clinprost has been researched along with Gangrene* in 1 studies
1 other study(ies) available for clinprost and Gangrene
| Article | Year |
|---|---|
Effect of isocarbacyclin methyl ester incorporated in lipid microspheres on experimental models of peripheral obstructive disease.
The effect of TTC-909 (isocarbacyclin methyl ester (CAS 88931-51-5, TEI-9090) incorporated into lipid microspheres) on obstruction of the peripheral artery was studied in two different animal models. The first was a peripheral occlusion model induced by intra-arterial injection of sodium laurate in rats. The second was a tail gangrene model induced by subcutaneous injection of both ergotamine and epinephrine in rats. Intravenous bolus-administered TTC-909 at 1.0 microgram/kg resulted in the inhibition of both progression of lesions induced by sodium laurate and the extension of tail gangrene by ergotamine and epinephrine. Moreover, the inhibitory effect of TTC-909 was more potent than that of PGE1 (LM) (prostaglandin E1 incorporated into lipid microspheres). These findings suggested that TTC-909 may be clinically useful for the therapy of peripheral vascular disorders such as thromboangiitis obliterans (TAO) and atherosclerosis obliterans (ASO). Topics: Alprostadil; Animals; Drug Carriers; Epinephrine; Epoprostenol; Ergotamine; Gangrene; Lauric Acids; Liposomes; Male; Peripheral Vascular Diseases; Rats; Rats, Wistar; Tail; Vasodilator Agents | 1995 |