cladribine has been researched along with Leucocythaemia in 46 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (4.35) | 18.7374 |
| 1990's | 35 (76.09) | 18.2507 |
| 2000's | 7 (15.22) | 29.6817 |
| 2010's | 2 (4.35) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blicharski, K; Borowicz, P; Janota, B; Kłaput, U; Mazur, L; Opydo-Chanek, M; Stojak, M; Wojcieszek, K | 1 |
| Hentosh, P; Peffley, DM | 1 |
| Albertioni, F; Elford, H; Eriksson, S; Flordal, E; Lagercrantz, S; Liliemark, J; Månsson, E; Spasokoukotskaja, T | 1 |
| Bertrand, L; Bontemps, F; Cardoen, S; Delacauw, A; Ferrant, A; Smal, C; Van den Berghe, G; Van Den Neste, E | 1 |
| Lamanna, N; Weiss, M | 1 |
| Horny, HP; Noack, F; Notter, M; Penack, O; Sotlar, K; Thiel, E | 1 |
| Csoka, K; Larsson, R; Liliemark, J; Nygren, P | 1 |
| Bryson, HM; Sorkin, EM | 1 |
| Dighiero, G | 1 |
| Piro, LD; Saven, A | 3 |
| Baltz, JK; Montello, MJ | 1 |
| Beutler, E | 2 |
| Cheson, BD | 5 |
| Saven, A | 1 |
| Betticher, DC; Fey, MF; Gratwohl, A; Hess, U; Jenzer, H; Lohri, A; Pagani, O; Pugin, P; Tobler, A; von Rohr, A | 1 |
| Bosly, A; Brousset, P; Delannoy, A; Pris, J; Riga-Huguet, F; Schlaifer, D | 1 |
| Fedak, MN | 1 |
| Albertioni, F; Herngren, L; Juliusson, G; Liliemark, J | 1 |
| Evans, SS; Messenger, JC; Nagourney, RA; Su, YZ; Weisenthal, LM | 1 |
| Castaigne, S | 1 |
| Cheung, WK; Gollard, R; Johannsen, T; Kosty, M; Miller, WE; Moyer, M; Piro, LD; Rose, E; Saven, A; Smith, I | 1 |
| Arnér, ES | 1 |
| Faure, P; Madelaine-Chambrin, I; Piquet-Sevrin, V | 1 |
| Wiley, JS | 1 |
| Albertioni, F; Eriksson, S; Hullán, L; Sasvári-Székely, M; Spasokoukotskaja, T; Staub, M | 1 |
| Hentosh, P; Tibudan, M; Yuh, SH | 1 |
| Czochralska, B; Lindqvist, L | 1 |
| Albertioni, F; Eriksson, S; Liliemark, J; Lotfi, K; Månsson, E; Peterson, C; Pettersson, B; Spasokoukotskaja, T | 1 |
| Inanami, O; Kuwabara, M; Matsuda, A; Nomura, Y; Takahashi, K | 1 |
| Filippi, M; Rovaris, M; Tortorella, C | 1 |
| Piro, LD | 1 |
| Arnér, ES; Eriksson, S; Spasokoukotskaja, T | 1 |
| Grieb, P; Robak, T | 1 |
| Robak, T | 1 |
| Juliusson, G; Liliemark, J | 1 |
| Hiramoto-Yoshioka, A; Hirota, Y; Matsuda, A; Minowada, J; Otani, T; Tanaka, S; Ueda, T; Wataya, Y | 1 |
| Carrera, CJ; Carson, DA; Wasson, DB; Yamanaka, H | 1 |
19 review(s) available for cladribine and Leucocythaemia
| Article | Year |
|---|---|
The cladribine conundrum: deciphering the drug's mechanism of action.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line; Cell Survival; Cladribine; Humans; Leukemia | 2010 |
Purine analogs in leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia; Pentostatin; Purines; Stem Cell Transplantation; Vidarabine | 2004 |
Cladribine. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in haematological malignancies.
