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clenbuterol and Atrophy, Muscle

clenbuterol has been researched along with Atrophy, Muscle in 33 studies

Clenbuterol: A substituted phenylaminoethanol that has beta-2 adrenomimetic properties at very low doses. It is used as a bronchodilator in asthma.
clenbuterol : A substituted aniline that is 2,6-dichloroaniline in which the hydrogen at position 4 has been replaced by a 2-(tert-butylamino)-1-hydroxyethyl group.

Research Excerpts

ExcerptRelevanceReference
" We reported that clenbuterol (CB) induced masseter muscle hypertrophy and slow-to-fast myosin heavy chain (MHC) isoform transition through direct muscle β2-adrenergic receptor stimulation."3.81Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition. ( Fujita, T; Mototani, Y; Nakamura, Y; Ohnuki, Y; Okumura, S; Saeki, Y; Shiozawa, K; Suita, K; Umeki, D, 2015)
"The effects of clenbuterol, a beta 2-adrenergic agonist, on body weight, tissue masses, and protein and RNA contents were studied following scald injury (30 per cent TBSA) in the rat."3.68Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat. ( Fisher, MI; Little, RA; Martineau, L; Rothwell, NJ, 1993)
"The effects of a beta 2-adrenoceptor agonist, clenbuterol, on body weight and protein metabolism of gastrocnemius muscle, heart, and liver were studied in rats subjected to 50% food restriction or fasting."3.68Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat. ( Choo, JJ; Horan, MA; Little, RA; Rothwell, NJ, 1990)
"The attenuated muscle atrophy found with clenbuterol in the present study provides cellular evidence for the reported change in muscle strength after its administration after knee surgery."2.70Clenbuterol in the prevention of muscle atrophy: a study of hindlimb-unweighted rats. ( Dykstra, DD; Herrera, NM; Thompson, LV; Zimmerman, AN, 2001)
"Uremic sarcopenia is caused by ageing, malnutrition, and chronic inflammation, but the molecular mechanism and potential therapeutics have not been fully elucidated yet."1.62β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice. ( Higashihara, T; Inagi, R; Maruyama, T; Nangaku, M; Nishi, H; Takemura, K; Tanaka, T; Watanabe, H, 2021)
"Clenbuterol has been used to alleviate chronic obstructive pulmonary disease and elicit an anabolic response in muscles."1.42Negative effect of clenbuterol on physical capacities and neuromuscular control of muscle atrophy in adult rats. ( Bisson, JF; Dernoncourt, V; Lang, G, 2015)
"Clenbuterol treatment induced growth by 27-41% in normal rats and attenuated muscle loss during hindlimb suspension by 10-20%."1.34Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol. ( Bodine, SC; Kline, WO; Panaro, FJ; Yang, H, 2007)
"Clenbuterol has been shown to ameliorate denervation-induced atrophy and, therefore, clearly has therapeutic potential in the treatment of muscle wasting conditions in man."1.28Denervation increases clenbuterol sensitivity in muscle from young rats. ( Baillie, AG; Delday, MI; Hay, SM; Maltin, CA, 1992)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19903 (9.09)18.7374
1990's10 (30.30)18.2507
2000's13 (39.39)29.6817
2010's4 (12.12)24.3611
2020's3 (9.09)2.80

