cladribine has been researched along with B-Cell Chronic Lymphocytic Leukemia in 218 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (0.46) | 18.7374 |
1990's | 109 (50.00) | 18.2507 |
2000's | 76 (34.86) | 29.6817 |
2010's | 30 (13.76) | 24.3611 |
2020's | 2 (0.92) | 2.80 |
Authors | Studies |
---|---|
Korycka-Wołowiec, AB; Kubiak, AB; Robak, T; Wołowiec, D; Ziółkowska, EI | 1 |
Ahn, IE; Calvo, KR; Francischetti, IMB; Kreitman, RJ; Obiorah, IE; Raffeld, M; Wang, HW; Wang, W; Wiestner, A | 1 |
Gaherova, L; Havrda, M; Kozak, T; Novak, J; Spicka, J | 1 |
Bołkun, Ł; Budziszewska, BK; Błoński, J; Fidecka, M; Kłoczko, J; Piotrowska, M; Robak, T; Rybka, J; Skotnicki, AB; Smolewski, P; Uss, A; Walczak, U; Wróbel, T | 1 |
Bogusz, J; Cebula-Obrzut, B; Majchrzak, A; Mędra, A; Robak, T; Smolewski, P | 1 |
Blonski, JZ; Calbecka, M; Ceglarek, B; Chojnowski, K; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Hellmann, A; Kloczko, J; Kostyra, A; Kowal, M; Kuliczkowski, K; Lewandowski, K; Mital, A; Nowak, W; Potoczek, S; Robak, T; Seferynska, I; Skotnicki, A; Stella-Holowiecka, B; Sulek, K; Trelinski, J; Warzocha, K; Wiater, E; Zawilska, K | 1 |
Blonski, JZ; Boguradzki, P; Calbecka, M; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Jamroziak, K; Kloczko, J; Kowal, M; Kuliczkowski, K; Lech-Maranda, E; Moskwa, A; Piotrowska, M; Piszcz, J; Potoczek, S; Robak, T; Skotnicki, AB; Stella-Holowiecka, B; Sulek, K; Warzocha, K; Zawilska, K | 1 |
Borowiak, A; Błoński, JZ; Cebula-Obrzut, B; Kiliańska, ZM; Kotkowska, A; Robak, T; Rogalińska, M; Smolewski, P; Wawrzyniak, E; Żołnierczyk, JD | 1 |
Brandberg, Y; Gill, D; Hammerström, J; Hertzberg, M; Johansson, H; Juliusson, G; Jønsson, V; Karlsson, K; Liliemark, J; McLennan, R; Mulligan, SP; Norman, J; Strömberg, M; Sundström, G; Uggla, B; Wallvik, J | 1 |
Błoński, JZ; Góralski, P; Hartman, M; Kiliańska, ZM; Koceva-Chyła, A; Piekarski, H; Robak, P; Robak, T; Rogalińska, M; Rogalska, A; Wawrzyniak, E | 1 |
Gurram, V; Kaliyaperumal, M; Kreitman, RJ; Lakshman, MK; Martínez Montemayor, MM; Pottabathini, N; Relangi, SS; Satishkumar, S; Sharma, S; Vuram, PK; Yang, L; Zhou, H | 1 |
Arana Echarri, A; Beyaert, M; Bol, V; Bontemps, F; Michaux, L; Saussoy, P; Smal, C; Starczewska, E; Van Den Neste, E; Vekemans, MC | 1 |
Bednarek, JD; Blonski, JZ; Goralski, P; Hanausek, M; Kilianska, ZM; Piekarski, H; Robak, T; Rogalinska, M; Walaszek, Z; Wozniak, K | 1 |
Berchem, G; Bouzar, AB; Boxus, M; Bron, D; Burny, A; Chatelain, B; Chatelain, C; Defoiche, J; Lagneaux, L; Macallan, D; Pettengell, R; Willems, L; Willis, F | 1 |
Chtioui, H; Lämmle, B; Lauterburg, BH; Millius, C | 1 |
Blonski, JZ; Dmoszynska, A; Gora-Tybor, J; Jamroziak, K; Konopka, L; Palacz, A; Robak, T; Warzocha, K; Wawrzyniak, E | 1 |
Castejón, R; Citores, MJ; García-Marco, JA; Vargas, JA; Villarreal, M; Yebra, M | 1 |
Andreola, G; Bertolini, F; Billio, A; Calabrese, L; Fabbri, A; Frigeri, F; Laszlo, D; Martinelli, G; Rabascio, C; Radice, D; Rigacci, L; Saronni, L | 1 |
Błoński, JZ; Kiliańska, ZM; Robak, T; Wesierska-Gadek, J; Zolnierczyk, JD | 1 |
Beert, E; Bontemps, F; Connerotte, T; de Viron, E; Hermans, C; Knoops, L; Michaux, L; Saussoy, P; Smal, C; Van Den Neste, E; Vannuffel, P; Vekemans, MC | 1 |
Błoński, JZ; Góralski, P; Kiliańska, ZM; Komina, O; Piekarski, H; Robak, T; Rogalińska, M; Wesierska-Gadek, J; Zołnierczyk, JD | 1 |
Castejon, R; Citores, MJ; Garcia-Marco, JA; Rosado, S; Vargas, JA; Villarreal, M | 1 |
Polliack, A; Tadmor, T; Tam, CS | 1 |
Blonski, JZ; Calbecka, M; Ceglarek, B; Dmoszyñska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Hellmann, A; Jamroziak, K; Konopka, L; Kostyra, A; Lewandowski, K; Piotrowska, M; Piszcz, J; Potoczek, S; Robak, T; Seferynska, I; Stella-Holowiecka, B; Warzocha, K; Zawilska, K; Zdunczyk, A | 1 |
Bargetzi, MJ; Beretta, K; Brauchli, P; Gregor, M; Hanselmann, S; Heim, D; Himmelmann, A; Leupin, N; Rovo, A; Schuller, JC; Solenthaler, M; Zenhäusern, R | 1 |
Chocholska, S; Dmoszynska, A; Halicka, D; Klimek, P; Kowal, M; Podhorecka, M | 2 |
Bassi, S; Bertazzoni, P; Calabrese, L; Calleri, A; Gigli, F; Gregato, G; Laszlo, D; Liptrott, SJ; Martinelli, G; Nassi, L; Negri, M; Orlando, L; Preda, L; Pruneri, G; Rabascio, C; Radice, D; Sammassimo, S | 1 |
Miller, HJ; Saven, A; Schram, ED; Sigal, DS | 1 |
Baran, W; Batycka-Baran, A; Dzietczenia, J; Mazur, G | 1 |
Amsailale, R; Arts, A; Bastin-Coyette, L; Bontemps, F; Cardoen, S; de Viron, E; Smal, C; Van Den Neste, E | 1 |
Aguilar, J; Al-Katib, A; del Busto, R; Johnson, LB; Obeid, KM; Sharma, M; Szpunar, S | 1 |
Borowiak, A; Błoński, JZ; Cebula-Obrzut, B; Kiliańska, ZM; Komina, O; Robak, P; Smolewski, P; Węsierska-Gądek, J; Żołnierczyk, JD | 1 |
Fathi, AT; Hasserjian, R; Sadrzadeh, H | 1 |
Blonski, JZ; Franiak-Pietryga, I; Ghia, P; Janus, A; Korycka-Wolowiec, A; Kotkowska, A; Maciejewski, H; Mirowski, M; Robak, T; Salagacka, A; Wawrzyniak, E; Wolowiec, D | 1 |
Borowiec, M; Błoński, JZ; Franiak-Pietryga, I; Korycka-Wołowiec, A; Maciejewski, H; Mirowski, M; Robak, T; Sałagacka, A | 1 |
Almazi, JG; Christopherson, RI; Crossett, B; Kohnke, PL; Mactier, S | 1 |
Cebula-Obrzut, B; Robak, T; Smolewski, P; Wolska, A | 1 |
Błoński, JZ; Franiak-Pietryga, I; Góralski, P; Janus, A; Kiliańska, ZM; Maciejewski, H; Mirowski, M; Piekarski, H; Robak, P; Robak, T; Rogalińska, M | 1 |
Bosch, F; Campo, E; Colomer, D; Giné, E; López-Guillermo, A; Montserrat, E; Rozman, M; Villamor, N | 1 |
Aivado, M; Burger, J; Finke, J; Haas, R; Henze, L; Schulte, K | 1 |
Boński, JZ; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Góra-Tybor, J; Hellmann, A; Kasznicki, M; Konopka, L; Robak, T; Wołowiec, D | 1 |
Escribano, L; Núñez, R; Orfao, A; Pérez de Oteyza, J | 1 |
Bartkowiak, J; Biernat, W; Krykowski, E; Robak, E; Robak, T | 1 |
Błoński, JZ; Dwilewicz-Trojaczek, J; Góra-Tybor, J; Kasznicki, M; Robak, T; Stella-Hołowiecka, B; Wołowiec, D | 1 |
Di Raimondo, F; Ferrajoli, A; Keating, MJ; Lerner, S; Montillo, M; Morra, E; O'Brien, S; Tedeschi, A | 1 |
Byrd, JC; Larson, RA; Peterson, B; Piro, L; Saven, A; Schiffer, C; Vardiman, JW | 1 |
Albertioni, F; Eriksson, S; Gruber, A; Karlsson, MO; Liliemark, J; Lindemalm, S; Wang, Y | 1 |
Pettitt, AR | 1 |
Bartkowiak, J; Kordek, R; Korycka, A; Robak, T; Smolewski, P; Szmigielska-Kapłon, A; Wawrzyniak, E | 1 |
Blonski, JZ; Całbecka, M; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, A; Gora-Tybor, J; Hellmann, A; Kasznicki, M; Komarnicki, M; Konopka, L; Lewandowski, K; Moskwa, A; Robak, T; Sokołowska, B; Sułek, K; Tomaszewska, A | 1 |
Gartenhaus, RB; Nabhan, C; Tallman, MS | 1 |
Christopherson, RI; Mulligan, SP; Wilson, PK | 1 |
Armitage, JO; Hoelzer, D; Rummel, MJ; Tobinai, K | 1 |
Chiari, AC; Cintra, ML; de Souza, EM; Lorand-Metze, I; Pagnano, KB; Rossini, MS | 1 |
Caracciolo, F; Cecconi, N; Cervetti, G; Galimberti, S; Petrini, M | 1 |
Góra-Tybor, J; Jamroziak, K; Kordek, R; Majos, A; Rieske, P; Robak, P; Robak, T; Tybor, K; Urbańska-Ryś, H | 1 |
Aleskog, A; Höglund, M; Larsson, R; Laurell, A; Lindhagen, E; Nilsson, K; Nygren, P; Roos, G; Rosenquist, R; Sundström, C; Thunberg, U; Tobin, G | 1 |
Robak, T | 3 |
Bontemps, F; Cardoen, S; Ferrant, A; Rosier, JF; Smal, C; Van den Berghe, G; Van den Neste, E | 1 |
Błoński, JZ; Hanausek, M; Kiliańska, ZM; Robak, T; Rogalińska, M; Walaszek, Z | 1 |
Dziecioł, J; Kłoczko, J; Lemancewicz, D; Piszcz, J | 1 |
Arbiser, J; Battle, TE; Frank, DA | 1 |
Cebula, B; Duechler, M; Linke, A; Robak, T; Schwarzmeier, JD; Shehata, M; Smolewski, P | 1 |
Blonski, JZ; Dmoszyñska, A; Góra-Tybor, J; Kasznicki, M; Robak, T; Skotñicki, A | 1 |
Biernat, W; Jeziorski, A; Krykowski, E; Robak, E; Robak, T | 1 |
Błoński, JZ; Chojnowski, K; Kasznicki, M; Robak, T; Szmigielska-Kapłon, A | 1 |
Bontemps, F; Cardoen, S; Offner, F; Van den Neste, E | 1 |
Boguradzki, P; Błoński, JZ; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Góra-Tybor, J; Hellmann, A; Kasznicki, M; Konopka, L; Kuliczkowski, K; Lewandowski, K; Nowak, W; Robak, T; Skotnicki, AB; Sułek, K; Warzocha, K; Wojtaszko, M; Zdziarska, B | 1 |
Blonski, JZ; Calbecka, M; Ceglarek, B; Dmoszynska, A; Dwilewicz-Trojaczek, J; Gora-Tybor, J; Jamroziak, K; Kasznicki, M; Kloczko, J; Konopka, L; Kowal, M; Kuliczkowski, K; Robak, T; Skotnicki, AB; Stella-Holowiecka, B; Sulek, K; Tomaszewska, A; Warzocha, K; Zawilska, K | 1 |
Bohlius, J; Greil, R; Pall, G; Richards, S; Schwarzer, G; Steurer, M | 2 |
Bednarek, J; Blonski, JZ; Hanausek, M; Kilianska, ZM; Kobylinska, A; Robak, T; Walaszek, Z | 1 |
Ballabeni, P; Cerny, T; Fey, M; Hess, U; Laurencet, F; Luthi, JM; Plancherel, C; Rufener, B; Zulian, GB | 1 |
Bontemps, F; Ferrant, A; Lisart, S; Maerevoet, M; Smal, C; Van Den Neste, E | 1 |
Cebula, B; Linke, A; Robak, P; Robak, T; Smolewski, P | 1 |
Błonski, JZ; Góra-Tybor, J; Jesionek-Kupnicka, D; Kasznicki, M; Kordek, R; Lech-Marańda, E; Robak, T; Szmigielska-Kapłon, A | 1 |
Costantini, S; Delannoy, A; Deneys, V; Ferrant, A; Francart, J; Hagemeijer, A; Michaux, L; Robert, A; Robin, V; Sonet, A; Stul, M; Van Den Neste, E; Vandenberghe, P | 1 |
Błoński, JZ; Cebula, B; Grzybowska-Izydorczyk, O; Robak, T; Smolewski, P | 1 |
