citrulline has been researched along with Disease Models, Animal in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (3.97) | 18.7374 |
| 1990's | 11 (8.73) | 18.2507 |
| 2000's | 27 (21.43) | 29.6817 |
| 2010's | 68 (53.97) | 24.3611 |
| 2020's | 15 (11.90) | 2.80 |
| Authors | Studies |
|---|---|
| Jiang, P; Li, G; Mao, Y; Shi, D | 1 |
| Bendavid, C; Bordeau, V; Cattoir, V; Cogné, M; Coirier, V; Creusat, F; Daniel, Y; Delaloy, C; Dessauge, E; Dessauge, F; Fromenty, B; Gacouin, A; Gauthier, J; Grégoire, M; Lamaison, C; Le Naoures, C; Le Tulzo, Y; Lesouhaitier, M; Michelet, C; Moreau, C; Petitjean, K; Piau, C; Reizine, F; Roussel, M; Tadié, JM; Tarte, K; Thibault, R; Uhel, F; Zmijewski, J | 1 |
| Andersson, DC; Carlström, M; Gastaldello, S; Lanner, JT; Lund, LH; Pironti, G; Rassier, DE; Westerblad, H; Yamada, T | 1 |
| Ahmed, F; Coonrod, SA; Demeter, EA; Grenier, JK; Marks, BA; Mittal, C; Mukai, C; Nelissen, S; Sams, KL; Tate, AE | 1 |
| Belik, J; Gauda, EB; Higazy, R; Ivanovska, J; Ivanovski, N; Kim, P; Leung, S; Li, D; Miraglia, E; Mohammadi, A; Nagy, A; Palaniyar, N; Pan, J; Posiewko, M; Santyr, G; Tran, H; Wang, H | 1 |
| Brown, LAS; George, RP; Harris, F; Jo, H; Kelleman, M; Morris, CR; Reyes, LZ; Winterberg, PD | 1 |
| Jianxin Chen, -; Lifang Qiu, -; Rui Xu, - | 1 |
| Artuch, R; Bodoy, S; Espino-Guarch, M; Ormazabal, A; Palacín, M; Sebastio, G; Sotillo, F; Sperandeo, MP; Zorzano, A | 1 |
| Abdul-Hadi, K; Brown, A; Guan, E; Wagoner, M; Yoneyama, T; Zhu, AZX | 1 |
| Amarger, V; Bourdon, A; Darmaun, D; Ferchaud-Roucher, V; Hannigsberg, J; Misbert, E; Tran, TN; Winer, N | 1 |
| Cai, B; Chu, ZD; Huang, HL; Huang, XD; Li, CW; Zhou, AC; Zhou, MH | 1 |
| Delmônego, L; Delwing-Dal Magro, D; Delwing-de Lima, D; Lima, AB; Maia, TP; Pscheidt, LC; Vincenzi, KL | 1 |
| Caldovic, L; Haskins, N; McNutt, M; Morizono, H; Senkevitch, E; Sonaimuthu, P; Tuchman, M; Uapinyoying, P | 1 |
| Anderson, MN; Cui, W; Hull, L; Jiang, S; Kiang, JG; Li, X; Lin, B; Smith, JT; Umali, MV; Wang, L; Xiao, M; Zhai, M | 1 |
| Almeida-Gutiérrez, E; Flores-Chavez, S; Garcia-delaTorre, P; Martínez-González, K; Mejía-Aranguré, JM; Serrano-Cuevas, L | 1 |
| Baracos, VE; Breuillard, C; Cynober, L; De Reviers, A; Goron, A; Mazurak, VC; Moinard, C; Neveux, N | 1 |
| Fukunaga, K; Matsuo, K; Yabuki, Y | 1 |
| de Ru, AH; Dekkers, JS; Hegen, M; Huizinga, TWJ; Ioan-Facsinay, A; Janssen, GMC; Liu, B; Rapecki, S; Stoop, JN; Toes, REM; Trouw, LA; van Veelen, PA; Verheul, MK | 1 |
| Arnoux, F; Auger, I; Balandraud, N; Lambert, NC; Mariot, C; Peen, E; Roudier, J | 1 |
| Barra, L; Bell, DA; Cairns, E; Lac, P; Saunders, S; Tutunea-Fatan, E | 1 |
| Bonaventura, A; Camici, GG; Carbone, F; Dallegri, F; Diaz-Cañestro, C; Liberale, L; Montecucco, F; Vecchié, A | 1 |
| Authier, S; Brown, D; Donini, O; Measey, TJ; Pouliot, M; Swanson, C; Wierzbicki, W | 1 |
| Didelija, IC; Marini, JC; Mohammad, MA; Wang, X; Yuan, Y | 1 |
| Caparros-Wanderley, W; Chang, YS; Combes, V; Gramaglia, I; Grau, G; Stins, MF; van der Heyde, HC; Velez, J | 1 |
| Eto, K; Funahashi, A; Furuie, S; Furukawa, T; Gao, Q; Horiuchi, M; Kadowaki, T; Kuroda, E; Moriyama, M; Nakamura, Y; Saheki, T; Setogawa, Y; Sinasac, DS; Tai, YH; Takano, K; Ushikai, M; Yamamura, KI; Yasuda, I | 1 |
| Cynober, L; De Bandt, JP; Kuçi, O; Le Plenier, S; Nubret, E; Verlaan, D; Vicente, C | 1 |
| Blanchet, S; Delangle, P; Fontaine, E; Goron, A; Lamarche, F; Moinard, C; Schlattner, U | 1 |
| Bingham, CO; Moni, M | 1 |
| Fukunaga, K; Kumagai, K; Morita, M; Shigano, M; Shioda, N; Yabuki, Y; Yamamoto, Y | 1 |
| Hotta, Y; Kataoka, T; Kimura, K; Maeda, Y; Morita, M; Shiota, A | 1 |
| Adamowicz, K; Alzabin, S; Benedyk, M; Bielecka, E; Gawron, K; Hellvard, A; Jonsson, R; Koziel, J; Marcinska, KA; Maresz, KJ; Mizgalska, D; Mydel, P; Nguyen, KA; Potempa, J; Pyrc, K; Quirke, AM; Sroka, A; Venables, PJ | 1 |
| Chandler, RJ; Cusmano-Ozog, K; McGuire, PJ; Sun, Q; Sutton, VR; Tarasenko, TN; Venditti, CP | 1 |
| Caparon, MG; Cusumano, ZT; Watson, ME | 1 |
| Hotta, Y; Kataoka, T; Kimura, K; Maeda, Y; Morita, M; Motonari, M; Shiota, A | 1 |
| Beebe, DJ; Huttenlocher, A; Lahey, LJ; Robinson, WH; Sackmann, EK; Shelef, MA; Sokolove, J; Wagner, CA; Wang, Y; Warner, TF | 1 |
| Chowdhary, BP; Jackson, A; Johnson, P; Schulze, J; Steelman, SM | 1 |
| Broderick, JP; Clark, JF; Lu, A; Wagner, KR | 1 |
| Bang, HY; Jang, WS; Jeon, BS; Jin, S; Kim, J; Lee, SJ; Lee, SS; Park, S; Shim, S | 1 |
| Nehru, B; Thakur, P | 1 |
| Alam, HB; Chong, W; Li, Y; Liu, B; Liu, Z; Wang, Y; Zhao, T | 1 |
| Chappell, M; Christensen, C; Deutz, NE; Elliott, TB; Gulani, J; Koch, A; Moroni, M; Olsen, CH; Whitnall, MH | 1 |
| Alvarez-Leite, JI; Antunes, MM; Cara, DC; Cardoso, VN; Correia, MI; Generoso, Sde V; Leocádio, PC; Leonel, AJ; Menezes, GB; Teixeira, LG | 1 |
| Abrantes, FA; Andrade, ME; Araújo, RS; Cardoso, VN; de Barros, PA; Fernandes, SO; Generoso, Sde V; Soares, AD | 1 |
| Caldow, MK; Chee, A; Ham, DJ; Kennedy, TL; Koopman, R; Lynch, GS | 1 |
| Heij, HA; Hulscher, JB; Koffeman, GI; Schoots, IG; van Gemert, WG; van Gulik, TM | 1 |
| Amital, H; Gertel, S; Serre, G; Shoenfeld, Y | 1 |
| Bortolotti, M; Choisy, C; Cynober, L; De Bandt, JP; Jegatheesan, P; Ventura, G | 1 |
| Cheng, D; Fert-Bober, J; Gazitt, T; Lahey, LJ; Onuma, K; Rhodes, C; Robinson, WH; Sharpe, O; Shiao, R; Sohn, DH; Sokolove, J; Van Eyk, J; Wong, HH; Zhao, X | 1 |
| Capel, F; Chabrier, G; Cynober, L; de Bandt, JP; Durand, C; Jouve, C; Le Plenier, S; Moinard, C; Morio, B; Pitois, E; Rigaudière, JP | 1 |
| Groen, AK; Havinga, R; Kuiken, NS; Rings, EH; Tissing, WJ | 1 |
| Arvin, J; Aydin, E; Brune, M; Emami, G; Frongia, G; Garoussi, C; Golriz, M; Günther, P; Hafezi M, MR; Holland-Cunz, S; Kessler, M; Mehrabi, A; Nickkholgh, A; Okun, JG; Saffari, A; Schmidt, K; Thiel, C; Weih, S | 1 |
| Bennett, A; Booth, C; Carter, CL; Farese, AM; Hankey, KG; Jones, JW; Kane, MA; MacVittie, TJ; Tudor, G | 1 |