Topics: Animals; Cladribine; Hematologic Diseases; Humans; In Vitro Techniques; Leukemia; Lymphoma | 1993 |
Potential immunological action of purine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cladribine; Humans; Immunosuppressive Agents; Leukemia; Pentostatin; Purine Nucleosides; Vidarabine | 1994 |
The newer purine analogs. Significant therapeutic advance in the management of lymphoid malignancies.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia; Lymphoma; Pentostatin; Vidarabine | 1993 |
Cladribine for the treatment of hematologic malignancies.
Topics: Cladribine; Clinical Trials as Topic; Hematologic Diseases; Humans; In Vitro Techniques; Leukemia; Models, Biological | 1993 |
New chemotherapeutic agent: 2-chlorodeoxyadenosine.
Topics: Cladribine; Humans; Leukemia; Lymphoma | 1994 |
Purine analogs in lymphoproliferative disorders.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Multiple Myeloma; Pentostatin; Vidarabine | 1993 |
2-Chlorodeoxyadenosine: a newer purine analog active in the treatment of indolent lymphoid malignancies.
Topics: Animals; Cladribine; Humans; Leukemia; Lymphoma | 1994 |
Comparative efficacy of the newer nucleosides (fludarabine, 2'-deoxycoformycin, and 2-chlorodeoxyadenosine) in the treatment of indolent lymphoid malignancies.
Topics: Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Humans; Leukemia; Lymphoma; Molecular Structure; Pentostatin; Purine Nucleosides; Vidarabine | 1993 |
2-Chlorodeoxyadenosine: a new nucleoside agent effective in the treatment of lymphoid malignancies.
Topics: Cladribine; Humans; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous | 1993 |
2-Chlorodeoxyadenosine in haematological malignancies.
Topics: Cladribine; Humans; Leukemia; Lymphoma | 1993 |
On the phosphorylation of 2-chlorodeoxyadenosine (CdA) and its correlation with clinical response in leukemia treatment.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cladribine; Humans; Leukemia; Phosphorylation | 1996 |
[Current therapeutic methods in onco-hematology].
Topics: Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Cladribine; Docetaxel; Humans; Keratolytic Agents; Leukemia; Paclitaxel; Taxoids; Topoisomerase I Inhibitors; Tretinoin; Vidarabine | 1996 |
Perspectives on purine analogues.
Topics: Antineoplastic Agents; Cladribine; Forecasting; Humans; Leukemia; Pentostatin; Purines; Vidarabine | 1996 |
Cladribine. Ortho Biotech Inc.
Topics: Adenosine Deaminase Inhibitors; Animals; Antineoplastic Agents; Arthritis, Rheumatoid; Cladribine; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Enzyme Inhibitors; Humans; Immunosuppressive Agents; Leukemia; Multiple Sclerosis; Structure-Activity Relationship | 2001 |
Cladribine (2-chlorodeoxyadenosine)
Topics: Cladribine; Humans; Leukemia; Leukemia, Hairy Cell; Lymphoma | 1992 |
New antimetabolites in the treatment of human malignancies.
Topics: Animals; Antimetabolites, Antineoplastic; Cladribine; Clinical Trials as Topic; Drugs, Investigational; Forecasting; Humans; Immunosuppression Therapy; Leukemia; Lymphoma; Pentostatin; Purines; Vidarabine | 1992 |
[New analogs of deoxyadenosine for treatment of lymphoid malignancies].
