cl-115574 and Gastric-Fistula

cl-115574 has been researched along with Gastric-Fistula* in 1 studies

Other Studies

1 other study(ies) available for cl-115574 and Gastric-Fistula

Article	Year
A new prostaglandin E1 analogue (CL-115,574) II. Effects on gastric acid secretion in the dog. Prostaglandins, 1981, Volume: 22, Issue:6 The efficacy of CL-115,574, a prostaglandin E1 analogue, as an acid antisecretory agent was evaluated in dogs. CL-115,574 inhibited acid secretion maximally at an oral dose of 20 micrograms/kg causing 100% inhibition of acid secretion up to one hour after administration, with significant inhibition of secretion (30%) still present nearly four hours after drug administration. The wide disparity between the maximally effective antisecretory dose 20 micrograms/kg and the dose at which reproducible side effects occurred (1 mg/kg) suggests that this compound may be developed as an antisecretory compound for use in man. Topics: Administration, Oral; Animals; Dogs; Female; Gastric Acid; Gastric Fistula; Histamine; Prostaglandins E, Synthetic; Time Factors	1981

Article

Year

A new prostaglandin E1 analogue (CL-115,574) II. Effects on gastric acid secretion in the dog.

Prostaglandins, 1981, Volume: 22, Issue:6

The efficacy of CL-115,574, a prostaglandin E1 analogue, as an acid antisecretory agent was evaluated in dogs. CL-115,574 inhibited acid secretion maximally at an oral dose of 20 micrograms/kg causing 100% inhibition of acid secretion up to one hour after administration, with significant inhibition of secretion (30%) still present nearly four hours after drug administration. The wide disparity between the maximally effective antisecretory dose 20 micrograms/kg and the dose at which reproducible side effects occurred (1 mg/kg) suggests that this compound may be developed as an antisecretory compound for use in man.

Topics: Administration, Oral; Animals; Dogs; Female; Gastric Acid; Gastric Fistula; Histamine; Prostaglandins E, Synthetic; Time Factors

1981