Fukui, E; Funada, Y; Gomyo, H; Hanioka, K; Kajimoto, K; Koizumi, T; Maeda, A; Mizuno, I; Murayama, T; Ogura, M | 1 |
Dabrowska, M; Dzieciol, J; Kloczko, J; Lemancewicz, D; Piszcz, JA; Rusak, M | 1 |
Ashique, A; Begleiter, A; Israels, LG; Johnston, JB; Lee, K; Mowat, MR; Verburg, L | 1 |
Juliusson, G | 1 |
Alessi-Severini, S; Belch, AR; Gati, WP; Paterson, AR | 1 |
Cull, G; Hopkins, JA; Howe, DJ; Johnson, SA; Phillips, MJ; Richardson, DS | 1 |
Bosly, A; Delannoy, A; Deneys, V; Ferrant, A; Gala, JL; Martiat, P; Michaux, JL; Schieff, JM | 1 |
Mejer, J; Munch-Petersen, B; Nielsen, SE | 1 |
Brugiatelli, M; Callea, I; Callea, V; Iacopino, P; Messina, G; Morabito, F; Nobile, F; Rodinò, A | 1 |
Hiddemann, W; Pott-Hoeck, C | 1 |
Hakimian, D; Hogan, DK; Rademaker, A; Rose, E; Tallman, MS; Variakojis, D; Zanzig, C | 1 |
Croy, D; Fleischman, RA | 1 |
Arnér, ES; Brosjö, O; Eriksson, S; Gunvén, P; Juliusson, G; Liliemark, J; Spasokoukotskaja, T | 1 |
del Giglio, A; Keating, M; O'Brien, S | 1 |
Beutler, E; Kosty, M; Lemon, RH; Piro, LD; Saven, A | 1 |
Piatkowska-Jakubas, B; Skotnicki, AB | 1 |
Andreeff, M; Beran, M; Estey, E; Kantarjian, H; Keating, M; Koller, C; O'Brien, S; Pierce, S; Robertson, B | 1 |
Betticher, DC; Gratwohl, A; Haberthür, C; Pless, M; Speck, B; Tichelli, A | 1 |
Piro, LD; Saven, A | 2 |
Piro, LD | 1 |
Juliusson, G; Liliemark, J | 4 |
Piro, L; Saven, A | 1 |
Ciepłuch, H; Hałaburda, K; Hellmann, A; Zaucha, JM | 1 |
Csoka, K; de la Torre, M; Fridborg, H; Kristensen, J; Larsson, R; Liliemark, J; Nygren, P | 1 |
Delannoy, A; Doyen, C; Ferrant, A; Martiat, P; Michaux, JL; Montfort, L; Sokal, G | 1 |
Bosly, A; Brousset, P; Delannoy, A; Pris, J; Riga-Huguet, F; Schlaifer, D | 1 |
Albertioni, F; Juliusson, G; Liliemark, J; Pettersson, B; Reichelová, V | 1 |
Bendandi, M; Buzzi, M; Farabegoli, P; Martinelli, G; Ottaviani, E; Salvucci, M; Tosi, P; Visani, G; Zaccaria, A; Zinzani, PL | 1 |
Arnér, ES; Eriksson, S; Juliusson, G; Liliemark, J; Spasokoukotskaja, T | 1 |
Chubb, S; Ford, R; Hittelman, WN; Meyn, RE; Plunkett, W; Robertson, LE; Story, M | 1 |
Cunningham, D; Dorland, E; Hickish, T; Judson, I; Lister, TA; Millar, BC; Oza, A; Roldan, A; Serafinowski, P | 1 |
Carrera, CJ; Carson, DA; Kawasaki, H; Kipps, TJ; Piro, LD; Saven, A | 1 |
Delannoy, A; Ferrant, A; Hanique, G | 1 |
Lemon, RH; Piro, LD; Saven, A | 1 |
Larson, RA; Spielberger, RT; Stock, W | 1 |
Beran, M; Estey, E; Kantarjian, H; Keating, MJ; Koller, C; O'Brien, S; Robertson, LB | 1 |
Dann, EJ; Gillis, S; Okon, E; Polliack, A; Rachmilewitz, EA; Rund, D | 1 |
Keating, MJ; Lerner, S; O'Brien, S; Robertson, LE; Seymour, JF | 1 |
Hogan, DK; Nelson, MC | 1 |
Brown, RD; Gibson, J; Joshua, DE; Luo, XF; Petersen, AJ; Pope, B; Schutz, L; Wiley, JS | 1 |
Bosly, A; Delannoy, A; Ferrant, A; Filleul, B; Martiat, P; Michaux, JL; Mineur, P; Montfort, L; Straetmans, N; Van Den Neste, E; Vandercam, B | 1 |
Astrow, AB | 1 |
Busuttil, DP; Chasty, RC; Copplestone, JA; Fraser, M; Prentice, AG | 1 |
Christiansen, I; Elmhorn-Rosenborg, A; Hansen, MM; Johnson, S; Juliusson, G; Kimby, E; Liliemark, J | 1 |
Geisen, F; Konwalinka, G; Michlmayr, G; Schirmer, M | 1 |
Hakimian, D; Tallman, MS | 1 |
Saven, A | 1 |
Krykowski, E; Robak, T; Warzocha, K | 1 |
Brugiatelli, M; Callea, V; Dmoszynska, A; Holowiecka, B; Holowiecki, J; Jaksic, B; Krieger, O; Labar, B; Lutz, D; Morabito, F; Planinc-Peraica, A | 1 |
Lärfars, G; Samuelsson, J; Udén-Blohmé, AM | 1 |
Albertioni, F; Liliemark, J; Reichelova, V | 1 |
Gartenhaus, RB; Hoffman, M; Janson, D; Rai, KR; Wang, P | 1 |
Bashford, J; Bunce, I; Dodds, A; Eliadis, P; Firkin, F; Frost, T; Goldstein, D; Grigg, A; Kelly, C; Kimber, R; Lee, N; Lowenthal, R; Moore, D; Morton, J; Mulligan, S; Parkin, J; Rentoul, A; Rodwell, R; Rooney, K; Stone, J; Taylor, K; Wright, S | 1 |
Błasinka-Morawiec, M; Ceglarek, B; Dmoszynska, A; Durzynski, T; Dwilewicz-Trojaczek, J; Grieb, P; Hansz, J; Hellmann, A; Kasznicki, M; Komarnicki, M; Konopka, L; Kopec, I; Kotlarek-Haus, S; Krykowski, E; Lewandowski, K; Maj, S; Mazur, G; Potemski, P; Płuzanska, A; Robak, T; Sikorska, A; Skotnicki, AB; Urasinski, I; Zaucha, JM; Zdziarska, B | 1 |
Begleiter, A; Israels, LG; Johnston, JB; Lee, K; Mowat, MR; Verburg, L; Wang, H | 1 |
Adam, Z; Hejlová, N; Vorlícek, J | 1 |
Gjedde, SB; Hansen, MM; Juliusson, G | 1 |
Kroft, SH; Peterson, LC; Shaw, JM; Tallman, MS; Thangavelu, M | 1 |
Kantarjian, H; Keating, MJ; O'Brien, S | 1 |
Begleiter, A; Liliemark, JO; Plunkett, W; Reed, JC | 1 |
Dutcher, JP; Makower, D; Venkatraj, U; Wiernik, PH | 1 |
Bloński, J; Fabianowska-Majewska, K; Krykowski, E; Robak, T; Warzocha, K | 1 |
Błasińska-Morawiec, M; Hellmann, A; Konopka, L; Krykowski, E; Robak, T | 1 |
Dighiero, G | 1 |
Hiddemann, W; Pott, C | 1 |
Bergmann, L | 1 |
Hilgenfeld, E; Jäger, U; Knauf, WU; Mitterbauer, M; Wilfing, A | 1 |
Hotta, T; Kinoshita, T; Kobayashi, Y; Kozuru, M; Narabayashi, M; Ogura, M; Ohashi, Y; Suzuki, R; Tobinai, K; Uike, N | 1 |
Berrocal, E; Briz, M; Castejón, R; Durantez, A; Fernández, MN; Gea-Banacloche, JC; Romero, Y; Vargas, JA | 1 |
Blasinska-Morawiec, M; Dabkowski, J; Robak, E; Robak, T; Sysa-Jedrzejowska, A | 1 |
al-Katib, AM; Almatchy, VP; Katato, K; Liu, KZ; Mantsch, HH; Mohammad, RM; Schultz, CP; Varterasian, M; Wall, N | 1 |
Albertioni, F; Eriksson, S; Juliusson, G; Liliemark, J; Lindemalm, S; Pettersson, B; Reichelova, V | 1 |
Filangeri, M; Morabito, F; Oliva, B; Sculli, G | 2 |
Polliack, A | 1 |
Albertioni, F; Eriksson, S; Juliusson, G; Liliemark, J; Lindemalm, S | 1 |
Błasińska-Morawiec, M; Błoński, JZ; Dmoszyńska, A; Hansz, J; Kaźmierczuk, M; Komarnicki, M; Konopka, L; Kotlarek-Haus, S; Krykowski, E; Nowak, WS; Robak, T; Roliński, J; Skotnicki, AB; Trepińska, E; Urasiński, I; Zdziarska, B | 1 |
Al-Katib, AM; Johnston, JB; Liu, KZ; Mantsch, HH; Mohammad, RM; Schultz, CP | 1 |
Rai, KR | 1 |
Cheson, BD | 1 |
Albertioni, F; Edlund, C; Juliusson, G; Liliemark, J | 1 |
Bromidge, TJ; Howe, DJ; Johnson, SA; Rule, SA; Turner, DL | 1 |
Betticher, DC; Cerny, T; Fey, MF; Hess, U; Hsu Schmitz, SF; Ratschiller, D; Tichelli, A; Tobler, A; von Rohr, A; Wernli, M; Zulian, G | 1 |
Delannoy, A; Devogelaer, JP; Houssiau, FA | 1 |
Callea, I; Console, G; Filangeri, M; Messina, G; Morabito, F; Sculli, G | 1 |
Al-Katib, A; Beck, FW; Hamdy, N; Katato, K; Mohammad, RM; Wall, N | 1 |
Arat, M; Beksaç, M; Idilman, R | 1 |
Koski, T; Vilpo, J; Vilpo, L | 2 |
Alberto, P; Betticher, DC; Guetty-Alberto, M; Iten, PA; Laurencet, FM; Zulian, GB | 1 |
Błasińska-Morawiec, M; Błoński, JZ; Robak, T; Skotnicki, AB; Urbańska-Ryś, H | 1 |
Delannoy, A; Gala, JL; Guiot, Y; Martiat, P; Philippe, M; Scheiff, JM | 1 |
Błasińska-Morawiec, M; Błoński, JZ; Dmoszyńska, A; Robak, T | 1 |
Bontemps, F; Cardoen, S; Delacauw, A; Deneys, V; Ferrant, A; Gillis, E; Leveugle, P; Louviaux, I; Scheiff, JM; Van den Berghe, G; Van Den Neste, E | 1 |
Dmoszyńska, A; Legiec, W; Wach, M | 1 |
Bosanquet, AG; Copplestone, JA; Johnson, SA; Orchard, JA; Oscier, DG; Povey, SJ; Smith, AG | 1 |
Albertioni, F; Eriksson, S; Liliemark, J; Lotfi, K; Månsson, E; Peterson, C; Pettersson, B; Spasokoukotskaja, T | 1 |
Cawley, JC; Pettitt, AR; Sherrington, PD | 2 |
Krook, JE; Levitt, R; Li, CY; Michalak, JC; Schroeder, G; Tefferi, A; Tschetter, LK; Witzig, TE | 1 |
Barrett, J; Cheson, BD; Freidlin, B; Vena, DA | 1 |
Bloński, JZ; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Grieb, P; Hansz, J; Hellmann, A; Holowiecki, J; Kasznicki, M; Komarnicki, M; Konopka, L; Kroll, R; Kuliczkowski, K; Lewandowski, K; Nowak, W; Potoczek, S; Robak, T; Skotnicki, AB; Soroka-Wojtaszko, M; Tomaszewska, A; Zdziarska, B | 1 |
Ahmad, I; Al-Katib, AM; Beck, FW; Liu, KZ; Mantsch, HH; Mohammad, RM; Wall, NR | 1 |
Bosanquet, AG; Bosanquet, MI | 1 |
Ahmad, I; Al-Katib, AM; Beck, FW; Mohammad, RM | 1 |
Błasińska-Morawiec, M; Błoński, JZ; Korycka, A; Robak, T; Wierzbowska, A | 1 |
André, M; Bosly, A; Coche, E; Delannoy, A; Doyen, C; Duprez, T; Ferrant, A; Louviaux, I; Michaux, JL; Michaux, L; Mineur, P; Sonet, A; Straetmans, N; Van Den Neste, E; Venet, C | 1 |
Kipps, TJ | 1 |
Blasińska-Morawiec, M; Bloński, JZ; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Grieb, P; Hellmann, A; Kasznicki, M; Konopka, L; Kotlarek-Haus, S; Krykowski, E; Maj, S; Mrugala-Spiewak, H; Nowak, W; Potoczek, S; Robak, T; Skotnicki, AB; Urasiński, I; Zdziarska, B | 1 |
Adachi, S; Carrera, CJ; Carson, DA; Chao, Q; Cottam, HB; Genini, D; Leoni, LM; Rose, DW | 1 |
Johnson, SA; Thomas, W | 1 |
Weiss, MA | 1 |
Bloński, JZ; Dmoszyńska, A; Kasznicki, M; Robak, T; Skotnicki, AB | 1 |
Błoński, JZ; Góra-Tybor, J; Kasznicki, M; Lech-Marańda, E; Robak, T | 1 |
Błoński , JZ; Kasznicki, M; Robak, T | 1 |
Addo, F; Allmer, C; Geyer, SM; Krook, JE; Levitt, R; Li, CY; Mailliard, JA; Michalak, JC; Reeder, CB; Schaefer, PL; Tefferi, A; Witzig, TE | 1 |
Boguradzki, P; Błoński, JZ; Calbecka, M; Ceglarek, B; Dmoszyńska, A; Dwilewicz-Trojaczek, J; Góra-Tybor, I; Kasznicki, M; Konopka, L; Kuliczkowski, K; Moskwa-Sroka, B; Nowak, W; Robak, T; Skotnicki, AB; Stella-Hołowiecka, B; Sułek, J; Wołowiec, D | 1 |
