clioquinol has been researched along with Acute Liver Injury, Drug-Induced in 5 studies
Clioquinol: A potentially neurotoxic 8-hydroxyquinoline derivative long used as a topical anti-infective, intestinal antiamebic, and vaginal trichomonacide. The oral preparation has been shown to cause subacute myelo-optic neuropathy and has been banned worldwide.
5-chloro-7-iodoquinolin-8-ol : A monohydroxyquinoline that is quinolin-8-ol in which the hydrogens at positions 5 and 7 are replaced by chlorine and iodine, respectively. It has antibacterial and atifungal properties, and is used in creams for the treatment of skin infections. It has also been investigated as a chelator of copper and zinc ions for the possible treatment of Alzheimer's disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "When clioquinol was administered to Beagle dogs, disturbances in gait which were associated with abnormal reflexes and reactions, were seen in animals receiving 250 and 400 mg/kg body weight per day." | 3.65 | The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs. ( Chesterman, H; Heywood, R; Worden, AN, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 1 |
| van Staden, CJ | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Afshari, CA | 1 |
| Hamadeh, HK | 1 |
| Heywood, R | 1 |
| Chesterman, H | 1 |
| Worden, AN | 1 |
| Watanabe, S | 1 |
| Tateishi, J | 1 |
| Kuroda, S | 1 |
| Otsuki, S | 1 |
| Ogata, M | 1 |
| Hayakawa, K | 1 |
5 other studies available for clioquinol and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
The oral toxicity of clioquinol (5-chloro-7-iodo-8-hydroxyquinoline) in beagle dogs.
Topics: Animals; Behavior, Animal; Body Weight; Chemical and Drug Induced Liver Injury; Clioquinol; Dogs; Fe | 1976 |
Distribution of clioquinol in rats with hepatic dysfunction.
Topics: Animals; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Clioquinol; Fatty Liver; Iodi | 1973 |
[Experimental studies of influence of hepatic insufficiency on pathogenesis of S.M.O.N. (subacute myelo-optico neuropathy) caused by chinoform administration in dogs (author's transl)].
Topics: Administration, Oral; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injur | 1974 |