| Booth, C; Farese, AM; Jones, JW; Kane, MA; Katz, B; Li, F; MacVittie, TJ; Tong, Y; Tudor, G | 1 |
| Baumgardt, SL; Bosnjak, ZJ; Fang, J; Ge, ZD; Kersten, JR; Leucker, TM; Paterson, M; Warltier, DC; Zhang, DX | 1 |
| Koivula, MK; Risteli, J; Risteli, L; Turunen, S | 1 |
| Bergheim, I; De Bandt, JP; Engstler, AJ; Jin, CJ; Sellmann, C | 1 |
| Ayala, A; Biron, BM; Chen, Y; Chung, CS; O'Brien, XM; Reichner, JS | 1 |
| 'tHart, BA; Gran, B; Kap, YS; Laman, JD; Morandi, E | 1 |
| Aschner, M; Gupta, RC; Milatovic, D; Montine, TJ; Zaja-Milatovic, S | 1 |
| Agnew, C; Ding, Y; Li, YL; Schultz, HD | 1 |
| Alper, M; Atici, T; Bedirli, A; Katircioglu, H; Kerem, M; Ofluoglu, E; Pasaoglu, H; Percin, EF; Salman, B | 1 |
| Derrick, M; Igarashi, J; Ji, H; Li, H; Martásek, P; Poulos, TL; Roman, LJ; Silverman, RB; Tan, S; Vásquez-Vivar, J | 1 |
| Chan, CH; Pearce, DA; Ramirez-Montealegre, D | 1 |
| Baylis, C; Chen, GF | 1 |
| Ding, Y; Li, YL; Schultz, HD; Zheng, H | 1 |
| Albuquerque, MC; Campos, JM; Cavalcanti, MT; de Lima Aires, A; De Lima B Cavalcanti, C; De Lima Filho, JL; Ferraz, AA; Ferraz, EM; Ribeiro, MH; Siqueira, LT | 1 |
| Aschner, JL; Eaton, F; Magarik, J; Rey-Parra, GJ; Summar, M; Thébaud, B; Vadivel, A; Zeng, H | 1 |
| Govindasamy, C; Mustapha, Z; Sirajudeen, KN; Swamy, M; Yusof, WR | 1 |
| Aires, CC; de Almeida, IT; Duran, M; Ijlst, L; Silva, MF; van Cruchten, A; Wanders, RJ | 1 |
| Causey, CP; Chumanevich, AA; Chumanevich, AP; Davis, T; Hofseth, LJ; Jones, JE; Knuckley, BA; Matesic, LE; Poudyal, D; Thompson, PR | 1 |
| Alam, HB; Chong, W; Demoya, M; Fukudome, EY; Jin, G; King, DR; Li, Y; Liu, B; Liu, Z; Lu, J; Velmahos, GC | 1 |
| Arnaud, P; Chaumeil, JC; Curis, E; Cynober, L; Elwafi, F; Moinard, C; Neveux, N; Zerrouk, N | 1 |
| Bender, M; Edwards, L; Garzon-Muvdi, T; Momin, EN; Pradilla, G; Ruzevick, JJ; Tamargo, RJ; Thompson, RC | 1 |
| Asgeirsson, T; Cavey, GS; Dujovny, N; Luchtefeld, M; Mascarenas, C; Nunoo, R; Senagore, A; Zhang, S | 1 |
| Bhattacharya, SK; Dave, KR; Ding, D; Enriquez-Algeciras, M; Perez-Pinzon, M | 1 |
| Butcher, JP; Culshaw, S; Farquharson, D | 1 |
| Gross, C; Huang, W; John-Baptiste, A; Kindt, E; Ramaiah, SK; Schaiff, WT; Scott, W; Vitsky, A; Wu, A; Yang, AH | 1 |
| Dalton, RN; Davies, NA; Deutz, NE; Jalan, R; Mookerjee, RP; Revhaug, A; Rose, CF; Sen, S; Sharma, V; Ten Have, GA; Turner, C; van-Eijk, HM; Ytrebo, L | 1 |
| Albertin, G; Artusi, C; Bordigato, MA; Chiandetti, L; De Caro, R; Dedja, A; Fassina, A; Filippone, M; Grisafi, D; Guzzardo, V; Macchi, V; Masola, V; Milan, A; Onisto, M; Oselladore, B; Porzionato, A; Salmaso, R; Tassone, E; Zaninotto, M; Zaramella, P | 1 |
| Anderson, DR; Duryee, MJ; Dusad, A; Hunter, CD; Klassen, LW; Lacy, JP; Mikuls, TR; O'Dell, JR; Thiele, GM; Wang, D | 1 |
| Aschner, JL; Aschner, M; Cunningham, G; Fike, CD; Kaplowitz, M; Prince, LS; Sidoryk-Wegrzynowicz, M; Summar, M; Zhang, Y | 1 |
| Busanello, EN; Grings, M; Knebel, LA; Leipnitz, G; Lobato, VA; Moura, AP; Pettenuzzo, LF; Ritter, L; Tonin, AM; Vargas, CR; Viegas, CM; Wajner, M; Zanatta, A | 1 |
| Allinquant, B; Clamagirand, C; Cynober, L; Facchinetti, P; Guihenneuc-Jouyaux, C; Marquet-de Rougé, P; Moinard, C; Rose, C; Sargueil, F | 1 |
| Calvert, TJ; Chen, B; Chicoine, LG; Jin, Y; Liu, Y; Nelin, LD | 1 |
| Barr, FE; Choxi, AA; Davidson, MA; Mericle, RA; Reddy, VK; Shay, SD; Simon, SD; Spratt, DE; Summar, ML | 1 |
| Ackerley, C; Lei, H; Li, Z; Mastronardi, FG; Moscarello, MA; Raijmakers, R; Tsui, H; Winer, S; Wood, DD; Zhang, L | 1 |
| Hagisawa, K; Kato, K; Kemuriyama, T; Nishida, Y; Ohta, H; Tandai-Hiruma, M; Tashiro, A | 1 |
| Baeten, D; Cantaert, T; Tak, PP; Teitsma, C | 1 |
| Breyer, RM; Gupta, RC; Milatovic, D; Montine, TJ; Morrow, JD; Valyi-Nagy, T | 1 |
| Dettbarn, WD; Gupta, RC; Milatovic, D | 1 |
| Bhardwaj, A; Goyagi, T; Hurn, PD; Kirsch, JR; Koehler, RC; Toung, TJ; Traystman, RJ | 1 |
| Helsen, MM; Joosten, LA; Nijenhuis, S; Senshu, T; van den Berg, WB; van der Heijden, A; van Venrooij, WJ; Vossenaar, ER | 1 |
| Bhattacharyya, S; Ganguly, NK; Ghosh, S; Majumdar, S; Shant, J | 1 |
| Bajor, T; Farkas, A; Hrabák, A; Szabó, A; Vámos, R | 1 |
| Carson, DA; Silverman, GJ | 1 |
| Joosten, LA; López-Hoyoz, M; Merino, J; Merino, R; van Boekel, MA; van Venrooij, WJ; Vossenaar, ER | 1 |
| Bhattacharya, SK; Bonilha, VL; Crabb, JS; Crabb, JW; Gu, X; Takahara, H | 1 |
| Brunini, TM; Ellory, JC; Mann, GE; Mendes Ribeiro, AC; Moss, MB; Roberts, NB; Siqueira, MA; Yaqoob, MM | 1 |
| Leusink, J; Maarsingh, H; Meurs, H; Zaagsma, J | 1 |
| Casaccia-Bonnefil, P; Dosch, HM; Mastronardi, FG; Mei, J; Moscarello, MA; Probert, L; Raijmakers, R; Tseveleki, V; Wood, DD | 1 |
| Belforte, N; Bordone, M; Cymeryng, C; Keller Sarmiento, MI; Moreno, MC; Rosenstein, RE | 1 |
| Alayza, RC; Beaudry, M; Duvallet, A; El Hasnaoui-Saadani, R; Favret, F; Launay, T; Léon-Velarde, F; Pichon, A; Quidu, P; Richalet, JP | 1 |
| Castillo, L; Erez, A; Lee, B; Marini, JC | 1 |
| Dasgupta, T; Fabry, ME; Kaul, DK; Zhang, X | 1 |
| Glasgow, AM | 1 |
| Caldwell, M; Canney, M; Earley, B; Junien, JL; Kelly, J; Leonard, BE; O'Halloran, A; O'Neill, M | 1 |
| Chen, PY; Sanders, PW | 1 |
| Makino, T; Miyauchi, T; Muto, A; Nabata, H; Nagafuji, T; Sugiyama, M | 1 |
| Kanzaki, T; Mori, M; Murakami, T; Noda, T; Saheki, T; Shimada, T; Takiguchi, M; Tashiro, M; Yamamura, K | 1 |
| Beaudet, AL; Bradley, A; O'Brien, WE; Patejunas, G | 1 |
| Chapman, AG; Man, CM; Meldrum, BS; Smith, SE; Tang, E; Yip, PK | 1 |
| Kimes, AS; London, ED; Vaupel, DB | 1 |
| De Vries, R; Dzoljic, E; Dzoljic, MR | 1 |
| Quast, MJ; Wei, J | 1 |
| Chen, PY; Hamm, DA; Sanders, PW; Wood, PA | 1 |
| Beaudet, AL; Dennis, JA; Frazer, M; Healy, PJ; Lee, B; Mull, B; O'Brien, WE; Patejunas, G; Reeds, PJ; Warman, AW; Yu, H | 1 |
| Holt, PG; Sly, PD; Tulić, MK; Wale, JL | 1 |
| Asaga, H; Ishigami, A | 1 |
| Hebiguchi, T; Imai, H; Kato, T; Komatsuda, A; Mizuno, M; Wakui, H; Yoshino, H | 1 |
| Fabry, ME; Nagel, RL; Romero, JR; Suzuka, SM | 1 |
| Mastronardi, FG; Moscarello, MA; Pritzker, L; Wood, DD | 1 |