Bartkowiak, J; Błonski, JZ; Kasznicki, M; Kordek, R; Robak, T; Wawrzyniak, E | 1 |
Boehrer, S; Chow, KU; Hoelzer, D; Mitrou, PS; Rummel, MJ; Schneider, B; Seipelt, G; Sommerlad, WD; Weidmann, E | 1 |
Bontemps, F; Cardoen, S; Delacauw, A; Ferrant, A; Husson, B; Rosier, JF; Van den Berghe, G; Van Den Neste, E | 1 |
Celsing, F; Cristiansen, I; Delannoy, A; Johnson, SA; Juliusson, G; Karlsson, K; Kimby, E; Lärfars, G; Liliemark, J; Luthman, M; Nilsson, G; Porwit, A; Strömberg, M; Sundström, G; Tidefelt, U; Wallvik, J | 1 |
Kontoyiannis, DP; Samonis, G | 1 |
Kasznicki, M; Robak, T | 1 |
Bosanquet, AG; Bosanquet, MI; Daniel, PT; Dörken, B; Essmann, F; Head, DJ; Sturm, I; Wieder, T | 1 |
Blonski, JZ; Gora-Tybor, J; Robak, T | 1 |
Beutler, E; Carrera, CJ; Carson, DA; Kay, AC; Piro, LD; Saven, A; Thurston, D | 1 |
Carrera, CJ; Carson, DA; Cottam, HB; Esparza, LM; Kipps, TJ; Wasson, DB | 1 |
Elmhorn-Rosenborg, A; Juliusson, G; Liliemark, J | 1 |
Kantarjian, H; Keating, MJ; Koller, C; O'Brien, S; Plunkett, W; Robertson, L | 1 |
Gribbin, TE | 1 |
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD; Saven, A; Terai, C | 1 |
Beutler, E; Carrera, CJ; Carson, DA; Piro, LD; Wasson, DB | 1 |
38 review(s) available for cladribine and B-Cell Chronic Lymphocytic Leukemia
Article | Year |
---|---|
Beyond hairy cell: the activity of cladribine in other hematologic malignancies.
Topics: Antineoplastic Agents; Cladribine; Hematologic Neoplasms; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Waldenstrom Macroglobulinemia | 2010 |
Simultaneous diagnosis of hairy cell leukemia and chronic lymphocytic leukemia/small lymphocytic lymphoma: a frequent association?
Topics: Antimetabolites, Antineoplastic; B-Lymphocytes; Cell Lineage; Cladribine; Combined Modality Therapy; Comorbidity; Gene Rearrangement, B-Lymphocyte; Genes, Immunoglobulin; Hematopoietic Stem Cell Transplantation; Humans; Immunophenotyping; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mass Screening; Middle Aged; Neoplasms, Multiple Primary; Neoplastic Stem Cells; Pentostatin; Prospective Studies; Remission Induction; Salvage Therapy; Transplantation, Autologous | 2002 |
Mechanism of action of purine analogues in chronic lymphocytic leukaemia.
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Division; Cladribine; DNA Damage; Drug Resistance, Neoplasm; Drug Synergism; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Phosphorylation; Tumor Suppressor Protein p53; Vidarabine | 2003 |
Purine nucleoside analogues and combination therapies in B-cell chronic lymphocytic leukemia: dawn of a new era.
Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Rituximab; Vidarabine | 2004 |
Treatment of indolent non-Hodgkin's lymphoma with cladribine as single-agent therapy and in combination with mitoxantrone.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Mitoxantrone; Treatment Outcome | 2004 |
The place of cladribine in the treatment of chronic lymphocytic leukemia: a 10-year experience in Poland.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasms, Second Primary; Poland; Randomized Controlled Trials as Topic | 2005 |
Therapy of chronic lymphocytic leukemia with purine analogs and monoclonal antibodies.
Topics: Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antigens, CD; Antigens, Neoplasm; Antineoplastic Agents; CD52 Antigen; Cladribine; Clinical Trials as Topic; Glycoproteins; Humans; Immunotherapy; Leukemia, Lymphocytic, Chronic, B-Cell; Purines; Random Allocation; Rituximab; Time Factors; Vidarabine | 2005 |
Old and new insights into the mechanisms of action of two nucleoside analogs active in lymphoid malignancies: fludarabine and cladribine (review).
Topics: Antineoplastic Agents; Apoptosis; Caspases; Cell Cycle; Cell Membrane; Cell Proliferation; Cell Survival; Cladribine; DNA; DNA Damage; DNA Repair; DNA-Directed DNA Polymerase; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Models, Biological; Models, Chemical; Nucleosides; RNA; Signal Transduction; Tumor Suppressor Protein p53; Vidarabine | 2005 |
Single-agent purine analogues for the treatment of chronic lymphocytic leukaemia: a systematic review and meta-analysis.
Topics: Anemia, Hemolytic; Antineoplastic Agents; Cladribine; Disease-Free Survival; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Randomized Controlled Trials as Topic; Survival Analysis; Treatment Outcome; Vidarabine | 2006 |
Purine antagonists for chronic lymphocytic leukaemia.
Topics: Antineoplastic Agents; Chlorambucil; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Randomized Controlled Trials as Topic; Vidarabine | 2006 |
Immunological and genetic abnormalities in chronic lymphocytic leukaemia. Impact of the purine analogues.
Topics: Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 12; Chromosomes, Human, Pair 13; Cladribine; Humans; Immunity, Cellular; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Vidarabine | 1994 |
Purine analogs in the treatment of low-grade lymphomas and chronic lymphocytic leukemias.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Cladribine; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Pentostatin; Purines; Vidarabine | 1995 |
Advances in the biology and treatment of B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Autoimmune Diseases; Bone Marrow Transplantation; Chlorambucil; Chromosome Aberrations; Cladribine; Humans; Immunologic Factors; Immunotherapy; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocyte Activation; Practice Guidelines as Topic; Randomized Controlled Trials as Topic; Vidarabine | 1995 |
2-Chlorodeoxyadenosine in the treatment of hairy cell leukemia and chronic lymphocytic leukemia.
Topics: Cladribine; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell | 1993 |
2-Chlorodeoxyadenosine: treatment of hairy cell leukemia, chronic lymphocytic leukemia, and lymphocytic lymphoma.
Topics: Cladribine; Clinical Trials as Topic; Follow-Up Studies; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell | 1993 |
Nucleoside analogs in treatment of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Survival Rate; Vidarabine | 1993 |
2-Chlorodeoxyadenosine: a new nucleoside agent effective in the treatment of lymphoid malignancies.
Topics: Cladribine; Humans; Leukemia; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Cutaneous | 1993 |
The role of cladribine in the treatment of lymphoid malignancies.
Topics: Antineoplastic Agents; Cladribine; Drug Monitoring; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Oncology Nursing; Patient Care Planning | 1995 |
Current results and prospective trials of cladribine in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Clinical Trials as Topic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Prospective Studies; Vidarabine | 1996 |
The Scripps Clinic experience with cladribine (2-CdA) in the treatment of chronic lymphocytic leukemia.
Topics: Alkylation; Anemia, Hemolytic, Autoimmune; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1996 |
[Treatment of chronic lymphatic leukemia].
Topics: Antineoplastic Agents; Cladribine; Humans; Interferon-alpha; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Prognosis; Vidarabine | 1996 |
Purine analogs in chronic lymphocytic leukemia and Waldenström's macroglobulinemia.
Topics: Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Purine Nucleosides; Vidarabine; Waldenstrom Macroglobulinemia | 1996 |
Why do drugs work in CLL?
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Cladribine; Clinical Trials as Topic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine Phosphate | 1996 |
Adverse and beneficial immunological effects of purine nucleoside analogues.
Topics: Animals; Antineoplastic Agents; Cladribine; Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Purine Nucleosides; Vidarabine | 1996 |
Purine analogs in the treatment of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Clinical Trials as Topic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1997 |
Present status of purine analogs in the therapy of chronic lymphocytic leukemias.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Prognosis; Recurrence; Remission Induction; Vidarabine | 1997 |
Is there a place for 2-CDA in the treatment of B-CLL?
Topics: Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Recurrence; Thrombocytopenia; Vidarabine | 1997 |
Hairy cell leukemia and allied chronic lymphoid leukemias: current knowledge and new therapeutic options.
Topics: Antineoplastic Agents; Biomarkers, Tumor; Cladribine; Diagnosis, Differential; Humans; Interferon-alpha; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Prolymphocytic; Lymphoma, Non-Hodgkin; Pentostatin; Prognosis | 1997 |
Cladribine for the treatment of hairy cell leukemia and chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Remission Induction; Treatment Outcome | 1998 |
Therapy for previously untreated chronic lymphocytic leukemia: a reevaluation.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Randomized Controlled Trials as Topic; Vidarabine | 1998 |
Chronic lymphocytic leukemia.