Authors

AuthorsStudies
Hu, D1
Li, H1
Yu, H1
Zhao, M1
Ye, L1
Liu, B1
Ge, N1
Dong, N1
Wu, L1
Suzuki, H1
Yoshikawa, Y1
Tsujimoto, H1
Kitaura, T1
Muraoka, I1
Higashihara, T1
Nishi, H1
Takemura, K1
Watanabe, H1
Maruyama, T1
Inagi, R1
Tanaka, T1
Nangaku, M1
Lang, G1
Dernoncourt, V1
Bisson, JF1
Umeki, D1
Ohnuki, Y1
Mototani, Y1
Shiozawa, K1
Suita, K1
Fujita, T1
Nakamura, Y1
Saeki, Y1
Okumura, S1
Cancelliero, KM1
Durigan, JL1
Vieira, RP1
Silva, CA1
Polacow, ML1
Ung, RV1
Rouleau, P1
Guertin, PA1
Gonçalves, DA1
Silveira, WA1
Lira, EC1
Graça, FA1
Paula-Gomes, S1
Zanon, NM1
Kettelhut, IC1
Navegantes, LC1
Dodd, SL2
Koesterer, TJ1
Agrawal, S1
Thakur, P1
Katoch, SS1
Yimlamai, T1
Borst, SE1
Park, S1
Hinkle, RT1
Dolan, E1
Cody, DB1
Bauer, MB1
Isfort, RJ1
Kline, WO1
Panaro, FJ1
Yang, H1
Bodine, SC1
Martineau, L1
Little, RA4
Rothwell, NJ4
Fisher, MI1
Maltin, CA4
Delday, MI4
Watson, JS1
Heys, SD1
Nevison, IM1
Ritchie, IK1
Gibson, PH1
Apseloff, G1
Girten, B1
Walker, M1
Shepard, DR1
Krecic, ME1
Stern, LS1
Gerber, N1
Jiang, TX1
Cairns, A1
Road, JD1
Wilcox, PG1
Carbó, N1
López-Soriano, J1
Tarragó, T1
González, O1
Llovera, M1
López-Soriano, FJ1
Argilés, JM1
Jiang, G1
Gu, Y1
Zhang, L1
Ricart-Firinga, C1
Stevens, L1
Canu, MH1
Nemirovskaya, TL1
Mounier, Y1
Sneddon, AA1
Chen, KD1
Alway, SE1
Herrera, NM1
Zimmerman, AN1
Dykstra, DD1
Thompson, LV1
Cockman, MD1
Jones, MB1
Prenger, MC1
Sheldon, RJ1
Frerichs, O1
Fansa, H1
Ziems, P1
Schneider, W1
Keilhoff, G1
Wineski, LE1
von Deutsch, DA1
Abukhalaf, IK1
Pitts, SA1
Potter, DE1
Paulsen, DF1
Agbenyega, ET1
Wareham, AC1
Hay, SM2
Baillie, AG1
Choo, JJ3
Horan, MA3
Wareham, A1
Babij, P1
Booth, FW1
Reeds, PJ1
Smith, FG1
Lobley, GE1

Trials

3 trials available for clenbuterol and Atrophy, Muscle

ArticleYear
Clenbuterol, a beta-adrenoceptor agonist, increases relative muscle strength in orthopaedic patients.
    Clinical science (London, England : 1979), 1993, Volume: 84, Issue:6

    Topics: Adult; Clenbuterol; Double-Blind Method; Humans; Knee Joint; Male; Menisci, Tibial; Muscle Contracti

1993
[The effects of clenbuterol on intramuscular collagen metabolism in denervated muscle].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 1998, Volume: 12, Issue:1

    Topics: Adolescent; Adrenergic beta-Agonists; Adult; Arm; Brachial Plexus; Clenbuterol; Collagen; Denervatio

1998
Clenbuterol in the prevention of muscle atrophy: a study of hindlimb-unweighted rats.
    Archives of physical medicine and rehabilitation, 2001, Volume: 82, Issue:7

    Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Clenbuterol; Hindlimb Suspension; Muscular

2001

Other Studies

30 other studies available for clenbuterol and Atrophy, Muscle

ArticleYear
Clenbuterol Prevents Mechanical Unloading-Induced Myocardial Atrophy via Upregulation of Transient Receptor Potential Channel-3.
    International heart journal, 2023, Volume: 64, Issue:5

    Topics: Animals; Clenbuterol; Humans; Muscular Atrophy; Myocardium; Myocytes, Cardiac; Rats; Transient Recep

2023
Clenbuterol accelerates recovery after immobilization-induced atrophy of rat hindlimb muscle.
    Acta histochemica, 2020, Volume: 122, Issue:1

    Topics: Animals; Clenbuterol; Hindlimb Suspension; Male; Muscle Fibers, Skeletal; Muscular Atrophy; Rats; Ra

2020
β2-adrenergic receptor agonist counteracts skeletal muscle atrophy and oxidative stress in uremic mice.
    Scientific reports, 2021, 04-28, Volume: 11, Issue:1

    Topics: Adrenergic beta-2 Receptor Agonists; Animals; Ascorbic Acid; Cell Size; Clenbuterol; Female; Indican

2021
Negative effect of clenbuterol on physical capacities and neuromuscular control of muscle atrophy in adult rats.
    Muscle & nerve, 2015, Volume: 52, Issue:6