| Paul, V | 1 |
| Chan, W; Kopple, JD; Siassi, F; Swendseid, ME; Tam, CF; Vyhmeister, I; Wang, M | 1 |
| Buist, NR; Harwood, PJ; Kennaway, NG; Koler, RD; Ramberg, DA | 1 |
| Dennis, JA; Harper, PA; Healy, PJ | 1 |
| Azorín, I; Felipo, V; Grisolía, S; Miñana, MD | 1 |
6 review(s) available for citrulline and Disease Models, Animal
| Article | Year |
|---|---|
The Pathophysiological Role of Neutrophil Extracellular Traps in Inflammatory Diseases.
Topics: Animals; Autoantigens; Autoimmunity; Biomarkers; Cardiovascular Diseases; Chromatin; Citrullination; Citrulline; Communicable Diseases; Disease Models, Animal; Extracellular Traps; Histones; Humans; Hydrolases; Inflammation; Metabolic Diseases; Neoplasms; Peroxidase; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Risk Factors; Serine Proteases | 2018 |
Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bacteroidaceae Infections; Citrulline; Disease Models, Animal; Evidence-Based Medicine; Humans; Periodontal Diseases; Porphyromonas gingivalis | 2013 |
The role of immunomodulators on intestinal barrier homeostasis in experimental models.
Topics: Animals; Arginine; Bifidobacterium; Citrulline; Disease Models, Animal; Epithelial Cells; Fatty Acids, Omega-3; Glutamine; Homeostasis; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Linoleic Acids, Conjugated; Permeability; Probiotics; Saccharomyces; Tryptophan | 2015 |
EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model.
Topics: Animals; Antigen Presentation; B-Lymphocytes; Citrulline; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Immunity, Cellular; Major Histocompatibility Complex; Multiple Sclerosis; T-Lymphocytes | 2016 |
Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Autoantigens; Bacteroidaceae Infections; Citrulline; Disease Models, Animal; Humans; Periodontitis; Porphyromonas; Protein Processing, Post-Translational; Risk Factors | 2012 |
Roles of B cells in rheumatoid arthritis.
Topics: Animals; Antigen Presentation; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Disease Models, Animal; Glucose-6-Phosphate Isomerase; Humans; Mast Cells; Mice; Synovitis | 2003 |
120 other study(ies) available for citrulline and Disease Models, Animal
| Article | Year |
|---|---|
Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses.
Topics: Animals; Argininosuccinate Synthase; Citrulline; Disease Models, Animal; HEK293 Cells; Humans; Immunity, Innate; Inflammation; Inflammation Mediators; Janus Kinase 2; Listeria monocytogenes; Listeriosis; Macrophage Activation; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; RAW 264.7 Cells; Signal Transduction; STAT1 Transcription Factor | 2022 |
Beneficial effects of citrulline enteral administration on sepsis-induced T cell mitochondrial dysfunction.
Topics: Animals; Arginine; Biological Availability; Citrulline; Cytokines; Disease Models, Animal; Female; Immune Tolerance; Immunosuppression Therapy; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mitochondria; Myeloid-Derived Suppressor Cells; Sepsis; T-Lymphocytes; T-Lymphocytes, Regulatory | 2022 |
Citrullination is linked to reduced Ca
Topics: Actins; Animals; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Citrullination; Citrulline; Disease Models, Animal; Heart Failure; Hydrolases; Mice; Protein-Arginine Deiminases; Tumor Necrosis Factor-alpha | 2022 |
Delayed puberty, gonadotropin abnormalities and subfertility in male Padi2/Padi4 double knockout mice.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Female; Gonadotropins; Hydrolases; Infertility; Male; Mice; Mice, Knockout; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Testosterone | 2022 |
L-citrulline attenuates lipopolysaccharide-induced inflammatory lung injury in neonatal rats.
Topics: Animals; Animals, Newborn; Bronchopulmonary Dysplasia; Citrulline; Disease Models, Animal; Female; Humans; Hyperoxia; Infant, Newborn; Inflammation; Lipopolysaccharides; Lung; Lung Injury; Pneumonia; Pregnancy; Rats | 2023 |
Arginine Dysregulation and Myocardial Dysfunction in a Mouse Model and Children with Chronic Kidney Disease.
Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Mice; Renal Dialysis; Renal Insufficiency, Chronic | 2023 |
Protective effect of citrulline on the intestinal mucosal barrier of mice during sepsis.
Topics: Animals; Citrulline; Disease Models, Animal; Endotoxins; Intestinal Mucosa; Mice; Sepsis | 2023 |
Inducible
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Transport System y+L; Amino Acids; Animals; Citrulline; Disease Models, Animal; Hyperammonemia; Intestinal Mucosa; Kidney; Mice; Mice, Inbred C57BL; Mice, Knockout; Pulmonary Alveolar Proteinosis | 2019 |
A Citrulline-Based Translational Population System Toxicology Model for Gastrointestinal-Related Adverse Events Associated With Anticancer Treatments.
Topics: Animals; Antineoplastic Agents; Citrulline; Disease Models, Animal; Gastrointestinal Tract; Humans; Irinotecan; Rats; Toxicity Tests; Translational Research, Biomedical | 2019 |
Maternal supplementation with citrulline or arginine during gestation impacts fetal amino acid availability in a model of intrauterine growth restriction (IUGR).
Topics: Amino Acids; Animals; Arginine; Citrulline; Diet, Protein-Restricted; Dietary Supplements; Disease Models, Animal; Female; Fetal Development; Fetal Growth Retardation; Fetus; Maternal Nutritional Physiological Phenomena; Pregnancy; Prenatal Care; Rats | 2020 |
Protective effects of citrulline supplementation in ulcerative colitis rats.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Body Weight; Citrulline; Colitis, Ulcerative; Colon; Dietary Supplements; Disease Models, Animal; Interleukin-17; Interleukin-6; Male; Monocytes; Phosphorylation; Protective Agents; Rats; Rats, Wistar; STAT3 Transcription Factor | 2020 |
Effects of resveratrol on alterations in cerebrum energy metabolism caused by metabolites accumulated in type I citrullinemia in rats.