Topics: Adult; Antibodies, Monoclonal; Antigens, CD; Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Biomarkers, Tumor; CD79 Antigens; Chromosome Aberrations; Chromosomes, Human; Cladribine; Combined Modality Therapy; Cytokines; Female; Genes, Immunoglobulin; Genes, p53; Genetic Therapy; Hematopoietic Stem Cell Transplantation; Humans; Immunologic Deficiency Syndromes; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neoplastic Stem Cells; Prognosis; Risk Factors; Vidarabine | 2000 |
Therapeutic potential of purine analogue combinations in the treatment of lymphoid malignancies.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cladribine; Clinical Trials as Topic; Drug Synergism; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Pentostatin; Purines; Vidarabine | 2000 |
Novel treatment strategies in chronic lymphocytic leukemia.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Pentostatin; Randomized Controlled Trials as Topic; Sex Factors; Vidarabine | 2001 |
Cladribine in the treatment of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell | 2001 |
Infectious complications of purine analog therapy.
Topics: Antimetabolites, Antineoplastic; Cladribine; Humans; Immune Tolerance; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Vidarabine Phosphate | 2001 |
Alkylating agents and nucleoside analogues in the treatment of B cell chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Antineoplastic Agents, Alkylating; Chlorambucil; Cladribine; Drug Therapy, Combination; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Recurrence, Local; Nucleosides; Survival Rate; Treatment Failure; Vidarabine | 2002 |
New purine analogues for the treatment of chronic B-cell malignancies.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Vidarabine | 1991 |
Activity of 2-chloro-2'-deoxyadenosine in chronic lymphocytic leukemia, hairy cell leukemia, and autoimmune hemolytic anemia.
Topics: 2-Chloroadenosine; Adenosine Deaminase; Anemia, Hemolytic, Autoimmune; Cladribine; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell | 1989 |
49 trial(s) available for cladribine and B-Cell Chronic Lymphocytic Leukemia
Article | Year |
---|---|
Rituximab, cladribine, and cyclophosphamide (RCC) induction with rituximab maintenance in chronic lymphocytic leukemia: PALG - CLL4 (ML21283) trial.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Cladribine; Cyclophosphamide; Female; Humans; Immunophenotyping; Kaplan-Meier Estimate; Leukemia, Lymphocytic, Chronic, B-Cell; Maintenance Chemotherapy; Male; Neoplasm Staging; Prognosis; Proportional Hazards Models; Remission Induction; Rituximab; Treatment Outcome | 2018 |
Immune thrombocytopenia in patients with chronic lymphocytic leukemia treated with cladribine-based regiments or chlorambucil--follow-up of PALG-CLL randomized trials.
Topics: Aged; Chlorambucil; Cladribine; Female; Follow-Up Studies; Hemorrhage; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prevalence; Retrospective Studies; Thrombocytopenia; Time Factors; Treatment Outcome | 2013 |
Long-term results of the Polish Adult Leukemia Group PALG-CLL2 phase III randomized study comparing cladribine-based combinations in chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cladribine; Cyclophosphamide; Humans; Incidence; Leukemia, Lymphocytic, Chronic, B-Cell; Mitoxantrone; Neoplasms, Second Primary; Treatment Outcome | 2014 |
In vivo and ex vivo responses of CLL cells to purine analogs combined with alkylating agent.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cladribine; Cyclophosphamide; DNA Fragmentation; Electrophoresis, Agar Gel; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Vidarabine | 2013 |
Cladribine prolongs progression-free survival and time to second treatment compared to fludarabine and high-dose chlorambucil in chronic lymphocytic leukemia.
Topics: Aged; Antineoplastic Agents; Chlorambucil; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Quality of Life; Retreatment; Treatment Outcome; Vidarabine | 2014 |
Relationship between in vitro drug sensitivity and clinical response of patients to treatment in chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Survival; Cells, Cultured; Cladribine; Cyclophosphamide; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Treatment Outcome; Vidarabine | 2015 |
Expression of the human concentrative nucleotide transporter 1 (hCNT1) gene correlates with clinical response in patients affected by Waldenström's Macroglobulinemia (WM) and small lymphocytic lymphoma (SLL) undergoing a combination treatment with 2-chlor
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Cladribine; Female; Gene Expression Regulation, Neoplastic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Transport Proteins; Middle Aged; Models, Biological; Prognosis; Rituximab; Treatment Outcome; Waldenstrom Macroglobulinemia | 2010 |
Comparison of cladribine plus cyclophosphamide with fludarabine plus cyclophosphamide as first-line therapy for chronic lymphocytic leukemia: a phase III randomized study by the Polish Adult Leukemia Group (PALG-CLL3 Study).
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Cytogenetic Analysis; Female; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Remission Induction; Survival Rate; Treatment Outcome; Vidarabine | 2010 |
Efficacy of rituximab and cladribine in patients with chronic lymphocytic leukemia and feasibility of stem cell mobilization: a prospective multicenter phase II trial (protocol SAKK 34/02).
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Combined Modality Therapy; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Administration Schedule; Feasibility Studies; Female; Granulocyte Colony-Stimulating Factor; Hematopoietic Stem Cell Mobilization; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Remission Induction; Rituximab; Transplantation Conditioning; Treatment Outcome | 2010 |
Changes in the apoptotic gene expression profile in CLL patients treated with rituximab combined with cladribine and cyclophosphamide-preliminary results.
Topics: Adult; Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cladribine; Cluster Analysis; Cyclophosphamide; DNA Mutational Analysis; Female; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Genes, Immunoglobulin Heavy Chain; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pilot Projects; Rituximab; V(D)J Recombination | 2012 |
Cladribine combined with cyclophosphamide is highly effective in the treatment of chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm, Residual; Neutropenia; Opportunistic Infections; Remission Induction; Survival Analysis; Thrombocytopenia; Treatment Outcome | 2002 |
Phase II study of cladribine and cyclophosphamide in patients with chronic lymphocytic leukemia and prolymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Disease-Free Survival; Female; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Prolymphocytic; Leukopenia; Male; Middle Aged; Neoplasm Staging; Neutropenia; Salvage Therapy; Thrombocytopenia; Treatment Outcome | 2003 |
A phase II study of cladribine treatment for fludarabine refractory B cell chronic lymphocytic leukemia: results from CALGB Study 9211.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Confidence Intervals; Disease-Free Survival; Drug Administration Schedule; Drug Resistance, Neoplasm; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Neoplasm Staging; Patient Selection; Survival Rate; Time Factors; Vidarabine | 2003 |
Role of low-dose 2-CdA in refractory or resistant lymphoplasmocytic lymphoma.
Topics: Aged; Antineoplastic Agents; Cladribine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Infusions, Intravenous; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Probability; Prognosis; Prospective Studies; Risk Assessment; Severity of Illness Index; Survival Analysis; Treatment Outcome; Waldenstrom Macroglobulinemia | 2004 |
The effect of subsequent therapies in patients with chronic lymphocytic leukemia previously treated with prednisone and either cladribine or chlorambucil.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Cross-Over Studies; Cyclophosphamide; Doxorubicin; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Prednisone; Treatment Outcome; Vincristine | 2005 |
Activity of cladribine combined with etoposide in heavily pretreated patients with indolent lymphoid malignancies.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Etoposide; Female; Humans; Infections; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neutropenia; Recurrence; Survival Analysis; Treatment Outcome | 2005 |
Comparison of cladribine plus prednisone with chlorambucil plus prednisone in patients with chronic lymphocytic leukemia. Final report of the Polish Adult Leukemia Group (PALG CLL1).
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Cyclophosphamide; Doxorubicin; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Prednisone; Survival Analysis; Vincristine | 2005 |
Cladribine alone and in combination with cyclophosphamide or cyclophosphamide plus mitoxantrone in the treatment of progressive chronic lymphocytic leukemia: report of a prospective, multicenter, randomized trial of the Polish Adult Leukemia Group (PALG C
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Female; Humans; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitoxantrone; Neoplasm, Residual; Neutropenia; Remission Induction | 2006 |
The multicenter trial SAKK 37/95 of cladribine, cyclophosphamide and prednisone in the treatment of chronic lymphocytic leukemias and low-grade non-Hodgkin's lymphomas.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Combined Modality Therapy; Cyclophosphamide; Disease-Free Survival; Female; Hematologic Diseases; Humans; Immunocompromised Host; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasms, Second Primary; Prednisone; Prospective Studies; Remission Induction; Salvage Therapy; Survival Analysis; Treatment Outcome | 2007 |
Rituximab plus cladribine with or without cyclophosphamide in patients with relapsed or refractory chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Cladribine; Cyclophosphamide; Drug Therapy, Combination; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Recurrence; Rituximab; Survival Rate | 2007 |
2-Chlorodeoxyadenosine (CdA) for patients with previously untreated chronic lymphocytic leukemia (CLL).
Topics: Adult; Aged; Base Sequence; Blotting, Southern; Bone Marrow; Cladribine; Cohort Studies; Female; Follow-Up Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Molecular Sequence Data; Neoplasm, Residual; Polymerase Chain Reaction; Remission Induction | 1995 |
Cladribine in the treatment of relapsed or refractory chronic lymphocytic leukemia.
Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Cladribine; Drug Administration Schedule; Drug Resistance; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Recurrence; Remission Induction; Survival Rate | 1995 |
2-Chlorodeoxyadenosine activity in patients with untreated chronic lymphocytic leukemia.
Topics: Adult; Aged; Cladribine; Female; Follow-Up Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Remission Induction; Thrombocytopenia | 1995 |
2-Chlorodeoxyadenosine therapy in advanced chronic lymphocytic leukaemia.
Topics: Aged; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neutropenia; Remission Induction; Salvage Therapy; Seizures; Survival Rate; Thrombocytopenia; Treatment Outcome | 1994 |
2'-Chlorodeoxyadenosine: evaluation of a novel predominantly lymphocyte selective agent in lymphoid malignancies.
Topics: Adult; Aged; Cladribine; Drug Evaluation; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Lymphoma, Non-Hodgkin; Male; Middle Aged | 1993 |
2-Chlorodeoxyadenosine for patients with B-cell chronic lymphocytic leukemia resistant to fludarabine.
Topics: Antineoplastic Agents; Cladribine; Drug Resistance; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1993 |
Survival of young patients with chronic lymphocytic leukemia failing fludarabine therapy: a basis for the use of myeloablative therapies.
Topics: Adult; Antimetabolites, Antineoplastic; Bone Marrow Transplantation; Cladribine; Combined Modality Therapy; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Survival Analysis; Vidarabine | 1995 |
Fludarabine in chronic leukaemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Doxorubicin; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Prednisone; Vidarabine Phosphate | 1996 |
Oral cladribine as primary therapy for patients with B-cell chronic lymphocytic leukemia.
Topics: Administration, Oral; Aged; Antineoplastic Agents; Blood Cell Count; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Remission Induction; Survival Rate | 1996 |
2-Chlorodeoxyadenosine treatment in non-Hodgkin's lymphoma and B-cell chronic lymphocytic leukemia resistant to conventional chemotherapy: results of a multicentric experience. International Society for Chemo-Immunotherapy.
Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Cladribine; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lymphoma, Non-Hodgkin; Male; Middle Aged; Neoplasm Staging; Survival Rate; Time Factors | 1996 |
Intermittent 2-hour intravenous infusions of 2-chlorodeoxyadenosine in the treatment of 110 patients with refractory or previously untreated B-cell chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Cladribine; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Recurrence; Vidarabine | 1996 |
[Chronic lymphatic leukemia. Peroral cladribine as primary treatment].
Topics: Aged; Antineoplastic Agents; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged | 1996 |
Phase I study of cladribine (2-chlorodeoxyadenosine) in lymphoid malignancies. Cladribine Study Group.
Topics: Aged; Antineoplastic Agents; Cladribine; Female; Humans; Leukemia-Lymphoma, Adult T-Cell; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphoma, T-Cell, Cutaneous; Male; Middle Aged; Neutropenia; Thrombocytopenia | 1997 |
Pharmacokinetics of cladribine in plasma and its 5'-monophosphate and 5'-triphosphate in leukemic cells of patients with chronic lymphocytic leukemia.
Topics: Adenosine Monophosphate; Adenosine Triphosphate; Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Drug Administration Schedule; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Metabolic Clearance Rate; Middle Aged; Regression Analysis | 1998 |
Bioavailability and bacterial degradation of rectally administered 2-chloro-2'-deoxyadenosine.
