citrulline and Arthritis, Rheumatoid

citrulline has been researched along with Arthritis, Rheumatoid in 557 studies

Research

Studies (557)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's3 (0.54)18.2507
2000's197 (35.37)29.6817
2010's310 (55.66)24.3611
2020's47 (8.44)2.80

Authors

AuthorsStudies
Faßbender, J; Holthoff, HP; Li, Z; Reimann, A; Ungerer, M; Wenhart, C1
Berghmans, N; Boon, L; Conings, R; Fiten, P; Grillet, B; Janssens, R; Martens, E; Opdenakker, G; Pereira, RVS; Proost, P; Ronsse, I; Ugarte-Berzal, E; Van Aelst, I; Van Damme, J; Vandooren, J; Verschueren, P; Yu, K1
Amjadi, MF; Bashar, SJ; Denny, MF; Grönwall, C; Malmström, V; McCoy, SS; Mergaert, AM; Newton, MA; Shelef, MA; Zheng, Z1
Andrade, LEC; Colmegna, I; de França, NR; Hitchon, C; Lora, M; Ménard, HA; Rauch, J; Zhou, Z1
Sawada, T; Tahara, K; Yasuda, T1
Dua, K; Kumar Singh, S; Kuppusamy, G; Radhakrishnan, A; Thirugnanasambandham, I1
Auger, I; Hemon, MF; Lambert, NC; Roudier, J1
Aripova, N; Bierman, MM; Daubach, EC; Duryee, MJ; England, BR; Hunter, CD; Jones, SQ; Mikuls, TR; Mitra, A; Ragland, AS; Romberger, DJ; Ryan, EM; Thiele, GM1
Andrade, F; Gómez-Bañuelos, E; Konig, MF1
Andersson, DC; Carlström, M; Gastaldello, S; Lanner, JT; Lund, LH; Pironti, G; Rassier, DE; Westerblad, H; Yamada, T1
Brand, DD; Kang, AH; Myers, LK; Odens, HH; Ouyang, YX; Park, J; Patel, JR; Rosloniec, EF; Stuart, JM; Woo-Rasberry, V; Yi, AK1
Gao, Z; Lei, Y; Li, Z; Shen, H; Sun, T; Zhang, S1
Adrados-Planell, A; Brown, JL; Butcher, JP; Campbell, L; Culshaw, S; Glass, DG; Goodyear, CS; Malcolm, J; McInnes, IB; Millington, OR; Nyirenda, MH; Piela, K; Wright, AJ1
Chen, X; Du, R; Geng, H; Holmdahl, R; Nandakumar, KS; Wan, J; Wang, S; Xing, W; Xiong, L; Xu, M1
Amin, MA; Campbell, PL; Czarnik-Kwaśniak, J; Isozaki, T; Koch, AE; Korchynska, N; Korchynskyi, O; Pruijn, GJM; Ruth, JH; Tak, PP; Yoshida, K1
Bessa, H; Bossuyt, X; De Somer, L; Dillemans, L; Gouwy, M; Martens, E; Matthys, P; Metzemaekers, M; Proost, P; Verschueren, P; Wouters, C; Yu, K1
Bingham, CO; Coller, J; Crawford, JD; Curran, AM; Darrah, E; Girgis, AA; Jang, Y; Kawalerski, R; Na, CH; Thomas, MA1
Chemin, K; Malmström, V1
Catrina, AI; Diaz Boada, JS; Diaz-Gallo, LM; Gerstner, C; Grönwall, C; Hansson, M; Hensvold, A; Horuluoglu, B; Israelsson, L; Klareskog, L; Malmström, V; Mathsson-Alm, L; Réthi, B; Sahlström, P; Sippl, N; Steen, J; Thyagarajan, R; Wedin, R1
Auger, I; Roudier, J1
Catrina, A; Gerstner, C; Grönwall, C; Grunewald, J; Hansson, M; Hensvold, A; Israelsson, L; Joshua, V; Klareskog, L; Loberg Haarhaus, M; Malmström, V; Réthi, B; Sköld, M; Stålesen, R; Wähämaa, H1
Haraguchi, A; Kondo, M; Nakashima, Y; Niiro, H; Sagawa, F; Tsuru, T; Yamada, H1
Grönwall, C; Raposo, B1
Barasa, L; Thompson, PR1
de Bont, C; Pruijn, GJM1
Bay-Jensen, AC; Damgaard, D; Hägglund, P; Nielsen, CH; Senolt, L; Sharma, M; Svensson, B1
Amengual, O; Atsumi, T; Bohgaki, T; Fujieda, Y; Hatakeyama, S; Hisada, R; Kato, M; Kudo, Y; Lee, W; Oku, K; Onodera, T; Sugawara, E; Yasuda, S1
Bi, L; Li, B; Li, P1
Andrade, F; Darrah, E; Fert-Bober, J1
Andrade, F; Darrah, E; Romero, V1
Bang, H; Bonger, KM; Cavallari, M; Drijfhout, JW; Huizinga, T; Janssen, G; Kampstra, A; Kissel, T; Kwekkeboom, JC; Levarht, E; Reijm, S; Reth, M; Scherer, HU; Slot, LM; Stoeken-Rijsbergen, G; Toes, R; van Veelen, PA; Vergroesen, RD; Wortel, CM1
Bürgin, W; Eick, S; Imber, JC; Maldonado, A; Möller, B; Pirracchio, L; Sculean, A1
Astakhova, K; Hansen, J; Khatri, S1
Achour, A; Catrina, AI; Chemin, K; Dubnovitsky, A; Gerstner, C; Hensvold, AH; Kozhukh, G; Kwok, WW; Malmström, V; Ramwadhdoebe, TH; Rönnblom, L; Turcinov, S; Uchtenhagen, H; van Baarsen, LGM1
Brooks, SR; Buckner, JH; Carlucci, PM; Carmona-Rivera, C; Fox, DA; Goel, RR; Hoffmann, V; James, E; Kaplan, MJ; Rims, C1
Lai, JH; Wu, CY; Yang, HY1
Bassu, S; Carru, C; Castagna, F; Erre, GL; Mangoni, AA; Passiu, G; Piga, M; Sotgia, S; Zinellu, A1
Amado, F; Ferreira, R; Guedes, S; Van Eyk, JE; Vitorino, C; Vitorino, R1
Arai, T; Ise, N; Ishigami, A; Kondo, Y; Kurata, I; Matsumoto, I; Mikami, N; Ohyama, A; Osada, A; Sano, Y; Sumida, T; Tsuboi, H1
Choi, JY; Choi, M; Ivashkiv, LB; Kim, JS; Kim, JY; Lee, EY; Song, JS1
Lamers, S; Liu, X; Nicolaes, GAF; Reutelingsperger, CPM; Wichapong, K1
Barra, L; Cairns, E; Heit, B; Rajamohan, A1
Andrade, F; Gómez-Bañuelos, E; Trejo-Zambrano, MI1
Csősz, É; Kharlamova, N; Lundberg, K; Márton, I; Soós, B; Szekanecz, Z; Tar, I; Végh, E1
Chiba, A; Miyake, S; Nakao, T; Robinson, WH; Tsuritani, K; Watanabe, N; Yamada, T; Yoshizawa, Y1
Ishigami, A; Iwai, T; Kawaguchi, H; Kondo, Y; Kurata, I; Matsumoto, I; Nishiyama, T; Ohyama, A; Osada, A; Sumida, T; Tsuboi, H1
Chen, Z; Fang, W; Jin, YZ; Lou, J; Qin, Y; Yang, X1
Blackburn, JM; Damgaard, D; Jørgensen, MM; Nielsen, CH; Poulsen, TBG; Senolt, L; Stensballe, A1
de Ru, AH; Dekkers, JS; Hegen, M; Huizinga, TWJ; Ioan-Facsinay, A; Janssen, GMC; Liu, B; Rapecki, S; Stoop, JN; Toes, REM; Trouw, LA; van Veelen, PA; Verheul, MK1
Kampstra, ASB; Toes, REM1
Biniecka, M; Fearon, U; McGarry, T; Najm, A; Ng, CT; Orr, C; Veale, DJ; Young, F1
Anaparti, V; Bernstein, CN; Bridie Clemens, E; Deutsch, AJ; El-Gabalawy, H; Ferucci, ED; Heemst, JV; Hitchon, CA; Huizinga, T; Kedzierska, K; Law, SC; Meng, X; Moustakas, AK; Papadopoulos, GK; Raychaudhuri, S; Reid, HH; Robinson, DB; Rossjohn, J; Scally, SW; Smolik, I; Sokolove, J; Thomas, R; Ting, YT; Toes, RE; van der Woude, D1
Koziel, J; Mydel, P; Potempa, J2
Bleda, MJ; Gómara, MJ; Haro, I; Rodríguez, J; Salvador, JP; Sanmartí, R1
Andrade, F; Darrah, E1
Bentlage, AEH; Dekkers, G; Falkenburg, WJJ; Kempers, AC; Ooijevaar-de Heer, P; Rispens, T; Scherer, HU; Toes, REM; van Schaardenburg, D; Vidarsson, G1
Arnoux, F; Auger, I; Balandraud, N; Lambert, NC; Mariot, C; Peen, E; Roudier, J1
Barra, L; Bell, DA; Cairns, E; Lac, P; Racapé, M1
Barra, L; Bell, DA; Cairns, E; Lac, P; Saunders, S; Tutunea-Fatan, E1
Baker, DG; Loh, KL; Petersen, J; Purcell, AW; Ramarathinam, SH; Reid, HH; Rossjohn, J; Scally, SW; Suri, A; Thomas, R; Ting, YT1
Amital, H; Gertel, S; Houri-Levi, E; Karmon, G; Mozes, E; Shoenfeld, Y; Shovman, O; Szarka, E1
Aradi, P; Gyulai, G; Huber, K; Hudecz, F; Kiss, É; Magyar, A; Nagy, G; Pozsgay, J; Rojkovich, B; Sármay, G; Szarka, E; Végh, L1
Matsumoto, I; Sumida, T; Umeda, N1
Mittereder, N; Sims, GP; Zhou, Y1
Huizinga, TWJ; Krönke, G; Scherer, HU; Schett, G; Toes, REM1
Jian, L; Li, C; Liu, X; Ma, Z; Sun, L; Yu, R; Zhao, J1
Chapple, I; de Pablo, P; Dietrich, T; Filer, A; Grant, MM; Kumar, PS; Lopez-Oliva, I; Paropkari, AD; Raza, K; Saraswat, S; Serban, S; Sharma, P; Yonel, Z1
Drahos, L; Gömöry, Á; Hudecz, F; Schlosser, G; Steckel, A; Turiák, L; Uray, K1
Maurais, AJ; Nagar, M; Nagpal, S; Nemmara, VV; Nguyen, SH; Salinger, AJ; Thompson, PR; Tilvawala, R; Weerapana, E1
Cau, L; Méchin, MC; Simon, M1
Amara, K; Baharpoor, A; Barsness, LO; Ghodke-Puranik, Y; Hansson, M; Israelsson, L; Klareskog, L; Malmström, V; Mueller, DL; Niewold, TB; Sahlström, P; Shmagel, AK; Sippl, N; Skriner, K; Svensson, CI; Titcombe, PJ; Wigerblad, G; Zhang, N; Zhang, Y1
Brödje, D; Geyer, A; Pfefferle, P; Schrimpf, A1
Guo, B; He, M; Liu, Z; Shu, D; Si, S; Xiong, Y; Xu, S; Zhao, X1
Buckner, JH; Carlin, J; Carlucci, P; Carmona-Rivera, C; James, EA; Kaplan, MJ; Markovics, A; Mikecz, K; Rims, C; Uchtenhagen, H1
Hannig, M; Herrmann, M; Minnich, B; Vitkov, L1
Amital, H; Bragazzi, NL; Darawshe, S; Gertel, S; Watad, A1
Bednar, KJ; Fung-Leung, WP; Macauley, MS; Nycholat, CM; Paulson, JC; Rao, TS1
Holmes, CL; Johnson, CJ; Kernien, J; Nett, JE; Shelef, MA; Shim, D1
Bartels, CM; Bier, AM; Donlon, TZ; Holmes, CL; Osman, F; Peyton, CG; Shelef, MA1
El Sayed, R; El Shikh, MEM; Fossati-Jimack, L; Goldmann, K; Hands, R; John, CR; Lewis, MJ; Nerviani, A; Pitzalis, C1
Batmaz, I; Çevik, R; Guli Çetinçakmak, M; Nas, K; Sariyildiz, MA; Yıldız, I1
Barbosa, BB; da Luz, A; Nisihara, R; Picceli, V; Skare, TL; Utiyama, S1
Buckley, CD; Chapple, IL; Charles, PJ; Chowdhury, M; de Pablo, P; Dietrich, T; Milward, M; Venables, PJ1
Amara, K; Catrina, AI; Corti, D; Engström, M; Fernandez-Rodriguez, BM; Israelsson, L; Joshua, V; Klareskog, L; Malmström, V; Meffre, E; Morbach, H; Murray, F; Snir, O; Steen, J; Wardemann, H1
Barra, L; Bell, DA; Bhayana, R; Cairns, E; Coles, R; Racapé, M; Rohekar, S; Saunders, S; Scinocca, M1
Bingham, CO; Moni, M1
Charles, P; Chowdhury, M; Culshaw, S; Fisher, BA; Guo, Y; Hamilton, BC; Lugli, EB; Mikuls, TR; Potempa, J; Quirke, AM; Thiele, G; Venables, PJ; Wegner, N; Ytterberg, AJ; Zubarev, RA1
Bae, SC; Bang, SY; Charles, P; Chowdhury, M; Fisher, BA; Kim, JH; Lee, HS; Venables, P1
Bartold, PM; Kaur, S; White, S1
Carmona-Rivera, C; Chen, P; Fox, DA; Friday, S; Gizinski, A; Kaplan, MJ; Khandpur, R; Knight, JS; Li, S; Patel, RM; Pennathur, S; Subramanian, V; Thompson, P; Vivekanandan-Giri, A; Yalavarthi, S1
Aggarwal, A; Agrawal, S; Srivastava, R1
Brennan, MJ; Edmundowicz, D; Kao, AH; Krishnan, E; Lahey, LJ; Lepus, CM; Robinson, WH; Sharpe, O; Sokolove, J; Wasko, MC1
Dalmády, S; Gyulai, R; Kemény, L; Képíró, L; Kiss, M; Kovács, L; Sonkodi, G1
Aradi, B; Bősze, S; Buzás, EI; Falus, A; Glant, TT; György, B; Holub, MC; Horváti, K; Mikecz, K; Misják, P; Nagy, G; Pálóczi, K; Pásztói, M; Szabó, TG; Szakács, F1
Babos, F; Hudecz, F; Magyar, A; Majer, Z; Nagy, G; Sármay, G; Szarka, E1
Babos, F; Cantagrel, A; Cornillet, M; Hudecz, F; Magyar, A; Nogueira, L; Ruyssen-Witrand, A; Sebbag, M; Serre, G; Verrouil, E1
Guo, Y; Jiang, L; Shen, T; Wang, X; Zhang, X1
Klareskog, L; Lundberg, K; Malmström, V1
Abe, A; Ito, S; Kobayashi, T; Murasawa, A; Okada, M; Yokoyama, T; Yoshie, H1
Alcaro, MC; Barbetti, F; Boscaro, F; Dioni, I; Migliorini, P; Panza, F; Paolini, I; Pratesi, F; Puxeddu, I; Rovero, P; Tommasi, C1
Jacobsson, LT; Mathsson, L; Rönnelid, J; Sturfelt, G; Turesson, C1
Feng, L; Zhu, T1
Mariette, X1
Abdessemed, A; Allam, I; Bayou, M; Behaz, N; Djidjik, R; Ghaffor, M; Khaldoun, N; Ladjouze-Rezig, A; Louahchi, S; Ouikhlef, N; Raaf, N; Tahiat, A1
Alfredsson, L; Bengtsson, C; Holmqvist, M; Källberg, H; Karlson, EW; Orellana, C; Wedrén, S1
Herrath, J; Malmström, V; Muhammad, K; Pieper, J; Raghavan, S; Vollenhoven, Rv1
Draborg, AH; Hansen, PR; Houen, G; Trier, NH; Tronstrøm, J1
Harre, U; Kocijan, R; Schett, G1
Cornelis, F; Michou, L; Migliorini, P; Petit Teixeira, E; Pratesi, F; Puxeddu, I; Sette, A; Sidney, J1
Alasaarela, E; Koivula, MK; Lehenkari, P; Melkko, J; Risteli, J; Turunen, S1
Ádori, M; Babos, F; Baka, Z; Brózik, M; Gáti, T; Huber, K; Hudecz, F; Kelemen, J; Magyar, A; Nagy, G; Neer, Z; Papp, K; Pazár, B; Poór, G; Pozsgay, J; Prechl, J; Rojkovich, B; Sármay, G; Szarka, E; Szittner, Z1
Elkon, KB1
Andrade, F; Darrah, E; Fert-Bober, J; Haque, UJ; Lee, DM; Nigrovic, PA; Romero, V; Rosen, A; van Eyk, J1
Dudek, NL; Eckle, SB; La Gruta, NL; Law, SC; Loh, KL; McCluskey, J; Nel, HJ; Petersen, J; Pike, RN; Purcell, AW; Reid, HH; Rossjohn, J; Scally, SW; Thomas, R; Toes, RE; van Heemst, J; Wijeyewickrema, LC1
Cerqueira, CF; Jakobsson, PJ; Klareskog, L1
Fisher, BA; Montgomery, AB; Venables, PJ1
Ray, K1
Amara, K; Klareskog, L; Malmström, V1
Kleyer, A; Schett, G1
Askling, J; Catrina, AI; Ferreira, R; Hammarström, L; Hansson, M; Hensvold, AH; Holmdahl, R; Israelsson, L; Jakobsson, PJ; Joshua, V; Klareskog, L; Magnusson, PK; Malmström, V1
Drijfhout, JW; Engbers, GH; Jansen, JJ; Pruijn, GJ; Raats, J; Salden, M; Toes, RE; van Beers, JJ; van der Helm-van Mil, AH; Willemze, A1
Alfredsson, L; Bengtsson, C; Binder, SR; Bromberg, R; Chandra, PE; Delanoy, M; Klareskog, L; Lahey, LJ; Lindstrom, TM; Robinson, WH; Saevarsdottir, S; Sokolove, J; Wagner, CA; Walker, RP1
An, Y; Hu, FL; Li, GY; Li, Y; Li, ZG; Sun, XL1
Barra, L; Bell, DA; Cairns, E; Gladman, DD; Joseph, R; McCormick, JK; Pope, J; Racapé, M; Scinocca, M; Shaw, G1
Alfredsson, L; Allanore, Y; Amos, C; Balsa, A; Barnetche, T; Boileau, C; Cantagrel, A; Chiocchia, G; Chollet-Martin, S; Combe, B; Constantin, A; Coustet, B; Dieudé, P; El-Benna, J; Furukawa, H; Gazal, S; Gonzalez Gay, MA; Goodall, AH; Hurtado-Nedelec, M; Kawasaki, A; Khoryati, L; Le Loët, X; Martin, J; Nicaise, P; Okada, Y; Padyukov, L; Plenge, R; Richez, C; Rodriguez-Rodriguez, L; Sacre, K; Schaeverbeke, T; Siminovitch, K; Sumida, T; Teruel, M; Tohma, S; Tsuchiya, N; Vittecoq, O; Xie, G; Zhang, J1
Andersson, IE; Burkhardt, H; Haag, S; Holmdahl, R; Mason, DE; Peters, EC; Schneider, N; Tuncel, J1
Pruijn, GJ; van Venrooij, WJ2
Cañete, JD; Celis, R; Gómez-Puerta, JA; Haro, I; Hernández, MV; Ramírez, J; Ruiz-Esquide, V; Sanmartí, R1
Balsa, A; Bossini-Castillo, L; Brouwer, E; Coenen, M; Crusius, JB; de Kovel, C; de Vries, N; Dijkmans, BA; Franke, B; Gómez-Vaquero, C; González-Álvaro, I; González-Gay, MÁ; Huizinga, T; Italiaander, A; Kallberg, H; Klareskog, L; Koeleman, BP; Lie, BA; Maehlen, MT; Martin, J; Merriman, M; Merriman, T; Ophoff, RA; Padyukov, L; Posthumus, MD; Rodriguez-Rodriguez, L; Stoeken-Rijsbergen, G; Tak, PP; Toes, R; van 't Slot, R; van der Helm-van Mil, AH; van der Horst-Bruinsma, Ie; van Riel, P; Vermeulen, S; Wijmenga, C; Wolbink, GJ1
Anuruckparadorn, K; Katchamart, W; Pattrapornpisut, P; Rojanasantikul, P1
Buckner, JH; Gebe, JA; James, EA; Klareskog, L; Malmström, V; Peda, M; Pieper, J; Rieck, M; Sandin, C; Tatum, M; Yue, BB1
Brink, M; Hansson, M; Klareskog, L; Rantapää Dahlqvist, S; Rönnelid, J1
de Souza, GA; Fleckenstein, B; Tutturen, AE1
Buckley, CD; Chapple, IL; de Pablo, P; Dietrich, T; Milward, M; Venables, PJ1
Boissinot, M; Burska, AN; Emery, P; Hunt, L; Nissim, A; Ponchel, F; Ryan, BJ; Strollo, R; Vital, E; Winyard, PG1
Catrina, AI; Eklund, A; Grunewald, J; Haj Hensvold, A; Jakobsson, PJ; Joshua, V; Klareskog, L; Malmström, V; Ossipova, E; Padyukov, L; Reynisdottir, G; Rönnelid, J; Rutishauser, D; Sköld, CM; Tarasova, NK; Ytterberg, AJ; Zubarev, RA1
Andrade, F; Bingham, CO; Konig, MF; Moni, M; Paracha, AS1
Coonrod, SA; Horibata, S; Slade, DJ; Thompson, PR1
Buser, A; Giaglis, S; Hahn, S; Hasler, P; Sur Chowdhury, C; Walker, UA1
Cardona-Muñoz, EG; Castro-Contreras, U; Celis, A; Corona-Sanchez, EG; Díaz-Toscano, ML; Fajardo-Robledo, NS; Gamez-Nava, JI; Gonzalez-Lopez, L; Nava, A; Olivas-Flores, EM; Ponce-Guarneros, M; Salazar-Paramo, M; Zavaleta-Muñiz, SA1
Bae, SC; Bang, SY; Brown, MA; de Bakker, PI; Han, B; Jiang, L; Kim, K; Lee, HS; Luo, M; Okada, Y; Ong, RT; Pillai, NE; Raychaudhuri, S; Saw, WY; Teo, YY; Xu, H; Yin, J1
Catrina, AI; Klareskog, L; Malmström, V; Reynisdottir, G; Ytterberg, AJ1
Bergum, B; Bielecka, E; Binder, V; Blom, AM; Brun, JG; Dahl-Knudsen, A; Enghild, JJ; Hellvard, A; Jonsson, R; Koro, C; Mydel, P; Potempa, J; Scavenius, C1
Bogdanos, DP; Katsiari, C; Platsoucas, CD; Sakkas, LI1
Lundberg, K; Mikuls, TR; Potempa, J; Quirke, AM; Venables, PJ1
Huizinga, TWJ1
Amital, H; Gertel, S1
Andrade, F; Bingham, CO; Konig, MF1
Arstila, L; Elfving, P; Häyrynen, J; Kaipiainen-Seppänen, O; Kärkkäinen, M; Kautiainen, H; Koivula, MK; Kononoff, A; Niinisalo, H; Risteli, J; Savolainen, E1
Agmon-Levin, N; Amital, H; Gilburd, B; Lidar, M; Shoenfeld, Y; Watad, A1
Chipping, J; Humphreys, JH; Marshall, T; Symmons, DP; van der Helm-van Mil, AH; van Nies, JA; Verstappen, SM1
Damgaard, D; Nielsen, CH; Nielsen, MF; Pruijn, GJ; Senolt, L1
Gómara, MJ; Haro, I1
Gudmann, NS; Hansen, NU; Jensen, AC; Karsdal, MA; Siebuhr, AS1
Åhlin, E; Elshafie, AI; Nur, MA; Rönnelid, J1
Hannonen, P; Koivula, MK; Risteli, J; Risteli, L; Turunen, S1
Deelder, AM; Hoeben, RC; Huizinga, TW; Janssen, GM; Kerkman, PF; Pruijn, GJ; Rispens, T; Rombouts, Y; Scherer, HU; Shi, J; Toes, RE; Trouw, LA; van Beers, JJ; van Toorn, L; van Veelen, PA; Willemze, A; Wolbink, G; Wuhrer, M; Zaldumbide, A1
Bracke, KR; Brusselle, GG; Correia, RE; Fischer, R; Kessler, BM; Lugli, EB; Lundberg, K; Montgomery, AB; Venables, PJ1
Hofseth, LJ; Thompson, PR; Witalison, EE1
Alpayci, M; Aydin, MN; Bayram, Y; Delen, V; Guducuoglu, H; Milanlioglu, A1
Fathaldin, OA; Safi, MA1
Catrina, AI; Klareskog, L1
Ahmed, U; Anwar, A; Costa, ML; Filer, A; Haigh, RC; Mackay, N; Rabbani, N; Raza, K; Savage, RS; Tarr, J; Thornalley, PJ; Watts, RA; Winyard, PG1
Bartold, PM; Bright, R; Proudman, SM; Rosenstein, ED1
Alcaro, C; Ancillotti, D; Casigliani-Rabl, S; Migliorini, P; Panza, F; Paolini, I; Petrelli, F; Pratesi, F; Puxeddu, I; Rovero, P1
Asai, K; Bessho, K; Fujii, T; Hashimoto, M; Ishii, T; Kawaguchi, T; Kosugi, S; Matsuda, F; Mimori, T; Nakayama, T; Ohmura, K; Sekine, A; Tabara, Y; Takahashi, K; Takahashi, M; Takei, N; Terao, C; Yamada, R; Yamaguchi, A; Yamazaki, T1
Berglin, E; Brink, M; Holmdahl, R; Klareskog, L; Rantapää-Dahlqvist, S; Rönnelid, J; Toes, RE; Trouw, LA; Verheul, MK1
Fearon, U; Trouw, LA; Veale, DJ; Verheul, MK1
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Abbas, F; Brouwer, E; Nesse, W; Nicholas, AP; van der Wal, JE; Vissink, A; Westra, J1
Abdullah, NA; Alfredsson, L; Bengtsson, C; Dhaliwal, JS; Klareskog, L; Larsson, PT; Muhamad, NA; Murad, S; Mustafa, AN; Padyukov, L; Too, CL; Yahya, A1
Cantagrel, A; Chollet-Martin, S; Cornillet, M; de Chaisemartin, L; Demattei, C; Dieudé, P; Dougados, M; Grootenboer-Mignot, S; Meyer, O; Nicaise-Roland, P; Nogueira, L; Rincheval, N; Serre, G1
Božič, B; El-Azzouny, M; Heck, AJ; Pruijn, GJ; Raijmakers, R; van Beers, JJ; Visser, NF1
Capini, C; Hyde, C; Lau, K; Law, SC; Nel, HJ; Pahau, H; Purcell, AW; Ramnoruth, S; Street, S; Thomas, R; van Gorp, E; Yu, CH1
Fleck, M; Pongratz, G1
Anderson, DR; Duryee, MJ; Dusad, A; Hunter, CD; Klassen, LW; Lacy, JP; Mikuls, TR; O'Dell, JR; Thiele, GM; Wang, D1
Alfredsson, L; Bengtsson, C; Holmdahl, R; Israelsson, L; Jiang, X; Kallberg, H; Kessel, C; Kharlamova, N; Klareskog, L; Lundberg, K; Padyukov, L; Pollak-Dorocic, I; Reed, E1
Diamandis, EP; Konforte, D; Lories, R; van Venrooij, WJ; Ward, MM1
Cambon-Thomsen, A; Constantin, A; Ruyssen-Witrand, A; Thomsen, M1
Soubrier, M; Tatar, Z; Vayssade, M1
Božič, B; Oosterink, E; Pruijn, GJ; Schwarte, CM; Stammen-Vogelzangs, J; van Beers, JJ1
Grauwen, K; Moelants, EA; Mortier, A; Proost, P; Ronsse, I; Van Damme, J1
Hansen, PR; Houen, G; Leth, ML; Trier, NH1
van Schaardenburg, D1
Bennin, DA; Huttenlocher, A; Mosher, DF; Shelef, MA1
Aviñó, A; Eritja, R; Gómara, MJ; Haro, I; Malakoutikhah, M1
Ding, Y; Fan, L; He, D; Liu, R; Ma, J; Wang, Q; Zhang, H; Zong, M1
Lequerré, T; Richez, C1
Cline, EN; Fox, DA; Haug, TS; Holoshitz, J; Ling, S1
Brentano, F; Filkova, M; Gabucio, A; Gay, RE; Gay, S; Herrero-Beaumont, G; Juengel, A; Klein, M; Maciejewska-Rodrigues, H; Michel, BA; Neidhart, M; Ospelt, C; Sanchez-Pernaute, O1
Chang, X; Chen, Y; Wang, Y; Yan, X; Zhao, Y1
Huizinga, TW; Toes, RE; Trouw, LA1
Aleksandrova, EN; Cherkasova, MV; Luchikhina, EL; Nasonov, EL; Novikov, AA; Popkova, TV; Rytikova, NS1
Baeten, D; Cantaert, T; Tak, PP; Teitsma, C1
Bay-Jensen, AC; Christiansen, C; Karsdal, MA; Lories, R; Maksymowych, WP; Marcher-Mikkelsen, K; Vassiliadis, E; Wichuk, S1
Canestri, S; Ferraccioli, G; Frezza, D; Gremese, E; Serone, E; Tolusso, B; Totaro, MC1
Brink, M; Hallmans, G; Hansson, M; Holmdahl, R; Jakobsson, PJ; Klareskog, L; Mathsson, L; Rantapää-Dahlqvist, S; Rönnelid, J; Stenlund, H1
Cordova, KN; Haskins, K; Holers, VM; Willis, VC1
Alvarellos, A; Alvarez, AC; Caeiro, F; Cuiza, PE; Encinas, LM; Haye Salinas, MJ; Menescardi, MS; Miretti, EM; Peano, N; Retamozo, S; Saurit, V; Vetorazzi, L1
Brouwer, E; de Smit, MJ; Janssen, KM; Vissink, A; Westra, J1
Bhatti, A; John, P; Moeez, S1
Deane, KD; Nicolls, MR1
Ascherman, DP; Dellaripa, PF; Gochuico, BR; Harlow, L; Mikuls, TR; Oddis, CV; Rosas, IO1
Conrad, K; De Keyser, F; Humbel, RL; Meheus, L; Moereels, H; Pottel, H; Serre, G; Steiner, G; Union, A1
El-Gabalawy, HS; Hitchon, CA1
Cedergren, J; Forslund, T; Skogh, T; Sundqvist, T1
de Koning, MH; Dijkmans, BA; Jansen, AL; van de Stadt, RJ; van der Horst-Bruinsma, I; van Schaardenburg, D1
Smeets, TJ; Tak, PP; van Venrooij, WJ; Vossenaar, ER1
Brickman, CM; Gerli, R; Gilburd, B; Orbach, H; Shoenfeld, Y1
Cantagrel, A; Combe, B; Dougados, M; Dubois, A; Goupille, P; Labarre, C; Meyer, O; Nicaise-Roland, P; Sibilia, J1
Aho, K; Palosuo, T; Strandberg, T; Tilvis, R1
Hazes, JM; Visser, H1
van de Putte, LB; van den Hoogen, FH; van Venrooij, WJ1
van de Putte, LB; van Venrooij, WJ1
Orbach, H; Shoenfeld, Y1
Bas, S; Gabay, C; Genevay, S; Meyer, O1
Jansen, TL1
Dadoniene, J; Kirdaite, G; Redaitiene, E; Stropuviene, S1
Chang, X; Furukawa, H; Iida, A; Kawaida, R; Matsubara, T; Nagasaki, M; Nakamura, Y; Nakayama-Hamada, M; Nishioka, Y; Ohtsuki, M; Ono, M; Sawada, T; Sekine, A; Suzuki, A; Suzuki, M; Takahashi, A; Teshima, R; Tohma, S; Tokuhiro, S; Tsunoda, T; Wakitani, S; Yamada, R; Yamamoto, K; Yoshino, S; Yukioka, M1
Bell, DA; Cairns, E; Hill, JA; Jevnikar, AM; Sette, A; Southwood, S1
Ai, M; Gan, X; Shi, Y; Song, Q; Tang, F; Tian, X; Zeng, X1
Wollheim, FA1
Aparecida da Silva, M; Maciel, S; Pinheiro, GC; Scheinberg, MA1
González-Rojas, J; Izui, S; López-Hoyos, M; Marquina, R; Merino, J; Merino, R; Tamayo, E1
de Koning, MH; Dijkmans, BA; Jansen, LM; van der Horst-Bruinsma, I; van der Stadt, RJ; van Schaardenburg, D1
Pruijn, GJ; Raats, JM; van den Hoogen, FH; van Venrooij, WJ; Wijnen, EM1
Lee, DM; Schur, PH1
Helsen, MM; Joosten, LA; Nijenhuis, S; Senshu, T; van den Berg, WB; van der Heijden, A; van Venrooij, WJ; Vossenaar, ER1
Berglin, E; de Jong, BA; Hallmans, G; Rantapää-Dahlqvist, S; Stenlund, H; Sundin, U; van Venrooij, WJ; Wadell, G1
Chang, X; Suzuki, A; Yamada, R; Yamamoto, K2
Matsui, T; Mimori, T; Murakami, A; Nakazono, K; Sawada, T; Suzuki, K; Takasaki, Y; Takemura, M; Tohma, S; Yamamoto, K1
López-Hoyos, M; Ruiz-Alegría, C1
Daragon, A; Fardellone, P; Gayet, A; Gervasi, G; Incaurgarat, B; Jolivet, M; Jouen-Beades, F; le Loët, X; Legoedec, J; Letourneur, O; Ménard, JF; Rolland, D; Tron, F; Vittecoq, O1
Dziemianko, I; Szechiński, J; Szmyrka-Kaczmarek, M1
Baron, D; Bendaoud, B; Berthelot, JM; Chalès, G; Devauchelle, V; Hoang, S; Jousse, S; Le Goff, P; Le Henaff, C; Saraux, A; Thorel, JB; Youinou, P1
Altindiş, M1
Meyer, O1
de Koning, MH; Dijkmans, BA; Habibuw, MR; Nielen, MM; Reesink, HW; van de Stadt, RJ; van der Horst-Bruinsma, IE; van Schaardenburg, D; Vandenbroucke, JP1
Blanco, R; Crespo, J; Lopez-Hoyos, M; Martinez-Taboada, VM; Peña, M; Rodriguez-Valverde, V; Ruiz de Alegria, C1
Genovese, MC; Robinson, WH; Utz, PJ1
Barrera, P; de Rooij, DJ; Dieteren, C; Radstake, TR; van der Heijden, A; van Mansum, MA; van Venrooij, WJ; Vossenaar, ER; Zendman, AJ1
Dubucquoi, S; Dutoit, V; Fauchais, AL; Flipo, RM; Goetz, J; Hachulla, E; Lefranc, D; Marguerie, L; Prin, L; Sibilia, J; Solau-Gervais, E1
Breedveld, FC; de Jong, BA; Huizinga, TW; Linn-Rasker, SP; Toes, RE; van Gaalen, FA; van Venrooij, WJ; Verweij, CL1
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Carson, DA; Silverman, GJ1
O'Dell, JR1
Joosten, LA; López-Hoyoz, M; Merino, J; Merino, R; van Boekel, MA; van Venrooij, WJ; Vossenaar, ER1
Bell, DA; Cairns, E; Hill, J1
van Venrooij, WJ; Vossenaar, ER; Zendman, AJ2
Alessandri, C; Bombardieri, M; Cinquini, M; Magrini, L; Papa, N; Tincani, A; Valesini, G1
De Clercq, L; De Keyser, F; Hoffman, IE; Hulstaert, F; Lebeer, K; Meheus, L; Mielants, H; Peene, I; Poriau, S; Pottel, H; Schatteman, L; Union, A; Veys, EM1
Chang, X; Sawada, T; Suzuki, A; Tokuhiro, S; Yamada, R; Yamamoto, K; Yoshino, S1
Wong, ML1
Chapman, P; Moller, P; O'Donnell, J; Solanki, K; Spellerberg, M1
Alfredsson, L; Berglin, E; Klareskog, L; Padyukov, L; Rantapää-Dahlqvist, S; Stolt, P1
Kraan, MC; Raats, JM; Smeets, TJ; Tak, PP; van Venrooij, WJ; Vossenaar, ER1
Nijenhuis, S; Pruijn, GJ; vanVenrooij, WJ; Vossenaar, ER; Zendman, AJ1
Boullart, L; De Keyser, F; De Rycke, L; Hoffman, IE; Kruithof, E; Lebeer, K; Meheus, L; Mielants, H; Peene, I; Serre, G; Union, A; Veys, EM; Vincent, C; Wyns, B1
Chang, X; Kochi, Y; Sawada, T; Suzuki, A; Yamada, R; Yamamoto, K2
Auger, I; Chapuy-Regaud, S; Clavel, C; Cornélis, F; Nogueira, L; Petit-Texeira, E; Roudier, J; Sebbag, M; Serre, G; Vincent, C1
Arend, WP; Holers, VM; Mikuls, TR; Norris, JM; O'Dell, JR; Parrish, LA; Stoner, JA1
Kamoun, M1
Furukawa, H; Kasuya, A; Kawaida, R; Kubota, K; Nakayama-Hamada, M; Ohsaka, M; Ono, M; Suzuki, A; Takazawa, T; Yamada, R; Yamamoto, K1
Klareskog, L; Rönnelid, J; Skogh, T; Svensson, B1
Aarden, L; Dijkmans, BA; Hamann, D; Nielen, MM; van de Stadt, RJ; van der Horst, AR; van der Horst-Bruinsma, IE; van Schaardenburg, D1
Dubrous, P; Gardet, V; Hugard, L1
Aleksandrova, EN; Brodetskaia, KA; Chemeris, NA; Karateev, DE; Nasonov, EL; Novikov, AA1
Chapuy-Regaud, S; Clavel, C; Nogueira, L; Sebbag, M; Serre, G; Vincent, C1
Baeten, D; Boots, AM; De Keyser, F; De Rycke, L; Kruithof, E; Mielants, H; Veys, EM1
Yamada, R2
Baeten, D; Chapuy-Regaud, S; Clavel, C; De Keyser, F; Foulquier, C; Sebbag, M; Serre, G1
Bijlsma, JW; Jacobs, JW; Kruize, AA1
Bambery, P; Govindrajan, S; Khullar, M; Reddy, SV; Wanchu, A1
Bockermann, R; Burkhardt, H; Engström, A; Holmdahl, R; Kalden, JR; Sehnert, B1
Anaya, JM; Correa, PA; Tobón, GJ1
Coupillaud, C; Meffre, E; Ng, YS; Paget, D; Samuels, J1
Harris, HE; Klareskog, L; Lundberg, K; Nijenhuis, S; Palmblad, K; van Venrooij, WJ; Vossenaar, ER; Zendman, AJ1
Ohtake-Yamanaka, M; Okazaki, Y; Sawada, T; Suzuki, A; Yamada, R; Yamamoto, K1
Balsa, A; de la Concha, EG; Fernández-Arquero, M; Fernández-Gutiérrez, B; Lamas, JR; Martinez, A; Pascual-Salcedo, D; Urcelay, E; Valdivia, A1
Anzilotti, C; Bombardieri, S; Chimenti, D; Merlini, G; Migliorini, P; Tommasi, C1
Greiner, A; Gruber, R; Kellner, H; Plischke, H1
Becker, H; Domschke, W; Gaubitz, M; Sauerland, U; Schlüter, B; Schorat, A; Schotte, H; Seidel, M; Willeke, P1
Abreu, I; Bastos, A; Branco, J; Cruz, M; Fonseca, JE; Issert, V; Laroche, P; Machado Caetano, JA; Nero, P1
Barbieri, L; Drosera, M; Parodi, A; Rebora, A; Seriolo, B1
Baeten, D; Cantaert, T; De Keyser, F; De Rycke, L; Echols, JD; Kruithof, E; Nicholas, AP; Vandekerckhove, B; Veys, EM1
Cantaert, T; De Keyser, F; De Rycke, L; Hoffman, IE; Peene, I; Vander Cruyssen, B; Veys, EM1
Robinson, WH; Vossenaar, ER1
Akbas, H; Arman, M; Donmez, L; Gultekin, M; Mutlu, D; Ozdem, S; Samanci, N1
Breedveld, FC; Huizinga, TW; Toes, RE; van der Helm-van Mil, AH; Verpoort, KN1
Huizinga, TW; Ioan-Facsinay, A; Toes, RE; van Gaalen, F1
Ishigami, A; Maruyama, N1
Alfredsson, L; Bengtsson, C; Källberg, H; Klareskog, L; Lundberg, I; Padyukov, L; Sverdrup, B1
Donatien, P; Kinloch, A; Lundberg, K; Moyes, D; Peston, D; Tatzer, V; Taylor, PC; Venables, PJ; Wait, R1
Alfredsson, L; Bengtsson, C; Eklund, A; Grunewald, J; Harris, HE; Källberg, H; Klareskog, L; Lundberg, K; Padyukov, L; Rantapää-Dahlqvist, S; Rönnelid, J; Stolt, P; Ulfgren, AK1
Gorman, JD1
Baek, HJ; Choi, KH; Jeon, JH; Kang, SW; Kim, CW; Kim, HA; Kim, IG; Lee, EB; Lee, YJ; Shin, DM; Shin, KC; Son, YW; Yoo, CD1
Hasebe, T; Inoue, T; Ohtake-Yamanaka, M; Okazaki, Y; Sawada, T; Suzuki, A; Yamada, R; Yamamoto, K1
Inoue, T; Ohsaka, M; Sawada, T; Suzuki, A; Takizawa, Y; Yamada, R; Yamamoto, K1
Manger, B; Schulze-Koops, H1
Arlestig, L; Hallmans, G; Johansson, M; Rantapää-Dahlqvist, S1
Anzilotti, C; Chimenti, D; Migliorini, P; Pratesi, F; Tommasi, C1
Fleckenstein, B; Holm, A; Rise, F; Sessler, N; Sollid, LM; Undheim, K1
af Klint, E; Catrina, AI; Klareskog, L; Löfberg, R; Lundberg, IE; Makrygiannakis, D; Ulfgren, AK1
Goronzy, JJ; Weyand, CM1
Matsui, T1
de Vries, RR; Huizinga, TW; Toes, RE1
Boman, K; Hallmans, G; Rantapää-Dahlqvist, S; Tarkowski, A1
Atkins, SR; Baeten, D; Bongartz, T; Cantaert, T; Harle, P; Matteson, EL; Myers, JL; Ryu, JH; Turesson, C1
Arnaud, J; Auger, I; Clavel, C; Moinard, N; Nogueira, L; Roudier, J; Sebbag, M; Serre, G1
Cantaert, T; Clavel, C; De Keyser, F; De Rycke, L; Deforce, D; Dendoven, A; Elewaut, D; Nogueira, L; Sebag, M; Serre, G; Vander Cruyssen, B; Vincent, C1
Dejaco, C; Duftner, C; Herold, M; Klotz, W; Larcher, H; Schirmer, M1
Harauz, G; Musse, AA1
Drijfhout, JW; Fries, JF; Genovese, MC; Hueber, W; Kidd, BA; Metzger, AL; Robinson, WH; Tomooka, BH; van Venrooij, WJ; Zhao, X1
Al-Bishri, J; Bell, DA; Cairns, E; Gladman, DD; Hill, JA1
Miller, FW1
Alarcón, GS; Bridges, SL; Callahan, LF; Conn, DL; Gilkeson, G; Holers, VM; Howard, G; Jonas, BL; Kamen, DL; Kuhn, KA; Mikuls, TR; Moreland, LW; Parrish, L; Smith, EA1
Bakker-Jonges, LE; Bianchi, FB; Cheung, K; Dall'Aglio, AC; Drenth, JP; Fusconi, M; Pruijn, GJ; Stammen-Vogelzangs, J; van Venrooij, WJ; Vannini, A; Zendman, AJ1
Arita, K; Bhatia, M; Knuckley, B; Lee, YH; Luo, Y; Sato, M; Stallcup, MR; Thompson, PR1
Ito, Y; Kurosaka, D; Nishizawa, T; Tsuji, M; Yamada, A; Yasuda, J; Yoshida, M1
Baeten, D; Bongartz, T; Cantaert, T; De Rycke, L; Matteson, EL; Nicholas, AP; Tak, PP1
Burmester, GR; Feist, E2
Alonso, A; Ercilla, G; Gómara, MJ; Haro, I; Kasi, D; Pérez, ML; Sanmartí, R; Viñas, O1
Pruijn, GJ; van Venrooij, WJ; Zendman, AJ1
Kato, T; Masuko, K; Matsuo, K; Nakamura, H; Nishioka, K; Noyori, K; Saito, T; Xiang, Y; Yudoh, K1
Bi, LQ; Li, ZG; Tian, X1
Bossuyt, X; Coenen, D; Verschueren, P; Westhovens, R1
Tłustochowicz, W1
Boumpas, DT; Katsouraki, M; Raptopoulou, A; Sidiropoulos, P1
Ercilla, G; Gómara, MJ; Haro, I; Pérez, ML; Sanmartí, R1
Bizzaro, N; Tonutti, E; Tozzoli, R; Villalta, D1
Li, Z; Tian, X; Zhao, Y1
Bang, H; Berg, W; Burmester, GR; Egerer, K; Feist, E; Fredenhagen, G; Gauliard, A; Lüthke, K; Rudolph, PE1
Chirivi, RG; Drijfhout, JW; Nijenhuis, S; Pruijn, GJ; Raats, JM; Raijmakers, R; Tillaart, Mv; van Venrooij, WJ; Vossenaar, ER; Zendman, AJ1
Suzuki, A; Yamada, R; Yamamoto, K1
Bajema, IM; Diepenhorst, GM; Huizinga, TW; Jol-van der Zijde, EC; Teng, YK; Toes, RE; van Laar, JM; van Tol, MJ; Verburg, RJ; Verpoort, KN1
Al Badine, R; Chapuy-Regaud, S; Clavel, C; Foulquier, C; Guerrin, M; Méchin, MC; Nachat, R; Sebbag, M; Serre, G; Simon, M; Takahara, H; Vincent, C; Yamada, M1
Bugatti, S; Caporali, R; Codullo, V; Montecucco, C1
Allaart, CF; Breedveld, FC; Cheung, K; de Vries, RR; de Vries-Bouwstra, JK; Drijfhout, JW; Huizinga, TW; Ioan-Facsinay, A; Pruijn, GJ; Toes, RE; van der Helm-van Mil, AH; Verpoort, KN1
Klareskog, L; Mathsson, L; Mullazehi, M; Rönnelid, J; Sjöberg, O; van Vollenhoven, R; Wick, MC1
Alfredsson, L; Klareskog, L; Lundberg, K; Padyukov, L; Rönnelid, J1
Bayer, PM; Garczarek, U; Grunert, VP; Hasler, F; Karl, J; Krause, F; Mattey, DL; Schmitt, RI; Sharif, M; Thun, M; van Riel, PL; Wild, N; Zolg, W1
Bijlsma, JW; Jacobs, JW1
Boer, AK; van de Laar, MA; van der Lugt, CP; van der Sluijs Veer, G; Weekamp, HH1
Cantaert, T; De Keyser, F; Deforce, D; Elewaut, D; Tilleman, K; Van Steendam, K1
Baysal, O; Dizer, U; Inal, A; Keskin, D; Keskin, G; Pekel, A; Sengül, A1
Huizinga, TW; van der Helm-van Mil, AH1
Agnihotri, N; Deodhar, SD; Ganguly, NK; Wanchu, A1
Arnaud, M; Dalbon, P; Durieux, JJ; Girbal-Neuhauser, E; Jolivet, M; Jolivet-Reynaud, C; Masson-Bessière, C; Sebbag, M; Senshu, T; Serre, G; Simon, M; Vincent, C1
Breedveld, FC; de Jong, BA; Hazes, JM; Schellekens, GA; van den Hoogen, FH; van Venrooij, WJ; Visser, H1
de Jong, BA; Kroot, EJ; Swinkels, H; van de Putte, LB; van den Hoogen, FH; van Leeuwen, MA; van Riel, PL; van Rijswijk, MH; van Venrooij, WJ; van't Hof, M1
Berthelot, JM; Saraux, A1
El-Gabalawy, HS; Goldbach-Mansky, R; Hoxworth, J; Klippel, JH; Lee, J; McCoy, A; Ménard, HA; Palosuo, T; Rosen, A; Schumacher, HR; Smolen, JS; Steiner, G; Van Venrooij , WJ; Wilder, RL; Yarboro, C; Zhang, C; Zhou, ZJ1
Pruijn, GJ; van Venrooij , WJ1
Isenberg, DA; Mediwake, R; Schellekens, GA; van Venrooij, WJ1
Breedveld, FC; de Jong, BA; Reparon-Schuijt, CC; Schellekens, GA; van Esch, WJ; van Kooten, C; van Venrooij, WJ; Verweij, CL1
Bizzaro, N; Mazzanti, G; Tonutti, E; Tozzoli, R; Villalta, D1
Baeten, D; De Keyser, F; Meheus, L; Peene, I; Sebbag, M; Serre, G; Union, A; Veys, EM1
van Boekel, MA; van den Hoogen, FH; van Venrooij, WJ; Vossenaar, ER1
Boomsma, MM; Damoiseaux, J; Stegeman, CA; Tervaert, JW1
Ménard, HA; Zhou, Z1
Bas, S; Guerne, PA; Perneger, TV; Roux-Lombard, P; Seitz, M; Tiercy, JM1

