cl-075 and Inflammation
cl-075 has been researched along with Inflammation* in 1 studies
Other Studies
1 other study(ies) available for cl-075 and Inflammation
Article | Year |
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Potent adjuvantic activity of a CCR1-agonistic bis-quinoline.
A bis-quinoline compound, (7-chloro-N-(4-(7-chloroquinolin-4-ylamino)butyl)quinolin-4-amine; RE-660) was found to have C-C chemokine receptor type 1 (CCR1)-agonistic properties. RE-660 displayed strong adjuvantic activity in mice when co-administered with bovine α-lactalbumin used as a model subunit protein antigen. RE-660 evoked a balanced Th1 (IgG2)/Th2 (IgG1) antibody profile, and the quality of antibodies elicited by the bis-quinoline was found to be superior to that evoked by glucopyranosyl lipid A by surface plasmon resonance experiments. No evidence of proinflammatory activity was observed in human blood ex vivo models. In preliminary acute toxicity studies, the compound was found to be of lower toxicity than chloroquine in mice, and was non-mutagenic in an Ames screen. Topics: Animals; Cattle; Chloroquine; Dose-Response Relationship, Drug; Humans; Immunoglobulin G; Inflammation; Lactalbumin; Lipids; Mice; Models, Chemical; Mutagenicity Tests; Quinolines; Receptors, CCR1; Structure-Activity Relationship; Transcriptional Activation | 2012 |