Topics: Administration, Rectal; Aged; Bacteria; Biological Availability; Biotransformation; Cladribine; Feces; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Saliva | 1995 |
Reduced dose of subcutaneous cladribine induces identical response rates but decreased toxicity in pretreated chronic lymphocytic leukaemia. Swiss Group for Clinical Cancer Research (SAKK).
Topics: Adult; Aged; Antineoplastic Agents; Cladribine; Cohort Studies; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Injections, Subcutaneous; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prospective Studies; Remission Induction; Treatment Failure | 1998 |
2-Chlorodeoxyadenosine (cladribine) in the treatment of elderly patients with B-cell chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Drug Administration Schedule; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Retrospective Studies | 1999 |
Attempted reconstruction of the immune system using low doses of interleukin 2 in chronic lymphocytic leukemia patients treated with 2-chlorodeoxyadenosine: results of a pilot study.
Topics: Antineoplastic Agents; CD3 Complex; CD4 Antigens; CD8 Antigens; Cladribine; Female; Humans; Interleukin-2; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Male; Pilot Projects; T-Lymphocytes | 1999 |
Response to cladribine in previously treated patients with chronic lymphocytic leukaemia identified by ex vivo assessment of drug sensitivity by DiSC assay.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Drug Screening Assays, Antitumor; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Recurrence; Survival Analysis; Treatment Outcome | 1999 |
Phase II study of 2-chlorodeoxyadenosine in combination with chlorambucil in previously untreated B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Disease Progression; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Neoplasm, Residual; Survival Analysis; United States | 1999 |
Cladribine with or without prednisone in the treatment of previously treated and untreated B-cell chronic lymphocytic leukaemia - updated results of the multicentre study of 378 patients.
Topics: 2-Chloroadenosine; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Deoxyadenosines; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Prospective Studies; Survival Analysis | 2000 |
Phase I/II study of 2-chloro-2'-deoxyadenosine with cyclophosphamide in patients with pretreated B cell chronic lymphocytic leukemia and indolent non-Hodgkin's lymphoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Survival Analysis | 2000 |
Cladribine with prednisone versus chlorambucil with prednisone as first-line therapy in chronic lymphocytic leukemia: report of a prospective, randomized, multicenter trial.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chlorambucil; Cladribine; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Incidence; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Life Tables; Male; Middle Aged; Neutropenia; Poland; Prednisone; Prospective Studies; Remission Induction; Survival Rate; Thrombocytopenia; Treatment Outcome | 2000 |
Cladribine in combination with mitoxantrone and cyclophosphamide(CMC) in the treatment of heavily pre-treated patients with advanced indolent lymphoid malignancies.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow Diseases; Cladribine; Cyclophosphamide; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Mitoxantrone; Remission Induction; Salvage Therapy; Treatment Outcome | 2001 |
A phase II study of sequential combination chemotherapy with cyclophosphamide, prednisone, and 2-chlorodeoxyadenosine in previously untreated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Disease-Free Survival; Female; Follow-Up Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Remission Induction | 2001 |
Cladribine combined with cyclophosphamide and mitoxantrone as front-line therapy in chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cladribine; Cohort Studies; Cyclophosphamide; Female; Humans; Infections; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitoxantrone; Pancytopenia; Treatment Outcome; Vomiting | 2001 |
Oral cladribine for B-cell chronic lymphocytic leukaemia: report of a phase II trial with a 3-d, 3-weekly schedule in untreated and pretreated patients, and a long-term follow-up of 126 previously untreated patients.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Disease Progression; Disease-Free Survival; Drug Administration Schedule; Follow-Up Studies; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Neoplasm, Residual; Opportunistic Infections; Prognosis; Retrospective Studies; Survival Rate; Treatment Outcome | 2002 |
2-Chlorodeoxyadenosine treatment of low-grade lymphomas.
Topics: 2-Chloroadenosine; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Bacterial Infections; Bone Marrow Diseases; Cladribine; Deoxyadenosines; Drug Evaluation; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Male; Middle Aged; Remission Induction; Treatment Outcome | 1992 |
Response to 2-chlorodeoxyadenosine in patients with B-cell chronic lymphocytic leukemia resistant to fludarabine.
Topics: 2-Chloroadenosine; Adult; Antineoplastic Agents; Cladribine; Deoxyadenosines; Drug Resistance; Female; Haptoglobins; Humans; Immunoglobulins; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Lymphocytes; Male; Middle Aged; Remission Induction; Vidarabine | 1992 |
131 other study(ies) available for cladribine and B-Cell Chronic Lymphocytic Leukemia
Article | Year |
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The influence of venetoclax, used alone or in combination with cladribine (2-CdA), on CLL cells apoptosis in vitro: Preliminary results.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bridged Bicyclo Compounds, Heterocyclic; Caspase 3; Caspase 9; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Sulfonamides | 2022 |
Concurrent chronic lymphocytic leukemia/small lymphocytic lymphoma and hairy cell leukemia: clinical, pathologic and molecular features.
Topics: Cladribine; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Rituximab | 2020 |
Clinical case: idelalisib-induced immunoglobulin flare.
Topics: Aged; Cladribine; Female; Humans; Immunoglobulin M; Leukemia, Lymphocytic, Chronic, B-Cell; Purines; Quinazolinones; Rituximab; Waldenstrom Macroglobulinemia | 2017 |
Mechanisms of action of the anti-VEGF monoclonal antibody bevacizumab on chronic lymphocytic leukemia cells.
Topics: Alemtuzumab; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bevacizumab; Caspase 3; Caspase 9; Cladribine; Cyclophosphamide; Down-Regulation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Proteasome Inhibitors; Rituximab; Sirolimus; Tumor Cells, Cultured; Vascular Endothelial Growth Factor A; Vidarabine | 2013 |
Cladribine Analogues via O⁶-(Benzotriazolyl) Derivatives of Guanine Nucleosides.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cladribine; Guanosine; Humans; Inhibitory Concentration 50; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Lymphoma, T-Cell; Organophosphorus Compounds; Primary Cell Culture; Structure-Activity Relationship | 2015 |
Targeting DNA repair with aphidicolin sensitizes primary chronic lymphocytic leukemia cells to purine analogs.
Topics: Antineoplastic Agents; Aphidicolin; Apoptosis; Cladribine; DNA Damage; DNA Repair; Drug Synergism; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 2016 |
Calorimetric study as a potential test for choosing treatment of B-cell chronic lymphocytic leukemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Calorimetry, Differential Scanning; Cell Survival; Cells, Cultured; Cladribine; Cyclophosphamide; DNA Damage; Drug Combinations; Drug Monitoring; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Myeloid Cell Leukemia Sequence 1 Protein; Phase Transition; Proto-Oncogene Proteins c-bcl-2; Vidarabine | 2009 |
Valproate synergizes with purine nucleoside analogues to induce apoptosis of B-chronic lymphocytic leukaemia cells.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; Blotting, Western; Cladribine; Drug Synergism; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Microscopy, Confocal; Middle Aged; Reactive Oxygen Species; Tumor Cells, Cultured; Valproic Acid; Vidarabine | 2009 |
Concomitant treatment with lamivudine renders cladribine inactive by inhibition of its phosphorylation.
Topics: Antineoplastic Agents; Cladribine; Drug Interactions; Humans; Lamivudine; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Phosphorylation; Treatment Failure | 2009 |
Activity of cladribine combined with cyclophosphamide in frontline therapy for chronic lymphocytic leukemia with 17p13.1/TP53 deletion: report from the Polish Adult Leukemia Group.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chromosomes, Human, Pair 17; Cladribine; Cyclophosphamide; Drug Administration Schedule; Female; Genes, p53; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Retrospective Studies; Sequence Deletion | 2009 |
Drug induction apoptosis assay as predictive value of chemotherapy response in patients with B-cell chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Apoptosis; B-Lymphocytes; Chlorambucil; Cladribine; Female; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Predictive Value of Tests; Prognosis; Time Factors; Tumor Cells, Cultured; Vidarabine | 2009 |
Roscovitine triggers apoptosis in B-cell chronic lymphocytic leukemia cells with similar efficiency as combinations of conventional purine analogs with cyclophosphamide.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 9; Cell Survival; Cells, Cultured; Cladribine; Cyclin E; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Cyclophosphamide; Drug Synergism; Female; Flow Cytometry; Humans; Intracellular Signaling Peptides and Proteins; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Myeloid Cell Leukemia Sequence 1 Protein; Proto-Oncogene Proteins c-bcl-2; Purines; Roscovitine; Vidarabine | 2009 |
Impaired up-regulation of polo-like kinase 2 in B-cell chronic lymphocytic leukaemia lymphocytes resistant to fludarabine and 2-chlorodeoxyadenosine: a potential marker of defective damage response.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Biomarkers, Tumor; Cell Death; Cladribine; Cohort Studies; DNA Damage; DNA, Neoplasm; Drug Resistance, Neoplasm; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; RNA, Neoplasm; Tumor Cells, Cultured; Up-Regulation; Vidarabine | 2009 |
R-roscovitine (Seliciclib) affects CLL cells more strongly than combinations of fludarabine or cladribine with cyclophosphamide: Inhibition of CDK7 sensitizes leukemic cells to caspase-dependent apoptosis.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Caspases; Cell Survival; Cells, Cultured; Cladribine; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Cyclophosphamide; Female; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Staging; Purines; Roscovitine; Vidarabine | 2010 |
CD154 expression triggered by purine analogues in vitro: Correlation with treatment response and autoimmune events in chronic lymphocytic leukemia.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Autoimmunity; CD40 Ligand; Cells, Cultured; Cladribine; Female; Flow Cytometry; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Outcome Assessment, Health Care; Prognosis; Vidarabine | 2010 |
The efficacy and stem cell toxicity of cladribine and rituximab in the treatment of patients with chronic lymphocytic leukemia: are all purine analogs created equal?
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Clinical Trials, Phase II as Topic; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplastic Stem Cells; Purines; Rituximab; Treatment Outcome | 2010 |
Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells.
Topics: ADP-ribosyl Cyclase 1; Anticholesteremic Agents; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Proteins; Cladribine; DNA-Binding Proteins; Enzyme Activation; Histones; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Prognosis; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Simvastatin; Tumor Cells, Cultured; Tumor Suppressor Proteins; Vidarabine; ZAP-70 Protein-Tyrosine Kinase | 2010 |
Rituximab and subcutaneous cladribine in chronic lymphocytic leukemia for newly diagnosed and relapsed patients.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Case-Control Studies; Cladribine; Equilibrative Nucleoside Transporter 1; Female; Flow Cytometry; Humans; In Situ Hybridization, Fluorescence; Infusions, Subcutaneous; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Membrane Transport Proteins; Middle Aged; Neoplasm Recurrence, Local; Reverse Transcriptase Polymerase Chain Reaction; Rituximab; RNA, Messenger; Salvage Therapy; Survival Rate; Treatment Outcome | 2010 |
Resveratrol increases rate of apoptosis caused by purine analogues in malignant lymphocytes of chronic lymphocytic leukemia.
Topics: ADP-ribosyl Cyclase 1; Adult; Antineoplastic Agents; Apoptosis; Ataxia Telangiectasia Mutated Proteins; bcl-2-Associated X Protein; Caspase 3; Cell Cycle Proteins; Cladribine; DNA-Binding Proteins; Drug Therapy, Combination; Enzyme Activation; Histones; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Membrane Glycoproteins; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-bcl-2; Purines; Resveratrol; Stilbenes; Tumor Suppressor Proteins; Vidarabine; ZAP-70 Protein-Tyrosine Kinase | 2011 |
Effective treatment of leukemia cutis with combination of rituximab, cladribine, and cyclophosphamide in patient with B-cell chronic lymphocytic leukemia.