Topics: Ammonia; Animals; Cerebellum; Cerebral Cortex; Citrulline; Citrullinemia; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Free Radical Scavengers; Hippocampus; Male; Rats; Rats, Wistar; Resveratrol | 2021 |
Gene delivery corrects N-acetylglutamate synthase deficiency and enables insights in the physiological impact of L-arginine activation of N-acetylglutamate synthase.
Topics: Amino-Acid N-Acetyltransferase; Animals; Arginine; Citrulline; Dependovirus; Disease Models, Animal; Gene Transfer Techniques; Glutamates; Humans; Hyperammonemia; Mice; Mice, Knockout; Mutant Proteins; Urea; Urea Cycle Disorders, Inborn | 2021 |
PEG-G-CSF and L-Citrulline Combination Therapy for Mitigating Skin Wound Combined Radiation Injury in a Mouse Model.
Topics: Animals; Body Weight; Bone Marrow; Burns; Citrulline; Disease Models, Animal; Drug Therapy, Combination; Female; Granulocyte Colony-Stimulating Factor; Mice; Polyethylene Glycols; Radiation Injuries, Experimental; Recombinant Proteins; Skin; Survival Analysis; Weight Loss; Whole-Body Irradiation; Wound Healing | 2021 |
Citrulline supplementation improves spatial memory in a murine model for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Citrulline; Dietary Supplements; Disease Models, Animal; Female; Humans; Male; Maze Learning; Mice; Mice, Transgenic; Spatial Memory | 2021 |
Dietary citrulline does not modify rat colon tumor response to chemotherapy, but failed to improve nutritional status.
Topics: Animals; Antineoplastic Agents; Citrulline; Colonic Neoplasms; Dietary Supplements; Disease Models, Animal; Drug Monitoring; Intestinal Mucosa; Muscle, Skeletal; Nutritional Status; Rats; Treatment Outcome; Tumor Burden | 2021 |
Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia.
Topics: Animals; Apoptosis; Brain Ischemia; CA1 Region, Hippocampal; Cell Death; Citrulline; Disease Models, Animal; Glutathione; Hippocampus; Ischemia; Ischemic Attack, Transient; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Neurons; Neuroprotective Agents; Nitric Oxide Synthase Type III | 2017 |
Breach of autoreactive B cell tolerance by post-translationally modified proteins.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; B-Lymphocytes; Carbamates; Case-Control Studies; Citrulline; Cross Reactions; Disease Models, Animal; Humans; Mass Spectrometry; Mice; Protein Processing, Post-Translational; Self Tolerance; Synovial Membrane | 2017 |
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.
Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrullination; Citrulline; Disease Models, Animal; Fibrinogen; Haptens; Humans; Immunization; Major Histocompatibility Complex; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Protein-Arginine Deiminases; T-Lymphocytes | 2017 |
Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis.
Topics: Animals; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Citrulline; Disease Models, Animal; Epitopes; Female; Histocompatibility Antigens Class II; Humans; Immunity, Humoral; Immunization; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptides | 2018 |
Pilot Study of Radiation-induced Gastrointestinal Injury in a Hemi-body Shielded Göttingen Minipig Model.
Topics: Acute Radiation Syndrome; Animals; Apoptosis; Blood Platelets; Citrulline; Collagen; Disease Models, Animal; Female; Fibrosis; Gastrointestinal Tract; Inflammation; Male; Pilot Projects; Radiation Dosage; Radiation Injuries, Experimental; Radiation Protection; Swine; Swine, Miniature; Whole-Body Irradiation | 2018 |
Ex Vivo Enteroids Recapitulate In Vivo Citrulline Production in Mice.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Intestines; Liver; Male; Mice; Mice, Inbred ICR; Mice, Mutant Strains; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Tissue Culture Techniques; Urea | 2018 |
Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.
Topics: Animals; Arginase; Arginine; Blood-Brain Barrier; Citrulline; Dietary Supplements; Disease Models, Animal; Free Radical Scavengers; Humans; Malaria, Cerebral; Mice; Mice, Inbred C57BL; Nitric Oxide; Plasmodium berghei; Superoxides; Urea | 2019 |
Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model.
Topics: Amino Acids; Ammonia; Ammonium Chloride; Animals; Aspartic Acid; Citrulline; Citrullinemia; Disease Models, Animal; Glycerolphosphate Dehydrogenase; Hyperammonemia; Intestine, Small; Lactates; Liver; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Membrane Transport Proteins; Organ Specificity; Ornithine; Perfusion; Portal Vein; Pyruvic Acid; Urea | 2019 |
Citrulline and muscle protein homeostasis in three different models of hypercatabolism.
Topics: Animals; Brain Injuries, Traumatic; Citrulline; Critical Illness; Disease Models, Animal; Endotoxemia; Escherichia coli Infections; Male; Metabolic Diseases; Proteostasis; Rats; Rats, Sprague-Dawley | 2020 |
Citrulline stimulates muscle protein synthesis, by reallocating ATP consumption to muscle protein synthesis.
Topics: Adenosine Triphosphate; Animals; Citrulline; Disease Models, Animal; Humans; Male; Mice; Muscle Proteins; Protein Biosynthesis | 2019 |
Oral L-citrulline administration improves memory deficits following transient brain ischemia through cerebrovascular protection.
Topics: Administration, Oral; Animals; Cell Death; Cerebrovascular Circulation; Citrulline; Disease Models, Animal; Immunohistochemistry; Ischemic Attack, Transient; Male; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Microdialysis; Neurons; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type III | 2013 |
Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction.
Topics: Administration, Oral; Animals; Arterial Pressure; Biomarkers; Citrulline; Collagen; Disease Models, Animal; Electric Stimulation; Impotence, Vasculogenic; Male; Muscle, Smooth, Vascular; Nitric Oxide; Penile Erection; Penis; Rats; Rats, Wistar; Time Factors | 2013 |
Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).
Topics: Animals; Arthritis; Autoantibodies; Bacterial Proteins; Bacteroidaceae Infections; Bone Resorption; Citrulline; Disease Models, Animal; Disease Progression; Gene Deletion; Hydrolases; Joints; Male; Mice, Inbred DBA; Neutrophil Infiltration; Periodontitis; Porphyromonas gingivalis; Prevotella intermedia; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Severity of Illness Index | 2013 |
Liver-directed adeno-associated virus serotype 8 gene transfer rescues a lethal murine model of citrullinemia type 1.
Topics: Ammonia; Animals; Argininosuccinate Synthase; Citrulline; Citrullinemia; Dependovirus; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Humans; Liver; Mice; Organ Specificity; Phenotype; Thyroxine-Binding Globulin | 2013 |
Streptococcus pyogenes arginine and citrulline catabolism promotes infection and modulates innate immunity.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Gene Expression Regulation, Bacterial; Hydrolases; Immunity, Innate; Macrophages; Mice; Nitric Oxide Synthase Type II; Streptococcus pyogenes; Virulence | 2014 |
Oral L-citrulline supplementation improves erectile function and penile structure in castrated rats.
Topics: Administration, Oral; Animals; Castration; Citrulline; Disease Models, Animal; Electric Stimulation Therapy; Erectile Dysfunction; Male; Penile Erection; Penis; Rats; Rats, Wistar | 2014 |
Peptidylarginine deiminase 4 contributes to tumor necrosis factor α-induced inflammatory arthritis.
Topics: Animals; Arthritis, Experimental; Autoantibodies; B-Lymphocytes; Citrulline; Disease Models, Animal; Hydrolases; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Protein-Arginine Deiminase Type 4; T-Lymphocytes; Tumor Necrosis Factor-alpha | 2014 |
Serum metabolomics identifies citrulline as a predictor of adverse outcomes in an equine model of gut-derived sepsis.
Topics: Amino Acids; Analysis of Variance; Animals; Biomarkers; Citrulline; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Fatty Acids; Hoof and Claw; Horses; Immunoglobulin A; Inflammation; Metabolomics; Polymerase Chain Reaction; Predictive Value of Tests; Principal Component Analysis; Reference Values; ROC Curve; Systemic Inflammatory Response Syndrome | 2014 |
Administration of S-methyl-L-thiocitrulline protects against brain injuries after intracerebral hemorrhage.
