citrinin and Liver-Diseases

The toxic effects of citrinin in turkeys and ducklings was studied in four trials. Citrinin dissolved in dimethyl sulfoxide-70% ethanol solution (3:1, volume/volume) was administered by gavage to male turkey poults and male white Pekin ducklings. When seven-day-old ducklings were given doses of citrinin between 30 to 110 mg/kg body weight, most of the treated ducklings which died (49/80) did so within four to 12 hours. Blood samples were collected sequentially at 3, 6, 12, and 24 hours after administration from seven-day-old ducklings given the single lethal dose (LD50). The alterations included hyperkalemia (P less than or equal to 0.01) and metabolic acidosis characterized by reduced blood pH (P less than or equal to 0.01) and base excess (P less than or equal to 0.01). Fourteen-day-old turkeys and ducklings given 56 or 57 mg/kg, respectively, were killed at 1, 3, 6, 12, 24, 48, and 72 hours after treatment. The principal alteration in both species was nephrosis that was more severe in turkeys than in ducklings. Tubular necrosis was the dominant lesion at three to 72 hours in turkeys and at six to 24 hours in ducklings. Hepatic and lymphoid lesions occurred in both turkeys and ducklings treated with citrinin.

Topics: Animals; Benzopyrans; Citrinin; Ducks; Kidney Diseases; Liver Diseases; Lymphatic Diseases; Male; Mycotoxins; Necrosis; Poultry Diseases; Rats; Turkeys