Topics: Antineoplastic Agents; Cladribine; Deoxyadenosines; Formycins; Humans; Leukemia; Lymphoma; Vidarabine | 1992 |
1 trial(s) available for cladribine and Leucocythaemia
| Article | Year |
|---|---|
High incidence of infections after 2-chlorodeoxyadenosine (2-CDA) therapy in patients with malignant lymphomas and chronic and acute leukaemias.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Bone Marrow Diseases; Chronic Disease; Cladribine; Female; Humans; Immunocompromised Host; Incidence; Leukemia; Lymphoma; Male; Middle Aged; Opportunistic Infections; Prospective Studies; Treatment Outcome | 1994 |
26 other study(ies) available for cladribine and Leucocythaemia
| Article | Year |
|---|---|
In vitro response of human pathological hematopoietic cells to cladribine.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cladribine; Dose-Response Relationship, Drug; Humans; Leukemia; Lymphoma | 2013 |
Down-regulation of deoxycytidine kinase in human leukemic cell lines resistant to cladribine and clofarabine and increased ribonucleotide reductase activity contributes to fludarabine resistance.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cell Line; Cladribine; Clofarabine; Cytogenetics; Deoxycytidine Kinase; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Leukemia; Phenotype; Phosphorylation; Ribonucleotide Reductases; Vidarabine | 2003 |
Fighting leukemia. Survival rates have tripled thanks to new, more effective treatments.
Topics: Acute Disease; Age Factors; Antineoplastic Agents; Benzamides; Chronic Disease; Cladribine; Humans; Imatinib Mesylate; Leukemia; Piperazines; Pyrimidines; Survival Rate | 2003 |
Activation of deoxycytidine kinase by protein kinase inhibitors and okadaic acid in leukemic cells.
Topics: Antineoplastic Agents; Carrier Proteins; Cladribine; Deoxycytidine Kinase; Enzyme Activation; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Mitogen-Activated Protein Kinases; Okadaic Acid; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 2004 |
Cladribine therapy in a patient with an aleukemic subvariant of mast cell leukemia.
Topics: Aged; Antineoplastic Agents; Cladribine; Humans; Leukemia; Leukemia, Mast-Cell; Male; Radiography | 2005 |
Evaluation of the cytotoxic activity of gemcitabine in primary cultures of tumor cells from patients with hematologic or solid tumors.
Topics: Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cisplatin; Cladribine; Colorectal Neoplasms; Cytarabine; Deoxycytidine; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Female; Gemcitabine; Humans; In Vitro Techniques; Leukemia; Lung Neoplasms; Lymphoma; Ribonucleotide Reductases; Tumor Cells, Cultured; Urogenital Neoplasms | 1995 |
Antileukemic and Immunosuppressive Properties of 2-Chloro-2'-Deoxyadenosine (2-CdA). Symposium proceedings. Warsaw, Poland, November 23, 1992.
Topics: Animals; Antineoplastic Agents; Cladribine; Humans; Immunosuppressive Agents; Leukemia | 1994 |
Secondary neoplasms in two patients treated with purine analogues.
Topics: Acute Disease; Aged; Cladribine; Female; Humans; Immunocompromised Host; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Melanoma; Neoplasms, Second Primary; Skin Neoplasms; Vidarabine; Waldenstrom Macroglobulinemia | 1994 |
Criteria for use of cladribine in adults.
Topics: Adult; Cladribine; Female; Humans; Leukemia; Leukemia, Hairy Cell; Treatment Outcome | 1994 |
Protein binding of 2-chloro 2'-deoxyadenosine (cladribine) in healthy subjects and in patients with leukaemia.
Topics: Adult; Aged; Aged, 80 and over; Blood Proteins; Cladribine; Female; Humans; Leukemia; Male; Middle Aged; Protein Binding | 1994 |
2 chlorodeoxyadenosine activity and cross resistance patterns in primary cultures of human hematologic neoplasms.
Topics: Cladribine; Cytarabine; Doxorubicin; Drug Resistance; Drug Screening Assays, Antitumor; Humans; Leukemia; Lymphoma, Non-Hodgkin; Mechlorethamine; Multiple Myeloma; Protein Binding; Tumor Cells, Cultured; Vincristine | 1993 |
Pharmacokinetic study of oral and bolus intravenous 2-chlorodeoxyadenosine in patients with malignancy.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Biological Availability; Cladribine; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Leukemia; Male; Middle Aged; Neoplasms; Neutropenia; Treatment Outcome | 1996 |
Seeking the nucleoside transporter.
