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clioquinol and Aging

clioquinol has been researched along with Aging in 8 studies

Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research Excerpts

ExcerptRelevanceReference
"Clioquinol is a metal chelator that has beneficial effects in several cellular and animal models of neurodegenerative diseases as well as on Alzheimer disease patients."5.35The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. ( Branicky, R; Carroll, M; Guimond, MP; Hayes, S; Hekimi, S; Hihi, A; McBride, K; Stepanyan, Z; Wang, Y, 2009)
" We also describe how the development of therapeutic agents designed to modulate metal bioavailability has provided promising results in the treatment of Alzheimer's disease."2.43Therapeutic treatments for Alzheimer's disease based on metal bioavailability. ( Barnham, KJ; Bush, AI; Crouch, PJ; White, AR, 2006)
" The present study was designed to investigate the effect of metal ionophores on long term administration of zinc in D-galactose induced senescent mice."1.43Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice. ( Bharti, K; Majeed, AB; Prakash, A, 2016)
"Clioquinol is a metal chelator that has beneficial effects in several cellular and animal models of neurodegenerative diseases as well as on Alzheimer disease patients."1.35The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1. ( Branicky, R; Carroll, M; Guimond, MP; Hayes, S; Hekimi, S; Hihi, A; McBride, K; Stepanyan, Z; Wang, Y, 2009)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's3 (37.50)29.6817
2010's3 (37.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Pretsch, D1
Rollinger, JM1
Schmid, A1
Genov, M1
Wöhrer, T1
Krenn, L1
Moloney, M1
Kasture, A1
Hummel, T1
Pretsch, A1
Konishi, T1
Hayashi, K1
Sugiyama, H1
Adlard, PA1
Sedjahtera, A1
Gunawan, L1
Bray, L1
Hare, D1
Lear, J1
Doble, P1
Bush, AI2
Finkelstein, DI1
Cherny, RA1
Bharti, K1
Majeed, AB1
Prakash, A1
Wang, Y1
Branicky, R1
Stepanyan, Z1
Carroll, M1
Guimond, MP1
Hihi, A1
Hayes, S1
McBride, K1
Hekimi, S1
Kaur, D1
Rajagopalan, S1
Andersen, JK1
Crouch, PJ1
Barnham, KJ1
White, AR1
Matsuda, M1
Yanagisawa, N1
Tsukada, N1

Reviews

1 review available for clioquinol and Aging

ArticleYear
Therapeutic treatments for Alzheimer's disease based on metal bioavailability.
    Drug news & perspectives, 2006, Volume: 19, Issue:8

    Topics: Aging; Alzheimer Disease; Amyloid beta-Peptides; Animals; Biological Availability; Brain; Clioquinol

2006

Other Studies

7 other studies available for clioquinol and Aging

ArticleYear
Prolongation of metallothionein induction combats Aß and α-synuclein toxicity in aged transgenic Caenorhabditis elegans.
    Scientific reports, 2020, 07-16, Volume: 10, Issue:1

    Topics: Aging; alpha-Synuclein; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modi

2020
The Aggravation of Depression with Aging in Japanese Patients with Subacute Myelo-optico-neuropathy (SMON).
    Internal medicine (Tokyo, Japan), 2017, Aug-15, Volume: 56, Issue:16

    Topics: Aged; Aged, 80 and over; Aging; Asian People; Clioquinol; Depressive Disorder; Female; Humans; Male;

2017
A novel approach to rapidly prevent age-related cognitive decline.
    Aging cell, 2014, Volume: 13, Issue:2

    Topics: Aging; Animals; Behavior, Animal; Biomarkers; Cell Count; Clioquinol; Cognition Disorders; Dendritic

2014
Possible role of metal ionophore against zinc induced cognitive dysfunction in D-galactose senescent mice.
    Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2016, Volume: 29, Issue:3

    Topics: Administration, Oral; Aging; Amyloid beta-Peptides; Animals; Clioquinol; Cognition Disorders; Dose-R

2016
The anti-neurodegeneration drug clioquinol inhibits the aging-associated protein CLK-1.
    The Journal of biological chemistry, 2009, Jan-02, Volume: 284, Issue:1

    Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chelating Agents; Clioquino

2009
Chronic expression of H-ferritin in dopaminergic midbrain neurons results in an age-related expansion of the labile iron pool and subsequent neurodegeneration: implications for Parkinson's disease.
    Brain research, 2009, Nov-10, Volume: 1297

    Topics: Aging; Animals; Apoferritins; Chelating Agents; Clioquinol; Dopamine; Gene Expression Regulation; Ir

2009
[Subsets of peripheral blood lymphocytes and ageing in patients with SMON].
    Arerugi = [Allergy], 1991, Volume: 40, Issue:9

    Topics: Aged; Aging; Clioquinol; Humans; Leukocyte Count; Lymphocyte Subsets; Middle Aged; Myelitis; Nervous

1991