Reviews

116 review(s) available for citrulline and Arthritis, Rheumatoid

ArticleYear
Peptidylarginine deiminase-4: Medico-formulative strategy towards management of rheumatoid arthritis.
    Biochemical pharmacology, 2022, Volume: 200

    Topics: Arthritis, Rheumatoid; Citrulline; Humans; Protein-Arginine Deiminase Type 4

2022
Microbial pathways to subvert host immunity generate citrullinated neoantigens targeted in rheumatoid arthritis.
    Current opinion in structural biology, 2022, Volume: 75

    Topics: Arthritis, Rheumatoid; Autoimmunity; Citrullination; Citrulline; Humans; Protein Processing, Post-Translational

2022
Protein citrullination: inhibition, identification and insertion.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023, 11-20, Volume: 378, Issue:1890

    Topics: Arthritis, Rheumatoid; Citrullination; Citrulline; Epigenesis, Genetic; Humans; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Proteins

2023
Citrulline is not a major determinant of autoantibody reactivity to neutrophil extracellular traps.
    Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2023, 11-20, Volume: 378, Issue:1890

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Extracellular Traps; Humans; Neutrophils

2023
Insights into the study and origin of the citrullinome in rheumatoid arthritis.
    Immunological reviews, 2020, Volume: 294, Issue:1

    Topics: Animals; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrullination; Citrulline; Extracellular Traps; Female; Humans; Protein-Arginine Deiminases

2020
Anti-Citrullinated Protein Antibodies in Patients with Rheumatoid Arthritis: Biological Effects and Mechanisms of Immunopathogenesis.
    International journal of molecular sciences, 2020, Jun-04, Volume: 21, Issue:11

    Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; Biomarkers; Citrulline; Disease Management; Disease Susceptibility; Humans; Molecular Targeted Therapy

2020
Elucidating Citrullination by Mass Spectrometry and Its Role in Disease Pathogenesis.
    Journal of proteome research, 2021, 01-01, Volume: 20, Issue:1

    Topics: Arthritis, Rheumatoid; Citrullination; Citrulline; Humans; Mass Spectrometry; Protein Processing, Post-Translational; Protein-Arginine Deiminases

2021
Redox-Mediated Carbamylation As a Hapten Model Applied to the Origin of Antibodies to Modified Proteins in Rheumatoid Arthritis.
    Antioxidants & redox signaling, 2022, Volume: 36, Issue:7-9

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Haptens; Humans; Oxidation-Reduction; Protein Carbamylation

2022
HLA class II and rheumatoid arthritis: the bumpy road of revelation.
    Immunogenetics, 2017, Volume: 69, Issue:8-9

    Topics: Alleles; Animals; Antigen-Presenting Cells; Arthritis, Rheumatoid; Citrulline; Epitopes; HLA-DR Antigens; Humans; Mice

2017
The case for periodontitis in the pathogenesis of rheumatoid arthritis.
    Nature reviews. Rheumatology, 2017, Volume: 13, Issue:10

    Topics: Arthritis, Rheumatoid; Bacterial Proteins; Citrulline; Epitopes; Female; Humans; Hydrolases; Male; Periodontitis; Porphyromonas gingivalis; Protein Processing, Post-Translational; Protein-Arginine Deiminases

2017
Rheumatoid arthritis and citrullination.
    Current opinion in rheumatology, 2018, Volume: 30, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Calcium; Cell Death; Citrullination; Citrulline; Complement Membrane Attack Complex; Humans; Neutrophils; Perforin; Protein-Arginine Deiminases; Proteins; Synovial Fluid

2018
[The pathogenic role of ACPA in rheumatoid arthritis].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2017, Volume: 40, Issue:6

    Topics: Anti-Citrullinated Protein Antibodies; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cartilage; Citrulline; HLA-DR Antigens; Humans; Inflammation Mediators; Osteogenesis; Periodontal Diseases; Protein-Arginine Deiminases; Smoking; Synovial Membrane; Tumor Necrosis Factor-alpha

2017
The B cell response to citrullinated antigens in the development of rheumatoid arthritis.
    Nature reviews. Rheumatology, 2018, Volume: 14, Issue:3

    Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; B-Lymphocytes; Citrulline; Early Diagnosis; Glycosylation; HLA Antigens; Humans

2018
Peptidylarginine deiminases and deiminated proteins at the epidermal barrier.
    Experimental dermatology, 2018, Volume: 27, Issue:8

    Topics: Animals; Arginine; Arthritis, Rheumatoid; Calcium; Citrulline; Epidermal Cells; Epidermis; Filaggrin Proteins; Gene Expression Profiling; Gene Expression Regulation; Humans; Hydrolases; Inflammation; Mice; Neoplasms; Neurodegenerative Diseases; Protein Processing, Post-Translational; Protein-Arginine Deiminases

2018
Periodontal sources of citrullinated antigens and TLR agonists related to RA.
    Autoimmunity, 2018, Volume: 51, Issue:6

    Topics: Aggregatibacter actinomycetemcomitans; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantigens; Bacterial Proteins; Citrullination; Citrulline; DNA, Bacterial; Endotoxemia; Extracellular Traps; Hemolysin Proteins; Humans; Neutrophils; Periodontitis; Periodontium; Porphyromonas gingivalis; Protein-Arginine Deiminases; Toll-Like Receptor 4; Toll-Like Receptor 9

2018
Periodontal disease and rheumatoid arthritis: the evidence accumulates for complex pathobiologic interactions.
    Current opinion in rheumatology, 2013, Volume: 25, Issue:3

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Bacteroidaceae Infections; Citrulline; Disease Models, Animal; Evidence-Based Medicine; Humans; Periodontal Diseases; Porphyromonas gingivalis

2013
Periodontal disease and rheumatoid arthritis: a systematic review.
    Journal of dental research, 2013, Volume: 92, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; C-Reactive Protein; Citrulline; Cross Reactions; Evidence-Based Medicine; Female; Humans; Interleukin-1beta; Male; Middle Aged; Periodontal Diseases

2013
ACPA and bone loss in rheumatoid arthritis.
    Current rheumatology reports, 2013, Volume: 15, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Bone and Bones; Citrulline; Humans; Peptides, Cyclic

2013
HLA shared epitope and ACPA: just a marker or an active player?
    Autoimmunity reviews, 2013, Volume: 12, Issue:12

    Topics: Animals; Antibodies, Anti-Idiotypic; Antigen Presentation; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Proteins

2013
Neutralization of anticitrullinated protein antibodies in rheumatoid arthritis - a way to go?
    Basic & clinical pharmacology & toxicology, 2014, Volume: 114, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Fibrinogen; Filaggrin Proteins; Gene-Environment Interaction; Humans; Rheumatoid Factor

2014
The case for measuring antibodies to specific citrullinated antigens.
    Expert review of clinical immunology, 2013, Volume: 9, Issue:12

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Biomarkers, Pharmacological; Citrulline; Cross Reactions; Epitopes; Filaggrin Proteins; Humans; Prognosis; Sensitivity and Specificity; Serology

2013
Adaptive immunity in rheumatoid arthritis: anticitrulline and other antibodies in the pathogenesis of rheumatoid arthritis.
    Current opinion in rheumatology, 2014, Volume: 26, Issue:1

    Topics: Adaptive Immunity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross Reactions; Humans; Peptides, Cyclic

2014
Arthritis and bone loss: a hen and egg story.
    Current opinion in rheumatology, 2014, Volume: 26, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Bone Resorption; Citrulline; Humans; Osteoporosis; Peptides, Cyclic; Synovitis

2014
The link between periodontal disease and rheumatoid arthritis: an updated review.
    Current rheumatology reports, 2014, Volume: 16, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Bacteroidaceae Infections; Citrulline; Humans; Hydrolases; Immune Evasion; Periodontitis; Porphyromonas gingivalis; Protein-Arginine Deiminases

2014
A genome-wide association study of rheumatoid arthritis without antibodies against citrullinated peptides.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:3

    Topics: Alleles; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Genome-Wide Association Study; HLA Antigens; HLA-B Antigens; HLA-DRB1 Chains; Humans; Logistic Models; Peptides; Polymorphism, Single Nucleotide; Principal Component Analysis; White People

2015
Autoantibodies to posttranslational modifications in rheumatoid arthritis.
    Mediators of inflammation, 2014, Volume: 2014

    Topics: Animals; Antigens; Antioxidants; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Biomarkers; Citrulline; Humans; Inflammation; Oxygen; Protein Processing, Post-Translational; Reactive Oxygen Species

2014
Lungs, joints and immunity against citrullinated proteins in rheumatoid arthritis.
    Nature reviews. Rheumatology, 2014, Volume: 10, Issue:11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Inflammation; Irritants; Joints; Lung; Peptides, Cyclic; Smoking

2014
Anti-citrullinated peptides as autoantigens in rheumatoid arthritis-relevance to treatment.
    Autoimmunity reviews, 2014, Volume: 13, Issue:11

    Topics: Animals; Arthritis, Rheumatoid; Autoantigens; B-Lymphocytes; Citrulline; Humans; Peptides

2014
Personalized medicine in rheumatoid arthritis: is the glass half full or half empty?
    Journal of internal medicine, 2015, Volume: 277, Issue:2

    Topics: Algorithms; Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B7-1 Antigen; B7-2 Antigen; Citrulline; Evidence-Based Medicine; Humans; Infliximab; Interleukin-6; Precision Medicine; Risk Factors; Rituximab; Treatment Outcome; Tumor Necrosis Factor-alpha

2015
Putative approaches to bypass the citrulline-specific autoimmune response in rheumatoid arthritis.
    The Israel Medical Association journal : IMAJ, 2014, Volume: 16, Issue:9

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Inflammation; Molecular Targeted Therapy; Sensitivity and Specificity; Synovial Membrane

2014
Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options.
    Autoimmunity, 2015, Volume: 48, Issue:2

    Topics: Arginine; Arthritis, Rheumatoid; Autoantibodies; Benzamidines; Biomarkers; Citrulline; Enzyme Inhibitors; Fibrosis; Humans; Hydrolases; Isoenzymes; Multiple Sclerosis; Neoplasms; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Spondylitis, Ankylosing

2015
Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation.
    Current drug targets, 2015, Volume: 16, Issue:7

    Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Citrulline; Humans; Hydrolases; Ornithine; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Psoriasis

2015
Fingerprinting of anti-citrullinated protein antibodies (ACPA): specificity, isotypes and subclasses.
    Lupus, 2015, Volume: 24, Issue:4-5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Complement Activation; Humans; Hydrolases; Immunoglobulin G; Protein-Arginine Deiminases; Receptors, Fc

2015
Biomarkers for rheumatoid and psoriatic arthritis.
    Clinical immunology (Orlando, Fla.), 2015, Volume: 161, Issue:1

    Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Early Diagnosis; Humans; Prognosis; Rheumatoid Factor; Sensitivity and Specificity

2015
Mechanisms involved in triggering rheumatoid arthritis.
    Immunological reviews, 2016, Volume: 269, Issue:1

    Topics: Adaptive Immunity; Animals; Arthritis, Rheumatoid; Autoantigens; Citrulline; Disease Progression; Genetic Predisposition to Disease; Humans; Immunity, Innate; Protein Processing, Post-Translational

2016
Is rheumatoid arthritis an autoimmune disease?
    Current opinion in rheumatology, 2016, Volume: 28, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Humans; Immune Tolerance; Polymorphism, Single Nucleotide; T-Lymphocyte Subsets

2016
Smoking and Air Pollution as Pro-Inflammatory Triggers for the Development of Rheumatoid Arthritis.
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2016, Volume: 18, Issue:7