Topics: Animals; Antimetabolites, Antineoplastic; Carrier Proteins; Cell Membrane; Cladribine; Cloning, Molecular; Cytarabine; Deoxycytidine; Erythrocytes; Gemcitabine; Glucose Transporter Type 1; Humans; Leukemia; Lymphoma; Membrane Proteins; Monosaccharide Transport Proteins; Nucleosides; Oocytes; Recombinant Proteins; Uridine; Vidarabine; Xenopus | 1997 |
Activation of deoxycytidine kinase by various nucleoside analogues.
Topics: Adenine Nucleotides; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Cycle; Cells, Cultured; Cladribine; Clofarabine; Cytarabine; Deoxycytidine Kinase; Enzyme Activation; HL-60 Cells; Humans; Leukemia; Lymphocytes; Palatine Tonsil; Thymidine Kinase; Tumor Cells, Cultured; Vidarabine | 1998 |
Analysis of 2-chloro-2'-deoxyadenosine incorporation into cellular DNA by quantitative polymerase chain reaction.
Topics: Antineoplastic Agents; Cisplatin; Cladribine; DNA; Genes, ras; Humans; Leukemia; Polymerase Chain Reaction; Taq Polymerase; Tumor Cells, Cultured | 1998 |
Reaction mechanism in the photochemistry of the antileukaemic agents 2-chloro- and 2-bromo-2'-deoxyadenosine, studied by nanosecond laser flash photolysis.
Topics: Antineoplastic Agents; Cladribine; Deoxyadenosines; Lasers; Leukemia; Photolysis | 1999 |
Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cladribine; Clofarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Phosphorylation; Recombinant Proteins; Tumor Cells, Cultured | 1999 |
2-Chloro-2'-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cladribine; Cycloheximide; Cysteine Proteinase Inhibitors; Deoxycytidine; DNA Fragmentation; DNA, Neoplasm; Enzyme Activation; fas Receptor; Flow Cytometry; Fluorometry; Humans; In Situ Nick-End Labeling; Leukemia; Oligopeptides; Phosphorylation; Tumor Cells, Cultured | 2000 |
2-Chlorodeoxyadenosine treatment of lymphoid malignancies.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Lymphoma | 1992 |
The purine analogs--a therapeutic beauty contest.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Lymphoma, Non-Hodgkin; Pentostatin; Vidarabine | 1992 |
The purine analogs--a therapeutic beauty contest.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Deoxyadenosines; Humans; Leukemia; Pentostatin; Vidarabine | 1992 |
Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and their activities in extracts from human cells and tissues.
Topics: Arabinonucleosides; Cladribine; Deoxycytidine; Deoxycytidine Kinase; Humans; Isoenzymes; Kinetics; Leukemia; Leukocytes; Mitochondria; Organ Specificity; Phosphorylation; Radioisotope Dilution Technique; Reference Values; Substrate Specificity; Thymidine; Thymidine Kinase; Tritium; Tumor Cells, Cultured; Zidovudine | 1992 |
[2-chlorodeoxyadenosine (2-CDA)--a new antineoplastic and immunosuppressive drug].
Topics: Adult; Animals; Autoimmune Diseases; Child; Cladribine; Drug Evaluation; Drug Evaluation, Preclinical; Humans; Immunosuppressive Agents; Leukemia; Leukemia, Experimental; Lymphoma; Mice | 1992 |
On the pharmacokinetics of 2-chloro-2'-deoxyadenosine in humans.
Topics: 2-Chloroadenosine; Chromatography, High Pressure Liquid; Cladribine; Deoxyadenosines; Humans; Leukemia | 1991 |
The mechanism of 2-chlorodeoxyadenosine-induced cell death.
Topics: 2-Chloroadenosine; Cell Survival; Cladribine; Cycloheximide; Deoxyadenosines; Deoxycytidine; DNA Damage; Humans; Leukemia; Lymphoma; Tumor Cells, Cultured | 1989 |
Programmed cell death and adenine deoxynucleotide metabolism in human lymphocytes.
Topics: Cell Survival; Cladribine; Deoxyadenosines; DNA Damage; Humans; Leukemia; Lymphocytes; Lymphoma; NAD | 1988 |