cl-075 has been researched along with Hepatitis-B--Chronic* in 1 studies
1 other study(ies) available for cl-075 and Hepatitis-B--Chronic
| Article | Year |
|---|---|
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Toll-like receptor 8 (TLR8) recognizes pathogen-derived single-stranded RNA fragments to trigger innate and adaptive immune responses. Chronic hepatitis B (CHB) is associated with a dysfunctional immune response, and therefore a selective TLR8 agonist may be an effective treatment option. Structure-based optimization of a dual TLR7/8 agonist led to the identification of the selective TLR8 clinical candidate ( Topics: Administration, Oral; Animals; Antiviral Agents; Crystallography, X-Ray; Dogs; Drug Discovery; Hepatitis B virus; Hepatitis B, Chronic; Hexanols; Humans; Macaca fascicularis; Molecular Structure; Protein Domains; Pyridines; Pyrimidines; Rats; Structure-Activity Relationship; Toll-Like Receptor 8 | 2020 |