    Topics: Analysis of Variance; Animals; Bronchodilator Agents; Clenbuterol; Disease Models, Animal; Explorato

2015
Protective Effects of Clenbuterol against Dexamethasone-Induced Masseter Muscle Atrophy and Myosin Heavy Chain Transition.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: Administration, Oral; Animals; Body Weight; Clenbuterol; Dexamethasone; Energy Metabolism; Feeding B

2015
The effect of a low dose of clenbuterol on rat soleus muscle submitted to joint immobilization.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:12

    Topics: Adrenergic beta-Agonists; Animals; Clenbuterol; Connective Tissue; Glycogen; Immobilization; Male; M

2008
Effects of co-administration of clenbuterol and testosterone propionate on skeletal muscle in paraplegic mice.
    Journal of neurotrauma, 2010, Volume: 27, Issue:6

    Topics: Adrenergic beta-Agonists; Analysis of Variance; Androgens; Animals; Body Weight; Clenbuterol; Drug I

2010
Clenbuterol suppresses proteasomal and lysosomal proteolysis and atrophy-related genes in denervated rat soleus muscles independently of Akt.
    American journal of physiology. Endocrinology and metabolism, 2012, Jan-01, Volume: 302, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Cathepsin L; Clenbuterol; Cyclic AMP-Dependent Protein Kinases; E

2012
Clenbuterol attenuates muscle atrophy and dysfunction in hindlimb-suspended rats.
    Aviation, space, and environmental medicine, 2002, Volume: 73, Issue:7

    Topics: Adrenergic beta-Agonists; Animals; Body Weight; Calcium-Transporting ATPases; Clenbuterol; Disease M

2002
Beta adrenoceptor agonists, clenbuterol, and isoproterenol retard denervation atrophy in rat gastrocnemius muscle: use of 3-methylhistidine as a marker of myofibrillar degeneration.
    The Japanese journal of physiology, 2003, Volume: 53, Issue:3

    Topics: Acid Phosphatase; Adrenergic beta-Agonists; Alkaline Phosphatase; Amino Acids; Animals; Biomarkers;

2003
Clenbuterol induces muscle-specific attenuation of atrophy through effects on the ubiquitin-proteasome pathway.
    Journal of applied physiology (Bethesda, Md. : 1985), 2005, Volume: 99, Issue:1

    Topics: Administration, Oral; Animals; Clenbuterol; Female; Gene Expression Regulation; Hindlimb Suspension;

2005
Phosphodiesterase 4 inhibition reduces skeletal muscle atrophy.
    Muscle & nerve, 2005, Volume: 32, Issue:6

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adrenergic beta-Agonists; Analysis of Variance; Animals; Clenbu

2005
Rapamycin inhibits the growth and muscle-sparing effects of clenbuterol.
    Journal of applied physiology (Bethesda, Md. : 1985), 2007, Volume: 102, Issue:2

    Topics: Adrenergic beta-Agonists; Animals; Clenbuterol; Drug Interactions; Female; Hindlimb Suspension; Immu

2007
Clenbuterol, a beta 2-adrenergic agonist, reverses muscle wasting due to scald injury in the rat.
    Burns : journal of the International Society for Burn Injuries, 1993, Volume: 19, Issue:1

    Topics: Animals; Body Weight; Burns; Clenbuterol; Male; Muscles; Muscular Atrophy; Proteins; Rats; Rats, Spr

1993
Aminohydroxybutane bisphosphonate and clenbuterol prevent bone changes and retard muscle atrophy respectively in tail-suspended rats.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Alendronate; Animals; Bone and Bones; Bone Density; Clenbuterol; Diphosphonates; Male; Muscles; Musc

1993
Effect of the beta-agonist clenbuterol on dexamethasone-induced diaphragm dysfunction in rabbits.
    American journal of respiratory and critical care medicine, 1996, Volume: 154, Issue:6 Pt 1

    Topics: Adrenergic beta-Agonists; Animals; Clenbuterol; Dexamethasone; Diaphragm; Female; Glucocorticoids; M

1996
Comparative effects of beta2-adrenergic agonists on muscle waste associated with tumour growth.
    Cancer letters, 1997, May-01, Volume: 115, Issue:1

    Topics: Adipose Tissue; Adrenergic beta-Agonists; Albuterol; Animals; Body Weight; Cachexia; Clenbuterol; Ea