Topics: Animals; Brain; Cell Death; Cerebral Hemorrhage; Citrulline; Corpus Striatum; Disease Models, Animal; Enzyme Inhibitors; Laminin; Male; Microvessels; Motor Activity; NADPH Dehydrogenase; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Occludin; Posture; Rats, Sprague-Dawley; Thiourea | 2014 |
Development of a new minipig model to study radiation-induced gastrointestinal syndrome and its application in clinical research.
Topics: Anastomosis, Surgical; Animals; Cell Proliferation; Citrulline; Disease Models, Animal; Ileum; Male; Radiation Injuries; Swine; Swine, Miniature | 2014 |
Inhibition of neuroinflammation and mitochondrial dysfunctions by carbenoxolone in the rotenone model of Parkinson's disease.
Topics: Animals; Antioxidants; Astrocytes; Carbenoxolone; Citrulline; Cytokines; Disease Models, Animal; Electron Transport; Enzyme Activation; Glial Fibrillary Acidic Protein; Glutathione; Inflammation; Inflammation Mediators; Male; Mesencephalon; Mitochondria; Nervous System; Nitric Oxide; Nitric Oxide Synthase Type II; Parkinson Disease; Rats, Sprague-Dawley; Rotenone | 2015 |
Citrullinated histone H3: a novel target for the treatment of sepsis.
Topics: Animals; Antibodies, Neutralizing; Biomarkers; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; HL-60 Cells; Humans; Hydrolases; Hydroxamic Acids; Male; Mice; Mice, Inbred C57BL; Ornithine; Protein-Arginine Deiminase Type 4; Sepsis; Shock, Septic; Vorinostat | 2014 |
Gastrointestinal acute radiation syndrome in Göttingen minipigs (Sus scrofa domestica).
Topics: Acute Radiation Syndrome; Animals; Citrulline; Disease Models, Animal; Dose-Response Relationship, Radiation; Endpoint Determination; Gamma Rays; Gastrointestinal Diseases; Histological Techniques; Linear Models; Male; Swine; Swine, Miniature | 2014 |
Pretreatment With L-Citrulline Positively Affects the Mucosal Architecture and Permeability of the Small Intestine in a Murine Mucositis Model.
Topics: Animals; Citrulline; Dietary Supplements; Disease Models, Animal; Fluorouracil; Intestinal Mucosa; Male; Mice; Mucositis; Oxidative Stress; Permeability | 2016 |
Citrulline does not prevent skeletal muscle wasting or weakness in limb-casted mice.
Topics: Animals; Autophagy; Biomarkers; Citrulline; Dietary Supplements; Disease Models, Animal; Fracture Fixation; Gene Expression Regulation; Hindlimb; Male; Membrane Proteins; Mice, Inbred C57BL; Microtubule-Associated Proteins; Mitochondrial Proteins; Muscle Proteins; Muscle Weakness; Muscle, Skeletal; Muscular Atrophy; Nitric Oxide Synthase Type II; Protein Isoforms; Restraint, Physical | 2015 |
Intestinal lengthening and reversed segment in a piglet short bowel syndrome model.
Topics: Animals; Citrulline; Disease Models, Animal; Female; Intestines; Nutritional Status; Short Bowel Syndrome; Sus scrofa | 2015 |
Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats.
Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Disease Models, Animal; Epitopes; Female; Filaggrin Proteins; Immune Tolerance; Immunophenotyping; Peptides; Phenotype; Rats; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory | 2015 |
Impact of qualitative and quantitative variations in nitrogen supply on catch-up growth in food-deprived-refed young rats.
Topics: Animals; Biomarkers; Citrulline; Dietary Proteins; Digestion; Disease Models, Animal; Energy Intake; Enteral Nutrition; Feasibility Studies; Food Deprivation; Food, Formulated; Intestinal Absorption; Intestinal Mucosa; Male; Malnutrition; Molecular Weight; Nutritive Value; Peptide Fragments; Protein Hydrolysates; Random Allocation; Rats, Sprague-Dawley; Weight Gain | 2016 |
Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis.
Topics: Animals; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Disease Models, Animal; Disease Progression; Histones; Humans; Inflammation; Joints; Proteomics | 2015 |
Combining citrulline with atorvastatin preserves glucose homeostasis in a murine model of diet-induced obesity.
Topics: AMP-Activated Protein Kinases; Animals; Atorvastatin; Cell Line, Tumor; Citrulline; Diabetes Mellitus, Type 2; Diet; Dietary Fats; Dietary Sucrose; Disease Models, Animal; Drug Therapy, Combination; Glucose; Homeostasis; Humans; Lipid Metabolism; Liver; Male; Mice, Inbred C57BL; Obesity; Sterol Regulatory Element Binding Protein 1 | 2015 |
Effect of minimal enteral feeding on recovery in a methotrexate-induced gastrointestinal mucositis rat model.
Topics: Animals; Antimetabolites, Antineoplastic; Citrulline; Disease Models, Animal; Enteral Nutrition; Humans; Intestinal Mucosa; Male; Methotrexate; Mucositis; Rats; Rats, Wistar | 2016 |
Significance of the Extent of Intestinal Resection on the Outcome of a Short-bowel Syndrome in a Porcine Model.
Topics: Animals; Citrulline; Diarrhea; Disease Models, Animal; Electrolytes; Female; Intestinal Mucosa; Intestine, Small; Prealbumin; Serum Albumin; Short Bowel Syndrome; Sus scrofa; Transferrin; Weight Loss | 2016 |
Citrulline as a Biomarker in the Non-human Primate Total- and Partial-body Irradiation Models: Correlation of Circulating Citrulline to Acute and Prolonged Gastrointestinal Injury.
Topics: Animals; Biomarkers; Citrulline; Disease Models, Animal; Gastrointestinal Diseases; Macaca mulatta; Male; Radiation Dosage; Radiation Injuries; Reproducibility of Results; Sensitivity and Specificity; Survival Rate; Whole-Body Irradiation | 2015 |
Citrulline as a Biomarker in the Murine Total-Body Irradiation Model: Correlation of Circulating and Tissue Citrulline to Small Intestine Epithelial Histopathology.
Topics: Animals; Biomarkers; Citrulline; Disease Models, Animal; Dose-Response Relationship, Radiation; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Radiation Dosage; Radiation Injuries; Reproducibility of Results; Sensitivity and Specificity; Survival Rate; Whole-Body Irradiation | 2015 |
Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.
Topics: Age Factors; Animals; Biopterins; Cardiotonic Agents; Cells, Cultured; Citrulline; Coronary Circulation; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Disease Models, Animal; Drug Administration Schedule; Drug Therapy, Combination; Endothelial Cells; Isolated Heart Preparation; Mice, Inbred C57BL; Mice, Obese; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Phosphorylation; Protein Multimerization; Pterins; Time Factors; Vasodilation; Ventricular Function, Left | 2016 |
Ureido group-specific antibodies are induced in rabbits immunized with citrulline- or homocitrulline-containing antigens.
Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Carrier Proteins; Citrulline; Collagen; Disease Models, Animal; Immunization; Peptides; Protein Binding; Rabbits | 2016 |
Oral citrulline supplementation protects female mice from the development of non-alcoholic fatty liver disease (NAFLD).
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Body Weight; Citrulline; Diet, Western; Dietary Supplements; Disease Models, Animal; Duodenum; Endotoxins; Female; Insulin; Liver; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease; Occludin; Plasminogen Activator Inhibitor 1; Protective Agents; Tight Junction Proteins; Toll-Like Receptor 4; Triglycerides; Zonula Occludens-1 Protein | 2017 |
Cl-Amidine Prevents Histone 3 Citrullination and Neutrophil Extracellular Trap Formation, and Improves Survival in a Murine Sepsis Model.
Topics: Animals; Arginine; Cecum; Cell Movement; Cells, Cultured; Citrulline; Disease Models, Animal; Extracellular Traps; Histones; Humans; Hydrolases; Male; Mice; Mice, Inbred C57BL; Neutrophils; Ornithine; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Sepsis | 2017 |
Pharmacologic suppression of oxidative damage and dendritic degeneration following kainic acid-induced excitotoxicity in mouse cerebrum.
