citric-acid--iron--sorbitol-drug-combination has been researched along with Disease-Models--Animal* in 1 studies
1 other study(ies) available for citric-acid--iron--sorbitol-drug-combination and Disease-Models--Animal
Article | Year |
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Role of iron and iron chelation therapy in oxygen free radical mediated tissue injury in an ascending mouse model of chronic pyelonephritis.
The contribution of iron towards the free radical generation leading to renal tissue damage was assessed using a non-obstructive ascending mouse model for chronic pyelonephritis. The parameters studied include luminol dependent chemiluminescence (LDCL), histopathology and some biochemical investigations. We found that iron enhanced the renal tissue damage and led to renal scarring, and end point in chronic renal inflammation, irrespective of the bacterial strain studied. In addition a role of iron chelation therapy as a treatment for chronic renal inflammation is also suggested. Topics: Animals; Chelation Therapy; Chronic Disease; Citric Acid; Deferoxamine; Disease Models, Animal; Drug Combinations; Escherichia coli; Escherichia coli Infections; Female; Ferric Compounds; Free Radicals; Glucosephosphate Dehydrogenase; Glutathione Reductase; Histocytochemistry; Iron; Kidney; L-Lactate Dehydrogenase; Lipid Peroxides; Luminescent Measurements; Mice; Mice, Inbred BALB C; Pyelonephritis; Reactive Oxygen Species; Sorbitol | 1997 |