Topics: Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Diagnostic Errors; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged; Remission Induction; Rituximab; Rosacea | 2011 |
Nucleoside analogs induce proteasomal down-regulation of p21 in chronic lymphocytic leukemia cell lines.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cladribine; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; Enzyme Activation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Proliferating Cell Nuclear Antigen; Proteasome Endopeptidase Complex; Purine Nucleosides; Tumor Suppressor Protein p53; Ubiquitination; Up-Regulation; Vidarabine | 2011 |
Risk factors for Pneumocystis jirovecii pneumonia in patients with lymphoproliferative disorders.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Case-Control Studies; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Lymphoproliferative Disorders; Male; Middle Aged; Pneumocystis carinii; Pneumonia, Pneumocystis; Retrospective Studies; Risk Factors; Time Factors; Treatment Outcome; Trimethoprim, Sulfamethoxazole Drug Combination; Vidarabine | 2012 |
Can ex vivo evaluation (testing) predict the sensitivity of CLL cells to therapy with purine analogs in conjunction with an alkylating agent? A comparison of in vivo and ex vivo responses to treatment.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Apoptosis; Cell Line; Cladribine; Cyclophosphamide; Drug Resistance, Neoplasm; Female; Flow Cytometry; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Purines; Roscovitine; Vidarabine | 2012 |
Pure erythroid leukemia evolving from a therapy-related myelodysplastic syndrome secondary to treatment for chronic lymphocytic leukemia.
Topics: Abnormal Karyotype; Aged; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Fatal Outcome; Humans; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Myelodysplastic Syndromes; Prednisone; Vidarabine; Vincristine | 2013 |
Apoptotic gene expression under influence of fludarabine and cladribine in chronic lymphocytic leukemia-microarray study.
Topics: Antineoplastic Agents; Apoptosis; Cladribine; DNA, Complementary; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Transcriptome; Tumor Cells, Cultured; Vidarabine | 2012 |
Fludarabine and cladribine induce changes in surface proteins on human B-lymphoid cell lines involved with apoptosis, cell survival, and antitumor immunity.
Topics: Antigens, CD; Apoptosis; B-Lymphocytes; Burkitt Lymphoma; Cell Adhesion; Cell Line; Cell Line, Tumor; Cell Survival; Cladribine; Drug Resistance, Neoplasm; Flow Cytometry; Glycoproteins; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Proteins; Reproducibility of Results; Signal Transduction; Up-Regulation; Vidarabine | 2012 |
Effects of Toll-like receptor 7 and Toll-like receptor 9 signaling stimulators and inhibitors on chronic lymphocytic leukemia cells ex vivo and their interactions with cladribine.
Topics: Aged; Antigens, CD; Antineoplastic Agents; Cladribine; Cytokines; DNA; Drug Interactions; Female; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Ligands; Male; Middle Aged; Signal Transduction; Toll-Like Receptor 7; Toll-Like Receptor 9; Tumor Cells, Cultured | 2013 |
Toward personalized therapy for chronic lymphocytic leukemia: DSC and cDNA microarray assessment of two cases.
Topics: Aged; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Calorimetry, Differential Scanning; Cell Nucleus; Cell Survival; Cladribine; Cyclophosphamide; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Precision Medicine; Proto-Oncogene Proteins c-bcl-2; Rituximab; Transcriptome; Treatment Outcome; Tumor Cells, Cultured | 2013 |
Bendamustine in the treatment of chronic lymphocytic leukemia: results and future perspectives.
Topics: Aged; Aged, 80 and over; Alemtuzumab; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; B-Lymphocytes; Bendamustine Hydrochloride; Cladribine; Drug Administration Schedule; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm Recurrence, Local; Nitrogen Mustard Compounds; Remission Induction; Rituximab; Salvage Therapy; Vidarabine | 2002 |
Re-treatment with cladribine-based regimens in relapsed patients with B-cell chronic lymphocytic leukemia. Efficacy and toxicity in comparison with previous treatment.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Disease-Free Survival; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mitoxantrone; Prednisone; Recurrence; Survival Analysis; Treatment Outcome | 2002 |
Cladribine induces immunophenotypical changes in bone marrow mast cells from mastocytosis. Report of a case of mastocytosis associated with a lymphoplasmacytic lymphoma.
Topics: Aged; Antigens, CD; Antineoplastic Agents; Bone Marrow Cells; Cladribine; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mast Cells; Mastocytosis | 2002 |
Successful treatment of leukaemia cutis with cladribine in a patient with B-cell chronic lymphocytic leukaemia.
Topics: Aged; Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemic Infiltration; Male; Skin | 2002 |
Comparison of cytotoxicity of 2-chloro- 2'-arabino-fluoro-2'-deoxyadenosine (clofarabine) with cladribine in mononuclear cells from patients with acute myeloid and chronic lymphocytic leukemia.
Topics: Acute Disease; Adenine Nucleotides; Adult; Aged; Aged, 80 and over; Arabinonucleosides; Cell Survival; Cladribine; Clofarabine; Drug Evaluation; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid; Leukocytes, Mononuclear; Male; Middle Aged | 2003 |
Hodgkin's type of Richter's syndrome in familial chronic lymphocytic leukemia treated with cladribine and cyclophosphamide.
Topics: Abdominal Neoplasms; Antineoplastic Combined Chemotherapy Protocols; Cell Transformation, Neoplastic; Cladribine; Cyclophosphamide; Family Health; Herpesvirus 4, Human; Hodgkin Disease; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Male; Middle Aged; Neoplasms, Second Primary; Syndrome | 2003 |
Second malignancies and Richter's syndrome in patients with chronic lymphocytic leukaemia treated with cladribine.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Doxorubicin; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lung Neoplasms; Male; Middle Aged; Neoplasms, Second Primary; Prednisone; Retrospective Studies; Syndrome; Vincristine | 2004 |
Metabolic response patterns of nucleotides in B-cell chronic lymphocytic leukaemias to cladribine, fludarabine and deoxycoformycin.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Humans; Ionomycin; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Nucleotides; Pentostatin; Prognosis; Tumor Cells, Cultured; Vidarabine | 2004 |
Cutaneous adverse reaction to 2-chlorodeoxyadenosine with histological flame figures in patients with chronic lymphocytic leukaemia.
Topics: Aged; Antineoplastic Agents; Cladribine; Diagnosis, Differential; Drug Eruptions; Exanthema; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged | 2004 |
Richter's syndrome in the brain first manifested as an ischaemic stroke.
Topics: Brain; Brain Ischemia; Brain Neoplasms; Cell Transformation, Neoplastic; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Syndrome | 2004 |
VH gene mutation status and cellular drug resistance in chronic lymphocytic leukaemia.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Cladribine; Cyclophosphamide; Cytarabine; DNA Mutational Analysis; Doxorubicin; Drug Resistance, Neoplasm; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Genes, Immunoglobulin; Humans; Idarubicin; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Leukemia, Lymphocytic, Chronic, B-Cell; Life Tables; Melphalan; Prednisolone; Survival Analysis; Vidarabine; Vincristine | 2004 |
Effects of 2-chloro-2'-deoxyadenosine on the cell cycle in the human leukemia EHEB cell line.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Blotting, Western; Bromodeoxyuridine; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cladribine; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine Kinase; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; G1 Phase; Humans; Inhibitory Concentration 50; Leukemia, Lymphocytic, Chronic, B-Cell; Models, Biological; Phosphorylation; S Phase; Time Factors | 2004 |
2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; Cladribine; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Middle Aged; Mitoxantrone | 2004 |
The influence of chemotherapy on bone marrow in patients with chronic lymphocytic leukaemia.
Topics: Adult; Aged; Antineoplastic Agents; Biopsy; Bone Marrow; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm, Residual; Vidarabine | 2004 |
The natural product honokiol induces caspase-dependent apoptosis in B-cell chronic lymphocytic leukemia (B-CLL) cells.
Topics: Antineoplastic Agents; Apoptosis; Biphenyl Compounds; Caspases; Chlorambucil; Cladribine; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Humans; In Vitro Techniques; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Lignans; Magnolia; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Phytotherapy; Proto-Oncogene Proteins c-bcl-2; Vidarabine | 2005 |
In vitro cytotoxic effect of proteasome inhibitor bortezomib in combination with purine nucleoside analogues on chronic lymphocytic leukaemia cells.
Topics: Annexin A5; Antineoplastic Agents; Apoptosis; Boronic Acids; Bortezomib; Cell Survival; Cladribine; Dose-Response Relationship, Drug; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Proteasome Inhibitors; Pyrazines; Tumor Cells, Cultured | 2005 |
Merkel cell carcinoma in a patient with B-cell chronic lymphocytic leukemia treated with cladribine and rituximab.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Agents; Carcinoma, Merkel Cell; Cladribine; Female; Humans; Immunosuppressive Agents; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic Metastasis; Middle Aged; Remission Induction; Rituximab; Skin Neoplasms; Treatment Outcome | 2005 |
In vitro sensitivity of B-cell chronic lymphocytic leukemia to cladribine and its combinations with mafosfamide and/or mitoxantrone.
Topics: Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; Blotting, Western; Caspases; Cladribine; Cyclophosphamide; DNA Fragmentation; Female; Humans; In Vitro Techniques; Lamin Type B; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Mitochondria; Mitoxantrone; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Protein Transport; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured | 2006 |
Pharmacological inhibition of the MAPK/ERK pathway increases sensitivity to 2-chloro-2'-deoxyadenosine (CdA) in the B-cell leukemia cell line EHEB.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cladribine; Drug Interactions; Extracellular Signal-Regulated MAP Kinases; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; MAP Kinase Signaling System; Phosphorylation; Protein Kinase Inhibitors | 2007 |
Cytotoxic effect of R-etodolac (SDX-101) in combination with purine analogs or monoclonal antibodies on ex vivo B-cell chronic lymphocytic leukemia cells.
Topics: Alemtuzumab; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibodies, Monoclonal, Murine-Derived; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cladribine; Etodolac; Humans; Leukemia, B-Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Purines; Rituximab; Spectrometry, Fluorescence; Vidarabine | 2006 |
Influence of cladribine alone and in combination with cyclophosphamide or cyclophosphamide and mitoxantrone on bone marrow angiogenesis in chronic lymphocytic leukemia.
Topics: Adult; Aged; Bone Marrow Cells; Cladribine; Cyclophosphamide; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Microcirculation; Middle Aged; Mitoxantrone; Neovascularization, Pathologic; Treatment Outcome | 2007 |
Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Chromosome Aberrations; Chromosomes, Human, Pair 11; Chromosomes, Human, Pair 13; Chromosomes, Human, Pair 17; Cladribine; Female; Humans; In Situ Hybridization, Fluorescence; Interphase; Karyotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Mutation; Prognosis; Risk Factors; Survival Rate; Translocation, Genetic; Treatment Failure; Tumor Suppressor Protein p53 | 2007 |
t(14;18)(q32;q21)-bearing pleural MALT lymphoma with IgM paraproteinemia: value of detection of specific cytogenetic abnormalities in the differential diagnosis of MALT lymphoma and lymphoplasmacytic lymphoma.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Caspases; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 18; Cladribine; Diagnosis, Differential; Diagnostic Errors; Female; Humans; Immunoglobulin Heavy Chains; Immunoglobulin M; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell, Marginal Zone; Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein; Neoplasm Proteins; Paraproteins; Pleural Neoplasms; Remission Induction; Rituximab; Translocation, Genetic | 2007 |
Cannabinoid receptors expression in bone marrow trephine biopsy of chronic lymphocytic leukaemia patients treated with purine analogues.
Topics: Antineoplastic Agents; B-Lymphocytes; Biopsy; Bone Marrow Cells; Cladribine; Flow Cytometry; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Purines; Receptors, Cannabinoid; Vidarabine | 2007 |
Comparison of antitumor activities of 2-chlorodeoxyadenosine and 9-beta-arabinosyl-2-fluoroadenine in chronic lymphocytic leukemia and marrow cells in vitro.
Topics: Antineoplastic Agents; Biological Transport; Bone Marrow; Cell Survival; Cells, Cultured; Chlorambucil; Cladribine; Drug Administration Schedule; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1995 |
Intracellular pharmacokinetics of 2-chlorodeoxyadenosine in leukemia cells from patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Biological Transport; Cladribine; Female; Half-Life; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Thioinosine | 1995 |
Molecular complete response in a patient with chronic lymphocytic leukaemia treated with 2-chlorodeoxyadenosine.
Topics: Blotting, Southern; Cladribine; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Polymerase Chain Reaction | 1995 |
Increased ratio between deoxycytidine kinase and thymidine kinase 2 in CLL lymphocytes compared to normal lymphocytes.
Topics: Cells, Cultured; Cladribine; Deoxycytidine Kinase; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Phosphorylation; Substrate Specificity; Thymidine Kinase; Tumor Cells, Cultured | 1995 |
Modulation of purine analogs- and chlorambucil-induced cytotoxicity by alpha-interferon and interleukin-2 in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Apoptosis; Cell Survival; Chlorambucil; Cladribine; Dose-Response Relationship, Drug; Humans; Interferon-alpha; Interleukin-1; Interleukin-2; Leukemia, Lymphocytic, Chronic, B-Cell; Tumor Necrosis Factor-alpha; Vidarabine | 1995 |
Acute onset of severe autoimmune hemolytic anemia after treatment with 2-chlorodeoxyadenosine for chronic lymphocytic leukemia.
