cj-042794 and Arthritis

cj-042794 has been researched along with Arthritis* in 1 studies

Other Studies

1 other study(ies) available for cj-042794 and Arthritis

Article	Year
Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain. Bioorganic & medicinal chemistry letters, 2010, Jun-15, Volume: 20, Issue:12 The discovery of a highly potent and selective EP(4) antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and unprecedented in vivo potency in the rat AIA model. Topics: Animals; Arthritis; Benzoates; Cells, Cultured; Dogs; Drug Discovery; Drug Stability; Hepatocytes; Humans; Indoles; Inflammation; Pain; Pharmacokinetics; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Structure-Activity Relationship	2010

Article

Year

Discovery of 4-[1-[([1-[4-(trifluoromethyl)benzyl]-1H-indol-7-yl]carbonyl)amino]cyclopropyl]benzoic acid (MF-766), a highly potent and selective EP4 antagonist for treating inflammatory pain.

Bioorganic & medicinal chemistry letters, 2010, Jun-15, Volume: 20, Issue:12

The discovery of a highly potent and selective EP(4) antagonist MF-766 is discussed. This N-benzyl indole derivative exhibits good pharmacokinetic profile and unprecedented in vivo potency in the rat AIA model.

Topics: Animals; Arthritis; Benzoates; Cells, Cultured; Dogs; Drug Discovery; Drug Stability; Hepatocytes; Humans; Indoles; Inflammation; Pain; Pharmacokinetics; Rats; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Structure-Activity Relationship

2010