clioquinol has been researched along with Age-Related Memory Disorders in 6 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Further drug-like property analysis demonstrated that the optimized compound, 8d (WI-1758), had liver microsomal metabolic stability, was well tolerated (>2000 mg/kg), and had a rational pharmacokinetic profile, as well as an oral bioavailability of 14." | 1.48 | Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease. ( Chan, ASC; Feng, X; Hu, J; Huang, L; Li, X; Wang, Z; Yang, X, 2018) |
| "Clioquinol (CQ) is a "metal protein attenuating compound" that crosses the blood-brain barrier and binds, with high affinity, copper(II) and zinc(II), two metal ions critically involved in amyloid-beta aggregation and toxicity." | 1.35 | Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease. ( Casamenti, F; Casini, A; Fiorentini, A; Francese, S; Gabbiani, C; Grossi, C; Luccarini, I; Messori, L; Moneti, G; Rosi, MC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, Z | 2 |
| Hu, J | 1 |
| Yang, X | 2 |
| Feng, X | 2 |
| Li, X | 1 |
| Huang, L | 1 |
| Chan, ASC | 1 |
| Cao, M | 1 |
| Xiang, H | 1 |
| Wang, W | 1 |
| Cahoon, L | 1 |
| Grossi, C | 1 |
| Francese, S | 1 |
| Casini, A | 1 |
| Rosi, MC | 1 |
| Luccarini, I | 1 |
| Fiorentini, A | 1 |
| Gabbiani, C | 1 |
| Messori, L | 1 |
| Moneti, G | 1 |
| Casamenti, F | 1 |
| Bareggi, SR | 1 |
| Braida, D | 1 |
| Pollera, C | 1 |
| Bondiolotti, G | 1 |
| Formentin, E | 1 |
| Puricelli, M | 1 |
| Poli, G | 1 |
| Ponti, W | 1 |
| Sala, M | 1 |
| Ferrier, TM | 1 |
| Eadie, MJ | 1 |
6 other studies available for clioquinol and Age-Related Memory Disorders
| Article | Year |
|---|---|
Design, Synthesis, and Evaluation of Orally Bioavailable Quinoline-Indole Derivatives as Innovative Multitarget-Directed Ligands: Promotion of Cell Proliferation in the Adult Murine Hippocampus for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Proliferation; Drug Des | 2018 |
WBQ5187, a Multitarget Directed Agent, Ameliorates Cognitive Impairment in a Transgenic Mouse Model of Alzheimer's Disease and Modulates Cerebral β-Amyloid, Gliosis, cAMP Levels, and Neurodegeneration.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Anesthetics, General; Animals; Benzofurans; Biological Ava | 2019 |
The curious case of clioquinol.
Topics: Alzheimer Disease; Anti-Infective Agents, Local; Blindness; Clioquinol; Humans; Japan; Memory; Memor | 2009 |
Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Anim | 2009 |
Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters.
Topics: Analysis of Variance; Animals; Antioxidants; Avoidance Learning; Biogenic Amines; Brain; Chelating A | 2009 |
Clioquinol encephalopathy.
Topics: Adult; Brain Diseases; Clioquinol; Cognition Disorders; Female; Headache; Humans; Male; Memory Disor | 1973 |