Topics: Animals; Cerebrum; Citrulline; Dendrites; Disease Models, Animal; Drug Interactions; Female; Functional Laterality; Isoprostanes; Kainic Acid; Mice; Mice, Inbred C57BL; Nerve Degeneration; Neuroprotective Agents; Neurotoxicity Syndromes; Nitric Oxide Synthase; Oxidative Stress | 2008 |
Exercise training improves peripheral chemoreflex function in heart failure rabbits.
Topics: Action Potentials; Angiotensin II; Animals; Cardiac Pacing, Artificial; Carotid Body; Chronic Disease; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Exercise Therapy; Heart Failure; Hemodynamics; Hypoxia; Kidney; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Physical Exertion; Rabbits; Receptor, Angiotensin, Type 1; Reflex; Signal Transduction; Sympathetic Nervous System; Thiourea | 2008 |
Effects of microalgae Chlorella species crude extracts on intestinal adaptation in experimental short bowel syndrome.
Topics: Animals; Apoptosis; Cell Proliferation; Chlorella; Citrulline; Disease Models, Animal; DNA; Ileum; Intestinal Absorption; Intestinal Mucosa; Plant Extracts; Rats; Rats, Wistar; Serum Albumin; Short Bowel Syndrome | 2008 |
Selective neuronal nitric oxide synthase inhibitors and the prevention of cerebral palsy.
Topics: Animals; Animals, Newborn; Arginine; Behavior, Animal; Blood Pressure; Brain; Cerebral Palsy; Citrulline; Crystallography, X-Ray; Disease Models, Animal; Drug Design; Enzyme Inhibitors; Female; Male; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type I; Pregnancy; Rabbits; Structure-Activity Relationship | 2009 |
Altered arginine metabolism in the central nervous system (CNS) of the Cln3-/- mouse model of juvenile Batten disease.
Topics: Animals; Arginine; Brain; Cationic Amino Acid Transporter 1; Cells, Cultured; Citrulline; Disease Models, Animal; Female; Gene Expression; Liver; Male; Membrane Glycoproteins; Mice; Mice, Knockout; Molecular Chaperones; Neuronal Ceroid-Lipofuscinoses; Neurons; Nitric Oxide; Nitric Oxide Synthase; Protein Isoforms; RNA, Messenger; Urea | 2009 |
In vivo renal arginine release is impaired throughout development of chronic kidney disease.
Topics: Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Chronic Disease; Citrulline; Disease Models, Animal; Kidney Cortex; Kidney Diseases; Male; Rats; Rats, Sprague-Dawley; Regional Blood Flow | 2010 |
Expression of neuronal nitric oxide synthase in rabbit carotid body glomus cells regulates large-conductance Ca2+-activated potassium currents.
Topics: Analysis of Variance; Animals; Body Weight; Calcium; Carotid Body; Chemoreceptor Cells; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Genetic Vectors; Green Fluorescent Proteins; Heart Failure; Large-Conductance Calcium-Activated Potassium Channels; Male; Membrane Potentials; Nitric Oxide Synthase Type I; Pacemaker, Artificial; Patch-Clamp Techniques; Peptides; Potassium Channel Blockers; Rabbits; RNA, Messenger; Thiourea; Transduction, Genetic; Tyrosine 3-Monooxygenase | 2010 |
Analysis of plasma citrulline and intestinal morphometry in mice with hepatosplenic schistosomiasis.
Topics: Animals; Body Weight; Citrulline; Disease Models, Animal; Female; Histocytochemistry; Intestinal Mucosa; Jejunum; Liver Diseases; Mice; Microscopy; Plasma; Schistosomiasis; Splenectomy; Splenic Diseases | 2010 |
L-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats.
Topics: Animals; Animals, Newborn; Arginine; Bronchopulmonary Dysplasia; Citrulline; Disease Models, Animal; Humans; Hypertension, Pulmonary; Infant, Newborn; Lung; Lung Injury; Nitric Oxide; Pulmonary Alveoli; Rats | 2010 |
Decreased glutamine synthetase, increased citrulline-nitric oxide cycle activities, and oxidative stress in different regions of brain in epilepsy rat model.
Topics: Animals; Antioxidants; Arginase; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Brain Stem; Cerebellum; Cerebral Cortex; Citrulline; Disease Models, Animal; Epilepsy; Glutamate-Ammonia Ligase; Kainic Acid; Male; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2011 |
New insights on the mechanisms of valproate-induced hyperammonemia: inhibition of hepatic N-acetylglutamate synthase activity by valproyl-CoA.
Topics: Acyl Coenzyme A; Amino-Acid N-Acetyltransferase; Ammonia; Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Glutamates; Glutamine; Humans; Hyperammonemia; In Vitro Techniques; Liver; Male; Mice; Mice, Inbred C57BL; Models, Biological; Rats; Rats, Wistar; Urea; Valproic Acid | 2011 |
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Apoptosis; Arginine; Citrulline; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Agents; HT29 Cells; Humans; Hydrolases; Mice; Mice, Inbred C57BL; Ornithine; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Up-Regulation | 2011 |
Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock.
Topics: Animals; Biomarkers; Blotting, Western; Citrulline; Disease Models, Animal; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Random Allocation; Sensitivity and Specificity; Shock, Hemorrhagic; Survival Rate; Tumor Necrosis Factor-alpha; Vorinostat | 2011 |
Endotoxemia affects citrulline, arginine and glutamine bioavailability.
Topics: Animals; Area Under Curve; Arginine; Biological Availability; Citrulline; Disease Models, Animal; Endotoxemia; Glutamine; Lipopolysaccharides; Male; Random Allocation; Rats; Rats, Sprague-Dawley | 2012 |
Systemic L-citrulline prevents cerebral vasospasm in haptoglobin 2-2 transgenic mice after subarachnoid hemorrhage.
Topics: Animals; Arginine; Basilar Artery; Cerebrovascular Circulation; Citrulline; Disease Models, Animal; Dose-Response Relationship, Drug; Genotype; Haptoglobins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2012 |
Citrulline: a potential immunomodulator in sepsis.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Endothelial Cells; Immunologic Factors; Inflammation Mediators; Interleukin-10; Interleukin-6; Interleukin-8; Nitric Oxide; Rats; Rats, Wistar; Sepsis | 2011 |
The role of deimination in ATP5b mRNA transport in a transgenic mouse model of multiple sclerosis.
Topics: Adenosine Triphosphate; Animals; ATP Synthetase Complexes; Cell Line; Citrulline; Disease Models, Animal; Enzyme Activation; Gene Expression; Mice; Mice, Transgenic; Mitochondria; Mitochondrial Proton-Translocating ATPases; Multiple Sclerosis; Nuclear Proteins; Protein Binding; Protein Transport; Rats; RNA Transport; RNA-Binding Proteins; RNA, Messenger; Transcription Factors | 2012 |
Evaluation of potential gastrointestinal biomarkers in a PAK4 inhibitor-treated preclinical toxicity model to address unmonitorable gastrointestinal toxicity.
Topics: Amine Oxidase (Copper-Containing); Animals; Bile Acids and Salts; Biomarkers; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Feces; Gastric Mucosa; Gastrointestinal Tract; Histocytochemistry; Jejunum; Leukocyte L1 Antigen Complex; MicroRNAs; p21-Activated Kinases; Rats; Rats, Wistar; Stomach; Toxicity Tests | 2012 |
Nitric oxide and L-arginine metabolism in a devascularized porcine model of acute liver failure.
Topics: Animals; Arginase; Arginine; Citrulline; Disease Models, Animal; Female; Liver; Liver Failure, Acute; Nitric Oxide; Ornithine; Portacaval Shunt, Surgical; Sus scrofa | 2012 |
L-citrulline prevents alveolar and vascular derangement in a rat model of moderate hyperoxia-induced lung injury.
Topics: Animals; Animals, Newborn; Arginine; Citrulline; Disease Models, Animal; Endothelium, Vascular; Female; Hyperoxia; Lung; Lung Injury; Matrix Metalloproteinase 2; Nitric Oxide; Pulmonary Alveoli; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Vascular Endothelial Growth Factor A | 2012 |
Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis.
Topics: Animals; Antibodies; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantigens; Citrulline; Collagen Type II; Disease Models, Animal; Freund's Adjuvant; Humans; Immunity; Male; Mice; Mice, Inbred DBA; Peptide Fragments; T-Lymphocytes | 2012 |
Prolonged hypoxia augments L-citrulline transport by system A in the newborn piglet pulmonary circulation.
