cl 387785 has been researched along with Lung Neoplasms in 8 studies
CL 387785: structure in first source
N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}but-2-ynamide : A member of the class of quinazolines that is 4,6-diaminoquinazoine in which the one of the hydrogens attached to the amino group at position 4 has been replaced by a m-bromophenyl group while one of the hydrogens attached to the amino group at position 6 has been replaced by a but-2-ynoyl group.
Lung Neoplasms: Tumors or cancer of the LUNG.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Y | 1 |
| Sheng, Z | 1 |
| Dong, Z | 1 |
| Wang, J | 1 |
| Yano, S | 1 |
| Nakagawa, T | 1 |
| Chung, JH | 1 |
| Rho, JK | 1 |
| Xu, X | 1 |
| Lee, JS | 1 |
| Yoon, HI | 1 |
| Lee, CT | 1 |
| Choi, YJ | 1 |
| Kim, HR | 1 |
| Kim, CH | 1 |
| Lee, JC | 1 |
| Zannetti, A | 1 |
| Iommelli, F | 1 |
| Speranza, A | 1 |
| Salvatore, M | 1 |
| Del Vecchio, S | 1 |
| Desai, AA | 1 |
| Ratain, MJ | 1 |
| Engelman, JA | 1 |
| Mukohara, T | 1 |
| Zejnullahu, K | 1 |
| Lifshits, E | 1 |
| Borrás, AM | 1 |
| Gale, CM | 1 |
| Naumov, GN | 1 |
| Yeap, BY | 1 |
| Jarrell, E | 1 |
| Sun, J | 1 |
| Tracy, S | 1 |
| Zhao, X | 1 |
| Heymach, JV | 1 |
| Johnson, BE | 1 |
| Cantley, LC | 1 |
| Jänne, PA | 1 |
| Kobayashi, S | 2 |
| Shimamura, T | 1 |
| Monti, S | 1 |
| Steidl, U | 1 |
| Hetherington, CJ | 1 |
| Lowell, AM | 1 |
| Golub, T | 1 |
| Meyerson, M | 1 |
| Tenen, DG | 2 |
| Shapiro, GI | 1 |
| Halmos, B | 2 |
| Yu, Z | 1 |
| Boggon, TJ | 1 |
| Jin, C | 1 |
| Ma, PC | 1 |
| Dowlati, A | 1 |
| Kern, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An EGFR-TKIs Benefit Non-small Cell Lung Carcinoma Patients Identification Strategy and Treatment Response Using Molecular Imaging[NCT02717221] | 100 participants (Anticipated) | Interventional | 2014-11-30 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 other studies available for cl 387785 and Lung Neoplasms
| Article | Year |
|---|---|
EGFR Inhibitor CL-387785 Suppresses the Progression of Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Drug R | 2023 |
The current state of molecularly targeted drugs targeting HGF/Met.
Topics: Acrylamides; Afatinib; Aminopyridines; Antibodies, Monoclonal; Antineoplastic Agents; Carcinoma, Non | 2014 |
Clinical and molecular evidences of epithelial to mesenchymal transition in acquired resistance to EGFR-TKIs.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carboplati | 2011 |
3'-deoxy-3'-18F-fluorothymidine PET/CT to guide therapy with epidermal growth factor receptor antagonists and Bcl-xL inhibitors in non-small cell lung cancer.
Topics: Aniline Compounds; Animals; Antineoplastic Agents; Apoptosis; bcl-X Protein; Blotting, Western; Carc | 2012 |
EGFR pharmacogenomics: the story continues to mutate and evolve.
Topics: Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase III as Topic; ErbB Receptors; Gefitinib; Huma | 2005 |
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.
Topics: Alleles; Animals; Apoptosis; Base Sequence; Cell Line, Tumor; Cell Proliferation; Drug Resistance, N | 2006 |
Transcriptional profiling identifies cyclin D1 as a critical downstream effector of mutant epidermal growth factor receptor signaling.
Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Non-Small-Cell Lung; Cell L | 2006 |
Resistance to an irreversible epidermal growth factor receptor (EGFR) inhibitor in EGFR-mutant lung cancer reveals novel treatment strategies.
Topics: Cell Line, Tumor; Cyclin-Dependent Kinase 4; Drug Resistance, Neoplasm; ErbB Receptors; Humans; Lung | 2007 |