    Topics: Air Pollution; Arthritis, Rheumatoid; Citrulline; Female; Genetic Predisposition to Disease; Humans; Hydrolases; Lung; Middle Aged; Models, Biological; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Smoking

2016
A new strategy for the early diagnosis of rheumatoid arthritis: a combined approach.
    Autoimmunity reviews, 2009, Volume: 8, Issue:3

    Topics: Arthritis, Rheumatoid; Biomarkers; Citrulline; Disease Progression; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Humans; Peptides; Predictive Value of Tests; Prospective Studies; Rheumatoid Factor; Sensitivity and Specificity; Severity of Illness Index

2009
[New autoanti-bodies in rheumatoid arthritis: anti-citrullinated protein or peptide autoanti-bodies and the others].
    Presse medicale (Paris, France : 1983), 2008, Volume: 37, Issue:12

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Genomics; Humans; Peptides; Proteomics; Sensitivity and Specificity

2008
Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review.
    Annals of the rheumatic diseases, 2010, Volume: 69, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Humans; Peptides, Cyclic; Prognosis; Rheumatoid Factor; Vimentin

2010
Anti-citrullinated protein/peptide autoantibodies in association with genetic and environmental factors as indicators of disease outcome in rheumatoid arthritis.
    Autoimmunity reviews, 2010, Volume: 9, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Genetic Testing; Humans; Peptides; Prognosis

2010
Diagnostic and prognostic usefulness of antibodies to citrullinated peptides.
    Joint bone spine, 2009, Volume: 76, Issue:4

    Topics: Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Humans; Peptides; Prognosis

2009
Peptidylarginine deiminase 4 and citrullination in health and disease.
    Autoimmunity reviews, 2010, Volume: 9, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; Gene Expression Regulation; Genetic Predisposition to Disease; Humans; Hydrolases; Multiple Sclerosis; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2010
The use of post-translationally modified peptides for detection of biomarkers of immune-mediated diseases.
    Journal of peptide science : an official publication of the European Peptide Society, 2009, Volume: 15, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Autoimmunity; Biomarkers; Citrulline; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Lupus Erythematosus, Systemic; Multiple Sclerosis; Myelin Proteins; Myelin-Associated Glycoprotein; Myelin-Oligodendrocyte Glycoprotein; Peptide Library; Peptides; Protein Processing, Post-Translational

2009
[The vicious circle that leads to rheumatoid arthritis; experimental evidence of the steps involved in this circle].
    Nederlands tijdschrift voor geneeskunde, 2009, Volume: 153

    Topics: Apoptosis; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic

2009
Autoantibodies in rheumatoid arthritis: rheumatoid factors and anticitrullinated protein antibodies.
    QJM : monthly journal of the Association of Physicians, 2010, Volume: 103, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Rheumatoid Factor

2010
[Is rheumatoid arthritis without anti-citrullinated peptide antibody a genetically distinct subset?].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2009, Volume: 32, Issue:6

    Topics: Alleles; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Peptides; Risk Factors

2009
Antibodies to citrullinated proteins: molecular interactions and arthritogenicity.
    Immunological reviews, 2010, Volume: 233, Issue:1

    Topics: Animals; Antibody Specificity; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Collagen Type II; Disease Progression; Extracellular Matrix Proteins; Humans; Inflammation Mediators; Protein Conformation; Protein Processing, Post-Translational

2010
Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis.
    Immunological reviews, 2010, Volume: 233, Issue:1

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Collagen Type II; Epitopes; Extracellular Matrix Proteins; Fibrinogen; Genetic Predisposition to Disease; Humans; Periodontitis; Phosphopyruvate Hydratase; Porphyromonas gingivalis; Protein Conformation; Protein Processing, Post-Translational; Risk Factors; Smoking; Vimentin

2010
Role of HLA class II genes in susceptibility/resistance to inflammatory arthritis: studies with humanized mice.
    Immunological reviews, 2010, Volume: 233, Issue:1

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Collagen; Epitopes; Female; Genetic Predisposition to Disease; HLA-DQ Antigens; HLA-DR Antigens; Humans; Male; Mice; Mice, Transgenic; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Sex Factors; T-Lymphocytes

2010
The use of citrullinated peptides and proteins for the diagnosis of rheumatoid arthritis.
    Arthritis research & therapy, 2010, Volume: 12, Issue:1

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Humans; Immunoassay; Peptides; Proteins; Sensitivity and Specificity

2010
Genetic background of tolerance breakdown in rheumatoid arthritis.
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2010, Volume: 33, Issue:2

    Topics: Animals; Arginine; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Hydrolases; Immune Tolerance; Lymphocytes; Mice; Multifactorial Inheritance; Peptides; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Receptors, Immunologic

2010
[Anti-cyclic citrullinated peptide antibodies and rheumatoid arthritis].
    Rinsho byori. The Japanese journal of clinical pathology, 2010, Volume: 58, Issue:5

    Topics: Animals; Arginine; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Early Diagnosis; Humans; Hydrolases; Peptides, Cyclic; Prognosis; Protein-Arginine Deiminases; Reference Standards; Rheumatoid Factor; Sensitivity and Specificity

2010
All you wanted to know about anti-CCP but were afraid to ask.
    Autoimmunity reviews, 2010, Volume: 10, Issue:2

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Peptides, Cyclic; Rats; Sensitivity and Specificity

2010
Periodontitis in RA-the citrullinated enolase connection.
    Nature reviews. Rheumatology, 2010, Volume: 6, Issue:12

    Topics: Arthritis, Rheumatoid; Autoimmunity; Bacteroidaceae Infections; Citrulline; Humans; Periodontitis; Phosphopyruvate Hydratase; Porphyromonas gingivalis; Risk Factors

2010
The swollen joint, the thickened artery, and the smoking gun: tobacco exposure, citrullination and rheumatoid arthritis.
    Rheumatology international, 2011, Volume: 31, Issue:5

    Topics: Animals; Arthritis, Rheumatoid; Atherosclerosis; Autoimmunity; Citrulline; Endothelium, Vascular; Genetic Predisposition to Disease; Humans; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Self Tolerance; Smoking; Synovial Membrane

2011
Citrullinated peptide and its relevance to rheumatoid arthritis: an update.
    International journal of rheumatic diseases, 2010, Volume: 13, Issue:4

    Topics: Arginine; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Epitopes; Genetic Predisposition to Disease; Humans; Peptides; Peptides, Cyclic; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors

2010
Smoking, citrullination and genetic variability in the immunopathogenesis of rheumatoid arthritis.
    Seminars in immunology, 2011, Volume: 23, Issue:2

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; Genetic Predisposition to Disease; Humans; Smoking

2011
Pathophysiology of rheumatoid arthritis.
    Current opinion in rheumatology, 2011, Volume: 23, Issue:3

    Topics: Alcohol Drinking; Animals; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Genome-Wide Association Study; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Neurosecretory Systems; Periodontitis; Protein Processing, Post-Translational; Risk Factors; Signal Transduction; Smoking; Synovial Membrane; T-Lymphocyte Subsets

2011
[Anticitrullin antibodies--modern markers of rheumatoid arthritis].
    Terapevticheskii arkhiv, 2011, Volume: 83, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Filaggrin Proteins; Humans; Immunoglobulin M; Peptides, Cyclic; Rheumatoid Factor

2011
Clinical applications of autoimmunity to citrullinated proteins in rheumatoid arthritis, from improving diagnostics to future therapies.
    Recent patents on inflammation & allergy drug discovery, 2011, Volume: 5, Issue:2

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Biomarkers; Citrulline; Humans; Immunologic Tests; Immunotherapy; Peptides, Cyclic; Predictive Value of Tests; Prognosis; Protein Processing, Post-Translational; Reagent Kits, Diagnostic; Treatment Outcome

2011
Rheumatoid arthritis and periodontitis; a possible link via citrullination.
    Anaerobe, 2011, Volume: 17, Issue:4

    Topics: Arthritis, Rheumatoid; Citrulline; Humans; Periodontitis; Porphyromonas gingivalis; Risk Factors

2011
Citrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis.
    FEBS letters, 2011, Dec-01, Volume: 585, Issue:23

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Models, Immunological; Tumor Necrosis Factor-alpha

2011
[Biomarkers in rheumatoid arthritis].
    Reumatologia clinica, 2011, Volume: 6S3

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Body Fluids; Citrulline; Humans; Joints; Peptides; Prognosis; Sensitivity and Specificity; Treatment Outcome

2011
Mutated citrullinated vimentin antibodies in rheumatoid arthritis.
    Clinica chimica acta; international journal of clinical chemistry, 2012, Jan-18, Volume: 413, Issue:1-2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Disease Progression; Enzyme-Linked Immunosorbent Assay; Humans; Mutation; Vimentin

2012
Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis.
    Mucosal immunology, 2012, Volume: 5, Issue:2

    Topics: Animals; Arthritis, Rheumatoid; Autoantigens; Bacteroidaceae Infections; Citrulline; Disease Models, Animal; Humans; Periodontitis; Porphyromonas; Protein Processing, Post-Translational; Risk Factors

2012
The influence of ACPA status and characteristics on the course of RA.
    Nature reviews. Rheumatology, 2012, Jan-31, Volume: 8, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans

2012
Citrullination under physiological and pathological conditions.
    Joint bone spine, 2012, Volume: 79, Issue:5

    Topics: Arthritis, Rheumatoid; Cell Transformation, Neoplastic; Central Nervous System; Citrulline; Gene Expression Regulation; Humans; Immune System; Multiple Sclerosis; Protein Processing, Post-Translational; Proteins; Psoriasis; Skin Physiological Phenomena

2012
[Rheumatic diseases and research on laboratory medicine: new applications of old knowledge].
    Rinsho byori. The Japanese journal of clinical pathology, 2012, Volume: 60, Issue:1

    Topics: Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Biomarkers; Citrulline; Ferritins; Humans; Immunoglobulins; Musculoskeletal System; Peptides; Rheumatic Diseases; Rheumatoid Factor; Ultrasonography

2012
Anti citrullinated protein antibodies and mechanism of action of common disease modifying drugs--insights in pathomechanisms of autoimmunity.
    Current pharmaceutical design, 2012, Volume: 18, Issue:29

    Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Autoimmunity; Citrulline; Humans

2012
New insights into the genetics of immune responses in rheumatoid arthritis.
    Tissue antigens, 2012, Volume: 80, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Biomarkers; Citrulline; Gene Expression; Genetic Loci; Genome-Wide Association Study; HLA-DRB1 Chains; Humans; Polymorphism, Single Nucleotide; Protein Processing, Post-Translational; Risk Factors; Signal Transduction

2012
[Palindromic rheumatism].
    La Revue de medecine interne, 2013, Volume: 34, Issue:1

    Topics: Arthritis; Arthritis, Rheumatoid; Citrulline; Cytoskeletal Proteins; Diagnosis, Differential; Disease Progression; Hereditary Autoinflammatory Diseases; Humans; Mutation; Pyrin; Rheumatic Diseases; Rheumatoid Factor

2013
New biomarkers in rheumatoid arthritis.
    The Netherlands journal of medicine, 2012, Volume: 70, Issue:9

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Prognosis

2012
Autoimmunity in rheumatoid arthritis: different antigens--common principles.
    Annals of the rheumatic diseases, 2013, Volume: 72 Suppl 2

    Topics: Antibody Formation; Arthritis, Rheumatoid; Autoantigens; Autoimmunity; Citrulline; Humans

2013
Lessons to be learned from periodontitis.
    Current opinion in rheumatology, 2013, Volume: 25, Issue:2

    Topics: Arthritis, Rheumatoid; Bacteroidaceae Infections; Citrulline; Humans; Hydrolases; Immunity, Innate; Periodontitis; Porphyromonas gingivalis; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Risk Factors

2013
Anti-citrullinated protein antibodies: role in pathogenesis of RA and potential as a diagnostic tool.
    Rheumatology international, 2013, Volume: 33, Issue:7

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Humans; Predictive Value of Tests; Prognosis; Risk Factors

2013
Immune features of seronegative and seropositive arthritis in early synovitis studies.
    Current opinion in rheumatology, 2002, Volume: 14, Issue:4

    Topics: Arthritis, Rheumatoid; Citrulline; Cytokines; Filaggrin Proteins; Haptens; Humans; Intermediate Filament Proteins; Rheumatoid Factor; Synovitis; Th1 Cells; Th2 Cells

2002
[Early diagnosis of rheumatoid arthritis with a test based upon a specific antigen: cyclic citrullinated peptide].
    Nederlands tijdschrift voor geneeskunde, 2003, Feb-01, Volume: 147, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Diagnosis, Differential; Humans; Peptides, Cyclic; Rheumatoid Factor; Sensitivity and Specificity; Synovial Membrane

2003
[Anticitrulline antibodies - new marker in rheumatoid arthritis diagnostics].
    Medicina (Kaunas, Lithuania), 2003, Volume: 39, Issue:5

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Fluorescent Antibody Technique, Indirect; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Keratins; Prognosis; Rheumatoid Factor; Time Factors

2003
Peptidylarginine deiminase type 4: identification of a rheumatoid arthritis-susceptible gene.
    Trends in molecular medicine, 2003, Volume: 9, Issue:11

    Topics: Animals; Antibodies; Arthritis, Rheumatoid; Autoimmunity; Citrulline; Genetic Predisposition to Disease; Humans; Hydrolases; Lymphocytes; Peptides; Polymorphism, Genetic; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2003
[Autoantibodies in the diagnosis of rheumatoid arthritis. Utility of anti-cyclic citrullinated peptides].
    Medicina clinica, 2003, Nov-08, Volume: 121, Issue:16

    Topics: Algorithms; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic

2003
[New diagnostic tests for rheumatoid arthritis].
    Rinsho byori. The Japanese journal of clinical pathology, 2003, Volume: 51, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Immunoglobulin G; Matrix Metalloproteinase 3; ROC Curve; Sensitivity and Specificity

2003
[Anti-citrulline antibodies in rheumatoid arthritis; diagnostic and prognostic values].
    Polskie Archiwum Medycyny Wewnetrznej, 2003, Volume: 110, Issue:2

    Topics: Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Prognosis; Severity of Illness Index

2003
[A new marker for the diagnosis of rheumatoid arthritis: cyclic citrullinated peptide antibodies (anti-CCP)].
    Mikrobiyoloji bulteni, 2003, Volume: 37, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Immunoenzyme Techniques; Immunoglobulin G; Peptides, Cyclic

2003
Is the celiac disease model relevant to rheumatoid arthritis?
    Joint bone spine, 2004, Volume: 71, Issue:1

    Topics: Arthritis, Rheumatoid; Celiac Disease; Citrulline; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Models, Immunological; Peptides, Cyclic

2004
Roles of B cells in rheumatoid arthritis.
    Arthritis research & therapy, 2003, Volume: 5 Suppl 4

    Topics: Animals; Antigen Presentation; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Disease Models, Animal; Glucose-6-Phosphate Isomerase; Humans; Mast Cells; Mice; Synovitis

2003
Therapeutic strategies for rheumatoid arthritis.
    The New England journal of medicine, 2004, Jun-17, Volume: 350, Issue:25

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Comorbidity; Drug Therapy, Combination; Humans; Prognosis; Rheumatoid Factor

2004
The joy of citrulline: new insights into the diagnosis, pathogenesis, and treatment of rheumatoid arthritis.
    The Journal of rheumatology, 2004, Volume: 31, Issue:8

    Topics: Animals; Arthritis, Rheumatoid; Asian People; Citrulline; Humans; Hydrolases; Immunoglobulin G; Isoenzymes; Polymorphism, Single Nucleotide; Protein-Arginine Deiminases

2004
Anti-CCP antibodies: the new rheumatoid factor in the serology of rheumatoid arthritis.
    Autoimmunity reviews, 2004, Volume: 3 Suppl 1

    Topics: Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Biomarkers; Citrulline; Clinical Laboratory Techniques; Humans; Immunologic Techniques; Immunologic Tests; Rheumatoid Factor; Sensitivity and Specificity; Serologic Tests; Serology

2004
What precedes development of rheumatoid arthritis?
    Annals of the rheumatic diseases, 2004, Volume: 63 Suppl 2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Environmental Exposure; Genetic Predisposition to Disease; Humans; Smoking

2004
Autoantibodies to citrullinated (poly)peptides: a key diagnostic and prognostic marker for rheumatoid arthritis.
    Autoimmunity, 2004, Volume: 37, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Peptides, Cyclic

2004
Autoantibodies to citrullinated proteins in rheumatoid arthritis: clinical performance and biochemical aspects of an RA-specific marker.
    Clinica chimica acta; international journal of clinical chemistry, 2004, Volume: 350, Issue:1-2

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Clinical Laboratory Techniques; Humans; Hydrolases; Immunologic Techniques; Protein-Arginine Deiminases

2004
Citrullinated proteins in rheumatoid arthritis.
    Frontiers in bioscience : a journal and virtual library, 2005, Jan-01, Volume: 10

    Topics: Arginine; Arthritis, Rheumatoid; Autoimmunity; Citrulline; Genetic Predisposition to Disease; Humans; Hydrolases; Models, Biological; Peptides; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synovial Membrane

2005
Clinical and pathophysiological significance of the autoimmune response to citrullinated proteins in rheumatoid arthritis.
    Joint bone spine, 2004, Volume: 71, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; Filaggrin Proteins; Humans; Proteins

2004
[Antibodies against citrullinated proteins--a breakthrough in rheumatologic diagnostics].
    Lakartidningen, 2004, Dec-09, Volume: 101, Issue:50

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Prognosis; Rheumatoid Factor; Sensitivity and Specificity

2004
[Susceptibility genes in rheumatoid arthritis: peptidylarginine deiminase (PADI) type 4].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63 Suppl 1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Calcium; Citrulline; Genetic Predisposition to Disease; Humans; Hydrolases; Peptides; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2005
Peptidylarginine deiminase type 4, anticitrullinated peptide antibodies, and rheumatoid arthritis.
    Autoimmunity reviews, 2005, Volume: 4, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Hydrolases; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2005
Anti-citrullinated protein/peptide antibodies (ACPA) in rheumatoid arthritis: specificity and relation with rheumatoid factor.
    Autoimmunity reviews, 2005, Volume: 4, Issue:7

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Biomarkers; Citrulline; Humans; Peptides; Peptides, Cyclic; Rheumatoid Factor

2005
The immune response to citrullinated antigens in autoimmune diseases.
    Autoimmunity reviews, 2005, Volume: 4, Issue:8

    Topics: Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Citrulline; Fibrin; Humans; Hydrolases; Protein-Arginine Deiminases

2005
The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Nov-01, Volume: 175, Issue:9

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Humans; Hydrolases; Protein-Arginine Deiminases

2005
Smoking and rheumatoid arthritis: another reason to just say no.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:1

    Topics: Arthritis, Rheumatoid; Citrulline; Humans; Smoking

2006
[Diagnostic and prognostic significance of antibodies against citrullinated peptides].
    Deutsche medizinische Wochenschrift (1946), 2006, Feb-10, Volume: 131, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Epitopes; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Peptides; Prognosis; Sensitivity and Specificity

2006
[Antibodies to citrullinated proteins in rheumatoid arthritis].
    Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology, 2006, Volume: 29, Issue:2

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Immunoglobulin M; Peptides, Cyclic; Prognosis; Rheumatoid Factor

2006
HLA and RA revisited: citrullinated food for the SE hypothesis, the DR6 effect, and NIMA.
    Human immunology, 2006, Volume: 67, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Genetic Predisposition to Disease; HLA Antigens; HLA-DR Antigens; HLA-DR beta-Chains; HLA-DRB1 Chains; Humans; Immunity, Maternally-Acquired; Models, Immunological

2006
A tale of two citrullines--structural and functional aspects of myelin basic protein deimination in health and disease.
    Neurochemical research, 2007, Volume: 32, Issue:2

    Topics: Amino Acid Sequence; Animals; Arthritis, Rheumatoid; Citrulline; Humans; Hydrolases; Molecular Sequence Data; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Protein Conformation; Protein Processing, Post-Translational; Protein-Arginine Deiminases

2007
Citrullinated proteins in rheumatoid arthritis: crucial...but not sufficient!
    Arthritis and rheumatism, 2006, Volume: 54, Issue:11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Humans; Proteins

2006
Autoantibodies to citrullinated antigens in (early) rheumatoid arthritis.
    Autoimmunity reviews, 2006, Volume: 6, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic; Prognosis

2006
Anti-citrulline antibodies in the diagnosis and prognosis of rheumatoid arthritis: evolving concepts.
    Critical reviews in clinical laboratory sciences, 2007, Volume: 44, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Environment; Humans; Peptides, Cyclic; Prognosis

2007
[Rheumatology 2007].
    Deutsche medizinische Wochenschrift (1946), 2007, Jun-22, Volume: 132, Issue:25-26

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Collagen Diseases; Drug Therapy, Combination; Humans; Hypertension, Pulmonary; Rare Diseases; Scleroderma, Systemic; Vasculitis

2007
Citrullination by peptidylarginine deiminase in rheumatoid arthritis.
    Annals of the New York Academy of Sciences, 2007, Volume: 1108

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Genetic Predisposition to Disease; Humans; Hydrolases; Isoenzymes; Mice; Polymorphism, Single Nucleotide; Protein-Arginine Deiminases; Proteins

2007
B cells in rheumatoid arthritis.
    Autoimmunity reviews, 2007, Volume: 7, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; B-Lymphocytes; Citrulline; Cytokines; Germinal Center; Humans; Immunoglobulin G; Lymphocyte Activation; Prognosis; Rheumatoid Factor; Synovial Membrane; T-Lymphocytes

2007
Immunity to citrullinated proteins in rheumatoid arthritis.
    Annual review of immunology, 2008, Volume: 26

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Protein Processing, Post-Translational; Proteins

2008
Advances in the genetics of rheumatoid arthritis point to subclassification into distinct disease subsets.
    Arthritis research & therapy, 2008, Volume: 10, Issue:2

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Genetic Predisposition to Disease; Humans

2008
Citrullination: a small change for a protein with great consequences for rheumatoid arthritis.
    Arthritis research, 2000, Volume: 2, Issue:4

    Topics: Animals; Apoptosis; Arginine; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans

2000
Autoantibody systems in rheumatoid arthritis: specificity, sensitivity and diagnostic value.
    Arthritis research, 2002, Volume: 4, Issue:2

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; Citrulline; Humans; Serologic Tests

2002
Autoantigenic posttranslational modifications of proteins: does it apply to rheumatoid arthritis?
    Current opinion in rheumatology, 2002, Volume: 14, Issue:3

    Topics: Apoptosis; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Chronic Disease; Citrulline; Humans; Protein Processing, Post-Translational; Proteins

2002

Trials

10 trial(s) available for citrulline and Arthritis, Rheumatoid

ArticleYear
Salivary citrullinated proteins in rheumatoid arthritis and associated periodontal disease.
    Scientific reports, 2021, 06-29, Volume: 11, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Citrullination; Citrulline; Female; Humans; Male; Middle Aged; Periodontal Diseases; Saliva; Salivary Proteins and Peptides

2021
Periodontal treatment decreases levels of antibodies to Porphyromonas gingivalis and citrulline in patients with rheumatoid arthritis and periodontitis.
    Journal of periodontology, 2013, Volume: 84, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Bacterial; Antigens, Bacterial; Arthritis, Rheumatoid; C-Reactive Protein; Carrier Proteins; Citrulline; Dental Scaling; Female; Follow-Up Studies; Heme-Binding Proteins; Hemeproteins; Humans; Immunoglobulin G; Interleukin-6; Male; Matrix Metalloproteinase 3; Middle Aged; Oral Hygiene; Periodontal Attachment Loss; Periodontal Pocket; Periodontitis; Porphyromonas gingivalis; Rheumatoid Factor; Tumor Necrosis Factor-alpha

2013
Antibodies to mutated citrullinated vimentin for diagnosing rheumatoid arthritis in anti-CCP-negative patients and for monitoring infliximab therapy.
    Arthritis research & therapy, 2008, Volume: 10, Issue:6

    Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Drug Monitoring; Humans; Infliximab; Mutation; Peptides, Cyclic; Vimentin

2008
[T cell proliferative response and antibody formation to citrullinated collagen type II in patients with rheumatoid arthritis].
    Zhonghua yi xue za zhi, 2009, Mar-17, Volume: 89, Issue:10

    Topics: Adult; Aged; Antibody Formation; Arthritis, Rheumatoid; Case-Control Studies; Cell Proliferation; Citrulline; Collagen Type II; Female; Humans; Lymphocyte Activation; Male; Middle Aged; Osteoarthritis; T-Lymphocytes

2009
Peptidyl-arginine deiminase: an additional marker of rheumatoid arthritis.
    Clinical laboratory, 2011, Volume: 57, Issue:11-12

    Topics: Adult; Aged; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Blood Sedimentation; C-Reactive Protein; Citrulline; Female; Humans; Hydrolases; Male; Middle Aged; Musculoskeletal Diseases; Predictive Value of Tests; Protein Processing, Post-Translational; Protein-Arginine Deiminases

2011
Local administration of glucocorticoids decreases synovial citrullination in rheumatoid arthritis.
    Arthritis research & therapy, 2012, Jan-27, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Dexamethasone; Double-Blind Method; Female; Glucocorticoids; Humans; Hydrolases; Immunohistochemistry; Injections, Intra-Articular; Male; Methotrexate; Middle Aged; Peptides; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synovial Membrane; Time Factors; Tissue Culture Techniques; Treatment Outcome; Triamcinolone Acetonide

2012
Smoking interacts with HLA-DRB1 shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA).
    Arthritis research & therapy, 2012, Apr-26, Volume: 14, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Epitopes; Female; HLA-DRB1 Chains; Humans; Malaysia; Male; Middle Aged; Smoking

2012
Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNFalpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:10

    Topics: Adult; Aged; Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Drug Therapy, Combination; Female; Humans; Infliximab; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome

2004
Leflunomide reduces nitric oxide production in patients with active rheumatoid arthritis.
    International immunopharmacology, 2005, Volume: 5, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Biomarkers; Citrulline; Female; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Middle Aged; Nitric Oxide

2005
Anti-citrullinated collagen type I antibody is a target of autoimmunity in rheumatoid arthritis.
    Biochemical and biophysical research communications, 2005, Jul-29, Volume: 333, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Collagen Type I; Female; Humans; Hydrolases; Male; Middle Aged; Protein-Arginine Deiminases; Synovial Membrane

2005

Other Studies

431 other study(ies) available for citrulline and Arthritis, Rheumatoid

ArticleYear
A fructosylated peptide derived from a collagen II T cell epitope for long-term treatment of arthritis (FIA-CIA) in mice.
    Scientific reports, 2021, 08-30, Volume: 11, Issue:1

    Topics: Animals; Antigens, Differentiation, B-Lymphocyte; Arthritis; Arthritis, Rheumatoid; Autoimmunity; Cattle; Citrulline; Collagen Type II; Epitopes, T-Lymphocyte; Fructose; Histocompatibility Antigens Class II; Inflammation; Male; Mice; Mice, Inbred DBA; Peptides; Peptides, Cyclic

2021
Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids.
    Frontiers in immunology, 2021, Volume: 12

    Topics: Animals; Arthritis, Rheumatoid; Citrullination; Citrulline; Matrix Metalloproteinase 9; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Protein Processing, Post-Translational; Synovial Fluid

2021
Rheumatoid Factor and Anti-Modified Protein Antibody Reactivities Converge on IgG Epitopes.
    Arthritis & rheumatology (Hoboken, N.J.), 2022, Volume: 74, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Humans; Immunoglobulin G; Peptides; Rheumatoid Factor; Sjogren's Syndrome

2022
Characterization and use of the ECV304 autoantigenic citrullinome to understand anti-citrullinated protein/peptide autoantibodies in rheumatoid arthritis.
    Arthritis research & therapy, 2022, 01-13, Volume: 24, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Peptides; Proteomics

2022
Detection of salivary citrullinated cytokeratin 13 in healthy individuals and patients with rheumatoid arthritis by proteomics analysis.
    PloS one, 2022, Volume: 17, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Keratin-13; Peptides; Peptides, Cyclic; Proteomics

2022
PAD2 immunization induces ACPA in wild-type and HLA-DR4 humanized mice.
    European journal of immunology, 2022, Volume: 52, Issue:9

    Topics: Alleles; Animals; Arginine; Arthritis, Rheumatoid; Autoantibodies; Citrulline; HLA-DR4 Antigen; HLA-DRB1 Chains; Immunization; Mice; Mice, Inbred C3H; Mice, Inbred C57BL

2022
Peptidyl arginine deiminase expression and macrophage polarization following stimulation with citrullinated and malondialdehyde-acetaldehyde modified fibrinogen.
    International immunopharmacology, 2022, Volume: 110

    Topics: Acetaldehyde; Arthritis, Rheumatoid; Citrulline; Fibrinogen; Humans; Hydrolases; Macrophages; Malondialdehyde; Protein-Arginine Deiminases; RNA, Messenger

2022
Citrullination is linked to reduced Ca
    Acta physiologica (Oxford, England), 2022, Volume: 236, Issue:3

    Topics: Actins; Animals; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Citrullination; Citrulline; Disease Models, Animal; Heart Failure; Hydrolases; Mice; Protein-Arginine Deiminases; Tumor Necrosis Factor-alpha

2022
Role of Citrullinated Collagen in Autoimmune Arthritis.
    International journal of molecular sciences, 2022, Aug-30, Volume: 23, Issue:17

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoimmune Diseases; Citrulline; Collagen; Mice; Mice, Transgenic

2022
Elevated levels of Metrnl in rheumatoid arthritis: Association with disease activity.
    Cytokine, 2022, Volume: 159

    Topics: Adipokines; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Citrulline; Cytokines; Humans; Osteoarthritis; Peptides, Cyclic; Rheumatoid Factor

2022
C-terminal citrullinated peptide alters antigen-specific APC:T cell interactions leading to breach of immune tolerance.
    Journal of autoimmunity, 2023, Volume: 135

    Topics: Arthritis, Rheumatoid; Cell Communication; Citrulline; Humans; Immune Tolerance; Peptides

2023
Platelets derived citrullinated proteins and microparticles are potential autoantibodies ACPA targets in RA patients.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Cell-Derived Microparticles; Citrulline; Humans; Protein-Arginine Deiminases

2023
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation.
    International journal of molecular sciences, 2023, Jan-18, Volume: 24, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Chemokine CCL2; Citrulline; Endothelial Cells; Glycosylation; Humans; Mammals; Proteins

2023
Novel method to quantify peptidylarginine deiminase activity shows distinct citrullination patterns in rheumatoid and juvenile idiopathic arthritis.
    Frontiers in immunology, 2023, Volume: 14

