clioquinol has been researched along with Amyloid Deposits in 10 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Clioquinol is a drug that acts on amyloid by perturbing amyloid's metallo-chemistry, and Clioquinol treatment has been shown to be beneficial in a mouse model of AD." | 2.41 | '...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease. ( Melov, S, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 8 (80.00) | 29.6817 |
| 2010's | 2 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, YH | 1 |
| Raymick, J | 1 |
| Sarkar, S | 1 |
| Lahiri, DK | 1 |
| Ray, B | 1 |
| Holtzman, D | 1 |
| Dumas, M | 1 |
| Schmued, LC | 1 |
| Bolognin, S | 2 |
| Zatta, P | 2 |
| Drago, D | 2 |
| Tognon, G | 1 |
| Parnigotto, PP | 1 |
| Ricchelli, F | 1 |
| Sensi, SL | 1 |
| Wang, T | 1 |
| Wang, CY | 1 |
| Shan, ZY | 1 |
| Teng, WP | 1 |
| Wang, ZY | 1 |
| Schäfer, S | 1 |
| Pajonk, FG | 1 |
| Multhaup, G | 1 |
| Bayer, TA | 1 |
| Filiz, G | 1 |
| Price, KA | 1 |
| Caragounis, A | 1 |
| Du, T | 1 |
| Crouch, PJ | 1 |
| White, AR | 1 |
| Helmuth, L | 1 |
| Gouras, GK | 1 |
| Beal, MF | 1 |
| Cherny, RA | 1 |
| Atwood, CS | 1 |
| Xilinas, ME | 1 |
| Gray, DN | 1 |
| Jones, WD | 1 |
| McLean, CA | 1 |
| Barnham, KJ | 1 |
| Volitakis, I | 1 |
| Fraser, FW | 1 |
| Kim, Y | 1 |
| Huang, X | 1 |
| Goldstein, LE | 1 |
| Moir, RD | 1 |
| Lim, JT | 1 |
| Beyreuther, K | 1 |
| Zheng, H | 1 |
| Tanzi, RE | 1 |
| Masters, CL | 1 |
| Bush, AI | 1 |
| Melov, S | 1 |
4 reviews available for clioquinol and Amyloid Deposits
| Article | Year |
|---|---|
Alzheimer's disease, metal ions and metal homeostatic therapy.
Topics: Alzheimer Disease; Animals; Clioquinol; Homeostasis; Humans; Metals; Plaque, Amyloid | 2009 |
The role of metals in modulating metalloprotease activity in the AD brain.
Topics: Alzheimer Disease; Amyloid; Amyloid beta-Peptides; Animals; Brain; Cell Culture Techniques; Chelatin | 2008 |
Metal chelator decreases Alzheimer beta-amyloid plaques.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Chelating Agents; Clioquinol; Plaque, Amyloid | 2001 |
'...and C is for Clioquinol' - the AbetaCs of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Chelating Agents; Clioquinol; Disease Models, Ani | 2002 |
6 other studies available for clioquinol and Amyloid Deposits
| Article | Year |
|---|---|
Efficacy and toxicity of clioquinol treatment and A-beta42 inoculation in the APP/PSI mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Ant | 2013 |
Mutual stimulation of beta-amyloid fibrillogenesis by clioquinol and divalent metals.
Topics: Alzheimer Disease; Amino Acid Substitution; Amyloid beta-Peptides; Animals; Cell Line, Tumor; Chelat | 2008 |
Clioquinol reduces zinc accumulation in neuritic plaques and inhibits the amyloidogenic pathway in AβPP/PS1 transgenic mouse brain.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Chelating | 2012 |
Copper and clioquinol treatment in young APP transgenic and wild-type mice: effects on life expectancy, body weight, and metal-ion levels.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Animals, Genetica | 2007 |
Neuroscience. An antibiotic to treat Alzheimer's?
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Clinical Trials, Phase II as Topic; Clioqu | 2000 |
Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer's disease transgenic mice.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Animals; Chelating Agents; Clioquinol; Copper | 2001 |