Topics: Amino Acid Transport System A; Animals; Animals, Newborn; Biological Transport; Cells, Cultured; Chronic Disease; Citrulline; Disease Models, Animal; Endothelial Cells; Familial Primary Pulmonary Hypertension; Hypertension, Pulmonary; Hypoxia; Membrane Transport Modulators; Nitric Oxide; Pulmonary Artery; Pulmonary Circulation; Swine; Time Factors | 2012 |
Chronic postnatal ornithine administration to rats provokes learning deficit in the open field task.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Animals, Newborn; Avoidance Learning; Behavior, Animal; Citrulline; Cognition; Developmental Disabilities; Disease Models, Animal; Half-Life; Learning Disabilities; Maze Learning; Memory; Memory, Long-Term; Ornithine; Postural Balance; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2012 |
Citrulline diet supplementation improves specific age-related raft changes in wild-type rodent hippocampus.
Topics: Aging; Alzheimer Disease; Animals; Blotting, Western; Cholesterol; Citrulline; Dietary Supplements; Disease Models, Animal; Hippocampus; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Neurons; Rats; Rats, Sprague-Dawley | 2013 |
Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.
Topics: Animals; Arginine; Blood Pressure; Chronic Disease; Citrulline; Compliance; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hemodynamics; Hypertension, Pulmonary; Hypoxia; Lung; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Perfusion; Pulmonary Artery; Pulmonary Veins; Rats; Rats, Sprague-Dawley; Time Factors; Vascular Resistance; Vasoconstriction; Ventricular Dysfunction, Right | 2013 |
Dexamethasone significantly attenuates sub-arachnoid hemorrhage-induced elevation in cerebrospinal fluid citrulline and leukocytes.
Topics: Animals; Citrulline; Dexamethasone; Disease Models, Animal; Glucocorticoids; Leukocytes; Nitric Oxide; Rabbits; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2012 |
Inhibition of peptidyl-arginine deiminases reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis.
Topics: Amidines; Animals; Brain; CD3 Complex; Citrulline; Demyelinating Diseases; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Enzyme Inhibitors; Humans; Hydrolases; Lymphocytes; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Optic Nerve; Protein-Arginine Deiminases; Spleen; Survival Analysis | 2013 |
High blood pressure enhances brain stem neuronal nitric oxide synthase activity in Dahl salt-sensitive rats.
Topics: Animals; Arterial Pressure; Brain Stem; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase Type I; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Telemetry; Thiourea | 2013 |
Presence and role of anti-citrullinated protein antibodies in experimental arthritis models.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Collagen Type II; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Fibrinogen; Freund's Adjuvant; Genetic Predisposition to Disease; Immunotherapy, Active; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Myelin Basic Protein; Protein Processing, Post-Translational; Proteins | 2013 |
Neuronal oxidative damage from activated innate immunity is EP2 receptor-dependent.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoimmune Diseases of the Nervous System; Biomarkers; Brain Chemistry; Citrulline; Disease Models, Animal; Docosahexaenoic Acids; F2-Isoprostanes; Immunity, Innate; Isoprostanes; Kainic Acid; Lipid Peroxidation; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Neurons; Oxidation-Reduction; Oxidative Stress; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP2 Subtype | 2002 |
Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain.
Topics: Adenosine Triphosphate; Animals; Brain; Cell Death; Citrulline; Cyclic N-Oxides; Disease Models, Animal; Free Radical Scavengers; Kainic Acid; Male; Neurons; Neuroprotective Agents; Neurotoxins; Nitric Oxide; Nitrogen Oxides; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Status Epilepticus; Up-Regulation; Vitamin E | 2002 |
Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats.
Topics: Animals; Arginine; Cerebral Infarction; Citrulline; Corpus Striatum; Disease Models, Animal; Ischemic Attack, Transient; Male; Microdialysis; Neuroprotective Agents; Nitric Oxide; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid, kappa; Treatment Outcome | 2003 |
Citrullination of synovial proteins in murine models of rheumatoid arthritis.
Topics: Animals; Antibody Specificity; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Biopsy; Citrulline; Disease Models, Animal; Epitopes; Gene Expression Regulation, Enzymologic; Hydrolases; Male; Mice; Mice, Inbred DBA; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 3; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Proteins; RNA, Messenger; Synovial Fluid; Synovial Membrane | 2003 |
Role of the W07-toxin on Vibrio cholerae-induced diarrhoea.
Topics: Animals; Bacterial Toxins; Calcium; Catalase; Cells, Cultured; Citrulline; Diarrhea; Disease Models, Animal; Dose-Response Relationship, Drug; Enterocytes; Inositol Phosphates; Intestine, Small; Luminescent Measurements; Mice; Mice, Inbred BALB C; Nitrites; Phospholipase C gamma; Protein Kinase C; Signal Transduction; Time Factors; Type C Phospholipases; Vibrio cholerae | 2004 |
The inhibition of retinal inducible nitric oxide synthase overexpression and the attenuation of experimental uveitis by anti-inflammatory drugs in rats.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Citrulline; Dexamethasone; Disease Models, Animal; Enzyme Inhibitors; Female; Indomethacin; Inflammation; Leukocytes; Lipopolysaccharides; Macrophages; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phagocytosis; Rats; Rats, Wistar; Retina; Time Factors; Uveitis | 2004 |
Absence of citrulline-specific autoantibodies in animal models of autoimmunity.
Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Disease Models, Animal; Humans; Mice; Mice, Inbred MRL lpr; Mice, Transgenic; Peptides, Cyclic | 2004 |
Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis.
Topics: Aged; Aged, 80 and over; Animals; Arginine; Astrocytes; Blotting, Western; Citrulline; Disease Models, Animal; Down-Regulation; Female; Glaucoma, Open-Angle; Humans; Hydrolases; Immunohistochemistry; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Middle Aged; Optic Nerve Diseases; Proteomics; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2006 |
Characterization of cationic amino acid transport systems in rat erythrocytes: lack of effect of uraemia on L-arginine influx.
Topics: Amino Acid Transport System y+; Amino Acid Transport System y+L; Animals; Arginine; Citrulline; Disease Models, Animal; Erythrocytes; Kinetics; Leucine; Lysine; Male; Nephrectomy; Ornithine; Rats; Rats, Wistar; Uremia | 2006 |
Role of the L-citrulline/L-arginine cycle in iNANC nerve-mediated nitric oxide production and airway smooth muscle relaxation in allergic asthma.
Topics: Allergens; Animals; Arginine; Argininosuccinate Lyase; Argininosuccinate Synthase; Asthma; Citrulline; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Guinea Pigs; Male; Muscle Relaxation; Muscle, Smooth; N-Methylaspartate; Neural Inhibition; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Ovalbumin; Specific Pathogen-Free Organisms; Succinic Acid; Trachea | 2006 |
Increased citrullination of histone H3 in multiple sclerosis brain and animal models of demyelination: a role for tumor necrosis factor-induced peptidylarginine deiminase 4 translocation.
Topics: Active Transport, Cell Nucleus; Animals; Brain; Citrulline; Demyelinating Diseases; Disease Models, Animal; Female; Histones; Humans; Hydrolases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multiple Sclerosis; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Tumor Necrosis Factor-alpha | 2006 |
Effect of ocular hypertension on retinal nitridergic pathway activity.
Topics: Amino Acid Transport Systems, Basic; Animals; Anterior Chamber; Arginine; Blotting, Western; Citrulline; Cyclic GMP; Disease Models, Animal; Hyaluronic Acid; Intraocular Pressure; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ocular Hypertension; Radioimmunoassay; Rats; Rats, Wistar; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2007 |
Brain stem NO modulates ventilatory acclimatization to hypoxia in mice.
Topics: Acclimatization; Animals; Blotting, Western; Brain Stem; Chronic Disease; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Hypoxia; Male; Mice; Mice, Inbred CBA; Nitric Oxide; Nitric Oxide Synthase Type I; Polymerase Chain Reaction; Pulmonary Ventilation; Receptors, N-Methyl-D-Aspartate; Research Design; RNA, Messenger; Thiourea; Tidal Volume; Up-Regulation | 2007 |
Interaction between murine spf-ash mutation and genetic background yields different metabolic phenotypes.
Topics: Alanine; Ammonia; Animals; Arginine; Citrulline; Disease Models, Animal; Female; Glycine; Injections, Intravenous; Intestinal Mucosa; Liver; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Mice, Mutant Strains; Models, Biological; Mutation; Nitric Oxide; Ornithine; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Phenotype; Phenylalanine; Urea | 2007 |
Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress.