    Topics: Arginine; Arthritis, Juvenile; Arthritis, Rheumatoid; Citrullination; Citrulline; Humans; Hydrolases; Protein-Arginine Deiminases; Proteins

2023
Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis.
    Nature communications, 2023, 02-24, Volume: 14, Issue:1

    Topics: Antigen Presentation; Arthritis, Rheumatoid; Autoantigens; Citrullination; Citrulline; Epitopes; Humans; Peptides

2023
Citrulline immunity in RA: CD8
    Nature reviews. Rheumatology, 2023, Volume: 19, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; CD8-Positive T-Lymphocytes; Citrulline; Humans

2023
The human bone marrow plasma cell compartment in rheumatoid arthritis - Clonal relationships and anti-citrulline autoantibody producing cells.
    Journal of autoimmunity, 2023, Volume: 136

    Topics: Arthritis, Rheumatoid; Autoantibodies; Bone Marrow; Citrulline; Clone Cells; Humans; Immunoglobulin G; Peptides, Cyclic; Plasma Cells

2023
How does citrullination contribute to RA autoantibody development?
    Nature reviews. Rheumatology, 2023, Volume: 19, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrullination; Citrulline; Humans

2023
Rheumatoid Arthritis-Specific Autoimmunity in the Lung Before and at the Onset of Disease.
    Arthritis & rheumatology (Hoboken, N.J.), 2023, Volume: 75, Issue:11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Humans; Immunoglobulin Variable Region; Lung

2023
Low avidity observed for anti-citrullinated peptide antibody is not a general phenomenon for autoantibodies.
    Annals of the rheumatic diseases, 2023, Volume: 82, Issue:12

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides; Peptides, Cyclic

2023
The diversity of anti-citrulline reactivity and ACPA-associated phenotypes.
    Joint bone spine, 2023, Volume: 90, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic; Phenotype

2023
Expanding the citrullinome of synovial fibrinogen from rheumatoid arthritis patients.
    Journal of proteomics, 2019, 09-30, Volume: 208

    Topics: Aged; Arthritis, Rheumatoid; Citrulline; Female; Fibrinogen; Humans; Male; Middle Aged; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 2; Proteomics; Synovial Membrane

2019
Autophagy promotes citrullination of VIM (vimentin) and its interaction with major histocompatibility complex class II in synovial fibroblasts.
    Autophagy, 2020, Volume: 16, Issue:5

    Topics: Arthritis, Rheumatoid; Autophagy; Citrullination; Citrulline; Fibroblasts; Histocompatibility Antigens Class II; Humans; Vimentin

2020
Iguratimod dose dependently inhibits the expression of citrullinated proteins and peptidylarginine deiminases 2 and 4 in neutrophils from rheumatoid arthritis patients.
    Clinical rheumatology, 2020, Volume: 39, Issue:3

    Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Cells, Cultured; Chromones; Citrulline; Cytokines; Female; Humans; Male; Middle Aged; Neutrophils; Peptides, Cyclic; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Sulfonamides

2020
Generation of Distinct Patterns of Rheumatoid Arthritis Autoantigens by Peptidylarginine Deiminase Types 2 and 4 During Perforin-Induced Cell Damage.
    Arthritis & rheumatology (Hoboken, N.J.), 2020, Volume: 72, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantigens; Citrullination; Citrulline; HEK293 Cells; Humans; Perforin; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4

2020
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications.
    Annals of the rheumatic diseases, 2020, Volume: 79, Issue:4

    Topics: Acetylation; Aged; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrullination; Citrulline; Cross Reactions; Female; Humans; Immunoglobulin G; Male; Middle Aged; Protein Carbamylation; Protein Processing, Post-Translational; Receptors, Antigen, B-Cell

2020
Citrullination in periodontium is associated with Porphyromonas gingivalis.
    Archives of oral biology, 2020, Volume: 114

    Topics: Aggregatibacter actinomycetemcomitans; Arthritis, Rheumatoid; Bacteroidaceae Infections; Citrullination; Citrulline; Gingival Crevicular Fluid; Humans; Periodontitis; Periodontium; Porphyromonas gingivalis

2020
Antibodies to synthetic citrullinated peptide epitope correlate with disease activity and flares in rheumatoid arthritis.
    PloS one, 2020, Volume: 15, Issue:4

    Topics: Adolescent; Adult; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Citrulline; Early Diagnosis; Epitopes; Female; Fibrinogen; Humans; Male; Peptides, Cyclic; Severity of Illness Index; Symptom Flare Up; Young Adult

2020
Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis.
    BMC immunology, 2020, 05-18, Volume: 21, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; CD4-Positive T-Lymphocytes; Citrulline; Epitopes, T-Lymphocyte; Extracellular Matrix Proteins; Female; Fibrinogen; Flow Cytometry; Histocompatibility Antigens Class II; Humans; Male; Middle Aged; Pyrophosphatases; Vimentin

2020
Neutrophil extracellular traps mediate articular cartilage damage and enhance cartilage component immunogenicity in rheumatoid arthritis.
    JCI insight, 2020, 07-09, Volume: 5, Issue:13

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Cartilage, Articular; Citrulline; Extracellular Traps; Humans; Inflammation; Mice; Neutrophils

2020
Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study.
    Microvascular research, 2020, Volume: 131

    Topics: Aged; Aged, 80 and over; Arginine; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Cross-Sectional Studies; Female; Fingers; Homoarginine; Humans; Italy; Male; Metabolomics; Middle Aged; Vasodilation

2020
Citrullinated inter-alpha-trypsin inhibitor heavy chain 4 in arthritic joints and its potential effect in the neutrophil migration.
    Clinical and experimental immunology, 2021, Volume: 203, Issue:3

    Topics: Adult; Aged; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Movement; Citrulline; Female; Humans; Immunohistochemistry; Joints; Male; Mice, Inbred DBA; Microscopy, Fluorescence; Middle Aged; Neutrophils; Proteinase Inhibitory Proteins, Secretory; Young Adult

2021
Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis.
    Cells, 2020, 12-20, Volume: 9, Issue:12

    Topics: Animals; Arthritis, Rheumatoid; Bone and Bones; Bone Resorption; Cattle; Cell Differentiation; Citrullination; Citrulline; Fibrinogen; Humans; Inflammation; Integrin beta3; Leukocytes, Mononuclear; Lipopolysaccharide Receptors; NFATC Transcription Factors; Oligonucleotide Array Sequence Analysis; Osteoclasts; Osteogenesis; Synovial Fluid

2020
Autocitrullination of PAD4 does not alter its enzymatic activity: In vitro and in silico studies.
    The international journal of biochemistry & cell biology, 2021, Volume: 134

    Topics: Arginine; Arthritis, Rheumatoid; Citrullination; Citrulline; Computer Simulation; Enzyme Assays; Humans; In Vitro Techniques; Mass Spectrometry; Molecular Dynamics Simulation; Protein-Arginine Deiminase Type 4; Recombinant Proteins

2021
Citrullinated and homocitrullinated low- density lipoprotein in rheumatoid arthritis.
    Scandinavian journal of rheumatology, 2021, Volume: 50, Issue:5

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Cardiovascular Diseases; Citrulline; Female; Humans; Immunoglobulin G; Lipoproteins, LDL; Male; Mice; Middle Aged; Rabbits

2021
The importance of specific citrullinated clusterin and vimentin found in a multi-coloured bead-based citrulline-peptide array system in rheumatoid arthritis.
    Clinical and experimental rheumatology, 2022, Volume: 40, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Clusterin; Humans; Peptides; Peptides, Cyclic; Vimentin

2022
Specific Increase in Joint Neutrophil Extracellular Traps and Its Relation to Interleukin 6 in Autoimmune Arthritis.
    International journal of molecular sciences, 2021, Jul-16, Volume: 22, Issue:14

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Citrulline; Extracellular Traps; Histones; Interleukin-6; Joints; Leukocyte Elastase; Male; Mice; Mice, Inbred DBA; Neutrophils; Receptors, Interleukin-6

2021
Citrullinated Antigens with Multiple Citrulline Similar Motif in the Diagnosis of Rheumatoid Arthritis: A Preliminary Single-Center Study.
    Journal of immunology research, 2021, Volume: 2021

    Topics: Aged; Amino Acid Motifs; Anti-Citrullinated Protein Antibodies; Antigens; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Prognosis; ROC Curve; Sensitivity and Specificity

2021
Identification of potential autoantigens in anti-CCP-positive and anti-CCP-negative rheumatoid arthritis using citrulline-specific protein arrays.
    Scientific reports, 2021, 08-27, Volume: 11, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantigens; Biomarkers; Chromatography, High Pressure Liquid; Citrullination; Citrulline; Female; Humans; Male; Middle Aged; Protein Array Analysis; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Tandem Mass Spectrometry

2021
Breach of autoreactive B cell tolerance by post-translationally modified proteins.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:8

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; B-Lymphocytes; Carbamates; Case-Control Studies; Citrulline; Cross Reactions; Disease Models, Animal; Humans; Mass Spectrometry; Mice; Protein Processing, Post-Translational; Self Tolerance; Synovial Membrane

2017
Synovial Immunophenotype and Anti-Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients: Relationship to Treatment Response and Radiologic Prognosis.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:11

    Topics: Adult; Aged; Antigens, CD; Antigens, CD19; Antigens, Differentiation, Myelomonocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; CD3 Complex; CD4 Antigens; CD8 Antigens; Chemokine CXCL13; Citrulline; Enzyme-Linked Immunosorbent Assay; Factor VIII; Female; Humans; Immunohistochemistry; Immunophenotyping; Macrophages; Male; Middle Aged; Peptides; Peptides, Cyclic; Phenotype; Prognosis; Prospective Studies; Synovial Membrane; T-Lymphocytes; Treatment Outcome

2017
Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:11

    Topics: Alaska; Alaskan Natives; Alleles; Arginine; Arthritis, Rheumatoid; Autoantibodies; Canada; Case-Control Studies; CD4-Positive T-Lymphocytes; Citrulline; Female; Flow Cytometry; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Humans; Indians, North American; Male; Peptides, Cyclic; Polymorphism, Genetic; Risk Factors; Vimentin

2017
Comparative study of the diagnostic and prognostic value of antibodies against chimeric citrullinated synthetic peptides and CCP3/CCP3.1 assays.
    Clinical chemistry and laboratory medicine, 2018, 01-26, Volume: 56, Issue:2

    Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Peptides, Cyclic; Prognosis; Protein Array Analysis; Protein Domains

2018
Rheumatoid factors do not preferentially bind to ACPA-IgG or IgG with altered galactosylation.
    Rheumatology (Oxford, England), 2017, 11-01, Volume: 56, Issue:11

    Topics: Arthritis, Rheumatoid; Binding Sites, Antibody; Citrulline; Enzyme-Linked Immunosorbent Assay; Galactose; Humans; Immunoglobulin Domains; Immunoglobulin G; Immunoglobulin M; Protein Binding; Protein Processing, Post-Translational; Rheumatoid Factor

2017
Peptidyl arginine deiminase immunization induces anticitrullinated protein antibodies in mice with particular MHC types.
    Proceedings of the National Academy of Sciences of the United States of America, 2017, 11-21, Volume: 114, Issue:47

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrullination; Citrulline; Disease Models, Animal; Fibrinogen; Haptens; Humans; Immunization; Major Histocompatibility Complex; Mice; Mice, Inbred C3H; Mice, Inbred DBA; Protein-Arginine Deiminases; T-Lymphocytes

2017
Relatedness of Antibodies to Peptides Containing Homocitrulline or Citrulline in Patients with Rheumatoid Arthritis.
    The Journal of rheumatology, 2018, Volume: 45, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Antibody Affinity; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Healthy Volunteers; Humans; Immunoglobulin G; Lupus Erythematosus, Systemic; Male; Middle Aged; Peptides, Cyclic; Statistics, Nonparametric; Young Adult

2018
Immune responses to peptides containing homocitrulline or citrulline in the DR4-transgenic mouse model of rheumatoid arthritis.
    Journal of autoimmunity, 2018, Volume: 89

    Topics: Animals; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Citrulline; Disease Models, Animal; Epitopes; Female; Histocompatibility Antigens Class II; Humans; Immunity, Humoral; Immunization; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Peptides

2018
The interplay between citrullination and HLA-DRB1 polymorphism in shaping peptide binding hierarchies in rheumatoid arthritis.
    The Journal of biological chemistry, 2018, 03-02, Volume: 293, Issue:9

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantigens; Citrullination; Citrulline; HLA-DRB1 Chains; Humans; Models, Molecular; Peptides; Polymorphism, Genetic; Protein Binding; Protein Conformation, beta-Strand; Substrate Specificity

2018
Anticitrullinated Protein Antibodies Induce Inflammatory Gene Expression Profile in Peripheral Blood Cells from CCP-positive Patients with RA.
    The Journal of rheumatology, 2018, Volume: 45, Issue:3

    Topics: Antibody Affinity; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Filaggrin Proteins; Humans; Immunoglobulin Fab Fragments; Immunoglobulin Fc Fragments; Interleukin-1beta; Interleukin-6; Leukocytes, Mononuclear; Peptides, Cyclic; Real-Time Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Transcriptome

2018
Affinity Purification and Comparative Biosensor Analysis of Citrulline-Peptide-Specific Antibodies in Rheumatoid Arthritis.
    International journal of molecular sciences, 2018, Jan-22, Volume: 19, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Biosensing Techniques; Chromatography, Affinity; Citrulline; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Humans; Immunoglobulin G; Lymphocyte Depletion; Male; Middle Aged; Peptides; Surface Plasmon Resonance

2018
Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.
    Frontiers in immunology, 2018, Volume: 9

    Topics: Arthritis, Rheumatoid; Bicarbonates; Calcium; Citrullination; Citrulline; Humans; Neutrophils; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2018
Hypoxia induces production of citrullinated proteins in human fibroblast-like synoviocytes through regulating HIF1α.
    Scandinavian journal of immunology, 2018, Volume: 87, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantibodies; Cell Hypoxia; Cell Movement; Cell Proliferation; Cells, Cultured; Citrullination; Citrulline; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; RNA Interference; RNA, Small Interfering; Synoviocytes

2018
Dysbiotic Subgingival Microbial Communities in Periodontally Healthy Patients With Rheumatoid Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2018, Volume: 70, Issue:7

    Topics: Adult; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Dysbiosis; Female; Gingiva; Humans; Male; Microbiota; Middle Aged

2018
Mapping the tandem mass spectrometric characteristics of citrulline-containing peptides.
    Rapid communications in mass spectrometry : RCM, 2018, Jun-15, Volume: 32, Issue:11

    Topics: Arthritis, Rheumatoid; Citrulline; Epitopes; Humans; Peptide Fragments; Peptide Mapping; Peptides; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2018
The Rheumatoid Arthritis-Associated Citrullinome.
    Cell chemical biology, 2018, 06-21, Volume: 25, Issue:6

    Topics: Arthritis, Rheumatoid; Citrulline; Filaggrin Proteins; Humans; Proteomics

2018
Pathogenic Citrulline-Multispecific B Cell Receptor Clades in Rheumatoid Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2018, Volume: 70, Issue:12

    Topics: Adult; Anti-Citrullinated Protein Antibodies; Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Case-Control Studies; Citrulline; Cross Reactions; Female; Filaggrin Proteins; Humans; Male; Peptides, Cyclic; Receptors, Antigen, B-Cell

2018
A set of conformationally well-defined L/D-peptide epitopes provides a serological bar code for autoantibody subtypes.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Disulfides; Epitopes; Peptides; Protein Conformation; Serologic Tests

2018
Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Aug-20, Volume: 24

    Topics: Adult; Arthritis, Rheumatoid; Blood Sedimentation; C-Reactive Protein; Citrulline; Down-Regulation; Female; Humans; Male; Periodontitis; Statistics, Nonparametric

2018
Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2019, Volume: 71, Issue:4

    Topics: Aggrecans; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; CD4-Positive T-Lymphocytes; Citrulline; Epitopes, T-Lymphocyte; HLA-DRB1 Chains; Humans; Registries

2019
The role of synthetic manufactured peptides containing common citrullinated epitopes in rheumatoid arthritis diagnosis.
    Clinical immunology (Orlando, Fla.), 2019, Volume: 199

    Topics: Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Filaggrin Proteins; Humans; Reagent Kits, Diagnostic

2019
Exploiting CD22 To Selectively Tolerize Autoantibody Producing B-Cells in Rheumatoid Arthritis.
    ACS chemical biology, 2019, 04-19, Volume: 14, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Case-Control Studies; Citrulline; Humans; Immunologic Memory; Mice; Sialic Acid Binding Ig-like Lectin 2

2019
Insight into Neutrophil Extracellular Traps through Systematic Evaluation of Citrullination and Peptidylarginine Deiminases.
    Journal of immunology research, 2019, Volume: 2019

    Topics: Animals; Arthritis, Rheumatoid; Citrullination; Citrulline; Extracellular Traps; Humans; Ionomycin; Mice; Mice, Inbred DBA; Mice, Knockout; Neutrophils; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Tetradecanoylphorbol Acetate; Uric Acid

2019
Reduced IgG titers against pertussis in rheumatoid arthritis: Evidence for a citrulline-biased immune response and medication effects.
    PloS one, 2019, Volume: 14, Issue:5

    Topics: Adolescent; Arthritis, Rheumatoid; Bordetella pertussis; Case-Control Studies; Citrulline; Female; Humans; Immunoglobulin G; Immunosuppressive Agents; Male; Methotrexate; Pertussis Vaccine; Whooping Cough

2019
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis.
    Journal of autoimmunity, 2019, Volume: 105

    Topics: Animals; Antibody Formation; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Autoimmunity; Citrullination; Citrulline; Extracellular Traps; Histones; Macrophages; Male; Mice; Mice, Inbred DBA; Protein-Arginine Deiminase Type 4; Synovial Fluid; Synovial Membrane

2019
Relationship of the HLA-DRB1 alleles and seropositivity, anti-MCV, functional status and radiological damage in Turkish patients with rheumatoid arthritis.
    Journal of back and musculoskeletal rehabilitation, 2013, Volume: 26, Issue:1

    Topics: Adult; Alleles; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Disability Evaluation; Female; Gene Frequency; Genotype; HLA-DRB1 Chains; Humans; Male; Middle Aged; Radiography; Seroepidemiologic Studies; Severity of Illness Index; Turkey; Vimentin

2013
Anti-CCP in systemic lupus erythematosus patients: a cross sectional study in Brazilian patients.
    Clinical rheumatology, 2013, Volume: 32, Issue:7

    Topics: Adolescent; Adult; Antibodies; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Brazil; Citrulline; Cross-Sectional Studies; Diagnosis, Differential; Foot; Hand; Humans; Lupus Erythematosus, Systemic; Middle Aged; Peptides, Cyclic; Prevalence; Radiography; Ribonucleoproteins; SS-B Antigen; X-Rays; Young Adult

2013
The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis?
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; Biomarkers, Tumor; Citrulline; DNA-Binding Proteins; Female; Humans; Immune Tolerance; Linear Models; Male; Middle Aged; Peptides, Cyclic; Periodontitis; Phosphopyruvate Hydratase; Smoking; Tumor Suppressor Proteins; Vimentin

2014
Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.
    The Journal of experimental medicine, 2013, Mar-11, Volume: 210, Issue:3

    Topics: Adult; Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantigens; B-Lymphocytes; Citrulline; Female; Fibrinogen; Humans; Immunoglobulin G; Immunohistochemistry; Male; Middle Aged; Phosphopyruvate Hydratase; Somatic Hypermutation, Immunoglobulin; Vimentin

2013
Anti-citrullinated protein antibodies in unaffected first-degree relatives of rheumatoid arthritis patients.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Vimentin; Young Adult

2013
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:1

    Topics: Adult; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Bacteroidaceae Infections; Citrulline; Female; Humans; Hydrolases; Immune Tolerance; Male; Mass Spectrometry; Molecular Sequence Data; Mutagenesis, Site-Directed; Peptides, Cyclic; Periodontitis; Porphyromonas gingivalis; Protein-Arginine Deiminases

2014
Smoking, the HLA-DRB1 shared epitope and ACPA fine-specificity in Koreans with rheumatoid arthritis: evidence for more than one pathogenic pathway linking smoking to disease.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:4

    Topics: Adult; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Epitopes; Evidence-Based Medicine; Female; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Humans; Male; Middle Aged; Peptides, Cyclic; Phosphopyruvate Hydratase; Radiography; Smoking; Vimentin

2014
NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis.
    Science translational medicine, 2013, Mar-27, Volume: 5, Issue:178

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Interleukin-17; Interleukin-6; Interleukin-8; Microscopy, Fluorescence; Neutrophils; Real-Time Polymerase Chain Reaction; Tumor Necrosis Factor-alpha

2013
T cell responses to citrullinated self-peptides in patients with rheumatoid arthritis.
    Rheumatology international, 2013, Volume: 33, Issue:9

    Topics: Adult; Aggrecans; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; HLA-DR4 Antigen; Humans; Male; Middle Aged; T-Lymphocytes; Vimentin

2013
Brief report: citrullination within the atherosclerotic plaque: a potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:7

    Topics: Aged; Antigen-Antibody Complex; Aortography; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Calcinosis; Citrulline; Electrophoresis, Polyacrylamide Gel; Female; Fibrinogen; Humans; Hydrolases; Immunoassay; Male; Peptides, Cyclic; Plaque, Atherosclerotic; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Regression Analysis; Vimentin

2013
Higher levels of autoantibodies targeting mutated citrullinated vimentin in patients with psoriatic arthritis than in patients with psoriasis vulgaris.
    Clinical & developmental immunology, 2013, Volume: 2013

    Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Disease Progression; Female; Humans; Immunity, Humoral; Joints; Male; Middle Aged; Mutation; Prevalence; Skin; Vimentin

2013
The role of citrullination of an immunodominant proteoglycan (PG) aggrecan T cell epitope in BALB/c mice with PG-induced arthritis.
    Immunology letters, 2013, Volume: 152, Issue:1

    Topics: Aggrecans; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Citrulline; Epitopes, T-Lymphocyte; Female; Humans; Immunization; Immunodominant Epitopes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Peptide Fragments; T-Lymphocytes

2013
Role of N- or C-terminal biotinylation in autoantibody recognition of citrullin containing filaggrin epitope peptides in rheumatoid arthritis.
    Bioconjugate chemistry, 2013, May-15, Volume: 24, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Biotinylation; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Lupus Erythematosus, Systemic; Middle Aged; Models, Molecular; Molecular Sequence Data; Peptides; Protein Structure, Secondary

2013
The fibrin-derived citrullinated peptide β60-74Cit₆₀,₇₂,₇₄ bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Epitopes; Female; Fibrin; Fibrin Fibrinogen Degradation Products; Fibrinogen; Humans; Male; Middle Aged; Peptide Fragments; Peptides, Cyclic; Rheumatic Diseases; Rheumatoid Factor; Young Adult

2014
[Value of four serum markers in the diagnosis of rheumatoid arthritis].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2013, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Citrulline; Female; Glucose-6-Phosphate Isomerase; Humans; Keratins; Male; Middle Aged; Rheumatoid Factor; Young Adult

2013
Autoimmunity in rheumatoid arthritis: citrulline immunity and beyond.
    Advances in immunology, 2013, Volume: 118

    Topics: Amino Acid Motifs; Animals; Arthritis, Rheumatoid; Autoantigens; Autoimmune Diseases; Citrulline; Epitopes; Gene-Environment Interaction; Humans; Immunity, Innate; Protein Processing, Post-Translational

2013
Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Histones; Humans; Immunoblotting; Male; Middle Aged; Neutrophils; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Young Adult

2014
Antibodies to modified citrullinated vimentin are associated with severe extra-articular manifestations in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2013, Volume: 72, Issue:12

    Topics: Aged; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Female; Humans; Male; Middle Aged; Vimentin

2013
Comparison of anti-mutated citrullinated vimentin, anti-cyclic citrullinated peptides, anti-glucose-6-phosphate isomerase and anti-keratin antibodies and rheumatoid factor in the diagnosis of rheumatoid arthritis in Chinese patients.
    International journal of rheumatic diseases, 2013, Volume: 16, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; China; Citrulline; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique, Indirect; Glucose-6-Phosphate Isomerase; Humans; Keratins; Male; Middle Aged; Nephelometry and Turbidimetry; Peptides, Cyclic; Predictive Value of Tests; Serologic Tests; Vimentin; Young Adult

2013
[Pathophysiological advances underlying the biotherapeutic revolution in inflammatory rheumatism].
    Bulletin de l'Academie nationale de medecine, 2012, Volume: 196, Issue:7

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Citrulline; Connective Tissue Diseases; Cytokines; Humans; Lymphocyte Subsets; Protein Processing, Post-Translational; Rheumatic Diseases; Spondylarthritis; Treatment Outcome; Tumor Necrosis Factor-alpha

2012
[Interleukin-1 and the interleukin-1 receptor antagonist gene polymorphisms study in patients with rheumatoid arthritis].
    Pathologie-biologie, 2013, Volume: 61, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Male; Middle Aged; Minisatellite Repeats; Peptide Fragments; Polymorphism, Genetic

2013
Parity and the risk of developing rheumatoid arthritis: results from the Swedish Epidemiological Investigation of Rheumatoid Arthritis study.
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:4

    Topics: Adolescent; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Female; Humans; Maternal Age; Middle Aged; Parity; Peptides, Cyclic; Postpartum Period; Pregnancy; Reproductive History; Risk Factors; Sweden; Young Adult

2014
CTLA4-Ig (abatacept) therapy modulates T cell effector functions in autoantibody-positive rheumatoid arthritis patients.
    BMC immunology, 2013, Aug-05, Volume: 14

    Topics: Abatacept; Adolescent; Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Cell Proliferation; Citrulline; Cohort Studies; Cytokines; Female; Flow Cytometry; Humans; Immunoconjugates; Lymphocyte Count; Male; Middle Aged; Synovial Membrane; T-Lymphocyte Subsets; T-Lymphocytes; Young Adult

2013
Identification of a linear epitope recognized by a monoclonal antibody directed to the heterogeneous nucleoriboprotein A2.
    Protein and peptide letters, 2014, Volume: 21, Issue:1

    Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans

2014
Different amounts of protein-bound citrulline and homocitrulline in foot joint tissues of a patient with anti-citrullinated protein antibody positive erosive rheumatoid arthritis.
    Journal of translational medicine, 2013, Sep-23, Volume: 11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Chromatography, High Pressure Liquid; Citrulline; Female; Foot Joints; Humans; Middle Aged; Protein Binding; Radiography

2013
Recognition of new citrulline-containing peptide epitopes by autoantibodies produced in vivo and in vitro by B cells of rheumatoid arthritis patients.
    Immunology, 2014, Volume: 141, Issue:2

    Topics: Adult; Aged; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Collagen; Cross Reactions; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Molecular Sequence Data; Vimentin

2014
Poking holes in rheumatoid joints.
    Science translational medicine, 2013, Oct-30, Volume: 5, Issue:209

    Topics: Arthritis, Rheumatoid; Autoantigens; Citrulline; Humans

2013
Immune-mediated pore-forming pathways induce cellular hypercitrullination and generate citrullinated autoantigens in rheumatoid arthritis.
    Science translational medicine, 2013, Oct-30, Volume: 5, Issue:209

    Topics: Apoptosis; Arthritis, Rheumatoid; Autoantigens; Cells, Cultured; Citrulline; Complement Activation; Complement Membrane Attack Complex; Granzymes; Humans; Neutrophils; Synovial Fluid

2013
A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis.
    The Journal of experimental medicine, 2013, Nov-18, Volume: 210, Issue:12

    Topics: Aggrecans; Amino Acid Sequence; Animals; Antigen Presentation; Arthritis, Rheumatoid; Autoantigens; CD4-Positive T-Lymphocytes; Citrulline; Epitopes; Genetic Association Studies; HLA-DR beta-Chains; HLA-DR4 Antigen; HLA-DRB1 Chains; Humans; Mice; Mice, Transgenic; Models, Molecular; Molecular Sequence Data; Polymorphism, Genetic; Vimentin

2013
Rheumatoid arthritis: Understanding hypercitrullination in rheumatoid arthritis.
    Nature reviews. Rheumatology, 2014, Volume: 10, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantigens; Citrulline; Humans

2014
Environmental and genetic factors in the development of anticitrullinated protein antibodies (ACPAs) and ACPA-positive rheumatoid arthritis: an epidemiological investigation in twins.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:2

    Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; HLA-DRB1 Chains; Humans; Male; Middle Aged; Smoking; Socioeconomic Factors

2015
ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression.
    Arthritis research & therapy, 2013, Oct-01, Volume: 15, Issue:5

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Biosensing Techniques; Citrulline; Disease Progression; Humans; Molecular Sequence Data; Peptides; Peptides, Cyclic; Principal Component Analysis; Surface Plasmon Resonance; Time Factors

2013
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:3

    Topics: Adolescent; Adult; Aged; Alleles; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Gout; HLA-DRB1 Chains; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Peptides; Peptides, Cyclic; Smoking; Young Adult

2015
[Prevalence and significance of antibodies to citrullinated human fibrinogen β67-77 peptide in rheumatoid arthritis].
    Zhonghua yi xue za zhi, 2013, Sep-03, Volume: 93, Issue:33

    Topics: Antibodies; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Female; Fibrinogen; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Peptides; Sensitivity and Specificity

2013
Antihomocitrullinated fibrinogen antibodies are specific to rheumatoid arthritis and frequently bind citrullinated proteins/peptides.
    The Journal of rheumatology, 2014, Volume: 41, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Female; Fibrinogen; Humans; Male; Middle Aged; Young Adult

2014
Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:3

    Topics: Alleles; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Female; Genetic Predisposition to Disease; Haplotypes; Humans; Macrophages; Male; Osteopontin; Peptides; Polymorphism, Single Nucleotide

2015
Identification of new citrulline-specific autoantibodies, which bind to human arthritic cartilage, by mass spectrometric analysis of citrullinated type II collagen.
    Arthritis & rheumatology (Hoboken, N.J.), 2014, Volume: 66, Issue:6

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Cartilage, Articular; Case-Control Studies; Citrulline; Collagen Type II; Epitopes; Humans; Hydrolases; Immunoglobulin G; In Vitro Techniques; Protein-Arginine Deiminases; Rats; Tandem Mass Spectrometry

2014
How citrullination invaded rheumatoid arthritis research.
    Arthritis research & therapy, 2014, Jan-29, Volume: 16, Issue:1

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Proteins

2014
Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive and -negative rheumatoid arthritis patients.
    Arthritis research & therapy, 2013, Nov-07, Volume: 15, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross-Sectional Studies; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Humans; Immunohistochemistry; Male; Middle Aged; Synovial Fluid; Synovial Membrane

2013
The performance of a point of care test for detection of anti-mutated citrullinated vimentin and rheumatoid factor in early rheumatoid arthritis.
    Clinical rheumatology, 2014, Volume: 33, Issue:7

    Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Citrulline; False Positive Reactions; Female; Humans; Male; Middle Aged; Point-of-Care Systems; Predictive Value of Tests; Reproducibility of Results; Rheumatic Diseases; Rheumatoid Factor; Rheumatology; Sensitivity and Specificity; Vimentin

2014
Citrulline-specific Th1 cells are increased in rheumatoid arthritis and their frequency is influenced by disease duration and therapy.
    Arthritis & rheumatology (Hoboken, N.J.), 2014, Volume: 66, Issue:7

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Biological Factors; Citrulline; Epitopes, T-Lymphocyte; Haplotypes; HLA-DRB1 Chains; Humans; Immunologic Memory; Immunophenotyping; Mice; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Synovial Membrane; Th1 Cells; Vimentin

2014
The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding citrullinated p
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:7

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Periodontitis

2014
Assessing the citrullinome in rheumatoid arthritis synovial fluid with and without enrichment of citrullinated peptides.
    Journal of proteome research, 2014, Jun-06, Volume: 13, Issue:6

    Topics: Adult; Amino Acid Sequence; Arthritis, Rheumatoid; Chromatography, Ion Exchange; Citrulline; Female; Humans; Knee Joint; Molecular Sequence Data; Peptide Fragments; Protein Processing, Post-Translational; Proteome; Synovial Fluid; Tandem Mass Spectrometry

2014
Response to: 'The autoantibody repertoire in periodontitis: a role in the induction of autoimmunity to citrullinated proteins in rheumatoid arthritis? Antibodies against uncitrullinated peptides seem to occur prior to the antibodies to the corresponding c
    Annals of the rheumatic diseases, 2014, Volume: 73, Issue:7

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Periodontitis

2014
Shared immunological targets in the lungs and joints of patients with rheumatoid arthritis: identification and validation.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Bronchi; Case-Control Studies; Citrulline; Epitopes; Female; HLA-DRB1 Chains; Humans; Joints; Lung; Male; Mass Spectrometry; Middle Aged; Peptides; Peptides, Cyclic; Proteomics; Synovial Membrane; Vimentin; Young Adult

2015
Defining the role of Porphyromonas gingivalis peptidylarginine deiminase (PPAD) in rheumatoid arthritis through the study of PPAD biology.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:11

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Bacterial Proteins; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Female; Humans; Hydrolases; Immunoblotting; Immunoglobulin G; Male; Mass Spectrometry; Middle Aged; Peptides, Cyclic; Periodontal Diseases; Periodontitis; Porphyromonas gingivalis; Protein-Arginine Deiminases; Severity of Illness Index

2015
A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming.
    BioEssays : news and reviews in molecular, cellular and developmental biology, 2014, Volume: 36, Issue:8

    Topics: Animals; Arthritis, Rheumatoid; Cellular Reprogramming; Chromatin Assembly and Disassembly; Citrulline; Histones; Humans; Hydrolases; Induced Pluripotent Stem Cells; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Transcription Factors; Transcription, Genetic

2014
Enhanced neutrophil extracellular trap generation in rheumatoid arthritis: analysis of underlying signal transduction pathways and potential diagnostic utility.
    Arthritis research & therapy, 2014, Jun-13, Volume: 16, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Cells, Cultured; Citrulline; DNA; Extracellular Traps; Female; Histones; Humans; Hydrolases; Immunohistochemistry; Leukocyte Elastase; Male; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Middle Aged; Neutrophils; Nucleosomes; Peptides, Cyclic; Peroxidase; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Synovial Fluid

2014
Comparison of two assays to determine anti-citrullinated peptide antibodies in rheumatoid arthritis in relation to other chronic inflammatory rheumatic diseases: assaying anti-modified citrullinated vimentin antibodies adds value to second-generation anti
    BioMed research international, 2014, Volume: 2014

    Topics: Adult; Antibodies; Arthritis, Rheumatoid; Citrulline; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Rheumatic Fever; Vimentin

2014
Risk for ACPA-positive rheumatoid arthritis is driven by shared HLA amino acid polymorphisms in Asian and European populations.
    Human molecular genetics, 2014, Dec-20, Volume: 23, Issue:25

    Topics: Alleles; Amino Acids; Arthritis, Rheumatoid; Asian People; Autoantibodies; Chromosome Mapping; Citrulline; Epitopes; Gene Expression; Gene Frequency; HLA-B Antigens; HLA-DP beta-Chains; HLA-DRB1 Chains; Humans; Polymorphism, Genetic; Risk; White People

2014
Carbamylation of immunoglobulin abrogates activation of the classical complement pathway.
    European journal of immunology, 2014, Volume: 44, Issue:11

    Topics: Adhesins, Bacterial; Antibodies, Monoclonal, Murine-Derived; Antibody-Dependent Cell Cytotoxicity; Arthritis, Rheumatoid; Citrulline; Complement Activation; Complement C1q; Complement Pathway, Classical; Cyanates; Cysteine Endopeptidases; Gingipain Cysteine Endopeptidases; Humans; Immunoglobulin G; Immunologic Factors; Inflammation; Lysine; Mass Spectrometry; Protein Binding; Protein Processing, Post-Translational; Rituximab

2014
PPAD remains a credible candidate for inducing autoimmunity in rheumatoid arthritis: comment on the article by Konig et al.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:1

    Topics: Arthritis, Rheumatoid; Bacterial Proteins; Citrulline; Female; Humans; Hydrolases; Male; Peptides, Cyclic; Periodontitis; Porphyromonas gingivalis

2015
PPAD is not targeted as a citrullinated protein in rheumatoid arthritis, but remains a candidate for inducing autoimmunity.
    Annals of the rheumatic diseases, 2015, Volume: 74, Issue:1

    Topics: Arthritis, Rheumatoid; Bacterial Proteins; Citrulline; Female; Humans; Hydrolases; Male; Peptides, Cyclic; Periodontitis; Porphyromonas gingivalis

2015
Automated immunoassays for the autoantibodies to carbamylated or citrullinated telopeptides of type I and II collagens.
    Clinical chemistry and laboratory medicine, 2015, Volume: 53, Issue:9

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Automation; Citrulline; Collagen Type I; Collagen Type II; Female; Humans; Immunoassay; Luminescent Measurements; Male; Middle Aged; Peptide Fragments

2015
Predictive value of anti-citrullinated peptide antibodies: a real life experience.
    Immunologic research, 2014, Volume: 60, Issue:2-3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides; Prognosis; Reproducibility of Results; Retrospective Studies; Rheumatoid Factor; Sensitivity and Specificity

2014
Rheumatoid factor and anti-citrullinated protein antibody positivity, but not level, are associated with increased mortality in patients with rheumatoid arthritis: results from two large independent cohorts.
    Arthritis research & therapy, 2014, Dec-04, Volume: 16, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Mortality; Rheumatoid Factor; Survival Rate

2014
Demonstration of extracellular peptidylarginine deiminase (PAD) activity in synovial fluid of patients with rheumatoid arthritis using a novel assay for citrullination of fibrinogen.
    Arthritis research & therapy, 2014, Dec-05, Volume: 16, Issue:6

    Topics: Aged; Arthritis, Rheumatoid; Citrulline; Enzyme Activation; Enzyme-Linked Immunosorbent Assay; Extracellular Space; Female; Fibrinogen; Humans; Hydrolases; Male; Middle Aged; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Synovial Fluid

2014
The use of citrullinated peptides for the diagnosis and prognosis of rheumatoid arthritis.
    Current topics in medicinal chemistry, 2014, Volume: 14, Issue:23

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Early Diagnosis; Epitopes; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Joints; Molecular Sequence Data; Peptides; Prognosis; Protein Processing, Post-Translational; Protein Structure, Tertiary; Solid-Phase Synthesis Techniques; Vimentin

2014
Anti-citrullinated peptide antibodies in Sudanese patients with Leishmania donovani infection exhibit reactivity not dependent on citrullination.
    Scandinavian journal of immunology, 2015, Volume: 81, Issue:3

    Topics: Adolescent; Adult; Aged; Antibodies, Protozoan; Antigen-Antibody Complex; Arthritis, Rheumatoid; Child; Child, Preschool; Citrulline; Complement C1q; Female; Humans; Inflammation; Leishmania donovani; Leishmaniasis, Visceral; Male; Middle Aged; Peptides; Peptides, Cyclic; Rheumatoid Factor; Sudan; Young Adult

2015
Separate and overlapping specificities in rheumatoid arthritis antibodies binding to citrulline- and homocitrulline-containing peptides related to type I and II collagen telopeptides.
    Arthritis research & therapy, 2015, Jan-09, Volume: 17

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Collagen Type I; Collagen Type II; Female; Humans; Male; Middle Aged; Peptides; Protein Binding; Young Adult

2015
Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Chromatography, Gel; Citrulline; Electrophoresis; Enzyme-Linked Immunosorbent Assay; Female; Glycosylation; Humans; Immunoglobulin G; Male; Mass Spectrometry; Middle Aged; Molecular Weight; Polysaccharides; Surface Plasmon Resonance; Synovial Fluid

2016
Expression of citrulline and homocitrulline residues in the lungs of non-smokers and smokers: implications for autoimmunity in rheumatoid arthritis.
    Arthritis research & therapy, 2015, Jan-20, Volume: 17

    Topics: Arthritis, Rheumatoid; Autoimmunity; Citrulline; Female; Gene Expression Regulation; Humans; Lung; Male; Pulmonary Disease, Chronic Obstructive; Smoking

2015
Anti-CCP antibody levels are not associated with MS: results from a case-control study.
    BioMed research international, 2015, Volume: 2015

    Topics: Adult; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Central Nervous System; Citrulline; Early Diagnosis; Female; Humans; Male; Middle Aged; Multiple Sclerosis; Myelin Basic Protein; Peptides

2015
Pattern of drugs use and association with anti-mutated citrullinated vimentin antibody in rheumatoid arthritis.
    Saudi medical journal, 2015, Volume: 36, Issue:3

    Topics: Adult; Antibodies; Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Female; Humans; Male; Middle Aged; Vimentin

2015
Autoimmunity: lungs and citrullination.
    Nature reviews. Rheumatology, 2015, Volume: 11, Issue:5

    Topics: Arthritis, Rheumatoid; Autoimmunity; Citrulline; Humans; Lung; Pneumonia; Pulmonary Disease, Chronic Obstructive; Smoking

2015
Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.
    Scientific reports, 2015, Mar-19, Volume: 5

    Topics: Adult; Aged; Algorithms; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Chromatography, High Pressure Liquid; Citrulline; Early Diagnosis; Female; Humans; Hydroxyproline; Male; Middle Aged; Musculoskeletal Diseases; Osteoarthritis; ROC Curve; Sensitivity and Specificity; Tandem Mass Spectrometry

2015
Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis?
    Medical hypotheses, 2015, Volume: 84, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Carbamates; Citrulline; Humans; Models, Biological; Periodontal Diseases; Rheumatoid Factor

2015
Significant association of periodontal disease with anti-citrullinated peptide antibody in a Japanese healthy population - The Nagahama study.
    Journal of autoimmunity, 2015, Volume: 59

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Female; Humans; Immunoglobulin M; Japan; Male; Middle Aged; Peptides; Periodontal Diseases; Population Groups; Prospective Studies; Rheumatoid Factor; Risk; Smoking

2015
Anti-carbamylated protein antibodies in the pre-symptomatic phase of rheumatoid arthritis, their relationship with multiple anti-citrulline peptide antibodies and association with radiological damage.
    Arthritis research & therapy, 2015, Feb-07, Volume: 17

    Topics: Animals; Arthritis, Rheumatoid; Asymptomatic Diseases; Autoantibodies; Autoantigens; Case-Control Studies; Chick Embryo; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin A; Male; Middle Aged; Peptides, Cyclic; Radiography

2015
Crossreactivity to vinculin and microbes provides a molecular basis for HLA-based protection against rheumatoid arthritis.
    Nature communications, 2015, May-05, Volume: 6

    Topics: Amino Acid Sequence; Antigen Presentation; Arthritis, Rheumatoid; Autoantigens; Bacteria; Blotting, Western; Citrulline; Cross Reactions; Enzyme-Linked Immunospot Assay; Epitopes; HLA Antigens; HLA-DQ Antigens; HLA-DRB1 Chains; Humans; Interferon-gamma; Models, Immunological; Models, Molecular; Molecular Sequence Data; T-Lymphocytes; Tissue Donors; Vinculin; Viruses

2015
Immune tolerance induction with multiepitope peptide derived from citrullinated autoantigens attenuates arthritis manifestations in adjuvant arthritis rats.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Jun-15, Volume: 194, Issue:12

    Topics: Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Disease Models, Animal; Epitopes; Female; Filaggrin Proteins; Immune Tolerance; Immunophenotyping; Peptides; Phenotype; Rats; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory

2015
Periodontitis and Rheumatoid Arthritis: What Do We Know?
    Journal of periodontology, 2015, Volume: 86, Issue:9

    Topics: Animals; Antibodies, Bacterial; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Hydrolases; Immunity, Cellular; Neutrophils; Periodontitis; Porphyromonas gingivalis; Protein-Arginine Deiminases; RANK Ligand; Rheumatoid Factor; Risk Factors; Species Specificity; Th17 Cells

2015
Anti-mutated citrullinated vimentin antibody and rheumatoid factor (prevalence and association) in rheumatoid arthritis patients; Saudi and non-Saudi.
    Clinical laboratory, 2015, Volume: 61, Issue:3-4

    Topics: Adult; Antibodies; Arthritis, Rheumatoid; Citrulline; Clinical Laboratory Techniques; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Mutation; Odds Ratio; Prevalence; Retrospective Studies; Rheumatoid Factor; Saudi Arabia; Vimentin

2015
Isotypes of Epstein-Barr virus antibodies in rheumatoid arthritis: association with rheumatoid factors and citrulline-dependent antibodies.
    BioMed research international, 2015, Volume: 2015

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Viral; Antigens, Viral; Arthritis, Rheumatoid; Citrulline; Epstein-Barr Virus Nuclear Antigens; Female; Herpesvirus 4, Human; Humans; Immunoglobulin Isotypes; Male; Methotrexate; Middle Aged; Rheumatoid Factor; Young Adult

2015
Bronchiectasis is a Model for Chronic Bacterial Infection Inducing Autoimmunity in Rheumatoid Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Asthma; Autoantibodies; Autoimmunity; Bacterial Infections; Bronchiectasis; Case-Control Studies; Chronic Disease; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Humans; Male; Middle Aged; Peptides, Cyclic; Phosphopyruvate Hydratase; Rheumatoid Factor; Smoking; Vimentin

2015
The W620 Polymorphism in PTPN22 Disrupts Its Interaction With Peptidylarginine Deiminase Type 4 and Enhances Citrullination and NETosis.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:9

    Topics: Adult; Aged; Animals; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; DNA, Complementary; Extracellular Traps; Female; Humans; Hydrolases; Male; Mice; Mice, Knockout; Middle Aged; Peptides, Cyclic; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Young Adult

2015
Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype-positive rheumatoid arthritis patients.
    Science translational medicine, 2015, Jun-03, Volume: 7, Issue:290

    Topics: Aged; Arthritis, Rheumatoid; Citrulline; Dendritic Cells; Female; HLA Antigens; Humans; Immunotherapy; Male; Middle Aged; Peptides

2015
Targeting of anti-citrullinated protein/peptide antibodies in rheumatoid arthritis using peptides mimicking endogenously citrullinated fibrinogen antigens.
    Arthritis research & therapy, 2015, Jun-10, Volume: 17

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrinogen; Humans; Peptides; Peptides, Cyclic; Protein Array Analysis

2015
Anti-Citrullinated Protein Antibodies Induce Macrophage Subset Disequilibrium in RA Patients.
    Inflammation, 2015, Volume: 38, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Cells, Cultured; Citrulline; Female; Humans; Interferon Regulatory Factors; Macrophages; Male; Peptides; Phenotype; RNA Interference; Synovial Fluid; Transfection

2015
Characterization of the Hypercitrullination Reaction in Human Neutrophils and Other Leukocytes.
    Mediators of inflammation, 2015, Volume: 2015

    Topics: Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Citrulline; Humans; Ionomycin; Leukocytes; Neutrophils; Perforin

2015
Citrulline is an Essential Constituent of Antigenic Determinants Recognized by Rheumatoid Arthritis-specific Autoantibodies. 1998.
    Journal of immunology (Baltimore, Md. : 1950), 2015, Jul-01, Volume: 195, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; Citrulline; History, 20th Century; Humans

2015
Rheumatoid arthritis: First-in-human phase I trial of DC immunotherapy for early RA.
    Nature reviews. Rheumatology, 2015, Volume: 11, Issue:8

    Topics: Arthritis, Rheumatoid; Citrulline; Dendritic Cells; Female; HLA Antigens; Humans; Immunotherapy; Male; Peptides

2015
Comparative analysis of autoantibodies targeting peptidylarginine deiminase type 4, mutated citrullinated vimentin and cyclic citrullinated peptides in rheumatoid arthritis: associations with cytokine profiles, clinical and genetic features.
    Clinical and experimental immunology, 2015, Volume: 182, Issue:2

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Blood Sedimentation; Citrulline; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Gene Frequency; Genotype; Humans; Hydrolases; Male; Middle Aged; Mutant Proteins; Peptides, Cyclic; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Severity of Illness Index; Th1 Cells; Th17 Cells; Th2 Cells; Vimentin

2015
Crystal structure of Porphyromonas gingivalis peptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:6

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoimmunity; Catalysis; Citrulline; Crystallization; Crystallography, X-Ray; Humans; Hydrolases; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Porphyromonas gingivalis; Protein-Arginine Deiminases; Structure-Activity Relationship; Substrate Specificity

2016
Local Joint inflammation and histone citrullination in a murine model of the transition from preclinical autoimmunity to inflammatory arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:11

    Topics: Animals; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Disease Models, Animal; Disease Progression; Histones; Humans; Inflammation; Joints; Proteomics

2015
Release of Active Peptidyl Arginine Deiminases by Neutrophils Can Explain Production of Extracellular Citrullinated Autoantigens in Rheumatoid Arthritis Synovial Fluid.
    Arthritis & rheumatology (Hoboken, N.J.), 2015, Volume: 67, Issue:12

    Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantigens; Blotting, Western; Case-Control Studies; Cell Death; Citrulline; DNA; Extracellular Traps; Female; Fluorescent Antibody Technique; Humans; Hydrolases; Male; Mass Spectrometry; Middle Aged; Neutrophils; Osteoarthritis, Knee; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Synovial Fluid

2015
Radiographic Structural Damage Is Worse in the Dominant than the Non-Dominant Hand in Individuals with Early Rheumatoid Arthritis.
    PloS one, 2015, Volume: 10, Issue:8

    Topics: Arthritis, Rheumatoid; Arthrography; Autoantibodies; Bone Density; C-Reactive Protein; Citrulline; Disease Progression; Female; Functional Laterality; Hand; Humans; Male; Middle Aged; Retrospective Studies; Stress, Mechanical; Wrist Joint

2015
Anti-citrullinated protein antibodies contribute to platelet activation in rheumatoid arthritis.
    Arthritis research & therapy, 2015, Aug-24, Volume: 17

    Topics: Arthritis, Rheumatoid; Autoantibodies; Blood Platelets; CD40 Ligand; Citrulline; Female; Flow Cytometry; Humans; Immunoglobulin G; Male; Middle Aged; P-Selectin; Peptides, Cyclic; Platelet Activation

2015
Anti-citrullinated protein antibodies promote apoptosis of mature human Saos-2 osteoblasts via cell-surface binding to citrullinated heat shock protein 60.
    Immunobiology, 2016, Volume: 221, Issue:1

    Topics: Adult; Aged; Apoptosis; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Cell Line; Chaperonin 60; Citrulline; Cloning, Molecular; Female; Humans; Interleukin-6; Interleukin-8; Joints; Male; Middle Aged; Mitochondrial Proteins; Osteoblasts; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; Toll-Like Receptor 4

2016
Studies on ageing and the severity of radiographic joint damage in rheumatoid arthritis.
    Arthritis research & therapy, 2015, Aug-24, Volume: 17

    Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Aging; Arthritis, Rheumatoid; Autoantibodies; C-Reactive Protein; Citrulline; Cohort Studies; Europe; Female; Humans; Inflammation; Joints; Magnetic Resonance Imaging; Male; Middle Aged; North America; Peptides, Cyclic; Radiography; Severity of Illness Index

2015
Tolerogenic citrullinated peptide for arthritis.
    Oncotarget, 2015, Aug-14, Volume: 6, Issue:23

    Topics: Animals; Arthritis, Rheumatoid; Autoantigens; Citrulline; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Mice; Peptides, Cyclic; Protein Processing, Post-Translational

2015
Rheumatoid factor, not antibodies against citrullinated proteins, is associated with baseline disease activity in rheumatoid arthritis clinical trials.
    Arthritis research & therapy, 2015, Aug-26, Volume: 17

    Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Peptides, Cyclic; Randomized Controlled Trials as Topic; Rheumatoid Factor; Rituximab; Severity of Illness Index

2015
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate.
    Arthritis research & therapy, 2015, Sep-04, Volume: 17

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Linear Models; Male; Methotrexate; Middle Aged; Phosphopyruvate Hydratase; RANK Ligand; Synovial Membrane; Time Factors; Vimentin

2015
An investigation of the added value of an ACPA multiplex assay in an early rheumatoid arthritis setting.
    Arthritis research & therapy, 2015, Oct-05, Volume: 17

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Early Diagnosis; Enzyme-Linked Immunosorbent Assay; Humans; Peptides, Cyclic; Prognosis; Reproducibility of Results; Sensitivity and Specificity; Vimentin

2015
Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies.
    Arthritis research & therapy, 2015, Nov-20, Volume: 17

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Female; Humans; Leptin; Male; Middle Aged; Obesity; Receptors, Leptin; Young Adult

2015
Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Bone and Bones; Bone Resorption; Cell Culture Techniques; Chemokines; Citrulline; Female; Humans; Hydrolases; Immunohistochemistry; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Middle Aged; Osteoclasts; Protein-Arginine Deiminases; Receptors, Interleukin-8; Sulfonamides; Synovial Fluid; X-Ray Microtomography

2016
Contribution of Peptide Backbone to Anti-Citrullinated Peptide Antibody Reactivity.
    PloS one, 2015, Volume: 10, Issue:12

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cross Reactions; Epitopes; Fibrinogen; Glycine; Humans; Immunoassay; Molecular Sequence Data; Peptides; Peptides, Cyclic; Sequence Homology, Amino Acid

2015
Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:10

    Topics: Aged; Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; B-Lymphocytes; Citrulline; Extracellular Traps; Female; Histones; Humans; Joints; Middle Aged; Synovial Membrane

2016
Rheumatoid arthritis: Osteoclasts and ACPAs--the joint link.
    Nature reviews. Rheumatology, 2016, Volume: 12, Issue:2

    Topics: Animals; Arthralgia; Arthritis, Rheumatoid; Autoantibodies; Bone and Bones; Bone Resorption; Chemokine CXCL1; Citrulline; Female; Humans; Hydrolases; Interleukin-8; Male; Nociception; Osteoclasts

2016
Evaluation of the association between anticarbamylated protein antibodies and the longitudinal course of functional ability in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Carbamates; Citrulline; Cohort Studies; Disease Progression; Female; Humans; Linear Models; Male; Middle Aged; Netherlands; Prognosis; Rheumatoid Factor; Sweden

2016
A Novel HLA-DRB1*10:01-Restricted T Cell Epitope From Citrullinated Type II Collagen Relevant to Rheumatoid Arthritis.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:5

    Topics: Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Collagen Type II; Cytokines; Epitopes, T-Lymphocyte; Female; High-Throughput Nucleotide Sequencing; HLA-DRB1 Chains; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Male; Middle Aged; Receptors, Antigen, T-Cell, alpha-beta; Sequence Analysis, DNA

2016
Bone loss, pain and inflammation: three faces of ACPA in RA pathogenesis.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:4

    Topics: Animals; Arthralgia; Arthritis, Rheumatoid; Autoantibodies; Bone and Bones; Bone Resorption; Chemokine CXCL1; Citrulline; Female; Humans; Hydrolases; Interleukin-8; Male; Nociception; Osteoclasts

2016
In vitro eradication of citrullinated protein specific B-lymphocytes of rheumatoid arthritis patients by targeted bifunctional nanoparticles.
    Arthritis research & therapy, 2016, Jan-16, Volume: 18

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Cross-Sectional Studies; Drug Delivery Systems; Female; Humans; Male; Middle Aged; Nanoparticles; Pilot Projects

2016
Application of synthetic peptides for detection of anti-citrullinated peptide antibodies.
    Peptides, 2016, Volume: 76

    Topics: Amino Acid Sequence; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Herpesvirus 4, Human; Humans; Lupus Erythematosus, Systemic; Molecular Sequence Data; Peptide Fragments; Peptides; Viral Proteins

2016
Rheumatoid factor isotypes in relation to antibodies against citrullinated peptides and carbamylated proteins before the onset of rheumatoid arthritis.
    Arthritis research & therapy, 2016, Feb-09, Volume: 18

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Citrulline; Cohort Studies; Female; Filaggrin Proteins; Humans; Immunoglobulin Isotypes; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor

2016
Antibodies to native and citrullinated RA33 (hnRNP A2/B1) challenge citrullination as the inciting principle underlying loss of tolerance in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2016, Volume: 75, Issue:11

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Female; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Immune Tolerance; Longitudinal Studies; Male; Peptides, Cyclic; Synovial Fluid

2016
Characterization and Localization of Citrullinated Proteoglycan Aggrecan in Human Articular Cartilage.
    PloS one, 2016, Volume: 11, Issue:3

    Topics: Adult; Aggrecans; Antibody Specificity; Arginine; Arthritis, Rheumatoid; Blotting, Western; Cartilage, Articular; Citrulline; Complex Mixtures; Epitopes; Humans; Immunohistochemistry; Osteoarthritis; Protein Structure, Tertiary; Tissue Extracts

2016
Role of Anti-Carbamylated Protein Antibodies Compared to Anti-Citrullinated Protein Antibodies in Indigenous North Americans With Rheumatoid Arthritis, Their First-Degree Relatives, and Healthy Controls.
    Arthritis & rheumatology (Hoboken, N.J.), 2016, Volume: 68, Issue:9

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Indians, North American; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor

2016
Identification of citrullinated peptides in the synovial fluid of patients with rheumatoid arthritis using LC-MALDI-TOF/TOF.
    Clinical rheumatology, 2016, Volume: 35, Issue:9

    Topics: Aged; Arthritis, Rheumatoid; Autoantigens; Citrulline; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Synovial Fluid

2016
Comparative analysis of novel autoantibody isotypes against citrullinated-inter-alpha-trypsin inhibitor heavy chain 3 (ITIH3)(542-556) peptide in serum from Taiwanese females with rheumatoid arthritis, primary Sjögren's syndrome and secondary Sjögren's sy
    Journal of proteomics, 2016, 06-01, Volume: 141

    Topics: Adult; Alpha-Globulins; Arthritis, Rheumatoid; Autoantibodies; Blood Proteins; Citrulline; Female; Humans; Immunoglobulin Isotypes; Middle Aged; Sjogren's Syndrome; Taiwan

2016
Autophagy generates citrullinated peptides in human synoviocytes: a possible trigger for anti-citrullinated peptide antibodies.
    Rheumatology (Oxford, England), 2016, Volume: 55, Issue:8

    Topics: Antibodies; Arthritis, Rheumatoid; Autophagy; Cells, Cultured; Citrulline; Female; Fibroblasts; Filaggrin Proteins; Humans; Hydrolases; Intermediate Filament Proteins; Leukocytes, Mononuclear; Male; Middle Aged; Osteoarthritis; Peptides, Cyclic; Phosphopyruvate Hydratase; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synoviocytes; Vimentin

2016
Ureido group-specific antibodies are induced in rabbits immunized with citrulline- or homocitrulline-containing antigens.
    Autoimmunity, 2016, Volume: 49, Issue:7

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Carrier Proteins; Citrulline; Collagen; Disease Models, Animal; Immunization; Peptides; Protein Binding; Rabbits

2016
Reduced glutathione as a physiological co-activator in the activation of peptidylarginine deiminase.
    Arthritis research & therapy, 2016, 05-05, Volume: 18, Issue:1

    Topics: Arthritis, Rheumatoid; Citrulline; Enzyme Activation; Glutathione; Humans; Hydrolases; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Synovial Fluid

2016
Decreased severity of experimental autoimmune arthritis in peptidylarginine deiminase type 4 knockout mice.
    BMC musculoskeletal disorders, 2016, 05-05, Volume: 17

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Citrulline; Collagen Type II; Cytokines; Disease Progression; Enzyme-Linked Immunosorbent Assay; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Hydrolases; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein-Arginine Deiminase Type 4; Severity of Illness Index; Tumor Necrosis Factor-alpha

2016
Antibodies directed against endogenous and exogenous citrullinated antigens pre-date the onset of rheumatoid arthritis.
    Arthritis research & therapy, 2016, 06-03, Volume: 18, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; HLA-DRB1 Chains; Humans; Male; Middle Aged; Peptides, Cyclic; Sweden

2016
Antimodified protein antibody response pattern influences the risk for disease relapse in patients with rheumatoid arthritis tapering disease modifying antirheumatic drugs.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:2

    Topics: Acetates; Acetylation; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Carbamates; Citrulline; Humans; Logistic Models; Lysine; Multivariate Analysis; Ornithine; Peptides; Peptides, Cyclic; Prognosis; Randomized Controlled Trials as Topic; Recurrence; Vimentin

2017
The dependency on neighboring amino acids for reactivity of anti-citrullinated protein antibodies to citrullinated proteins.
    Scandinavian journal of clinical and laboratory investigation, 2016, Volume: 76, Issue:5

    Topics: Amino Acid Motifs; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Citrulline; Epitopes; Humans; Ovalbumin; Peptides

2016
The target of ACPA.
    Rheumatology (Oxford, England), 2016, Volume: 55, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic

2016
Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation.
    Arthritis research & therapy, 2016, 07-22, Volume: 18, Issue:1

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Blotting, Western; Citrulline; Humans; Hydrolases; Mice; Mice, Transgenic; Pneumonia; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Tumor Necrosis Factor-alpha

2016
Immune Recognition of Citrullinated Proteoglycan Aggrecan Epitopes in Mice with Proteoglycan-Induced Arthritis and in Patients with Rheumatoid Arthritis.
    PloS one, 2016, Volume: 11, Issue:7

    Topics: Aggrecans; Amino Acid Sequence; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; B-Lymphocytes; Case-Control Studies; Cell Proliferation; Cells, Cultured; Citrulline; Cytokines; Enzyme-Linked Immunosorbent Assay; Epitopes; Flow Cytometry; Humans; Mice; Proteoglycans; Spleen; T-Lymphocytes