Topics: Anemia, Hemolytic, Autoimmune; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged | 1995 |
Expression of deoxycytidine kinase and phosphorylation of 2-chlorodeoxyadenosine in human normal and tumour cells and tissues.
Topics: Blotting, Western; Cladribine; Colonic Neoplasms; Deoxycytidine Kinase; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Phosphorylation; Sarcoma; Stomach Neoplasms; Tissue Distribution; Tumor Cells, Cultured | 1995 |
[Hematologic remission and disappearance of hemolytic anemia in chronic lymphocytic leukemia after therapy with 2-chlorodeoxyadenosine (2-CDA)].
Topics: Anemia, Hemolytic; Autoimmune Diseases; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Male; Middle Aged; Remission Induction | 1993 |
Lack of effect of 2-chlorodeoxyadenosine therapy in patients with chronic lymphocytic leukemia refractory to fludarabine therapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neutropenia; Remission Induction; Thrombocytopenia; Vidarabine | 1994 |
[Pneumocystis carinii pneumonia during therapy with 2-chlorodeoxyadenosine (2-CDA)].
Topics: Aged; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pneumonia, Pneumocystis | 1994 |
2-Chlorodeoxyadenosine therapy in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1994 |
2-Chlorodeoxyadenosine therapy in chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1994 |
2-Chlorodeoxyadenosine treatment of patients with chronic lymphocytic leukaemia associated with autoimmune haemolysis.
Topics: Adult; Aged; Aged, 80 and over; Anemia, Hemolytic, Autoimmune; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Remission Induction; Treatment Outcome | 1994 |
In vitro activity of 2-chlorodeoxyadenosine (CdA) in primary cultures of human haematological and solid tumours.
Topics: Adrenocortical Carcinoma; Breast Neoplasms; Cladribine; Dose-Response Relationship, Drug; Drug Resistance; Drug Screening Assays, Antitumor; Female; Humans; Kidney Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Lung Neoplasms; Neoplasms; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tumor Cells, Cultured | 1994 |
Secondary neoplasms in two patients treated with purine analogues.
Topics: Acute Disease; Aged; Cladribine; Female; Humans; Immunocompromised Host; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Melanoma; Neoplasms, Second Primary; Skin Neoplasms; Vidarabine; Waldenstrom Macroglobulinemia | 1994 |
Analysis of 2-chloro-2'-deoxyadenosine in human blood plasma and urine by high-performance liquid chromatography using solid-phase extraction.
Topics: Chromatography, High Pressure Liquid; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged | 1994 |
Apoptosis induction with three nucleoside analogs on freshly isolated B-chronic lymphocytic leukemia cells.
Topics: Aged; Apoptosis; Cladribine; DNA Damage; Female; Humans; In Vitro Techniques; Interferon-alpha; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Pentostatin; Tumor Cells, Cultured; Vidarabine | 1994 |
Phosphorylation of 2-chlorodeoxyadenosine (CdA) in extracts of peripheral blood mononuclear cells of leukaemic patients.
Topics: Cladribine; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Leukocytes, Mononuclear; Phosphorylation | 1994 |
Complete remission of B-cell chronic lymphocytic leukaemia after oral cladribine.
Topics: Administration, Oral; Adult; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Remission Induction | 1993 |
Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine.
Topics: Adenosine Triphosphate; Apoptosis; Cladribine; Cycloheximide; Dactinomycin; DNA, Neoplasm; Egtazic Acid; Guanosine Triphosphate; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Microscopy, Electron; Puromycin; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Uridine Triphosphate; Vidarabine | 1993 |
Relationship of deoxycytidine kinase and cytoplasmic 5'-nucleotidase to the chemotherapeutic efficacy of 2-chlorodeoxyadenosine.
Topics: 5'-Nucleotidase; Aged; Antigens, CD; Cladribine; Cytoplasm; Deoxycytidine Kinase; False Positive Reactions; Female; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prognosis; Tumor Cells, Cultured | 1993 |
2-Chlorodeoxyadenosine for patients with B-cell chronic lymphocytic leukemia resistant to fludarabine.
Topics: Antineoplastic Agents; Cladribine; Drug Resistance; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Vidarabine | 1993 |
Listeriosis after 2-chlorodeoxyadenosine treatment.
Topics: Aged; Antineoplastic Agents; Cladribine; Drug Resistance; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Listeriosis; Vidarabine | 1993 |
High complete remission rate from 2-chloro-2'-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count.
Topics: Adult; Aged; Aged, 80 and over; Bone Marrow; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Lymphocytes; Male; Middle Aged; Recurrence; Remission Induction; Survival Rate | 1993 |
Brief report: tumor lysis syndrome following treatment with 2-chlorodeoxyadenosine for refractory chronic lymphocytic leukemia.
Topics: Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic Diseases; Male; Middle Aged; Tumor Lysis Syndrome | 1993 |
Nucleoside transporters, bcl-2 and apoptosis in CLL cells exposed to nucleoside analogues in vitro.
Topics: Antigens, CD19; Apoptosis; B-Lymphocytes; Carrier Proteins; CD5 Antigens; Cladribine; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Proteins; Neoplasm Proteins; Nucleoside Transport Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; S Phase; Tumor Cells, Cultured; Vidarabine | 1996 |
Infectious complications after 2-chlorodeoxyadenosine therapy.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cladribine; Cohort Studies; Disease Susceptibility; Female; Fever; Hematologic Diseases; Herpesviridae Infections; Humans; Immunologic Deficiency Syndromes; Incidence; Infections; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocyte Count; Lymphoma, Non-Hodgkin; Male; Middle Aged; Retrospective Studies; Risk Factors; Waldenstrom Macroglobulinemia | 1996 |
Delayed reactivation of hepatitis B infection after cladribine.
Topics: Aged; Cladribine; Hepatitis B; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Recurrence | 1996 |
2-Chlorodeoxyadenosine (2-CdA) in chronic lymphocytic leukemia refractory to fludarabine?
Topics: Antineoplastic Agents; Cladribine; Drug Resistance, Neoplasm; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Vidarabine | 1996 |
2-Chlorodeoxyadenosine (2-CdA) in the treatment of patients with relapsed chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Recurrence | 1995 |
Long-term survival following cladribine (2-chlorodeoxyadenosine) therapy in previously treated patients with chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cell Count; Cladribine; Combined Modality Therapy; Female; Follow-Up Studies; Hematopoietic Stem Cell Transplantation; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Opportunistic Infections; Remission Induction; Retreatment; Survival Rate; Treatment Outcome; Vidarabine | 1996 |
Fludarabine, as well as 2-chlorodeoxyadenosine, can induce eosinophilia during treatment of lymphoid malignancies.
Topics: Aged; Antineoplastic Agents; Cladribine; Eosinophilia; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphatic Diseases; Lymphoma, Follicular; Male; Middle Aged; Retrospective Studies; Vidarabine | 1996 |
Determination of 2-chloro-2'-deoxyadenosine nucleotides in leukemic cells by ion-pair high-performance liquid chromatography.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Circadian Rhythm; Cladribine; Drug Stability; Half-Life; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Temperature; Time Factors; Tumor Cells, Cultured | 1996 |
The induction of p53 and WAF1/CIP1 in chronic lymphocytic leukemia cells treated with 2-chlorodeoxyadenosine.
Topics: Antineoplastic Agents; Apoptosis; B-Lymphocytes; Cladribine; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Gene Expression; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1996 |
High response rates with short infusional 2-chlorodeoxyadenosine in de novo and relapsed low-grade lymphoma. Australian and New Zealand Lymphoma Study Group.
Topics: Adult; Aged; Antineoplastic Agents; Cladribine; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Leukopenia; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Male; Middle Aged; Opportunistic Infections; Recurrence; Survival Analysis; Thrombocytopenia; Treatment Outcome | 1996 |
In vitro cytotoxicity of 2-chlorodeoxyadenosine and chlorambucil in chronic lymphocytic leukemia.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cells, Cultured; Chlorambucil; Cladribine; DNA Damage; DNA Repair; DNA, Neoplasm; Drug Administration Schedule; Drug Interactions; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Tritium; Tumor Cells, Cultured | 1996 |
Myelodysplasia following treatment of chronic lymphocytic leukemia (CLL) with 2-chlorodeoxyadenosine (2-CdA)
Topics: Antineoplastic Agents; Chromosomes, Human, Pair 7; Cladribine; Fatal Outcome; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Monosomy; Myelodysplastic Syndromes | 1997 |
Occurrence of myeloma in a chronic lymphocytic leukemia patients after response to differentiation therapy with interleukin-4.
Topics: Antineoplastic Agents; Cell Differentiation; Cladribine; Humans; Interleukin-4; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Multiple Myeloma | 1996 |
2-Chlorodeoxyadenosine inhibits activity of adenosine deaminase and S-adenosylhomocysteine hydrolase in patients with chronic lymphocytic leukaemia.
Topics: Adenosine Deaminase Inhibitors; Adenosylhomocysteinase; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Cladribine; Humans; Hydrolases; Leukemia, Lymphocytic, Chronic, B-Cell; Middle Aged | 1997 |
Autoimmune haemolytic anaemia in patients with chronic lymphocytic leukaemia treated with 2-chlorodeoxyadenosine (cladribine).
Topics: Adult; Aged; Anemia, Hemolytic, Autoimmune; Antigens, CD; Antineoplastic Agents; B-Lymphocytes; Cladribine; Coombs Test; Female; Hemolysis; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Retrospective Studies | 1997 |
Induction of apoptosis by 2-chlorodeoxyadenosine in B cell chronic lymphocytic leukemia.
Topics: Adult; Aged; Apoptosis; Cladribine; DNA Fragmentation; DNA, Neoplasm; Female; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Tumor Cells, Cultured | 1997 |
2-chlorodeoxyadenosine (cladribine) induced allergic cutaneous reactions with eosinophilia in a patient with B-cell chronic lymphocytic leukemia.
Topics: Aged; Antineoplastic Agents; Cladribine; Drug Eruptions; Eosinophilia; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male | 1997 |
Sequential treatment of human chronic lymphocytic leukemia with bryostatin 1 followed by 2-chlorodeoxyadenosine: preclinical studies.
Topics: Acid Phosphatase; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Bryostatins; Cell Division; Cladribine; DNA, Neoplasm; Drug Administration Schedule; Drug Screening Assays, Antitumor; Humans; Lactones; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lipid Metabolism; Macrolides; Male; Mice; Mice, SCID; Neoplasm Proteins; Neoplasm Transplantation; Spectroscopy, Fourier Transform Infrared; Transplantation, Heterologous; Tumor Cells, Cultured | 1998 |
More on purine analog-induced apoptosis in B cell chronic lymphocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Apoptosis; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Tumor Cells, Cultured; Vidarabine Phosphate | 1998 |
Relationship between cladribine (CdA) plasma, intracellular CdA-5'-triphosphate (CdATP) concentration, deoxycytidine kinase (dCK), and chemotherapeutic activity in chronic lymphocytic leukemia (CLL).
Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Cladribine; Deoxycytidine Kinase; Female; Half-Life; Humans; Kinetics; Leukemia, Lymphocytic, Chronic, B-Cell; Leukocytes, Mononuclear; Male; Treatment Outcome | 1998 |
The effect of 2-h infusion of 2-chlorodeoxyadenosine (cladribine) with prednisone in previously untreated B-cell chronic lymphocytic leukaemia.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cladribine; Female; Humans; Infusions, Intravenous; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Retrospective Studies; Survival Analysis | 1997 |
Similarities between the sensitivity to 2-chlorodeoxyadenosine of lymphocytes from CLL patients and bryostatin 1-treated WSU-CLL cells: an infrared spectroscopic study.
Topics: Adult; Aged; Antineoplastic Agents; Bryostatins; Cladribine; Drug Resistance; Female; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Macrolides; Male; Middle Aged; Spectrophotometry, Infrared; Tumor Cells, Cultured | 1998 |
In vitro chemosensitivity of chronic lymphocytic leukaemia to purine analogues--correlation with clinical course.
