citrinin and Fatigue-Syndrome--Chronic

HemoHIM is an herbal preparation containing. The antifatigue effects of HemoHIM using models of citrinin and exercise-induced chronic fatigue syndrome were investigated.. Citrinin-induced L6 skeletal muscle cells were treated with HemoHIM (125, 250, and 500 μg/mL). The antioxidant factors were analysed. ICR mice were divided into four groups (n = 10): control, HemoHIM 250, 500 mg/kg, and creatine 300 mg/kg, respectively. Mice were orally administered HemoHIM or creatine for three weeks; during this time, both rotarod test and forced swimming test (FST) were conducted. The latency time was investigated and antioxidant, antifatigue factors were analysed.

Topics: Animals; Antioxidants; Cell Line; Citrinin; Disease Models, Animal; Dose-Response Relationship, Drug; Fatigue Syndrome, Chronic; Glucose; Glutathione; Male; Mice; Mice, Inbred ICR; Muscle, Skeletal; Plant Extracts; Rats