2016
Contribution of a Non-classical HLA Gene, HLA-DOA, to the Risk of Rheumatoid Arthritis.
    American journal of human genetics, 2016, Aug-04, Volume: 99, Issue:2

    Topics: Arthritis, Rheumatoid; Asian People; Autoantibodies; Citrulline; Ethnicity; Europe; Genetic Predisposition to Disease; Genome-Wide Association Study; HLA-D Antigens; HLA-DRB1 Chains; Humans; Japan; Linkage Disequilibrium; Phenotype; Polymorphism, Single Nucleotide; White People

2016
Regulatory CD4+ T-Cell Subsets and Anti-Citrullinated Protein Antibody Repertoire: Potential Biomarkers for Arthritis Development in Seropositive Arthralgia Patients?
    PloS one, 2016, Volume: 11, Issue:9

    Topics: Arthralgia; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Female; Flow Cytometry; Humans; Male; Middle Aged; Prospective Studies; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory

2016
Proteome Analysis of Rheumatoid Arthritis Gut Mucosa.
    Journal of proteome research, 2017, 01-06, Volume: 16, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Colon; Epithelial Cells; Female; Gene Expression Regulation; Humans; Intestinal Mucosa; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Peptides, Cyclic; Proteome; Tetrahydrofolate Dehydrogenase

2017
Rheumatoid arthritis: Smoking influences autoimmunity to vimentin.
    Nature reviews. Rheumatology, 2016, Volume: 12, Issue:11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Humans; Smoking; Vimentin

2016
Extracellular Proteome and Citrullinome of the Oral Pathogen Porphyromonas gingivalis.
    Journal of proteome research, 2016, 12-02, Volume: 15, Issue:12

    Topics: Arthritis, Rheumatoid; Bacterial Proteins; Bacteroidaceae Infections; Citrulline; Humans; Hydrolases; Periodontitis; Porphyromonas gingivalis; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Proteome; Virulence Factors

2016
Rheumatoid arthritis antigens homocitrulline and citrulline are generated by local myeloperoxidase and peptidyl arginine deiminases 2, 3 and 4 in rheumatoid nodule and synovial tissue.
    Arthritis research & therapy, 2016, 10-20, Volume: 18, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Autoantigens; Blotting, Western; Chromatography, High Pressure Liquid; Citrulline; Female; Humans; Hydrolases; Immunohistochemistry; Male; Middle Aged; Peroxidase; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases

2016
A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22.
    JCI insight, 2016, Oct-20, Volume: 1, Issue:17

    Topics: Adult; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Ataxia Telangiectasia Mutated Proteins; Citrulline; Cytokines; Female; Gene Expression Regulation; Humans; Interleukin-2; Leukocytes, Mononuclear; Male; Middle Aged; Phosphofructokinase-2; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Risk Factors; Th17 Cells

2016
Characterization of Autoantigens Targeted by Anti-Citrullinated Protein Antibodies In Vivo: Prominent Role for Epitopes Derived from Histone 4 Proteins.
    PloS one, 2016, Volume: 11, Issue:10

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Epitopes; Histones; Humans; Peptides, Cyclic; Synovial Fluid

2016
The increased ability to present citrullinated peptides is not unique to HLA-SE molecules: arginine-to-citrulline conversion also enhances peptide affinity for HLA-DQ molecules.
    Arthritis research & therapy, 2016, 11-03, Volume: 18, Issue:1

    Topics: Antigen Presentation; Arginine; Arthritis, Rheumatoid; Autoantigens; Cell Line; Citrulline; HLA-DQ Antigens; Humans; Models, Molecular; Peptides, Cyclic

2016
The lung microbiota in early rheumatoid arthritis and autoimmunity.
    Microbiome, 2016, 11-17, Volume: 4, Issue:1

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Bacteria; Base Sequence; Bronchoalveolar Lavage Fluid; CD4-CD8 Ratio; Citrulline; Dysbiosis; Female; High-Throughput Nucleotide Sequencing; Humans; Lung; Male; Microbiota; Middle Aged; RNA, Ribosomal, 16S; Sarcoidosis, Pulmonary; Sequence Analysis, DNA; Young Adult

2016
Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study.
    Arthritis research & therapy, 2016, 12-01, Volume: 18, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Fluorescent Antibody Technique; Humans; Japan; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Smoking

2016
Antibody responses to de novo identified citrullinated fibrinogen peptides in rheumatoid arthritis and visualization of the corresponding B cells.
    Arthritis research & therapy, 2016, 12-01, Volume: 18, Issue:1

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; B-Lymphocytes; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Flow Cytometry; Humans; Male; Middle Aged; Peptides; Young Adult

2016
Aggregatibacter actinomycetemcomitans-induced hypercitrullination links periodontal infection to autoimmunity in rheumatoid arthritis.
    Science translational medicine, 2016, 12-14, Volume: 8, Issue:369

    Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Citrullinated Protein Antibodies; Arthritis, Rheumatoid; Autoantigens; Case-Control Studies; Chronic Disease; Citrulline; Clinical Trials as Topic; Female; HLA-DRB1 Chains; Humans; Male; Middle Aged; Neutrophils; Pasteurellaceae Infections; Periodontitis; Prospective Studies

2016
Physical Characteristics of a Citrullinated Pro-Filaggrin Epitope Recognized by Anti-Citrullinated Protein Antibodies in Rheumatoid Arthritis Sera.
    PloS one, 2016, Volume: 11, Issue:12

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Biotin; Case-Control Studies; Citrulline; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitopes; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Peptides; Peptides, Cyclic

2016
High-Titer Rheumatoid Arthritis Antibodies Preferentially Bind Fibrinogen Citrullinated by Peptidylarginine Deiminase 4.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Case-Control Studies; Chromatography, Liquid; Citrulline; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Humans; Hydrolases; Mass Spectrometry; Peptides, Cyclic; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2017
In vitro allogeneic immune cell response to mesenchymal stromal cells derived from human adipose in patients with rheumatoid arthritis.
    Cellular immunology, 2017, Volume: 314

    Topics: Adipose Tissue; Adolescent; Adult; Antibodies; Arthritis, Rheumatoid; Cells, Cultured; Citrulline; Coculture Techniques; Cytokines; Female; Humans; Immunity; Immunotherapy; Inflammation Mediators; Isoantigens; Male; Mesenchymal Stem Cells; Middle Aged; T-Lymphocytes, Regulatory; Young Adult

2017
Protein arginine deiminase 4 inhibition is sufficient for the amelioration of collagen-induced arthritis.
    Clinical and experimental immunology, 2017, Volume: 188, Issue:2

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Benzimidazoles; Bone and Bones; Cartilage; Citrulline; Collagen; Complement C3; Hydrolases; Mice; Protein-Arginine Deiminase Type 4; Proteomics; Synovial Membrane

2017
Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2017, Volume: 76, Issue:7

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Carbamates; Case-Control Studies; Citrulline; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Humans; Immunoblotting; Immunoglobulin G; Mice; Nicotiana; Protein Isoforms; Rabbits; Smoke; Smoking; Vimentin

2017
To Prevent Rheumatoid Arthritis, Look Past the Joints to the Gums.
    JAMA, 2017, Mar-28, Volume: 317, Issue:12

    Topics: Aggregatibacter actinomycetemcomitans; Arthritis, Rheumatoid; Autoantibodies; Calcium; Citrulline; Gingiva; Humans; Neutrophils; Periodontitis; Proteins

2017
Identification of carbamylated alpha 1 anti-trypsin (A1AT) as an antigenic target of anti-CarP antibodies in patients with rheumatoid arthritis.
    Journal of autoimmunity, 2017, Volume: 80

    Topics: alpha 1-Antitrypsin; Arthralgia; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Chromatography, Ion Exchange; Citrulline; Computational Biology; Enzyme-Linked Immunosorbent Assay; Humans; Mass Spectrometry; Peptide Fragments; Protein Conformation; Protein Processing, Post-Translational; Synovial Membrane

2017
Brief Report: Anti-Carbamylated Protein Antibodies in Rheumatoid Arthritis Patients Are Reactive With Specific Epitopes of the Human Fibrinogen β-Chain.
    Arthritis & rheumatology (Hoboken, N.J.), 2017, Volume: 69, Issue:7

    Topics: Arthritis, Rheumatoid; Autoantibodies; Carbamates; Chromatography, Liquid; Citrulline; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrinogen; Humans; Immunoblotting; Mass Spectrometry

2017
The onset site of rheumatoid arthritis: the joints or the lung?
    Reumatismo, 2016, 12-31, Volume: 68, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Lung Diseases, Interstitial; Prognosis

2016
Prevalence and significance of antibodies to citrullinated human papilloma virus-47 E2345-362 in rheumatoid arthritis.
    Journal of autoimmunity, 2008, Volume: 31, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alphapapillomavirus; Antibodies; Arthritis, Rheumatoid; China; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Peptides; Prevalence; Reference Standards; Young Adult

2008
[The diagnostic accuracy of anti-citrulline antibody assessment in the diagnosis of patients suspected of rheumatoid arthritis by a general practitioner].
    Nederlands tijdschrift voor geneeskunde, 2008, May-24, Volume: 152, Issue:21

    Topics: Arthritis, Rheumatoid; Citrulline; Diagnostic Tests, Routine; Humans; Sensitivity and Specificity

2008
Detection of citrullinated proteins in synovial fluids derived from patients with rheumatoid arthritis by proteomics-based analysis.
    Annals of clinical biochemistry, 2008, Volume: 45, Issue:Pt 4

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Citrulline; Electrophoresis, Polyacrylamide Gel; Humans; Molecular Sequence Data; Proteins; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synovial Fluid; Trypsin

2008
Multiple antibody reactivities to citrullinated antigens in sera from patients with rheumatoid arthritis: association with HLA-DRB1 alleles.
    Annals of the rheumatic diseases, 2009, Volume: 68, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Alleles; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers, Tumor; Citrulline; Collagen Type II; Cross Reactions; DNA-Binding Proteins; Female; Fibrinogen; Genotype; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Immunoglobulin A; Male; Middle Aged; Peptides, Cyclic; Phosphopyruvate Hydratase; Tumor Suppressor Proteins; Young Adult

2009
Synovial fluid is a site of citrullination of autoantigens in inflammatory arthritis.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:8

    Topics: Arthritis, Rheumatoid; Autoantigens; Biomarkers, Tumor; Case-Control Studies; Citrulline; DNA-Binding Proteins; Humans; Hydrolases; Osteoarthritis; Peptides, Cyclic; Phosphopyruvate Hydratase; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Spondylarthritis; Synovial Fluid; Tumor Suppressor Proteins

2008
Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis.
    Arthritis research & therapy, 2008, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antigen-Antibody Complex; Arthritis, Juvenile; Arthritis, Rheumatoid; Autoimmunity; Case-Control Studies; Child; Citrulline; Complement C1q; Complement C3; Female; Fibrinogen; Humans; Immunoassay; Male; Middle Aged; Synovial Membrane; Young Adult

2008
[Diagnostic value of antibodies to modified citrullinized vimentin in early rheumatoid arthritis].
    Klinicheskaia laboratornaia diagnostika, 2008, Issue:8

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Middle Aged; Predictive Value of Tests; ROC Curve; Vimentin

2008
Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Bacterial Proteins; Bacteroidaceae Infections; Biomarkers, Tumor; Case-Control Studies; Citrulline; DNA-Binding Proteins; Epitope Mapping; Female; Humans; Male; Phosphopyruvate Hydratase; Porphyromonas gingivalis; Tumor Suppressor Proteins

2008
An intriguing relationship between the immune response to citrullinated vimentin and the HLA shared epitope: comment on the article by Verpoort et al.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:10

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; Epitopes; HLA-DR4 Antigen; Humans; Mice; Mice, Transgenic; Microarray Analysis; Peptides, Cyclic; Vimentin

2008
Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination.
    Arthritis research & therapy, 2008, Volume: 10, Issue:5

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Blotting, Western; Citrulline; Demyelinating Diseases; Encephalomyelitis, Autoimmune, Experimental; Enzyme-Linked Immunosorbent Assay; Epitopes, B-Lymphocyte; Mass Spectrometry; Mice; Protein Array Analysis

2008
Proinflammatory cytokine profiles of patients with elderly-onset rheumatoid arthritis: a comparison with younger-onset disease.
    Gerontology, 2009, Volume: 55, Issue:3

    Topics: Adult; Age of Onset; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Peptides, Cyclic; Rheumatoid Factor; Treatment Outcome

2009
Citrullinated fibrinogen shows defects in FPA and FPB release and fibrin polymerization catalyzed by thrombin.
    Clinica chimica acta; international journal of clinical chemistry, 2009, Volume: 401, Issue:1-2

    Topics: Animals; Arthritis, Rheumatoid; Catalysis; Citrulline; Fibrin; Fibrinogen; Fibrinopeptide A; Fibrinopeptide B; Microscopy, Electron, Scanning; Rabbits; Thrombin

2009
Different patterns of associations with anti-citrullinated protein antibody-positive and anti-citrullinated protein antibody-negative rheumatoid arthritis in the extended major histocompatibility complex region.
    Arthritis and rheumatism, 2009, Volume: 60, Issue:1

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Genetic Predisposition to Disease; Genotype; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Linkage Disequilibrium; Peptides, Cyclic; Polymorphism, Single Nucleotide; Risk Factors

2009
Antibody against mutated citrullinated vimentin: a new sensitive marker in the diagnosis of rheumatoid arthritis.
    Rheumatology international, 2009, Volume: 29, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Female; Humans; Male; Middle Aged; Mutation; Peptides, Cyclic; Sensitivity and Specificity; Sex Characteristics; Vimentin

2009
Expression and citrullination of keratin in synovial tissue of rheumatoid arthritis.
    Rheumatology international, 2009, Volume: 29, Issue:11

    Topics: Adult; Aged; Arthritis, Rheumatoid; Blotting, Western; Citrulline; Female; Fluorescent Antibody Technique; Humans; Immunohistochemistry; Keratins; Male; Middle Aged; Synovial Membrane

2009
Plasma asymmetric dimethylarginine is related to anticitrullinated protein antibodies in rheumatoid arthritis of short duration.
    Metabolism: clinical and experimental, 2009, Volume: 58, Issue:3

    Topics: Antibodies; Arginine; Arthritis, Rheumatoid; Blood Proteins; Citrulline; Humans; Nitric Oxide; Time Factors

2009
Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoantibody systems.
    Arthritis research & therapy, 2009, Volume: 11, Issue:3

    Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Databases, Factual; Female; Humans; Immunoglobulin M; Male; Middle Aged; Rheumatoid Factor

2009
Are anti-citrulline autoantibodies better serum markers for rheumatoid arthritis than rheumatoid factor in Thai population?
    Rheumatology international, 2010, Volume: 30, Issue:6

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Cohort Studies; Cost-Benefit Analysis; Female; Humans; Immunoenzyme Techniques; Male; Middle Aged; Predictive Value of Tests; Rheumatoid Factor; Sensitivity and Specificity; Severity of Illness Index; Thailand; Young Adult

2010
Prediction of radiographic progression in rheumatoid arthritis and the role of antibodies against mutated citrullinated vimentin: results from a 10-year prospective study.
    Annals of the rheumatic diseases, 2010, Volume: 69, Issue:2

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Disease Progression; Female; Hand Joints; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Middle Aged; Peptides, Cyclic; Prognosis; Prospective Studies; Radiography; Vimentin

2010
Diagnostic and prognostic value of antibodies against chimeric fibrin/filaggrin citrullinated synthetic peptides in rheumatoid arthritis.
    Arthritis research & therapy, 2009, Volume: 11, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Prognosis; Recombinant Fusion Proteins; Sensitivity and Specificity

2009
Dietary fish and fish oil and the risk of rheumatoid arthritis.
    Epidemiology (Cambridge, Mass.), 2009, Volume: 20, Issue:6

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Citrulline; Confidence Intervals; Female; Fish Oils; Fish Products; Humans; Male; Middle Aged; Rheumatoid Factor; Risk Assessment; Surveys and Questionnaires; Sweden; Young Adult

2009
Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems.
    Arthritis research & therapy, 2009, Volume: 11, Issue:5

    Topics: Acute-Phase Reaction; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Humans; Immunoglobulin M; Rheumatoid Factor

2009
Positive anti-citrullinated protein antibody status and small joint arthritis are consistent predictors of chronic disease in patients with very early arthritis: results from the NOR-VEAC cohort.
    Arthritis research & therapy, 2009, Volume: 11, Issue:5

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Chronic Disease; Citrulline; Cohort Studies; Disease Progression; Female; Humans; Male; Middle Aged

2009
Comparison of chemiluminescence enzyme immunoassay (CLEIA) with ELISA for the determination of anti-cyclic citrullinated peptide antibodies.
    Clinica chimica acta; international journal of clinical chemistry, 2010, Volume: 411, Issue:1-2

    Topics: Antibodies; Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Luminescence; Peptides, Cyclic; Reproducibility of Results; Sensitivity and Specificity

2010
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
    The Journal of rheumatology, 2009, Volume: 36, Issue:12

    Topics: Arthritis, Rheumatoid; Asian People; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Joints; Lupus Erythematosus, Systemic; Peptides, Cyclic

2009
Rheumatoid arthritis, Proteus, anti-CCP antibodies and Karl Popper.
    Autoimmunity reviews, 2010, Volume: 9, Issue:4

    Topics: Animals; Antibodies, Bacterial; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross Reactions; Epitopes; Hemolysin Proteins; HLA-DR1 Antigen; HLA-DR4 Antigen; Humans; Hyaline Cartilage; Molecular Mimicry; Proteus Infections; Proteus mirabilis; Urinary Tract Infections

2010
Specific interaction between genotype, smoking and autoimmunity to citrullinated alpha-enolase in the etiology of rheumatoid arthritis.
    Nature genetics, 2009, Volume: 41, Issue:12

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Case-Control Studies; Citrulline; Genetic Predisposition to Disease; Genotype; Humans; Phosphopyruvate Hydratase; Smoking

2009
[Rheumatoid arthritis (updated Current Care guideline)].
    Duodecim; laaketieteellinen aikakauskirja, 2009, Volume: 125, Issue:19

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Cardiovascular Diseases; Citrulline; Diagnosis, Differential; Humans

2009
Rheumatoid arthritis-specific autoantibodies to peptidyl arginine deiminase type 4 inhibit citrullination of fibrinogen.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Epitopes, B-Lymphocyte; Fibrinogen; Humans; Hydrolases; Peptides; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2010
Response of Th17 cells to a citrullinated arthritogenic aggrecan peptide in patients with rheumatoid arthritis.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:1

    Topics: Aggrecans; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; CD4-Positive T-Lymphocytes; Cells, Cultured; Citrulline; Culture Media, Conditioned; Cytokines; Enzyme-Linked Immunosorbent Assay; Epitopes, T-Lymphocyte; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Peptide Fragments

2010
Antibodies to several citrullinated antigens are enriched in the joints of rheumatoid arthritis patients.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers, Tumor; Citrulline; Collagen Type II; DNA-Binding Proteins; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Genotype; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Middle Aged; Mutation; Peptides, Cyclic; Phosphopyruvate Hydratase; Synovial Fluid; Tumor Suppressor Proteins; Vimentin; Young Adult

2010
Levels of anti-citrullinated protein antibodies and IgM rheumatoid factor are not associated with outcome in early arthritis patients: a cohort study.
    Arthritis research & therapy, 2010, Volume: 12, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin M; Male; Middle Aged; Proteins; Rheumatoid Factor; Severity of Illness Index; Treatment Outcome

2010
Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis.
    Proceedings of the National Academy of Sciences of the United States of America, 2010, Feb-09, Volume: 107, Issue:6

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Basophils; Citrulline; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Humans; Immunoglobulin E; Leukocytes, Mononuclear; Mast Cells; Osteoarthritis; Peptides, Cyclic; Protein Binding; Proto-Oncogene Proteins c-kit; Receptors, IgG; Synovial Membrane

2010
Evidence for interaction between 5-hydroxytryptamine (serotonin) receptor 2A and MHC type II molecules in the development of rheumatoid arthritis.
    European journal of human genetics : EJHG, 2010, Volume: 18, Issue:7

    Topics: Adult; Alleles; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Confidence Intervals; Epitopes; Female; Gene Expression Regulation; Haplotypes; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Middle Aged; Odds Ratio; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Synovial Membrane

2010
[Impact of citrullination upon antigenicity of fibrinogen].
    Zhonghua yi xue za zhi, 2010, Mar-09, Volume: 90, Issue:9

    Topics: Adult; Aged; Amino Acid Motifs; Arthritis, Rheumatoid; Case-Control Studies; Cells, Cultured; Citrulline; Female; Fibrinogen; HLA-DR4 Antigen; Humans; Male; Middle Aged; T-Lymphocytes

2010
Diagnostic performances of anti-cyclic citrullinated peptide antibodies type IgM, IgA and IgG in Syrian patients with rheumatoid arthritis.
    Clinical laboratory, 2010, Volume: 56, Issue:3-4

    Topics: Antibodies; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Autoantibodies; Blood Banks; Blood Donors; Citrulline; Female; Humans; Male; Reference Values; Sensitivity and Specificity; Syria

2010
Carbamylation-dependent activation of T cells: a novel mechanism in the pathogenesis of autoimmune arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2010, Jun-15, Volume: 184, Issue:12

    Topics: Adoptive Transfer; Adult; Aged; Aged, 80 and over; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Separation; Citrulline; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Humans; Lymphocyte Activation; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Middle Aged; Protein Processing, Post-Translational; T-Lymphocytes

2010
Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: implications for autoimmunity in rheumatoid arthritis.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:9

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoimmunity; Biomarkers, Tumor; Chromatography, High Pressure Liquid; Citrulline; DNA-Binding Proteins; Fibrinogen; Gene Knockout Techniques; Gene Silencing; Humans; Hydrolases; Molecular Sequence Data; Organisms, Genetically Modified; Peptide Mapping; Periodontitis; Phosphopyruvate Hydratase; Porphyromonas gingivalis; Protein-Arginine Deiminases; Self Tolerance; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Tumor Suppressor Proteins

2010
HLA-DR1001 presents "altered-self" peptides derived from joint-associated proteins by accepting citrulline in three of its binding pockets.
    Arthritis and rheumatism, 2010, Volume: 62, Issue:10

    Topics: Antibody Affinity; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; CD4-Positive T-Lymphocytes; Citrulline; Epitopes; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Peptides; Peptides, Cyclic

2010
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins.
    Arthritis research & therapy, 2010, Volume: 12, Issue:4

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Fibrinogen; Humans; Synovial Fluid; Vimentin

2010
Interstitial lung disease in rheumatoid arthritis.
    Current rheumatology reports, 2010, Volume: 12, Issue:5

    Topics: Adrenal Cortex Hormones; Antimetabolites; Arthritis, Rheumatoid; Biomarkers; Citrulline; Cyclophosphamide; Humans; Immunosuppressive Agents; Lung Diseases, Interstitial; Mycophenolic Acid; Proteins; Pulmonary Fibrosis; Radiography; Smoking

2010
Anti-cyclic citrullinated peptide antibodies are a collection of anti-citrullinated protein antibodies and contain overlapping and non-overlapping reactivities.
    Annals of the rheumatic diseases, 2011, Volume: 70, Issue:1

    Topics: Antibody Affinity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin G; Peptides, Cyclic

2011
Increased levels of citrullinated antithrombin in plasma of patients with rheumatoid arthritis and colorectal adenocarcinoma determined by a newly developed ELISA using a specific monoclonal antibody.
    Thrombosis and haemostasis, 2010, Volume: 104, Issue:6

    Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibody Specificity; Antithrombins; Arthritis, Rheumatoid; Biomarkers; Blood Coagulation; Citrulline; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Factor Xa Inhibitors; Humans; Protein Processing, Post-Translational; Up-Regulation; Venous Thrombosis

2010
Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis.
    Nature genetics, 2010, Volume: 42, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Citrulline; Environment; Humans; Phosphopyruvate Hydratase

2010
Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor.
    Arthritis and rheumatism, 2011, Volume: 63, Issue:1

    Topics: Animals; Antigen-Antibody Complex; Arthritis, Rheumatoid; Cells, Cultured; Citrulline; Fibrinogen; Humans; Macrophages; Mice; Osteoarthritis; Receptors, IgG; Signal Transduction; Toll-Like Receptor 4

2011
MS analysis of rheumatoid arthritic synovial tissue identifies specific citrullination sites on fibrinogen.
    Proteomics. Clinical applications, 2010, Volume: 4, Issue:5

    Topics: Aged; Amino Acid Sequence; Arthritis, Rheumatoid; Citrulline; Female; Fibrinogen; Humans; Male; Middle Aged; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Synovial Membrane

2010
Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance.
    Arthritis research & therapy, 2010, Volume: 12, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantigens; Blotting, Western; Chromatography, Liquid; Citrulline; Epitope Mapping; Epitopes, B-Lymphocyte; Fibrinogen; Humans; Mass Spectrometry; Microarray Analysis; Surface Plasmon Resonance

2010
Diagnostic value of anti-modified citrullinated vimentin in rheumatoid arthritis.
    International journal of rheumatic diseases, 2010, Volume: 13, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Citrulline; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulin G; Malaysia; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Rheumatoid Factor; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Vimentin

2010
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2011, Apr-01, Volume: 186, Issue:7

    Topics: Amidines; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Collagen Type II; Enzyme Inhibitors; Hydrolases; Immunosuppressive Agents; Male; Mice; Mice, Inbred DBA; Ornithine; Peptides, Cyclic; Protein-Arginine Deiminases; Severity of Illness Index; Synovial Membrane

2011
Association of anti-modified citrullinated vimentin with subclinical atherosclerosis in early rheumatoid arthritis compared with anti-cyclic citrullinated peptide.
    The Journal of rheumatology, 2011, Volume: 38, Issue:5

    Topics: Adult; Aged; Antibodies, Anti-Idiotypic; Apolipoprotein A-I; Apolipoproteins B; Arthritis, Rheumatoid; Atherosclerosis; Autoantibodies; Carotid Artery, Common; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Nephelometry and Turbidimetry; Peptides, Cyclic; Risk Factors; Sensitivity and Specificity; Severity of Illness Index; Ultrasonography; Vimentin

2011
Antibodies to a new viral citrullinated peptide, VCP2: fine specificity and correlation with anti-cyclic citrullinated peptide (CCP) and anti-VCP1 antibodies.
    Clinical and experimental immunology, 2011, Volume: 164, Issue:3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Computational Biology; Epitope Mapping; Epitopes; Epstein-Barr Virus Nuclear Antigens; Female; Herpesvirus 4, Human; Humans; Male; Middle Aged; Peptide Fragments; Viral Proteins

2011
Carbon nanotube composite peptide-based biosensors as putative diagnostic tools for rheumatoid arthritis.
    Biosensors & bioelectronics, 2011, Sep-15, Volume: 27, Issue:1

    Topics: Animals; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Biosensing Techniques; Citrulline; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Nanotubes, Carbon; Peptides; Rabbits; Transducers

2011
Weak CD4+ T-cell responses to citrullinated vimentin in rheumatoid arthritis patients carrying HLA-DR9 alleles.
    Rheumatology international, 2012, Volume: 32, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Proliferation; Cells, Cultured; Chile; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Flow Cytometry; Genotype; HLA-DR Serological Subtypes; Humans; Immunodominant Epitopes; Lymphocyte Activation; Middle Aged; Phenotype; Vimentin

2012
[Methotrexate-induced changes in the concentration of antibodies to mutaded citrullinated vimentin in blood serum of patients with rheumatoid arthritis].
    Terapevticheskii arkhiv, 2011, Volume: 83, Issue:5

    Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Methotrexate; Middle Aged; Mutation; Vimentin

2011
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis.
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:1

    Topics: Actins; Aged; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Cells, Cultured; Citrulline; Female; Humans; Hydrolases; Isoenzymes; Male; Middle Aged; Molecular Sequence Data; Neutrophil Activation; Neutrophils; Protein Structure, Tertiary; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; Substrate Specificity

2012
Clickable enzyme-linked immunosorbent assay.
    Biomacromolecules, 2011, Oct-10, Volume: 12, Issue:10

    Topics: Alkynes; Antibodies; Arthritis, Rheumatoid; Avidin; Azides; Biotin; Catalysis; Citrulline; Click Chemistry; Copper; Enzyme-Linked Immunosorbent Assay; Humans; Immobilized Proteins; Molecular Structure; Peptides

2011
The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted.
    Journal of autoimmunity, 2011, Volume: 37, Issue:4

    Topics: Antibody Specificity; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Fibrin; Humans; Immunodominant Epitopes; Models, Chemical; Peptide Fragments; Protein Conformation; Synovial Membrane

2011
Preventing and curing citrulline-induced autoimmune arthritis in a humanized mouse model using a Th2-polarizing iNKT cell agonist.
    Immunology and cell biology, 2012, Volume: 90, Issue:6

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Citrulline; Female; Galactosylceramides; Glycolipids; HLA-DR4 Antigen; Lymphocyte Activation; Male; Mice; Mice, Transgenic; Natural Killer T-Cells; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells

2012
The use of chimeric vimentin citrullinated peptides for the diagnosis of rheumatoid arthritis.
    Journal of medicinal chemistry, 2011, Nov-10, Volume: 54, Issue:21

    Topics: Aged; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Molecular Sequence Data; Peptide Library; Peptides; Peptides, Cyclic; Sensitivity and Specificity; Solid-Phase Synthesis Techniques; Vimentin

2011
Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.
    Proceedings of the National Academy of Sciences of the United States of America, 2011, Oct-18, Volume: 108, Issue:42

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Blood Proteins; Case-Control Studies; Citrulline; Humans; Immunoglobulin A; Immunoglobulin G; Joints

2011
Rheumatoid arthritis and periodontitis: a possible link via "citation".
    Anaerobe, 2012, Volume: 18, Issue:1

    Topics: Arthritis, Rheumatoid; Citrulline; Humans; Periodontitis; Porphyromonas gingivalis

2012
Anomalies of intra-synovial citrullination: is there any interest in the diagnosis of early rheumatoid arthritis?
    Rheumatology international, 2013, Volume: 33, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Hydrolases; Immunohistochemistry; Male; Middle Aged; Peptides, Cyclic; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synovial Membrane

2013
Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis.
    Arthritis research & therapy, 2011, Volume: 13, Issue:6

    Topics: Amino Acid Sequence; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Collagen Type II; Endoplasmic Reticulum Chaperone BiP; Epitope Mapping; Epitopes; Female; Fluorescent Antibody Technique; Heat-Shock Proteins; Humans; Immunoblotting; Lupus Erythematosus, Systemic; Mice; Mice, Inbred DBA; Molecular Sequence Data