Topics: Antineoplastic Agents; Apoptosis; Cladribine; DNA Nucleotidylexotransferase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Flow Cytometry; Humans; In Vitro Techniques; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Phenotype; Proto-Oncogene Proteins c-bcl-2; Vidarabine | 1998 |
Paradoxical immunologic effects of 2-CdA therapy: comment on the article by Davis et al.
Topics: Anemia, Hemolytic; Antibodies, Antinuclear; Arthritis, Rheumatoid; Cladribine; Female; Humans; Immune System Diseases; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Nephritis; Lymphopenia; Male; Middle Aged | 1998 |
Chlorambucil synergizes with purine analogs in inducing in vitro cytotoxicity in B-cell chronic lymphocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Chlorambucil; Cladribine; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplastic Stem Cells; Tumor Cells, Cultured; Vidarabine | 1998 |
Potentiation of 2-chlorodeoxyadenosine activity by bryostatin 1 in the resistant chronic lymphocytic leukemia cell line (WSU-CLL): association with increased ratios of dCK/5'-NT and Bax/Bcl-2.
Topics: 5'-Nucleotidase; Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bryostatins; Cell Division; Cladribine; Deoxycytidine Kinase; Drug Synergism; Female; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Mice; Mice, Inbred ICR; Mice, SCID; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1998 |
In vitro modulation of bcl-2 protein expression, drug-induced apoptosis and cytotoxicity by interleukin-10 in chronic lymphocytic leukemia.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cladribine; Drug Interactions; Drug Screening Assays, Antitumor; Gene Expression Regulation, Leukemic; Humans; Interleukin-10; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Cells, Cultured; Vidarabine | 1998 |
Long term follow-up and late complications of 2-chlorodeoxyadenosine in previously treated, advanced, indolent non-Hodgkin's lymphoma.
Topics: Antineoplastic Agents; Cladribine; Female; Follow-Up Studies; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Remission Induction | 1999 |
Chemosensitivity in vitro to 2-chlorodeoxyadenosine and 9-beta-D-arabinofuranosyl-2-fluoroadenine in previously unexposed cases of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cells, Cultured; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Vidarabine | 1999 |
Cladribine with cyclophosphamide and prednisone in the management of low-grade lymphoproliferative malignancies.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cladribine; Cyclophosphamide; Drug Administration Schedule; Feasibility Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Male; Middle Aged; Prednisone; Waldenstrom Macroglobulinemia | 1999 |
2-Chlorodeoxyadenosine (Cladribine) in the treatment of patients with chronic lymphocytic leukemia 55 years old and younger.
Topics: Adult; Alopecia; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemical and Drug Induced Liver Injury; Cladribine; Cyclophosphamide; Doxorubicin; Drug Eruptions; Drug Resistance, Neoplasm; Female; Fever; Hematologic Diseases; Humans; Immunophenotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Recurrence; Remission Induction; Salvage Therapy; Treatment Outcome; Vincristine | 1999 |
Use of image analysis and immunostaining of bone marrow trephine biopsy specimens to quantify residual disease in patients with B-cell chronic lymphocytic leukemia.
Topics: Adult; Aged; Antineoplastic Agents; B-Lymphocytes; Biopsy; Bone Marrow; Bone Marrow Examination; Cladribine; Female; Flow Cytometry; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasm, Residual; Proto-Oncogene Proteins c-bcl-2; Remission Induction | 1999 |
Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2'-deoxyadenosine.
Topics: Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cell Survival; Cladribine; Cyclophosphamide; Drug Screening Assays, Antitumor; Drug Synergism; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Time Factors; Tritium; Tumor Cells, Cultured | 1999 |
Biochemical pharmacology and resistance to 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine, a novel analogue of cladribine in human leukemic cells.
Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Cladribine; Clofarabine; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Leukemia, T-Cell; Phosphorylation; Recombinant Proteins; Tumor Cells, Cultured | 1999 |
The effect of p53 dysfunction on purine analogue cytotoxicity in chronic lymphocytic leukaemia.
Topics: Antineoplastic Agents; Cell Survival; Cladribine; Genes, p53; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Tumor Cells, Cultured; Vidarabine | 1999 |
Second malignancies as a consequence of nucleoside analog therapy for chronic lymphoid leukemias.
Topics: Aged; Antineoplastic Agents; Cladribine; Female; Follow-Up Studies; Humans; Immunosuppression Therapy; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Neoplasms, Second Primary; Pentostatin; Vidarabine | 1999 |
Bryostatin 1-induced modulation of nucleoside transporters and 2-chlorodeoxyadenosine influx in WSU-CLL cells.
Topics: Aged; Antineoplastic Agents; Biological Transport, Active; Bryostatins; Carrier Proteins; Cladribine; Deoxycytidine Kinase; Dipyridamole; Down-Regulation; Drug Resistance, Neoplasm; Humans; Lactones; Leukemia, Lymphocytic, Chronic, B-Cell; Macrolides; Male; Membrane Proteins; Nucleoside Transport Proteins; Phosphorylation; Thioinosine; Tumor Cells, Cultured; Vidarabine | 2000 |
Ex vivo assessment of drug response by differential staining cytotoxicity (DiSC) assay suggests a biological basis for equality of chemotherapy irrespective of age for patients with chronic lymphocytic leukaemia.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Chlorambucil; Cladribine; Comorbidity; Cyclophosphamide; Doxorubicin; Drug Resistance, Neoplasm; Epirubicin; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Methylprednisolone; Middle Aged; Neoplastic Stem Cells; Palliative Care; Pentostatin; Prednisolone; Prognosis; Staining and Labeling; Tumor Cells, Cultured; Vidarabine; Vincristine | 2000 |
Sequential treatment of a resistant chronic lymphocytic leukemia patient with bryostatin 1 followed by 2-chlorodeoxyadenosine: case report.
Topics: 5'-Nucleotidase; Aged; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Antineoplastic Combined Chemotherapy Protocols; bcl-2-Associated X Protein; Blotting, Western; Bryostatins; Cell Adhesion Molecules; Cladribine; Clinical Trials, Phase I as Topic; Deoxycytidine Kinase; Drug Resistance, Neoplasm; Flow Cytometry; Humans; Integrin alphaXbeta2; Lactones; Lectins; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Macrolides; Male; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Sialic Acid Binding Ig-like Lectin 2 | 2000 |
Serum levels of IL-6 type cytokines and soluble IL-6 receptors in active B-cell chronic lymphocytic leukemia and in cladribine induced remission.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Cladribine; Cytokine Receptor gp130; Female; Growth Inhibitors; Humans; Interleukin-6; Leukemia Inhibitory Factor; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphokines; Male; Membrane Glycoproteins; Middle Aged; Oncostatin M; Peptides; Receptors, Interleukin-6; Remission Induction; Solubility | 1999 |
Calcium antagonists potentiate P-glycoprotein-independent anticancer drugs in chronic lymphocytic leukemia cells in vitro.
Topics: Adult; Aged; Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; B-Lymphocytes; Calcium; Calcium Channel Blockers; Calcium Signaling; Chlorambucil; Cisplatin; Cladribine; Cyclosporine; DNA Fragmentation; Doxorubicin; Drug Synergism; Female; Flow Cytometry; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Nifedipine; Prednisolone; Tumor Cells, Cultured; Verapamil; Vidarabine; Vincristine | 2000 |
Role of poly(ADP-ribosyl)ation in the killing of chronic lymphocytic leukemia cells by purine analogues.
Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Membrane; Cell Size; Cladribine; DNA Fragmentation; Drug Interactions; Drug Resistance, Neoplasm; Enzyme Inhibitors; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Tumor Suppressor Protein p53; Vidarabine | 2000 |
Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Antineoplastic Agents; Apoptosis; Arabinonucleosides; B-Lymphocytes; Cell Survival; Cladribine; Clofarabine; Comet Assay; Deoxyadenosines; DNA Damage; DNA, Mitochondrial; Humans; Immunohistochemistry; Leukemia, Lymphocytic, Chronic, B-Cell; Membrane Potentials; Microinjections; Mitochondria; Time Factors; Tumor Cells, Cultured; Vidarabine | 2000 |
Pure red cell aplasia in patients with chronic lymphocytic leukaemia treated with cladribine.
Topics: Aged; Cladribine; Cyclosporine; Female; Humans; Immunosuppressive Agents; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Red-Cell Aplasia, Pure | 2001 |
Does intensive treatment with high dose chlorambucil and prednisone as first line and cladribine as second line influence the survival of the patients with chronic lymphocytic leukemia?
Topics: Actuarial Analysis; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Chlorambucil; Cladribine; Cohort Studies; Female; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Prednisone; Recurrence; Retrospective Studies; Survival Rate | 2001 |
Richter's syndrome following cladribine therapy for chronic lymphocytic leukemia first manifested as pathologic fracture of the femur.
Topics: Aged; Bone Marrow; Cell Transformation, Neoplastic; Cladribine; Femoral Fractures; Humans; Karyotyping; Leukemia, Lymphocytic, Chronic, B-Cell; Lymph Nodes; Lymphoma, B-Cell; Lymphoma, Non-Hodgkin; Male; Neoplasms, Second Primary; Radionuclide Imaging; Syndrome | 2001 |
Anti-CD20 antibody (IDEC-C2B8, rituximab) enhances efficacy of cytotoxic drugs on neoplastic lymphocytes in vitro: role of cytokines, complement, and caspases.
Topics: Amino Acid Chloromethyl Ketones; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antigens, CD20; Antigens, Neoplasm; Antineoplastic Agents; Apoptosis; Bendamustine Hydrochloride; Burkitt Lymphoma; Caspase 7; Caspase 8; Caspase 9; Caspase Inhibitors; Caspases; Cladribine; Complement Activation; Complement System Proteins; Cysteine Proteinase Inhibitors; Doxorubicin; Drug Synergism; Gene Expression Regulation, Leukemic; Gene Expression Regulation, Neoplastic; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukins; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, B-Cell; Lymphoma, Follicular; Mitoxantrone; Neoplasm Proteins; Nitrogen Mustard Compounds; Oligopeptides; Rabbits; Rituximab; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
2-Chloro-2'-deoxyadenosine inhibits DNA repair synthesis and potentiates UVC cytotoxicity in chronic lymphocytic leukemia B lymphocytes.
Topics: Alkylating Agents; Alkylation; Antimetabolites, Antineoplastic; Apoptosis; B-Lymphocytes; Caspase 3; Caspases; Cladribine; Depression, Chemical; DNA Damage; DNA Repair; DNA Replication; DNA, Neoplasm; Humans; Hydroxyurea; Leukemia, Lymphocytic, Chronic, B-Cell; Neoplasm Proteins; Neoplastic Stem Cells; Phosphorylation; Prodrugs; Radiation Tolerance; Radiation-Sensitizing Agents; Thymidine; Tumor Cells, Cultured; Ultraviolet Rays | 2002 |
Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia.
Topics: Aged; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Chlorambucil; Cladribine; Cyclophosphamide; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Glucocorticoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Vidarabine | 2002 |
Cladribine decreases the level of angiogenic factors in patients with chronic lymphocytic leukemia.
Topics: Aged; Angiogenesis Inducing Agents; Antineoplastic Agents; Cladribine; Female; Fibroblast Growth Factor 2; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Male; Middle Aged; Transforming Growth Factor beta | 2002 |
Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2'-arabino-fluoro-2'-deoxyadenosine.
Topics: 2-Chloroadenosine; Adenine Nucleotides; Animals; Antimetabolites, Antineoplastic; Arabinonucleosides; Cell Death; Cladribine; Clofarabine; Deoxyadenosines; DNA; DNA Damage; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Mice; Mice, SCID; Monocytes | 1992 |
Pentostatin and 2-chlorodeoxyadenosine for hairy-cell leukemia.
Topics: 2-Chloroadenosine; Antineoplastic Agents; Cladribine; Clinical Trials as Topic; Deoxyadenosines; Humans; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Non-Hodgkin; Pentostatin; Vidarabine | 1992 |
New drugs in the treatment of chronic lymphocytic leukemia.
Topics: Antineoplastic Agents; Cladribine; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Pentostatin; Vidarabine | 1992 |
2-Chlorodeoxyadenosine chemotherapy triggers programmed cell death in normal and malignant lymphocytes.
Topics: 2-Chloroadenosine; Cell Death; Cladribine; Deoxyadenosines; DNA; DNA Damage; Humans; In Vitro Techniques; Leukemia, Hairy Cell; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Nucleosomes; Reference Values | 1991 |