888)
Timeframe: Baseline to 26 weeks

Interventionparticipants (Number)
PBT2 250mg32
PBT2 100mg30
Sugar Pill28

Change From Baseline in Cognitive Test Battery - Composite z Scores

Cognition composite z-scores were calculated for each participant. The composite scores were defined as the mean of the individual z-scores for the various cognition assessments. The Main Composite z-score was calculated for Category Fluency Test, Trail Making Test Part B, Map Search, Symbol Digit Modalities Test and Stroop Word Reading Test. The Exploratory Composite z-score was calculated for Category Fluency Test, Trail Making Test Part B, Map Search, Symbol Digit Modalities Test, Stroop Word Reading Test and Speeded Tapping test. The Executive Function Composite z-score was calculated from Category Fluency Test and Trail Making Test Part B. There is no unit of measure for the z score as it is the pure number calculated from the SD from the mean. A higher z score indicates an improvement. (NCT01590888)
Timeframe: Baseline to 26 weeks

,,
Interventionz score (Mean)
Main Composite z-scoreExploratory Composite z-scoreExecutive Function z-score
PBT2 100mg-0.0413-0.0287-0.1026
PBT2 250mg0.05920.05300.2274
Sugar Pill-0.0194-0.01440.0553

Other Studies

1 other study available for clioquinol and Atrophy

ArticleYear
PBT2 Reduces Toxicity in a C. elegans Model of polyQ Aggregation and Extends Lifespan, Reduces Striatal Atrophy and Improves Motor Performance in the R6/2 Mouse Model of Huntington's Disease.
    Journal of Huntington's disease, 2012, Volume: 1, Issue:2

    Topics: Animals; Atrophy; Caenorhabditis elegans; Clioquinol; Corpus Striatum; Disease Susceptibility; Dose-

2012