Topics: Acetylcholine; Anemia, Sickle Cell; Animals; Arginine; Citrulline; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Enzyme Inhibitors; Globins; Heme Oxygenase-1; Hemodynamics; Hemoglobins; Hemolysis; Humans; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Tyrosine; Vasodilator Agents | 2008 |
Hypoglycin toxicity: studies of ammonia metabolism.
Topics: Ammonia; Animals; Citrulline; Cyclopropanes; Disease Models, Animal; Humans; Hypoglycins; Liver; Nitrogen; Plant Poisoning; Rats; Rats, Inbred Strains; Urea | 1983 |
The sigma receptor ligand JO 1784 (igmesine hydrochloride) is neuroprotective in the gerbil model of global cerebral ischaemia.
Topics: Animals; Brain Ischemia; Cell Count; Cinnamates; Citrulline; Cyclopropanes; Disease Models, Animal; Dose-Response Relationship, Drug; Gerbillinae; Hippocampus; Male; Neuroprotective Agents; Time Factors | 1995 |
Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Citrulline; Cyclic GMP; Dexamethasone; Disease Models, Animal; Homoarginine; Hypertension; Insulin; Male; Nitrates; Nitric Oxide; Ornithine; Rats; Rats, Inbred Strains | 1993 |
The neuroprotective effect of a potent and selective inhibitor of type I NOS (L-MIN) in a rat model of focal cerebral ischaemia.
Topics: Analysis of Variance; Animals; Arterial Occlusive Diseases; Cerebral Arteries; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Evaluation Studies as Topic; Ischemic Attack, Transient; Isoenzymes; Male; Neuroprotective Agents; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Thiourea | 1995 |
Normalization of hair growth in sparse fur-abnormal skin and hair (SPF-ASH) mice by introduction of the rat ornithine transcarbamylase (OTC) gene.
Topics: Animals; Arginine; Citrulline; Crosses, Genetic; Disease Models, Animal; Female; Genetic Linkage; Hair; Intestine, Small; Liver; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Mice, Transgenic; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Phenotype; Rats; Skin Abnormalities; X Chromosome | 1994 |
Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene.
Topics: Amino Acid Metabolism, Inborn Errors; Amino Acids; Ammonia; Animals; Argininosuccinate Synthase; Cells, Cultured; Citrulline; Disease Models, Animal; Heterozygote; Homozygote; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Plasmids; Recombination, Genetic; Stem Cells | 1994 |
Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from L-arginine accumulation or a reduction in nitric oxide or L-citrulline formation.
Topics: Animals; Anticonvulsants; Arginine; Blood Pressure; Citrulline; Disease Models, Animal; Epilepsy; Female; Heart Rate; Indazoles; Male; Mice; Mice, Inbred DBA; Motor Activity; Nitric Oxide; Nitric Oxide Synthase; Noise; Rats; Rats, Inbred Strains; Reflex; Seizures | 1996 |
Further in vivo studies on attenuating morphine withdrawal: isoform-selective nitric oxide synthase inhibitors differ in efficacy.
Topics: Analysis of Variance; Animals; Blood Pressure; Citrulline; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Induction; Enzyme Inhibitors; Guanidines; Heart Rate; Indazoles; Isoenzymes; Male; Morphine; Naloxone; Narcotic Antagonists; Nitric Oxide Synthase; Rats; Rats, Inbred F344; Substance Withdrawal Syndrome; Thiourea | 1997 |
Anticonvulsant activity of new and potent inhibitors of nitric oxide synthase.
Topics: Animals; Anticonvulsants; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Imidazoles; Male; Mice; Nitric Oxide Synthase; Seizures; Thiourea | 1997 |
Effect of nitric oxide synthase inhibitor on a hyperglycemic rat model of reversible focal ischemia: detection of excitatory amino acids release and hydroxyl radical formation.
Topics: Animals; Cell Survival; Citrulline; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutamic Acid; Hydroxyl Radical; Hyperglycemia; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1998 |
Studies of arginine metabolism and salt sensitivity in the Dahl/Rapp rat models of hypertension.
Topics: Alanine; Animals; Arginine; Argininosuccinate Synthase; Blood Pressure; Body Weight; Citrulline; Disease Models, Animal; Hypertension; Kidney; Liver; Male; Ornithine; Rats; Sodium Chloride, Dietary; Urea | 1998 |
Evaluation of gene therapy for citrullinaemia using murine and bovine models.
Topics: Adenoviruses, Human; Amino Acid Metabolism, Inborn Errors; Ammonia; Animals; Arginine; Argininosuccinate Synthase; Benzoates; Benzoic Acid; Cattle; Citrulline; Disease Models, Animal; Evaluation Studies as Topic; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Liver; Mice; Nitrogen; Treatment Outcome; Urea | 1998 |
Differential effects of nitric oxide synthase inhibitors in an in vivo allergic rat model.
Topics: Animals; Bronchoalveolar Lavage Fluid; Bronchoconstrictor Agents; Citrulline; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hypersensitivity; Male; Methacholine Chloride; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Thiourea | 2000 |
Protein deimination in the rat brain after kainate administration: citrulline-containing proteins as a novel marker of neurodegeneration.
Topics: Animals; Biomarkers; Citrulline; Disease Models, Animal; Epilepsy, Temporal Lobe; Excitatory Amino Acid Agonists; Glial Fibrillary Acidic Protein; Hydrolases; Imines; Kainic Acid; Microtubule-Associated Proteins; Nerve Degeneration; Nerve Tissue Proteins; Neuroglia; Neurons; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Rats; Rats, Wistar; Telencephalon | 2001 |
Extremely short small bowel induces focal tubulointerstitial fibrosis.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Fibrosis; Immunohistochemistry; Kidney; Male; Orotic Acid; Rats; Rats, Sprague-Dawley; Short Bowel Syndrome | 2001 |
Arginine supplementation of sickle transgenic mice reduces red cell density and Gardos channel activity.
Topics: Anemia, Sickle Cell; Animals; Arginine; Citrulline; Disease Models, Animal; Erythrocyte Count; Erythrocytes; Hemoglobins; Humans; Kinetics; Mice; Mice, Transgenic; Oxygen; Potassium; Potassium Channels, Calcium-Activated | 2002 |
Peptidylarginine deiminase: a candidate factor in demyelinating disease.
Topics: Age of Onset; Animals; Brain; Brain Chemistry; Citrulline; Demyelinating Diseases; Disease Models, Animal; Disease Progression; Enzyme Activation; Gene Dosage; Hydrolases; Mice; Mice, Transgenic; Myelin Basic Protein; Myelin Sheath; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; RNA, Messenger; Solubility; Transgenes; Up-Regulation | 2002 |
Evidence for the involvement of L-citrulline but not nitric oxide in the proconvulsant action of the precursor L-arginine on picrotoxin-induced convulsions in rats.
Topics: Animals; Arginine; Citrulline; Disease Models, Animal; Epilepsy; Male; Nitric Oxide; Rats; Rats, Wistar | 2002 |
Amino acid metabolism in the chronically uremic rat.
Topics: Amine Oxidase (Copper-Containing); Amines; Amino Acids; Animals; Argininosuccinate Lyase; Argininosuccinate Synthase; Brain; Chronic Disease; Citrulline; Dietary Proteins; Disease Models, Animal; Hydroxyindoleacetic Acid; Kidney; Liver; Monoamine Oxidase; Multienzyme Complexes; Muscles; Myocardium; Ornithine Carbamoyltransferase; Phenylalanine; Phenylalanine Hydroxylase; Rats; Tryptophan; Tryptophan Oxygenase; Tyrosine Transaminase; Uremia | 1975 |
Citrullinemia: enzymatic evidence for genetic heterogeneity.
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Argininosuccinate Synthase; Citrulline; Disease Models, Animal; Female; Fibroblasts; Heterozygote; Kinetics; L-Lactate Dehydrogenase; Ligases; Lymphocytes; Male; Phosphogluconate Dehydrogenase; Skin | 1975 |
Animal model of human disease. Citrullinemia (argininosuccinate synthetase deficiency).
Topics: Amino Acid Metabolism, Inborn Errors; Animals; Cattle; Cattle Diseases; Citrulline; Disease Models, Animal | 1989 |
A simple animal model of hyperammonemia.
Topics: Acetates; Ammonia; Animals; Citrulline; Disease Models, Animal; Glutamate Dehydrogenase; Liver; Male; Orotic Acid; Rats; Rats, Inbred Strains; Urea | 1989 |