cladinose and Staphylococcal-Infections

cladinose has been researched along with Staphylococcal-Infections* in 1 studies

Other Studies

1 other study(ies) available for cladinose and Staphylococcal-Infections

Article	Year
Cladinose analogues of sixteen-membered macrolide antibiotics. IV. Improved therapeutic effects of 4-O-acyl-L-cladinose analogues of sixteen-membered macrolide antibiotics. The Journal of antibiotics, 1997, Volume: 50, Issue:2 Six derivatives of sixteen-membered macrolides possessing 4-O-acyl-alpha-L-cladinose as a neutral sugar were synthesized via 3"-methylthiomethyl ether intermediates in reasonable yield. Introduction of a methyl group on the 3"-hydroxyl group of midecamycin A1 was effective for enhancing its antibacterial activity. All these derivatives exhibited excellent therapeutic effects in mice, and some of them showed improved pharmacokinetics compared with the natural antibiotics (mycarose type) in mice. Facile synthesis of 9-O-acylated analogues are also described. Topics: Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Hexoses; Macrolides; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pneumococcal Infections; Staphylococcal Infections	1997

Article

Year

Cladinose analogues of sixteen-membered macrolide antibiotics. IV. Improved therapeutic effects of 4-O-acyl-L-cladinose analogues of sixteen-membered macrolide antibiotics.

The Journal of antibiotics, 1997, Volume: 50, Issue:2

Six derivatives of sixteen-membered macrolides possessing 4-O-acyl-alpha-L-cladinose as a neutral sugar were synthesized via 3"-methylthiomethyl ether intermediates in reasonable yield. Introduction of a methyl group on the 3"-hydroxyl group of midecamycin A1 was effective for enhancing its antibacterial activity. All these derivatives exhibited excellent therapeutic effects in mice, and some of them showed improved pharmacokinetics compared with the natural antibiotics (mycarose type) in mice. Facile synthesis of 9-O-acylated analogues are also described.

Topics: Animals; Anti-Bacterial Agents; Drug Evaluation, Preclinical; Drug Resistance, Microbial; Hexoses; Macrolides; Magnetic Resonance Spectroscopy; Male; Mice; Mice, Inbred ICR; Molecular Structure; Pneumococcal Infections; Staphylococcal Infections

1997