1997
Effects of beta(2)-agonist clenbuterol on biochemical and contractile properties of unloaded soleus fibers of rat.
    American journal of physiology. Cell physiology, 2000, Volume: 278, Issue:3

    Topics: Adrenergic beta-Agonists; Animals; Body Weight; Calcium; Clenbuterol; Hindlimb Suspension; In Vitro

2000
Amelioration of denervation-induced atrophy by clenbuterol is associated with increased PKC-alpha activity.
    American journal of physiology. Endocrinology and metabolism, 2000, Volume: 279, Issue:1

    Topics: Adrenergic beta-Agonists; Animals; Biological Transport; Clenbuterol; Denervation; Fluorescent Antib

2000
A physiological level of clenbuterol does not prevent atrophy or loss of force in skeletal muscle of old rats.
    Journal of applied physiology (Bethesda, Md. : 1985), 2000, Volume: 89, Issue:2

    Topics: Adrenergic beta-Agonists; Aging; Animals; Body Weight; Clenbuterol; Isometric Contraction; Male; Mus

2000
Magnetic resonance imaging of denervation-induced muscle atrophy: effects of clenbuterol in the rat.
    Muscle & nerve, 2001, Volume: 24, Issue:12

    Topics: Animals; Clenbuterol; Female; Magnetic Resonance Imaging; Muscle Denervation; Muscle, Skeletal; Musc

2001
Regeneration of peripheral nerves after clenbuterol treatment in a rat model.
    Muscle & nerve, 2001, Volume: 24, Issue:12

    Topics: Animals; Cell Count; Clenbuterol; Disease Models, Animal; Male; Muscle Denervation; Muscle, Skeletal

2001
Muscle-specific effects of hindlimb suspension and clenbuterol in mature male rats.
    Cells, tissues, organs, 2002, Volume: 171, Issue:2-3

    Topics: Adrenergic beta-Agonists; Animals; Clenbuterol; Hindlimb Suspension; Humans; Male; Muscle, Skeletal;

2002
Effect of clenbuterol on skeletal muscle atrophy in mice induced by the glucocorticoid dexamethasone.
    Comparative biochemistry and physiology. Comparative physiology, 1992, Volume: 102, Issue:1

    Topics: Animals; Clenbuterol; Dexamethasone; Hypertrophy; Male; Mice; Mice, Inbred C57BL; Muscle Proteins; M

1992
Denervation increases clenbuterol sensitivity in muscle from young rats.
    Muscle & nerve, 1992, Volume: 15, Issue:2

    Topics: Animals; Clenbuterol; Dose-Response Relationship, Drug; Heart; Male; Muscle Denervation; Muscles; Mu

1992
Effects of the beta 2-adrenoceptor agonist, clenbuterol, on muscle atrophy due to food deprivation in the rat.
    Metabolism: clinical and experimental, 1990, Volume: 39, Issue:6

    Topics: Adrenergic beta-Agonists; Animals; Body Weight; Clenbuterol; Ethanolamines; Fasting; Food Deprivatio

1990
Anabolic beta-2-agonist clenbuterol fails to modify muscle atrophy due to femur fracture.
    Circulatory shock, 1990, Volume: 32, Issue:2

    Topics: Adipose Tissue, Brown; Animals; Body Weight; Clenbuterol; Eating; Femoral Fractures; Male; Muscle Pr

1990
Muscle wasting associated with endotoxemia in the rat: modification by the beta 2-adrenoceptor agonist clenbuterol.
    Bioscience reports, 1989, Volume: 9, Issue:5

    Topics: Animals; Body Weight; Clenbuterol; Endotoxins; Ethanolamines; Male; Muscular Atrophy; Rats; Rats, In

1989
Clenbuterol prevents or inhibits loss of specific mRNAs in atrophying rat skeletal muscle.
    The American journal of physiology, 1988, Volume: 254, Issue:5 Pt 1

    Topics: Actins; Animals; Body Weight; Clenbuterol; Cytochrome c Group; Denervation; Ethanolamines; Female; H

1988
Inhibition and reversal of denervation-induced atrophy by the beta-agonist growth promoter, clenbuterol.
    Bioscience reports, 1986, Volume: 6, Issue:9

    Topics: Animals; Clenbuterol; Ethanolamines; Glycolysis; Male; Muscle Contraction; Muscle Denervation; Muscl

1986