clioquinol has been researched along with Ataxia in 6 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Ataxia: Impairment of the ability to perform smoothly coordinated voluntary movements. This condition may affect the limbs, trunk, eyes, pharynx, larynx, and other structures. Ataxia may result from impaired sensory or motor function. Sensory ataxia may result from posterior column injury or PERIPHERAL NERVE DISEASES. Motor ataxia may be associated with CEREBELLAR DISEASES; CEREBRAL CORTEX diseases; THALAMIC DISEASES; BASAL GANGLIA DISEASES; injury to the RED NUCLEUS; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-treated dogs had proprioceptive loss involving both fore- and hindquarters, characterized by stiff, spastic, dysmetric leg movements." | 1.26 | The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. I. Clinical disease. ( Carlton, WW; Hoover, DM, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tamura, Z | 4 |
| Kotaki, H | 3 |
| Nakajima, K | 2 |
| Tanimura, Y | 2 |
| Saitoh, Y | 3 |
| Nakagawa, F | 3 |
| Goto, M | 1 |
| Akahane, K | 1 |
| Ono, H | 1 |
| Kaneko, T | 1 |
| Fukuda, H | 1 |
| Nagashima, K | 1 |
| Hoover, DM | 1 |
| Carlton, WW | 1 |
| Ohshima, N | 1 |
| Hori, S | 1 |
| Tateishi, J | 1 |
| Kuroda, S | 1 |
| Saito, A | 1 |
| Otsuki, S | 1 |
6 other studies available for clioquinol and Ataxia
| Article | Year |
|---|---|
clioquinol causes ataxia in rats.
Topics: Animals; Ataxia; Clioquinol; Injections, Intraperitoneal; Rats; Species Specificity | 1982 |
Deterioration of spinal reflex in beagles orally ingesting clioquinol.
Topics: Administration, Oral; Animals; Ataxia; Clioquinol; Dogs; Electromyography; Female; Muscle Contractio | 1982 |
Appearance of intoxication in rats by intraperitoneal administration of clioquinol.
Topics: Animals; Ataxia; Clioquinol; Hydroxyquinolines; Injections, Intraperitoneal; Male; Nervous System Di | 1983 |
The subacute neurotoxicity of excess pyridoxine HCl and clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. I. Clinical disease.
Topics: Animals; Ataxia; Blood Cell Count; Blood Proteins; Clioquinol; Diarrhea; Dogs; Eating; Female; Male; | 1981 |
Changes in lipid peroxide concentrations in plasma and tissues by repeated administration of clioquinol to neonatal rats.
Topics: Animals; Animals, Newborn; Ataxia; Body Weight; Central Nervous System; Clioquinol; Drug Resistance; | 1988 |
Experimental myelo-optic neuropathy induced by clioquinol.
Topics: Animals; Ataxia; Autopsy; Axons; Brain; Cats; Central Nervous System Diseases; Clioquinol; Demyelina | 1973 |