clenbuterol has been researched along with Cardiac Hypertrophy in 7 studies
Clenbuterol: A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
clenbuterol : A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.
Cardiac Hypertrophy: Enlargement of the HEART due to chamber HYPERTROPHY, an increase in wall thickness without an increase in the number of cells (MYOCYTES, CARDIAC). It is the result of increase in myocyte size, mitochondrial and myofibrillar mass, as well as changes in extracellular matrix.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The beta 2-adrenoceptor agonist clenbuterol was used to investigate its potential to selectively induce skeletal muscle hypertrophy, particularly the latissimus dorsi muscle (LDM), independent of adverse effects on cardiac muscle." | 7.69 | Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. ( Boheler, KR; Petrou, M; Wynne, DG; Yacoub, MH, 1995) |
| " When rats were fed with clenbuterol for 7 days skeletal muscle mass increased by 21% in the tonic soleus and phasic plantaris muscles and a 16% hypertrophy of the heart was also induced." | 7.68 | Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. ( Bain, P; Delday, MI; Maltin, CA; McMillan, DN; Noble, BS; Palmer, RM, 1990) |
| " We have studied the induction of cardiac hypertrophy after treatment with clenbuterol and the role of polyamines in this effect." | 3.70 | Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse. ( Balaña-Fouce, R; Cubría, JC; Ordóñez, C; Ordóñez, D; Reguera, R, 1998) |
| " The beta 2-adrenoceptor agonist clenbuterol was used to investigate its potential to selectively induce skeletal muscle hypertrophy, particularly the latissimus dorsi muscle (LDM), independent of adverse effects on cardiac muscle." | 3.69 | Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes. ( Boheler, KR; Petrou, M; Wynne, DG; Yacoub, MH, 1995) |
| " When rats were fed with clenbuterol for 7 days skeletal muscle mass increased by 21% in the tonic soleus and phasic plantaris muscles and a 16% hypertrophy of the heart was also induced." | 3.68 | Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. ( Bain, P; Delday, MI; Maltin, CA; McMillan, DN; Noble, BS; Palmer, RM, 1990) |
| "Clenbuterol treatment resulted in increased cell size of cardiac myocytes with increased protein accumulation and myofibrillar organisation characteristic of hypertrophic growth." | 1.36 | Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1. ( Barton, PJ; Bhavsar, PK; Brand, NJ; Cullen, ME; Felkin, LE; Luther, PK; Yacoub, MH, 2010) |
| "Clenbuterol treatment induced rapid development of cardiac hypertrophy with increased muscle mass at day 1 and elevated heart rate and QT interval throughout the 28-day period." | 1.35 | A gene expression profile of the myocardial response to clenbuterol. ( Barton, PJ; Felkin, LE; Lara-Pezzi, E; Smolenski, RT; Soppa, GK; Terracciano, CM; Yacoub, MH, 2009) |
| "Appropriate cardiac hypertrophy (CH) is necessary in several clinical settings, such as pulmonary artery banding in the two-stage arterial switch operation for transposition of the great arteries." | 1.30 | Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression. ( Boheler, KR; Petrou, M; Wong, K; Yacoub, MH, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lara-Pezzi, E | 1 |
| Terracciano, CM | 1 |
| Soppa, GK | 1 |
| Smolenski, RT | 1 |
| Felkin, LE | 2 |
| Yacoub, MH | 4 |
| Barton, PJ | 2 |
| Bhavsar, PK | 1 |
| Brand, NJ | 1 |
| Luther, PK | 1 |
| Cullen, ME | 1 |
| Petrou, M | 2 |
| Wynne, DG | 1 |
| Boheler, KR | 2 |
| Wong, K | 1 |
| Cubría, JC | 1 |
| Reguera, R | 1 |
| Balaña-Fouce, R | 1 |
| Ordóñez, C | 1 |
| Ordóñez, D | 1 |
| Murphy, RJ | 1 |
| Béliveau, L | 1 |
| Gardiner, PF | 1 |
| Calderone, A | 1 |
| Palmer, RM | 1 |
| Delday, MI | 1 |
| McMillan, DN | 1 |
| Noble, BS | 1 |
| Bain, P | 1 |
| Maltin, CA | 1 |
7 other studies available for clenbuterol and Cardiac Hypertrophy
| Article | Year |
|---|---|
A gene expression profile of the myocardial response to clenbuterol.
Topics: Adrenergic beta-Agonists; Animals; Cardiomegaly; Cell Proliferation; Cells, Cultured; Clenbuterol; E | 2009 |
Clenbuterol induces cardiac myocyte hypertrophy via paracrine signalling and fibroblast-derived IGF-1.
Topics: Actins; Adrenergic beta-2 Receptor Agonists; Animals; Animals, Newborn; Atrial Natriuretic Factor; B | 2010 |
Clenbuterol induces hypertrophy of the latissimus dorsi muscle and heart in the rat with molecular and phenotypic changes.
Topics: Adipose Tissue; Animals; Base Sequence; Body Weight; Cardiomegaly; Clenbuterol; Forelimb; Hypertroph | 1995 |
Pharmacological modulation of pressure-overload cardiac hypertrophy: changes in ventricular function, extracellular matrix, and gene expression.
Topics: Analysis of Variance; Animals; Blood Pressure; Calcium-Transporting ATPases; Cardiomegaly; Clenbuter | 1997 |
Polyamine-mediated heart hypertrophy induced by clenbuterol in the mouse.
Topics: Adrenergic beta-Agonists; Animals; Body Weight; Cardiomegaly; Clenbuterol; Heart; Male; Mice; Mice, | 1998 |
Nifedipine does not impede clenbuterol-stimulated muscle hypertrophy.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Body Weight; Calcium; Calcium Channels; Calcium C | 1999 |
Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cardiomegaly; Clenbuterol; Cyclooxygenase Inhibito | 1990 |