2011
Antibodies to mutated citrullinated vimentin and anti-cyclic citrullinated peptide antibodies in inflammatory bowel disease and related arthritis.
    Inflammatory bowel diseases, 2012, Volume: 18, Issue:9

    Topics: Adult; Antibodies, Anti-Idiotypic; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Case-Control Studies; Citrulline; Female; Humans; Inflammatory Bowel Diseases; Male; Mutation; Peptides, Cyclic; Prognosis; Vimentin; Young Adult

2012
Autoantibodies in early rheumatoid arthritis: Brasília cohort: results of a three-year serial analysis.
    Revista brasileira de reumatologia, 2011, Volume: 51, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Brazil; Citrulline; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Prospective Studies; Rheumatoid Factor; Time Factors; Vimentin; Young Adult

2011
Anti-citrullinated fibronectin antibodies in rheumatoid arthritis are associated with human leukocyte antigen-DRB1 shared epitope alleles.
    Arthritis research & therapy, 2012, Feb-17, Volume: 14, Issue:1

    Topics: Alleles; Amino Acid Sequence; Analysis of Variance; Arthritis, Rheumatoid; Autoantibodies; Binding Sites; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibronectins; HLA-DRB1 Chains; Humans; Immunoglobulin G; Logistic Models; Molecular Sequence Data; Peptides; Smoking; Synovial Fluid; Tandem Mass Spectrometry

2012
Production of autoantibodies against citrullinated antigens/peptides by human B cells.
    Journal of immunology (Baltimore, Md. : 1950), 2012, Apr-01, Volume: 188, Issue:7

    Topics: Adult; Aged; Animals; Antibody Specificity; Antigens, CD; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; B-Lymphocyte Subsets; Cell Line, Tumor; Cells, Cultured; Citrulline; Cytokines; Epitopes; Female; HLA-DR Antigens; Humans; Lymphoma; Male; Mice; Middle Aged; Peptides, Cyclic; Polymorphism, Single Nucleotide; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Smoking; Young Adult

2012
Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.
    Arthritis research & therapy, 2012, Feb-24, Volume: 14, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autopsy; Citrulline; Female; Fibrosis; Humans; Hydrolases; Immunohistochemistry; Male; Middle Aged; Myocarditis; Myocardium; Myocytes, Cardiac; Protein-Arginine Deiminase Type 1; Protein-Arginine Deiminase Type 3; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminase Type 6; Protein-Arginine Deiminases; Scleroderma, Localized; Scleroderma, Systemic

2012
Inhibiting citrullination in rheumatoid arthritis: taking fuel from the fire.
    Arthritis research & therapy, 2012, Feb-29, Volume: 14, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Female; Glucocorticoids; Humans; Male; Synovial Membrane

2012
Antibodies binding to citrullinated telopeptides of type I and type II collagens and to mutated citrullinated vimentin synergistically predict the development of seropositive rheumatoid arthritis.
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Case-Control Studies; Citrulline; Collagen Type I; Collagen Type II; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Mutation; Vimentin

2012
Relationship between area-level socio-economic deprivation and autoantibody status in patients with rheumatoid arthritis: multicentre cross-sectional study.
    Annals of the rheumatic diseases, 2012, Volume: 71, Issue:10

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Cross-Sectional Studies; Female; Humans; Logistic Models; Male; Middle Aged; Rheumatoid Factor; Smoking; Socioeconomic Factors

2012
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:5

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Bone and Bones; Bone Resorption; Case-Control Studies; Cell Differentiation; Cells, Cultured; Citrulline; Collagen Type I; Humans; Hydrolases; Mice; Mice, Transgenic; Osteoclasts; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Tumor Necrosis Factor-alpha; Vimentin

2012
The periodontium of periodontitis patients contains citrullinated proteins which may play a role in ACPA (anti-citrullinated protein antibody) formation.
    Journal of clinical periodontology, 2012, Volume: 39, Issue:7

    Topics: Antibodies, Monoclonal; Arthritis, Rheumatoid; Autoantibodies; Chronic Periodontitis; Citrulline; Connective Tissue; Epithelium; Female; Humans; Male; Middle Aged; Mouth Mucosa; Periodontium; Proteins; Smoking; Synovial Membrane

2012
Autoantibodies to citrullinated fibrinogen compared with anti-MCV and anti-CCP2 antibodies in diagnosing rheumatoid arthritis at an early stage: data from the French ESPOIR cohort.
    Annals of the rheumatic diseases, 2013, Volume: 72, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Early Diagnosis; Female; Fibrinogen; France; Humans; Immunoassay; Male; Middle Aged; Peptides, Cyclic; Sensitivity and Specificity; Vimentin

2013
Elevated levels of fibrinogen-derived endogenous citrullinated peptides in synovial fluid of rheumatoid arthritis patients.
    Arthritis research & therapy, 2012, May-14, Volume: 14, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantigens; Chromatography, Liquid; Citrulline; Fibrinogen; Humans; Mass Spectrometry; Peptides; Synovial Fluid

2012
T-cell autoreactivity to citrullinated autoantigenic peptides in rheumatoid arthritis patients carrying HLA-DRB1 shared epitope alleles.
    Arthritis research & therapy, 2012, May-17, Volume: 14, Issue:3

    Topics: Alleles; Arthritis, Rheumatoid; Autoantigens; Autoimmunity; CD4-Positive T-Lymphocytes; Citrulline; Cytokines; Epitopes; Flow Cytometry; HLA-DRB1 Chains; Humans; Lymphocyte Activation; Peptides

2012
Citrullinated mouse collagen administered to DBA/1J mice in the absence of adjuvant initiates arthritis.
    International immunopharmacology, 2012, Volume: 13, Issue:4

    Topics: Animals; Antibodies; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantigens; Citrulline; Collagen Type II; Disease Models, Animal; Freund's Adjuvant; Humans; Immunity; Male; Mice; Mice, Inbred DBA; Peptide Fragments; T-Lymphocytes

2012
Genetic and environmental determinants for disease risk in subsets of rheumatoid arthritis defined by the anticitrullinated protein/peptide antibody fine specificity profile.
    Annals of the rheumatic diseases, 2013, Volume: 72, Issue:5

    Topics: Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Collagen Type II; Cross Reactions; Epitopes; Fibrinogen; Genetic Predisposition to Disease; Genotype; HLA-DRB1 Chains; Humans; Logistic Models; Peptides; Phosphopyruvate Hydratase; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Risk Factors; Seroepidemiologic Studies; Smoking; Sweden; Vimentin

2013
Autoimmune diseases: early diagnosis and new treatment strategies.
    Clinical chemistry, 2012, Volume: 58, Issue:11

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoimmune Diseases; Biomarkers; Citrulline; Genetic Markers; Genome-Wide Association Study; Humans

2012
Quantification of IFNγ- and IL17-producing cells after stimulation with citrullinated proteins in healthy subjects and RA patients.
    Rheumatology international, 2013, Volume: 33, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Citrulline; Female; Humans; Interferon-gamma; Interleukin-17; Leukocytes, Mononuclear; Male; Middle Aged; T-Lymphocytes

2013
The rheumatoid arthritis synovial fluid citrullinome reveals novel citrullinated epitopes in apolipoprotein E, myeloid nuclear differentiation antigen, and β-actin.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:1

    Topics: Actins; Amino Acid Sequence; Antigens, Differentiation; Apolipoproteins E; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Humans; Immunoprecipitation; Mass Spectrometry; Molecular Sequence Data; Synovial Fluid

2013
Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines.
    Cytokine, 2013, Volume: 61, Issue:1

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Apoptosis; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Line; Citrulline; Female; Fibroblasts; Humans; Hydrolases; Infliximab; Interleukin-1beta; Leukocytes, Mononuclear; Mice; Neutrophil Activation; Neutrophils; Protein Binding; Protein-Arginine Deiminases; Tumor Necrosis Factor-alpha

2013
Cross-reactivity of a human IgG₁ anticitrullinated fibrinogen monoclonal antibody to a citrullinated profilaggrin peptide.
    Protein science : a publication of the Protein Society, 2012, Volume: 21, Issue:12

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Arthritis, Rheumatoid; Citrulline; Cross Reactions; Fibrinogen; Filaggrin Proteins; Humans; Immunoglobulin G; Intermediate Filament Proteins; Molecular Sequence Data; Peptides, Cyclic

2012
Gauging rheumatoid arthritis.
    The Netherlands journal of medicine, 2012, Volume: 70, Issue:9

    Topics: 14-3-3 Proteins; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Rheumatoid Factor

2012
Citrullination of fibronectin modulates synovial fibroblast behavior.
    Arthritis research & therapy, 2012, Nov-05, Volume: 14, Issue:6

    Topics: Animals; Ankle Joint; Arthritis; Arthritis, Rheumatoid; Blotting, Western; Cell Adhesion; Cell Movement; Cells, Cultured; Citrulline; Fibroblasts; Fibronectins; Focal Adhesion Protein-Tyrosine Kinases; Gelatin; Humans; Integrins; Mice, Inbred C57BL; Mice, Transgenic; Paxillin; Phosphorylation; Synovial Fluid

2012
Oligonucleotide-peptide conjugates: solid-phase synthesis under acidic conditions and use in ELISA assays.
    Molecules (Basel, Switzerland), 2012, Nov-22, Volume: 17, Issue:12

    Topics: Antibodies; Arginine; Arthritis, Rheumatoid; Citrulline; Epitopes; Fibrin; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Oligonucleotides; Peptides; Solid-Phase Synthesis Techniques

2012
Citrullinated fibronectin inhibits apoptosis and promotes the secretion of pro-inflammatory cytokines in fibroblast-like synoviocytes in rheumatoid arthritis.
    Arthritis research & therapy, 2012, Dec-10, Volume: 14, Issue:6

    Topics: Aged; Apoptosis; Arthritis, Rheumatoid; bcl-2-Associated X Protein; Blotting, Western; Cells, Cultured; Citrulline; Cyclin B1; Cytokines; Female; Fibroblasts; Fibronectins; Gene Expression; Humans; Hydrolases; Immunohistochemistry; Inflammation Mediators; Inhibitor of Apoptosis Proteins; Male; Microscopy, Fluorescence; Middle Aged; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Proto-Oncogene Proteins c-bcl-2; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; Survivin; Synovial Membrane

2012
[Pathophysiology of rheumatoid arthritis].
    La Revue du praticien, 2012, Volume: 62, Issue:8

    Topics: Arthritis, Rheumatoid; Citrulline; Humans

2012
Citrullinated calreticulin potentiates rheumatoid arthritis shared epitope signaling.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:3

    Topics: Animals; Antigens, Surface; Arginine; Arthritis, Rheumatoid; Binding Sites; Calreticulin; Cell Line; Citrulline; Epitopes; Fibroblasts; Gene-Environment Interaction; HLA-DRB1 Chains; Humans; Mice; Mice, Knockout; Mutagenesis, Site-Directed; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Surface Plasmon Resonance; Synovial Membrane

2013
Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts.
    Annals of the rheumatic diseases, 2013, Volume: 72, Issue:8

    Topics: Arthritis, Rheumatoid; Cell Survival; Cells, Cultured; Citrulline; Cytokines; Fibrin; Fibroblasts; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Hydrolases; Oligonucleotide Array Sequence Analysis; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Recombinant Proteins; RNA, Messenger; RNA, Small Interfering; Synovial Membrane; Toll-Like Receptors; Up-Regulation

2013
Screening citrullinated proteins in synovial tissues of rheumatoid arthritis using 2-dimensional western blotting.
    The Journal of rheumatology, 2013, Volume: 40, Issue:3

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Female; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis; Proteomics; Synovial Fluid; Synovial Membrane

2013
[The comparative evaluation of the diagnostic value of methods of detection of antibodies to citrullinized proteins under rheumatoid arthritis].
    Klinicheskaia laboratornaia diagnostika, 2012, Issue:10

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Middle Aged; Proteins; Rheumatoid Factor

2012
Presence and role of anti-citrullinated protein antibodies in experimental arthritis models.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:4

    Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Collagen Type II; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Fibrinogen; Freund's Adjuvant; Genetic Predisposition to Disease; Immunotherapy, Active; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Myelin Basic Protein; Protein Processing, Post-Translational; Proteins

2013
Circulating citrullinated vimentin fragments reflect disease burden in ankylosing spondylitis and have prognostic capacity for radiographic progression.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Disease Progression; Female; Follow-Up Studies; Humans; Hydrolases; Logistic Models; Male; Middle Aged; Odds Ratio; Peptide Fragments; Prognosis; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Radiography; ROC Curve; Severity of Illness Index; Spondylitis, Ankylosing; Vimentin; Young Adult

2013
Association between the response to B cell depletion therapy and the allele*2 of the HS1,2A enhancer in seropositive rheumatoid arthritis patients.
    Reumatismo, 2012, Dec-20, Volume: 64, Issue:6

    Topics: 3' Untranslated Regions; Adult; Aged; Alleles; Antibodies, Monoclonal, Murine-Derived; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; B-Lymphocytes; Blood Sedimentation; C-Reactive Protein; Citrulline; Female; Genes, Immunoglobulin; Genotype; Humans; Immunoglobulin Heavy Chains; Immunoglobulins; Lymphocyte Depletion; Male; Middle Aged; Rheumatoid Factor; Rituximab; Surveys and Questionnaires; Treatment Outcome

2012
Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:4

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biological Specimen Banks; Case-Control Studies; Citrulline; Collagen Type II; Female; Fibrinogen; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Peptides, Cyclic; Phosphopyruvate Hydratase; Prodromal Symptoms; Protein Array Analysis; Protein Processing, Post-Translational; Time Factors; Vimentin

2013
A citrullinated fibrinogen-specific T cell line enhances autoimmune arthritis in a mouse model of rheumatoid arthritis.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Feb-15, Volume: 190, Issue:4

    Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; CD4-Positive T-Lymphocytes; Cell Line; Cells, Cultured; Citrulline; Collagen; Collagen Type II; Fibrinogen; Humans; Mice; Mice, Inbred DBA; Mice, Transgenic; Up-Regulation

2013
[Anticitrulin antibody and the extra-articular manifestations in rheumatoid arthritis].
    Medicina, 2013, Volume: 73, Issue:1

    Topics: Aged; Arthritis, Rheumatoid; Citrulline; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Peptide Fragments; Pulmonary Fibrosis; Rheumatoid Factor; Risk Factors; Smoking; Xerophthalmia; Xerostomia

2013
Developing better biomarkers for connective tissue disease-associated interstitial lung disease: citrullinated hsp90 autoantibodies in rheumatoid arthritis.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantigens; Citrulline; Female; HSP90 Heat-Shock Proteins; Humans; Lung Diseases, Interstitial; Male; Protein Processing, Post-Translational

2013
Identification of citrullinated hsp90 isoforms as novel autoantigens in rheumatoid arthritis-associated interstitial lung disease.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:4

    Topics: Arthritis, Rheumatoid; Autoantigens; Biomarkers; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; HSP90 Heat-Shock Proteins; Humans; Idiopathic Pulmonary Fibrosis; Immunoprecipitation; Lung Diseases, Interstitial; Male; Mass Spectrometry; Mixed Connective Tissue Disease; Protein Isoforms; Protein Processing, Post-Translational; Sensitivity and Specificity

2013
Identification of citrullinated rheumatoid arthritis-specific epitopes in natural filaggrin relevant for antifilaggrin autoantibody detection by line immunoassay.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:5

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cross Reactions; Epitope Mapping; Filaggrin Proteins; Humans; Immunoassay; Immunoblotting; Immunodominant Epitopes; Intermediate Filament Proteins; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Recombinant Proteins; Reproducibility of Results

2002
Inducible nitric oxide synthase is expressed in synovial fluid granulocytes.
    Clinical and experimental immunology, 2002, Volume: 130, Issue:1

    Topics: Adult; Aged; Arginine; Arthritis, Rheumatoid; Autoimmune Diseases; Blood Cells; Chromatography, High Pressure Liquid; Citrulline; Colorimetry; Enzyme Induction; Exudates and Transudates; Female; Granulocytes; Humans; Knee; Male; Membrane Proteins; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Organ Specificity; Synovial Fluid

2002
Rheumatoid factor and antibodies to cyclic citrullinated Peptide differentiate rheumatoid arthritis from undifferentiated polyarthritis in patients with early arthritis.
    The Journal of rheumatology, 2002, Volume: 29, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Outpatients; Peptides, Cyclic; Rheumatoid Factor; Sensitivity and Specificity

2002
Is expression of intracellular citrullinated proteins in synovial tissue specific for rheumatoid arthritis? Comment on the article by Baeten et al.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:10

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Citrulline; Epitopes; Humans; Synovial Membrane

2002
Anti-cyclic citrullinated peptide antibodies as a diagnostic test for rheumatoid arthritis and predictor of an erosive disease.
    The Israel Medical Association journal : IMAJ, 2002, Volume: 4, Issue:11 Suppl

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Filaggrin Proteins; HLA-DR4 Antigen; Homozygote; Humans; Intermediate Filament Proteins; Predictive Value of Tests; Prognosis; Protein Precursors; Rheumatoid Factor; Severity of Illness Index; Time Factors

2002
Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:2

    Topics: Adult; Aged; Antibodies, Antinuclear; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Disease Progression; Female; Follow-Up Studies; Humans; Keratins; Male; Middle Aged; Peptides; Predictive Value of Tests; Prognosis; Prospective Studies; Radiography; Sensitivity and Specificity; Severity of Illness Index

2003
Filaggrin related antibodies among the aged.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:3

    Topics: Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Filaggrin Proteins; Humans; Immunoglobulin G; Intermediate Filament Proteins; Peptides, Cyclic; Sensitivity and Specificity

2003
The diagnosis and prognosis of early arthritis: comment on the editorial by Scott.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:3

    Topics: Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Predictive Value of Tests; Prognosis; Time Factors

2003
Anti-cyclic citrullinated peptide antibody in early rheumatoid arthritis: comment on the editorial by Scott.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:3

    Topics: Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Peptides, Cyclic; Predictive Value of Tests; Prognosis; Reagent Kits, Diagnostic

2003
[Anti-cyclic citrullinated peptide antibodies as a diagnostic test for rheumatoid arthritis].
    Harefuah, 2003, Volume: 142, Issue:3

    Topics: Antibodies; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Filaggrin Proteins; Humans; Peptides; Peptides, Cyclic; Reproducibility of Results

2003
Anti-cyclic citrullinated peptide antibodies, IgM and IgA rheumatoid factors in the diagnosis and prognosis of rheumatoid arthritis.
    Rheumatology (Oxford, England), 2003, Volume: 42, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Cross-Sectional Studies; Diagnosis, Differential; Female; Humans; Immunoglobulin A; Immunoglobulin M; Longitudinal Studies; Male; Middle Aged; Peptides, Cyclic; Prognosis; Rheumatic Diseases; Rheumatoid Factor; Sensitivity and Specificity

2003
[Early diagnosis of rheumatoid arthritis with a test based upon a specific antigen: cyclic citrullinated peptide].
    Nederlands tijdschrift voor geneeskunde, 2003, Apr-12, Volume: 147, Issue:15

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Humans; Peptides, Cyclic; Sensitivity and Specificity

2003
Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis.
    Nature genetics, 2003, Volume: 34, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Chromosomes, Human, Pair 1; Citrulline; Female; Filaggrin Proteins; Haplotypes; Humans; Hydrolases; Intermediate Filament Proteins; Linkage Disequilibrium; Male; Middle Aged; Peptides; Polymorphism, Single Nucleotide; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; RNA Stability; RNA, Messenger

2003
Cutting edge: the conversion of arginine to citrulline allows for a high-affinity peptide interaction with the rheumatoid arthritis-associated HLA-DRB1*0401 MHC class II molecule.
    Journal of immunology (Baltimore, Md. : 1950), 2003, Jul-15, Volume: 171, Issue:2

    Topics: Alleles; Animals; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cells, Cultured; Citrulline; HLA-DR Antigens; HLA-DR4 Antigen; HLA-DRB1 Chains; Humans; Lymphocyte Activation; Mice; Mice, Transgenic; Peptide Fragments; Protein Binding; Protein Processing, Post-Translational; T-Lymphocytes; Vimentin

2003
Diagnostic value of anti-cyclic citrullinated Peptide antibody in patients with rheumatoid arthritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:7

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; HLA-DR4 Antigen; Humans; Keratins; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Rheumatoid Factor; ROC Curve

2003
European collaboration at its best: 23rd European Workshop for Rheumatology Research.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:8

    Topics: Arthritis; Arthritis, Rheumatoid; Citrulline; Glycoproteins; Humans; Osteoarthritis; Research; Rheumatology

2003
Anti-cyclic citrullinated peptide antibodies in advanced rheumatoid arthritis.
    Annals of internal medicine, 2003, Aug-05, Volume: 139, Issue:3

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Peptides, Cyclic

2003
Defects in the regulation of B cell apoptosis are required for the production of citrullinated peptide autoantibodies in mice.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:8

    Topics: Animals; Apoptosis; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Cell Communication; Citrulline; Gene Expression; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred MRL lpr; Mice, Inbred NZB; Mice, Transgenic; Peptides; Proto-Oncogene Proteins c-bcl-2; Species Specificity; T-Lymphocytes

2003
The predictive value of anti-cyclic citrullinated peptide antibodies in early arthritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Female; Humans; Logistic Models; Male; Middle Aged; Peptides; Predictive Value of Tests; Prognosis

2003
Recombinant human monoclonal autoantibodies specific for citrulline-containing peptides from phage display libraries derived from patients with rheumatoid arthritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:8

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Citrulline; Filaggrin Proteins; HeLa Cells; Humans; Immunoglobulin Variable Region; Molecular Sequence Data; Peptide Library; Peptides; Recombinant Proteins

2003
Clinical utility of the anti-CCP assay in patients with rheumatic diseases.
    Annals of the rheumatic diseases, 2003, Volume: 62, Issue:9

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Radiography; Rheumatic Diseases; Rheumatoid Factor; Sensitivity and Specificity

2003
Citrullination of synovial proteins in murine models of rheumatoid arthritis.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:9

    Topics: Animals; Antibody Specificity; Arthritis, Experimental; Arthritis, Rheumatoid; Autoantibodies; Biopsy; Citrulline; Disease Models, Animal; Epitopes; Gene Expression Regulation, Enzymologic; Hydrolases; Male; Mice; Mice, Inbred DBA; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 3; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Proteins; RNA, Messenger; Synovial Fluid; Synovial Membrane

2003
Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.
    Arthritis and rheumatism, 2003, Volume: 48, Issue:10

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Cohort Studies; Female; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; Predictive Value of Tests; Rheumatoid Factor; Seroepidemiologic Studies

2003
High diagnostic performance of ELISA detection of antibodies to citrullinated antigens in rheumatoid arthritis.
    Scandinavian journal of rheumatology, 2003, Volume: 32, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Area Under Curve; Arthritis, Rheumatoid; Autoantibodies; Citrulline; DNA Primers; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Matrix Metalloproteinase 3; Middle Aged; Peptides, Cyclic; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Rheumatoid Factor; ROC Curve; Sensitivity and Specificity

2003
Autoantibodies recognizing citrullinated rat filaggrin in an ELISA using citrullinated and non-citrullinated recombinant proteins as antigens are highly diagnostic for rheumatoid arthritis.
    Clinical and experimental immunology, 2004, Volume: 135, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Fluorescent Antibody Technique, Indirect; Humans; Intermediate Filament Proteins; Keratins; Male; Middle Aged; Predictive Value of Tests; Prospective Studies; Rats; Recombinant Proteins; Rheumatoid Factor; Sensitivity and Specificity

2004
Value of antibodies to citrulline-containing peptides for diagnosing early rheumatoid arthritis.
    The Journal of rheumatology, 2003, Volume: 30, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Keratins; Logistic Models; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Rheumatology; ROC Curve

2003
Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Immunoglobulin M; Male; Middle Aged; Netherlands; Rheumatoid Factor; Risk Factors; Sensitivity and Specificity; Seroepidemiologic Studies

2004
Clinical utility of anti-CCP antibodies in the differential diagnosis of elderly-onset rheumatoid arthritis and polymyalgia rheumatica.
    Rheumatology (Oxford, England), 2004, Volume: 43, Issue:5

    Topics: Age of Onset; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Diagnosis, Differential; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Polymyalgia Rheumatica; Rheumatoid Factor

2004
Unlocking the "PAD" lock on rheumatoid arthritis.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:4

    Topics: Antigens; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Gene Expression; Haplotypes; Humans; Hydrolases; Protein-Arginine Deiminases

2004
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:4

    Topics: Arthritis, Rheumatoid; Calcium; Cell Differentiation; Cells, Cultured; Citrulline; Humans; Hydrolases; Lipopolysaccharide Receptors; Macrophages; Monocytes; Protein Biosynthesis; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminases; RNA, Messenger; Synovial Fluid; Transcription, Genetic; Vimentin

2004
Evaluation of anti-citrullinated filaggrin antibodies as hallmarks for the diagnosis of rheumatic diseases.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:4

    Topics: Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Filaggrin Proteins; Fluorescent Antibody Technique, Indirect; Humans; Immunoenzyme Techniques; Immunoglobulin G; Intermediate Filament Proteins; Keratins; Lupus Erythematosus, Systemic; Reagent Kits, Diagnostic; Rheumatoid Factor; Sensitivity and Specificity; Sjogren's Syndrome

2004
Autoantibodies to cyclic citrullinated peptides predict progression to rheumatoid arthritis in patients with undifferentiated arthritis: a prospective cohort study.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Cohort Studies; Disease Progression; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Prognosis; Prospective Studies; Radiography; Risk Factors

2004
Rheumatoid arthritis specific anti-Sa antibodies target citrullinated vimentin.
    Arthritis research & therapy, 2004, Volume: 6, Issue:2

    Topics: Antibodies, Anti-Idiotypic; Antibody Specificity; Antigens, Surface; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Peptides, Cyclic; Placenta; Recombinant Proteins; Synovial Membrane; Vimentin

2004
Peptidylarginine deiminase, the arginine to citrulline converting enzyme, is frequently recognized by sera of patients with rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren syndrome.
    Scandinavian journal of rheumatology, 2003, Volume: 32, Issue:6

    Topics: Adult; Antibodies, Antinuclear; Arthritis, Rheumatoid; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Humans; Hydrolases; Intermediate Filament Proteins; Lupus Erythematosus, Systemic; Male; Middle Aged; Probability; Prognosis; Protein-Arginine Deiminases; Sensitivity and Specificity; Severity of Illness Index; Sjogren's Syndrome

2003
Diagnostic value of anticyclic citrullinated peptide antibody in rheumatoid arthritis.
    The Journal of rheumatology, 2004, Volume: 31, Issue:5

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptides, Cyclic; Predictive Value of Tests; Rheumatology

2004
Absence of citrulline-specific autoantibodies in animal models of autoimmunity.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:7

    Topics: Animals; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Disease Models, Animal; Humans; Mice; Mice, Inbred MRL lpr; Mice, Transgenic; Peptides, Cyclic

2004
Diagnostic performance and predictive value of rheumatoid factor, anti-citrullinated peptide antibodies, and the HLA shared epitope for diagnosis of rheumatoid arthritis.
    Clinical chemistry, 2005, Volume: 51, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epitopes; Follow-Up Studies; HLA Antigens; Humans; Middle Aged; Peptide Fragments; Predictive Value of Tests; Retrospective Studies; Rheumatoid Factor

2005
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis.
    Rheumatology (Oxford, England), 2005, Volume: 44, Issue:1

    Topics: Apoptosis; Arthritis, Rheumatoid; Blotting, Western; Citrulline; Fibrin; Humans; Hydrolases; Immunophenotyping; Leukocytes; Osteoarthritis; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Synovial Membrane

2005
Rheumatologic diagnostic serology: tests which test clinicians.
    The New Zealand medical journal, 2004, Oct-08, Volume: 117, Issue:1203

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Diagnostic Techniques and Procedures; Humans; Peptides, Cyclic; Predictive Value of Tests; Sensitivity and Specificity

2004
Anti-cyclic citrullinated antibodies: complementary to IgM rheumatoid factor in the early diagnosis of rheumatoid arthritis.
    The New Zealand medical journal, 2004, Oct-08, Volume: 117, Issue:1203

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Humans; Immunoglobulin M; Peptides, Cyclic; Rheumatoid Factor; Sensitivity and Specificity

2004
The presence of citrullinated proteins is not specific for rheumatoid synovial tissue.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antibodies; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Female; Humans; Immunoglobulins; Immunohistochemistry; Joint Diseases; Male; Middle Aged; Peptides, Cyclic; Staining and Labeling; Synovial Membrane

2004
Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations.
    Annals of the rheumatic diseases, 2004, Volume: 63, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Disease Progression; Epitopes; Female; Follow-Up Studies; Humans; Male; Middle Aged; Radiography; Rheumatoid Factor; Rheumatoid Nodule; Sensitivity and Specificity; Vasculitis

2004
The inhibition of antithrombin by peptidylarginine deiminase 4 may contribute to pathogenesis of rheumatoid arthritis.
    Rheumatology (Oxford, England), 2005, Volume: 44, Issue:3

    Topics: Animals; Antithrombins; Arthritis, Rheumatoid; Citrulline; Dose-Response Relationship, Drug; Humans; Hydrolases; Muscles; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Rabbits; Recombinant Proteins; Thrombin

2005
Association of rheumatoid arthritis treatment response and disease duration with declines in serum levels of IgM rheumatoid factor and anti-cyclic citrullinated peptide antibody.
    Arthritis and rheumatism, 2004, Volume: 50, Issue:12

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Citrulline; Double-Blind Method; Female; Follow-Up Studies; Humans; Immunoglobulin M; Male; Middle Aged; Peptides, Cyclic; Randomized Controlled Trials as Topic; Rheumatoid Factor; Severity of Illness Index; Time Factors; Treatment Outcome

2004
Diagnostic performance and predictive value of anti-citrullinated peptide antibodies for diagnosis of rheumatoid arthritis: toward more accurate detection?
    Clinical chemistry, 2005, Volume: 51, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Peptide Fragments; Predictive Value of Tests

2005
Comparison of enzymatic properties between hPADI2 and hPADI4.
    Biochemical and biophysical research communications, 2005, Feb-04, Volume: 327, Issue:1

    Topics: Amino Acid Sequence; Arginine; Arthritis, Rheumatoid; Calcium; Catalysis; Citrulline; Fibrinogen; Filaggrin Proteins; Humans; Hydrogen-Ion Concentration; Hydrolases; Immunohistochemistry; Intermediate Filament Proteins; Kinetics; Molecular Sequence Data; Protein Denaturation; Protein-Arginine Deiminase Type 2; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Substrate Specificity; Synovial Membrane

2005
Antibodies to citrullinated human fibrinogen (ACF) have diagnostic and prognostic value in early arthritis.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:8

