clioquinol has been researched along with Amyotrophic Lateral Sclerosis in 1 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Recently, dysphagia has attracted attention as a complication of SMON." | 1.48 | Tongue strength in patients with subacute myelo-optico-neuropathy. ( Ando, Y; Honda, S; Kimura, E; Konagaya, M; Nakama, T; Ueda, M; Yamashita, S, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yamashita, S | 1 |
| Nakama, T | 1 |
| Ueda, M | 1 |
| Honda, S | 1 |
| Kimura, E | 1 |
| Konagaya, M | 1 |
| Ando, Y | 1 |
1 other study available for clioquinol and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Tongue strength in patients with subacute myelo-optico-neuropathy.
Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Clioquinol; Deglutition Disorders; Female; H | 2018 |