clindamycin-phosphate and Lung-Neoplasms

There are few reports on concentrations of antibiotics in human lung tissues. The concentrations of clindamycin (CLDM) in human lung tissues were determined in 11 patients with lung tumor who were treated with the antibiotic. In the case of 600 mg drip infusion for 1 hour, the concentrations of CLDM in lung tissues were 24 micrograms/g and 23 micrograms/g, 2 and 3 hours after the start of drip infusion, respectively. In the case of 1,200 mg drip infusion, the value reached 47 micrograms/g in 2 hours and 39 micrograms/g in 3 hours. The concentrations in lung tissues were about 4-5 times higher than in blood.

Topics: Aged; Clindamycin; Female; Humans; Infusions, Parenteral; Lung; Lung Neoplasms; Male; Middle Aged