    Topics: Adult; Aged; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Epidemiologic Methods; Female; Fibrinogen; Humans; Immunoglobulin M; Male; Middle Aged; Peptides, Cyclic; Prognosis; Rheumatoid Factor; Severity of Illness Index

2005
[Value of anti-cyclic citrullinated peptides antibodies in comparison with rheumatoid factor for rheumatoid arthritis diagnosis].
    Pathologie-biologie, 2005, Volume: 53, Issue:2

    Topics: Agglutination Tests; Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Humans; Immunoglobulin A; Immunoglobulin G; Immunoglobulin M; Peptides, Cyclic; Rheumatoid Factor; Sensitivity and Specificity

2005
[Antibodies to cyclic citrullinized peptide in rheumatoid arthritis].
    Terapevticheskii arkhiv, 2004, Volume: 76, Issue:12

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Sensitivity and Specificity

2004
IgG subclass distribution of the rheumatoid arthritis-specific autoantibodies to citrullinated fibrin.
    Clinical and experimental immunology, 2005, Volume: 139, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Analysis of Variance; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Fibrin; Fibrinogen; Humans; Immunoglobulin G; Male; Middle Aged

2005
Infiltration of the synovial membrane with macrophage subsets and polymorphonuclear cells reflects global disease activity in spondyloarthropathy.
    Arthritis research & therapy, 2005, Volume: 7, Issue:2

    Topics: Adult; Aged; Antigens, CD; Antigens, Differentiation; Antigens, Differentiation, Myelomonocytic; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoimmune Diseases; Biopsy, Needle; Blood Sedimentation; C-Reactive Protein; Citrulline; Cluster Analysis; Cohort Studies; Female; Humans; Hyperplasia; Inflammatory Bowel Diseases; Knee Joint; Macrophages; Male; Middle Aged; Neutrophils; Phenotype; Receptors, Cell Surface; Severity of Illness Index; Spondylarthropathies; Spondylitis, Ankylosing; Synovial Membrane; Synovitis

2005
Fibrin deimination in synovial tissue is not specific for rheumatoid arthritis but commonly occurs during synovitides.
    Journal of immunology (Baltimore, Md. : 1950), 2005, Apr-15, Volume: 174, Issue:8

    Topics: Adult; Aged; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Case-Control Studies; Citrulline; Epitopes; Female; Fibrin; Humans; Male; Middle Aged; Models, Immunological; Synovial Membrane; Synovitis

2005
[Rheumatoid arthritis: early detection may nip it in the bud].
    Nederlands tijdschrift voor geneeskunde, 2005, Mar-26, Volume: 149, Issue:13

    Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Dexamethasone; Humans; Immunoglobulin M; Netherlands; Rheumatoid Factor; Risk Factors; Sensitivity and Specificity; Time Factors

2005
Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis.
    European journal of immunology, 2005, Volume: 35, Issue:5

    Topics: Amino Acid Sequence; Animals; Antibody Formation; Arginine; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Citrulline; Collagen Type II; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Epitopes, B-Lymphocyte; Female; Filaggrin Proteins; Humans; Hydrolases; Immunoglobulin G; Male; Mice; Middle Aged; Molecular Sequence Data; Protein-Arginine Deiminases; T-Lymphocytes

2005
Anti-cyclic citrullinated peptide antibodies in patients with primary Sjögren's syndrome.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Middle Aged; Sjogren's Syndrome

2005
Impaired early B cell tolerance in patients with rheumatoid arthritis.
    The Journal of experimental medicine, 2005, May-16, Volume: 201, Issue:10

    Topics: Adult; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; B-Lymphocytes; Bone Marrow; Cell Differentiation; Citrulline; Female; Humans; Immune Tolerance; Male; Middle Aged; Peptides, Cyclic

2005
Citrullinated proteins have increased immunogenicity and arthritogenicity and their presence in arthritic joints correlates with disease severity.
    Arthritis research & therapy, 2005, Volume: 7, Issue:3

    Topics: Animals; Arthritis, Rheumatoid; Citrulline; Female; Joints; Male; Rats; Rats, Inbred Lew; Severity of Illness Index

2005
PADI4 polymorphisms are not associated with rheumatoid arthritis in the Spanish population.
    Rheumatology (Oxford, England), 2005, Volume: 44, Issue:10

    Topics: Adult; Aged; Arthritis, Rheumatoid; Citrulline; Female; Gene Frequency; Genetic Predisposition to Disease; Humans; Hydrolases; Male; Middle Aged; Polymorphism, Single Nucleotide; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2005
A deiminated viral peptide to detect antibodies in rheumatoid arthritis.
    Annals of the New York Academy of Sciences, 2005, Volume: 1050

    Topics: Adult; Aged; Aged, 80 and over; Antibodies; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Cryoglobulinemia; Enzyme-Linked Immunosorbent Assay; Female; Humans; Imines; Lupus Erythematosus, Systemic; Male; Middle Aged; Peptide Fragments; Scleroderma, Systemic; Viral Proteins

2005
Association of anti-cyclic citrullinated peptide antibodies, anti-citrullin antibodies, and IgM and IgA rheumatoid factors with serological parameters of disease activity in rheumatoid arthritis.
    Annals of the New York Academy of Sciences, 2005, Volume: 1050

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antibodies, Antinuclear; Arthritis, Rheumatoid; Biomarkers; Citrulline; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Germany; Humans; Immunoglobulin G; Immunoglobulin M; Intermediate Filament Proteins; Male; Middle Aged; Nephelometry and Turbidimetry; Outpatients; Peptides, Cyclic; Rats; Recombinant Proteins; Rheumatoid Factor; Sensitivity and Specificity

2005
Clinical utility of the anti-CCP assay: experiences with 700 patients.
    Annals of the New York Academy of Sciences, 2005, Volume: 1050

    Topics: Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Cohort Studies; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Humans; Nephelometry and Turbidimetry; Outpatient Clinics, Hospital; Outpatients; Peptides, Cyclic; Radiography; Rheumatic Diseases; Rheumatoid Factor; Sensitivity and Specificity

2005
Multiplexed immunoassay for detection of rheumatoid factors by FIDISTM technology.
    Annals of the New York Academy of Sciences, 2005, Volume: 1050

    Topics: Agglutination Tests; Animals; Antibody Specificity; Arthritis, Rheumatoid; Biomarkers; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Evaluation Studies as Topic; Fluorescent Antibody Technique, Indirect; Humans; Immunoassay; Immunoglobulin G; Immunoglobulin M; Keratins; Latex Fixation Tests; Peptides, Cyclic; Rabbits; Reagent Kits, Diagnostic; Rheumatoid Factor; Sensitivity and Specificity; Species Specificity

2005
Anti-citrulline antibodies in psoriatic patients with and without arthritis.
    Acta dermato-venereologica, 2005, Volume: 85, Issue:3

    Topics: Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Predictive Value of Tests; Sensitivity and Specificity

2005
Synovial intracellular citrullinated proteins colocalizing with peptidyl arginine deiminase as pathophysiologically relevant antigenic determinants of rheumatoid arthritis-specific humoral autoimmunity.
    Arthritis and rheumatism, 2005, Volume: 52, Issue:8

    Topics: Antibody Formation; Arthritis, Rheumatoid; Autoimmunity; Case-Control Studies; Citrulline; Epitopes; Humans; Hydrolases; Intracellular Membranes; Protein-Arginine Deiminases; Proteins; Synovial Membrane; Tissue Distribution

2005
Citrullination of fibronectin in rheumatoid arthritis synovial tissue.
    Rheumatology (Oxford, England), 2005, Volume: 44, Issue:11

    Topics: Apoptosis; Arthritis, Rheumatoid; Blotting, Western; Cells, Cultured; Citrulline; Enzyme-Linked Immunosorbent Assay; Fibronectins; HL-60 Cells; Humans; Integrin beta1; Osteoarthritis; Synovial Membrane; Vascular Endothelial Growth Factor A

2005
Citrullination and autoimmune disease: 8th Bertine Koperberg meeting.
    Annals of the rheumatic diseases, 2005, Volume: 64, Issue:10

    Topics: Arthritis, Rheumatoid; Autoimmune Diseases; Citrulline; Humans; Multiple Sclerosis

2005
Diagnostic value and clinical significance of anti-CCP in patients with advanced rheumatoid arthritis.
    Journal of the National Medical Association, 2005, Volume: 97, Issue:8

    Topics: Arthritis, Rheumatoid; Case-Control Studies; Chi-Square Distribution; Citrulline; Cross-Sectional Studies; Enzyme-Linked Immunosorbent Assay; Female; Humans; Logistic Models; Male; Middle Aged; Pain Measurement; Predictive Value of Tests; Prognosis; Rheumatoid Factor; ROC Curve; Severity of Illness Index; Surveys and Questionnaires

2005
Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis.
    Arthritis research & therapy, 2005, Volume: 7, Issue:5

    Topics: Adult; Aged; Antibody Specificity; Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; C-Reactive Protein; Citrulline; Cohort Studies; Disease Progression; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptides, Cyclic; Protein Processing, Post-Translational; Severity of Illness Index

2005
[Pathophysiological significances of citrullinated proteins in geriatric diseases].
    Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics, 2005, Volume: 42, Issue:5

    Topics: Aged; Alzheimer Disease; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Geriatrics; Humans; Hydrolases; Protein-Arginine Deiminases; Proteins; Skin

2005
Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case-control study.
    Arthritis research & therapy, 2005, Volume: 7, Issue:6

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Citrulline; Epitopes; Female; HLA-DR Antigens; Humans; Life Style; Male; Middle Aged; Mineral Oil; Occupational Diseases; Occupational Exposure; Odds Ratio; Rheumatoid Factor; Surveys and Questionnaires; Sweden

2005
Identification of citrullinated alpha-enolase as a candidate autoantigen in rheumatoid arthritis.
    Arthritis research & therapy, 2005, Volume: 7, Issue:6

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmunity; Biomarkers, Tumor; Citrulline; DNA-Binding Proteins; HL-60 Cells; Humans; Monocytes; Phosphopyruvate Hydratase; Spectrometry, Mass, Electrospray Ionization; Synovial Membrane; Tumor Suppressor Proteins

2005
A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:1

    Topics: Adolescent; Adult; Aged; Antibodies; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Epitopes; Female; HLA-DR Antigens; Humans; Male; Middle Aged; Smoking

2006
Clinical significance of anti-filaggrin antibody recognizing uncitrullinated filaggrin in rheumatoid arthritis.
    Experimental & molecular medicine, 2005, Dec-31, Volume: 37, Issue:6

    Topics: Amino Acid Sequence; Antibodies; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Molecular Sequence Data

2005
Identification of citrullinated eukaryotic translation initiation factor 4G1 as novel autoantigen in rheumatoid arthritis.
    Biochemical and biophysical research communications, 2006, Mar-03, Volume: 341, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantigens; Autoimmunity; Base Sequence; Citrulline; Eukaryotic Initiation Factor-4G; Female; Humans; Male; Middle Aged; Molecular Sequence Data

2006
Citrullinated fibrinogen detected as a soluble citrullinated autoantigen in rheumatoid arthritis synovial fluids.
    Annals of the rheumatic diseases, 2006, Volume: 65, Issue:8

    Topics: Animals; Antibodies, Monoclonal; Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantigens; Biomarkers; Blotting, Western; C-Reactive Protein; Case-Control Studies; Citrulline; Enzyme-Linked Immunosorbent Assay; Fibrinogen; Humans; Immunoprecipitation; Mice; Mice, Inbred BALB C; Statistics, Nonparametric; Synovial Fluid

2006
PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease.
    Arthritis research & therapy, 2006, Volume: 8, Issue:1

    Topics: Arthritis, Rheumatoid; Autoantibodies; Base Sequence; Case-Control Studies; Chi-Square Distribution; Citrulline; DNA Primers; Female; Genetic Variation; Genotype; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Male; Peptide Fragments; Polymorphism, Genetic; Predictive Value of Tests; Protein Tyrosine Phosphatase, Non-Receptor Type 22; Protein Tyrosine Phosphatases; Reference Values; Sensitivity and Specificity

2006
Deiminated Epstein-Barr virus nuclear antigen 1 is a target of anti-citrullinated protein antibodies in rheumatoid arthritis.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Antibodies, Viral; Arthritis, Rheumatoid; Chromatography, Affinity; Citrulline; Epstein-Barr Virus Infections; Epstein-Barr Virus Nuclear Antigens; Female; Filaggrin Proteins; Humans; Male; Middle Aged; Nucleoproteins

2006
Specific modification of peptide-bound citrulline residues.
    Analytical biochemistry, 2006, May-01, Volume: 352, Issue:1

    Topics: Antipyrine; Arthritis, Rheumatoid; Chromatography, Liquid; Citrulline; Diacetyl; Magnetic Resonance Spectroscopy; Mass Spectrometry; Peptide Fragments; Protein Processing, Post-Translational; Proteomics

2006
Citrullination is an inflammation-dependent process.
    Annals of the rheumatic diseases, 2006, Volume: 65, Issue:9

    Topics: Arthritis, Rheumatoid; Biopsy; Citrulline; Humans; Inflammatory Bowel Diseases; Muscle, Skeletal; Polymyositis; Statistics, Nonparametric; Synovial Membrane

2006
Pathomechanisms in rheumatoid arthritis--time for a string theory?
    The Journal of clinical investigation, 2006, Volume: 116, Issue:4

    Topics: Animals; Arthritis, Rheumatoid; Autoantibodies; Autoimmunity; Citrulline; Humans; Mice; Models, Theoretical

2006
Up regulation of monocyte chemoattractant protein-1 expression in anti-citrulline antibody and immunoglobulin M rheumatoid factor positive subjects precedes onset of inflammatory response and development of overt rheumatoid arthritis.
    Annals of the rheumatic diseases, 2007, Volume: 66, Issue:1

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Blood Donors; C-Reactive Protein; Case-Control Studies; Chemokine CCL2; Chi-Square Distribution; Citrulline; Disease Progression; Female; Humans; Immunoglobulin M; Male; Middle Aged; Rheumatoid Factor; Severity of Illness Index; Time Factors; Up-Regulation

2007
Citrullination in extra-articular manifestations of rheumatoid arthritis.
    Rheumatology (Oxford, England), 2007, Volume: 46, Issue:1

    Topics: Aged; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Biopsy; Citrulline; Collagen; Female; Humans; Immunoenzyme Techniques; Lung; Lung Diseases, Interstitial; Male; Mice; Mice, Inbred DBA; Middle Aged; Rheumatoid Nodule; Severity of Illness Index

2007
Epitopes of human fibrin recognized by the rheumatoid arthritis-specific autoantibodies to citrullinated proteins.
    European journal of immunology, 2006, Volume: 36, Issue:8

    Topics: Amino Acid Sequence; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrin; Fibrinogen; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Models, Molecular; Molecular Sequence Data; Protein Structure, Quaternary

2006
Diagnostic value of anti-human citrullinated fibrinogen ELISA and comparison with four other anti-citrullinated protein assays.
    Arthritis research & therapy, 2006, Volume: 8, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antibodies; Arthritis, Rheumatoid; Child; Citrulline; Cohort Studies; Enzyme-Linked Immunosorbent Assay; Female; Fibrinogen; Humans; Male; Middle Aged; Peptides, Cyclic; Protein Isoforms; Rheumatic Diseases; Rheumatoid Factor

2006
Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis.
    Arthritis research & therapy, 2006, Volume: 8, Issue:4

    Topics: Aged; Antibodies; Arthritis, Rheumatoid; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Protein Isoforms; Rheumatic Diseases; Sensitivity and Specificity; Single-Blind Method; Vimentin

2006
Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines.
    Annals of the rheumatic diseases, 2007, Volume: 66, Issue:6

    Topics: Adult; Aged; Arthritis, Psoriatic; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Chemokines; Citrulline; Cytokines; Female; Humans; Inflammation Mediators; Male; Middle Aged; Protein Array Analysis; Proteomics; Spondylitis, Ankylosing; Up-Regulation

2007
Serum autoantibodies that bind citrullinated fibrinogen are frequently found in patients with rheumatoid arthritis.
    The Journal of rheumatology, 2006, Volume: 33, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Fibrinogen; Humans; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Rheumatoid Factor; ROC Curve; Sensitivity and Specificity

2006
Is occupational exposure to mineral oil a risk factor for rheumatoid arthritis?
    Nature clinical practice. Rheumatology, 2006, Volume: 2, Issue:3

    Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Case-Control Studies; Citrulline; Emollients; Female; Humans; Male; Middle Aged; Mineral Oil; Occupational Diseases; Occupational Exposure; Rheumatoid Factor; Risk Factors; Seroepidemiologic Studies; Sweden

2006
Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis.
    Arthritis and rheumatism, 2006, Volume: 54, Issue:9

    Topics: Arthritis, Rheumatoid; Black People; Citrulline; Humans; Immunoglobulin Isotypes; Peptides; Reference Values; Rheumatoid Factor; Sensitivity and Specificity

2006
Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?
    Annals of the rheumatic diseases, 2007, Volume: 66, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Child; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Female; Hepatitis, Autoimmune; Humans; Male; Middle Aged; Peptides, Cyclic; Reagent Kits, Diagnostic; Rheumatic Diseases

2007
Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization.
    Biochemistry, 2006, Oct-03, Volume: 45, Issue:39

    Topics: Amidines; Arginine; Arthritis, Rheumatoid; Calcium; Chronic Disease; Citrulline; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrocarbons, Fluorinated; Hydrolases; Molecular Probes; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases

2006
Autoimmunity to citrullinated type II collagen in rheumatoid arthritis.
    Modern rheumatology, 2006, Volume: 16, Issue:5

    Topics: Antigen-Antibody Complex; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Autoimmune Diseases; Autoimmunity; Citrulline; Collagen Type II; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Synovial Fluid

2006
Citrullinated antigens: just diagnostic tools or pathogenic targets in rheumatoid arthritis?
    The Journal of rheumatology, 2006, Volume: 33, Issue:11

    Topics: Antigens; Arthritis, Rheumatoid; Citrulline; Fibrinogen; Humans; Peptides, Cyclic; Protein Processing, Post-Translational

2006
Synthesis of overlapping fibrin citrullinated peptides and their use for diagnosing rheumatoid arthritis.
    Chemical biology & drug design, 2006, Volume: 68, Issue:4

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitope Mapping; Fibrin; Filaggrin Proteins; Humans; Immunodominant Epitopes; Intermediate Filament Proteins; Molecular Sequence Data; Peptide Fragments; Peptides, Cyclic; Sensitivity and Specificity; Sequence Analysis, Protein

2006
Identification of novel citrullinated autoantigens of synovium in rheumatoid arthritis using a proteomic approach.
    Arthritis research & therapy, 2006, Volume: 8, Issue:6

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Blotting, Western; CapZ Actin Capping Protein; Citrulline; Electrophoresis, Gel, Two-Dimensional; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Osteoarthritis; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synovial Membrane

2006
[Significance of citrullinated collagen type II and its antibodies in rheumatoid arthritis].
    Zhonghua yi xue za zhi, 2006, Sep-05, Volume: 86, Issue:33

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Blood Sedimentation; Blotting, Western; C-Reactive Protein; Citrulline; Collagen Type II; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Rheumatoid Factor

2006
Technical and diagnostic performance of 6 assays for the measurement of citrullinated protein/peptide antibodies in the diagnosis of rheumatoid arthritis.
    Clinical chemistry, 2007, Volume: 53, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Peptides, Cyclic; Rats; Recombinant Proteins; Reproducibility of Results; Vimentin

2007
[Modern strategy of diagnostics and management of patients with rheumatoid arthritis].
    Polskie Archiwum Medycyny Wewnetrznej, 2006, Volume: 115, Issue:1

    Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Female; Humans; Male; Methotrexate; Prednisone; Pregnancy; Prognosis; Rheumatoid Factor

2006
Antibodies to citrullinated human fibrinogen synthetic peptides in diagnosing rheumatoid arthritis.
    Journal of medicinal chemistry, 2007, Jul-26, Volume: 50, Issue:15

    Topics: Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Enzyme-Linked Immunosorbent Assay; Epitopes; Fibrin; Fibrinogen; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Molecular Sequence Data; Peptides; Peptides, Cyclic

2007
Analytical and diagnostic characteristics of 11 2nd- and 3rd-generation immunoenzymatic methods for the detection of antibodies to citrullinated proteins.
    Clinical chemistry, 2007, Volume: 53, Issue:8

    Topics: Animals; Antigens, Nuclear; Antigens, Viral; Arthritis, Rheumatoid; Autoantibodies; Citrulline; False Positive Reactions; Filaggrin Proteins; Herpesvirus 4, Human; Humans; Immunoenzyme Techniques; Immunoglobulin G; Intermediate Filament Proteins; Mutation; Peptides; Peptides, Cyclic; Rats; Recombinant Proteins; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Vimentin

2007
Prevalence and clinical significance of antibodies to citrullinated fibrinogen (ACF) in Chinese patients with rheumatoid arthritis.
    Clinical rheumatology, 2007, Volume: 26, Issue:9

    Topics: Adult; Aged; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; China; Citrulline; Cohort Studies; Female; Fibrinogen; Humans; Male; Middle Aged; Peptides, Cyclic

2007
Mutation and citrullination modifies vimentin to a novel autoantigen for rheumatoid arthritis.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:8

    Topics: Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Biomarkers; Cell Line; Citrulline; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Humans; Hydrogen Peroxide; Male; Middle Aged; Mutation; Oxidative Stress; Protein Isoforms; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Synovial Fluid; Tandem Mass Spectrometry; Vimentin

2007
ABAP: antibody-based assay for peptidylarginine deiminase activity.
    Analytical biochemistry, 2007, Oct-15, Volume: 369, Issue:2

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Blotting, Western; Catalysis; Citrulline; Enzyme-Linked Immunosorbent Assay; Histones; Humans; Hydrolases; Immunoenzyme Techniques; Protein Processing, Post-Translational; Protein-Arginine Deiminases; Reproducibility of Results; Sensitivity and Specificity

2007
Differential responsiveness to immunoablative therapy in refractory rheumatoid arthritis is associated with level and avidity of anti-cyclic citrullinated protein autoantibodies: a case study.
    Arthritis research & therapy, 2007, Volume: 9, Issue:5

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Follow-Up Studies; Humans; Immunosuppressive Agents; Male; Middle Aged; Proteins; Tetanus Toxoid; Treatment Outcome

2007
Peptidyl arginine deiminase type 2 (PAD-2) and PAD-4 but not PAD-1, PAD-3, and PAD-6 are expressed in rheumatoid arthritis synovium in close association with tissue inflammation.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Citrulline; Female; Gene Expression Regulation, Enzymologic; Humans; Hydrolases; Isoenzymes; Leukocytes, Mononuclear; Macrophages; Male; Middle Aged; Monocytes; Protein-Arginine Deiminase Type 1; Protein-Arginine Deiminase Type 3; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminase Type 6; Protein-Arginine Deiminases; Synovial Membrane

2007
Fine specificity of the anti-citrullinated protein antibody response is influenced by the shared epitope alleles.
    Arthritis and rheumatism, 2007, Volume: 56, Issue:12

    Topics: Alleles; Antibodies, Anti-Idiotypic; Antibody Specificity; Arthritis, Rheumatoid; Citrulline; Cohort Studies; Epitopes; Fibrinogen; Genetic Predisposition to Disease; HLA-DR Antigens; HLA-DRB1 Chains; Humans; Vimentin

2007
Antibodies against citrullinated vimentin in rheumatoid arthritis: higher sensitivity and extended prognostic value concerning future radiographic progression as compared with antibodies against cyclic citrullinated peptides.
    Arthritis and rheumatism, 2008, Volume: 58, Issue:1

    Topics: Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Cohort Studies; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Follow-Up Studies; Humans; Male; Middle Aged; Peptides, Cyclic; Prognosis; Radiography; Vimentin

2008
Diagnosis of rheumatoid arthritis: multivariate analysis of biomarkers.
    Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals, 2008, Volume: 13, Issue:1

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Biomarkers; Citrulline; Female; Humans; Longitudinal Studies; Male; Middle Aged; Multivariate Analysis; Peptides, Cyclic; Prospective Studies; Sensitivity and Specificity; Serum Amyloid A Protein

2008
[The anticitrulline antibody test: unsuitable for screening for rheumatoid arthritis].
    Nederlands tijdschrift voor geneeskunde, 2008, Jan-12, Volume: 152, Issue:2

    Topics: Arthritis, Rheumatoid; Autoantibodies; Citrulline; Fibrinogen; Humans; Mass Screening; Rheumatoid Factor; Sensitivity and Specificity

2008
[The diagnostic accuracy of anti-citrullin antibody assessment in the diagnosis of patients suspected of rheumatoid arthritis by a general practitioner].
    Nederlands tijdschrift voor geneeskunde, 2008, Jan-12, Volume: 152, Issue:2

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Citrulline; Diagnosis, Differential; Family Practice; Humans; Immunoglobulin M; Retrospective Studies; Rheumatoid Factor; Sensitivity and Specificity

2008
Synovial detection and autoantibody reactivity of processed citrullinated isoforms of vimentin in inflammatory arthritides.
    Rheumatology (Oxford, England), 2008, Volume: 47, Issue:5

    Topics: Aged; Antigen-Antibody Reactions; Arthritis; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Blotting, Western; Caspase 3; Citrulline; Electrophoresis, Polyacrylamide Gel; Female; Humans; Immunoprecipitation; Male; Middle Aged; Protein Isoforms; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spondylitis, Ankylosing; Synovial Membrane; Vimentin

2008
Diagnostic utility of anti-cyclic citrullinated peptide and anti-modified citrullinated vimentin antibodies in rheumatoid arthritis.
    Protein and peptide letters, 2008, Volume: 15, Issue:3

    Topics: Adult; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Vimentin

2008
Plasma reactive nitrogen intermediate levels in patients with clinically active rheumatoid arthritis.
    The Indian journal of medical research, 1996, Volume: 104

    Topics: Adult; Arthritis, Rheumatoid; Citrulline; Female; Free Radicals; Humans; Male; Methotrexate; Nitrites; Nitrogen

1996
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.
    The Journal of clinical investigation, 1998, Jan-01, Volume: 101, Issue:1

    Topics: Amino Acid Sequence; Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Autoantigens; Citrulline; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Keratins; Molecular Sequence Data; Peptides

1998
The epitopes targeted by the rheumatoid arthritis-associated antifilaggrin autoantibodies are posttranslationally generated on various sites of (pro)filaggrin by deimination of arginine residues.
    Journal of immunology (Baltimore, Md. : 1950), 1999, Jan-01, Volume: 162, Issue:1

    Topics: Amino Acid Sequence; Amino Acid Substitution; Arginine; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Epidermis; Epithelium; Epitopes; Filaggrin Proteins; Humans; Hydrolases; Intermediate Filament Proteins; Molecular Sequence Data; Peptide Fragments; Protein Precursors; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases; Recombinant Proteins

1999
The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Arthritis, Rheumatoid; Autoantibodies; Bacterial Infections; Citrulline; Enzyme-Linked Immunosorbent Assay; False Positive Reactions; Female; Follow-Up Studies; Humans; Immunoglobulin M; Male; Middle Aged; Molecular Sequence Data; Peptides, Cyclic; Predictive Value of Tests; Prognosis; Rheumatoid Factor; Sensitivity and Specificity

2000
The prognostic value of anti-cyclic citrullinated peptide antibody in patients with recent-onset rheumatoid arthritis.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:8

    Topics: Adult; Aged; Antibodies; Arthritis, Rheumatoid; Citrulline; Female; Humans; Male; Middle Aged; Predictive Value of Tests; Prognosis

2000
Anticitrulline antibody assay specificity for rheumatoid arthritis: comment on the article by Schellekens et al.
    Arthritis and rheumatism, 2000, Volume: 43, Issue:8

    Topics: Antibodies; Antibody Specificity; Arthritis, Rheumatoid; Citrulline; Humans

2000
Rheumatoid arthritis associated autoantibodies in patients with synovitis of recent onset.
    Arthritis research, 2000, Volume: 2, Issue:3

    Topics: Acute Disease; Adult; Antibody Specificity; Arthritis, Rheumatoid; Autoantibodies; Calcium-Binding Proteins; Citrulline; Coenzyme A Ligases; Cohort Studies; Epitopes; Female; Filaggrin Proteins; Histocompatibility Testing; Humans; Intermediate Filament Proteins; Keratins; Male; Middle Aged; Peptides, Cyclic; Predictive Value of Tests; Proteins; Rheumatoid Factor; Seroepidemiologic Studies; Synovitis

2000
Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis.
    Annals of the rheumatic diseases, 2001, Volume: 60, Issue:1

    Topics: Antibodies, Antinuclear; Arthritis, Rheumatoid; Autoantibodies; Biomarkers; Citrulline; Diagnosis, Differential; Follow-Up Studies; Humans; Lupus Erythematosus, Systemic; Retrospective Studies; Rheumatoid Factor

2001
Secretion of anti-citrulline-containing peptide antibody by B lymphocytes in rheumatoid arthritis.
    Arthritis and rheumatism, 2001, Volume: 44, Issue:1

    Topics: Antibody Formation; Arthritis, Rheumatoid; Autoantibodies; B-Lymphocytes; Citrulline; Humans; Immunoglobulin M; Synovial Fluid

2001
Diagnostic accuracy of the anti-citrulline antibody assay for rheumatoid arthritis.
    Clinical chemistry, 2001, Volume: 47, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Diagnostic Techniques and Procedures; Enzyme-Linked Immunosorbent Assay; Female; Humans; Male; Middle Aged; Peptides, Cyclic; Rheumatoid Factor; Sensitivity and Specificity

2001
Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies.
    Arthritis and rheumatism, 2001, Volume: 44, Issue:10

    Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Citrulline; Female; Filaggrin Proteins; Humans; Intermediate Filament Proteins; Male; Middle Aged; Proteins; Synovial Membrane

2001
Absence of anti-cyclic citrullinated peptide antibodies in antineutrophil cytoplasmic antibody-associated vasculitis.
    Arthritis and rheumatism, 2002, Volume: 46, Issue:3

    Topics: Antibodies, Antineutrophil Cytoplasmic; Arthritis, Rheumatoid; Autoantibodies; Citrulline; Humans; Vasculitis

2002
Diagnostic tests for rheumatoid arthritis: comparison of anti-cyclic citrullinated peptide antibodies, anti-keratin antibodies and IgM rheumatoid factors.
    Rheumatology (Oxford, England), 2002, Volume: 41, Issue:7

    Topics: Aged; Antibodies; Arthritis, Rheumatoid; Biomarkers; Citrulline; Cross-Sectional Studies; Female; Humans; Immunoglobulin M; Keratins; Male; Middle Aged; Rheumatoid Factor; Severity of Illness Index

2002