citric-acid--iron--sorbitol-drug-combination and Anemia--Hypochromic

Topics: Acute Disease; Administration, Oral; Anemia, Hypochromic; Child; Child, Preschool; Chronic Disease; Citrates; Citric Acid; Delayed-Action Preparations; Dose-Response Relationship, Drug; Drug Combinations; Female; Ferric Compounds; Humans; Infant; Infant, Newborn; Infusions, Parenteral; Injections, Intramuscular; Iron; Iron-Dextran Complex; Pregnancy; Sorbitol

A new laboratory technique for determining the urine iron concentration is described. By means of another new method, the so-called intramuscular iron loading test, any iron deficiency can be recognized at an early stage.

Topics: Adult; Aged; Anemia, Hypochromic; Citrates; Citric Acid; Drug Combinations; Female; Ferric Compounds; Humans; Injections, Intramuscular; Iron; Male; Methods; Middle Aged; Sorbitol

Topics: Anemia; Anemia, Hypochromic; Arthritis; Arthritis, Rheumatoid; Biomedical Research; Blood; Citrates; Citric Acid; Drug Combinations; Drug Therapy; Ferric Compounds; Humans; Injections, Intramuscular; Iron; Iron Isotopes; Liver; Muscles; Myocardium; Radiometry; Sacrum; Sorbitol; Spleen; Urine

Topics: Anemia, Hypochromic; Citric Acid; Drug Combinations; Female; Ferric Compounds; Humans; Iron; Iron-Dextran Complex; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Sorbitol; Toxicology

One hundred and twenty-eight patients with iron deficiency anemia were treated with a new intramuscular iron preparation, iron-sorbitol-citric acid. One group of 10 patients received a total of 1000 mg. each of elemental iron intramuscularly. All obtained a rise in hemoglobin of over 2.1 g. %, an elevation of serum iron, and a reticulocyte response over 6%. A second larger group of subjects consisted of 113 prenatal and five gynecologic patients; these received an average total dose of 1050 mg. and 1020 mg., respectively, and the average increase in hemoglobin ranged from 1.6 g. % to 2.5 g. %.None of the patients developed significant side effects after injection or permanent staining at the site of injection. Three patients experienced a transient ache at the injection site, and three developed local urticaria-like reactions lasting 24 hours.This new preparation appears to be a safe and clinically effective therapeutic agent in situations in which parenteral iron is indicated.

Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Citrates; Citric Acid; Drug Combinations; Drug Therapy; Ferric Compounds; Hemoglobins; Humans; Injections, Intramuscular; Iron; Sorbitol; Toxicology

Topics: Anemia; Anemia, Hypochromic; Biomedical Research; Citrates; Citric Acid; Drug Combinations; Drug Therapy; Ferric Compounds; Humans; Injections, Intramuscular; Iron; Iron Isotopes; Iron-Dextran Complex; Pharmacology; Sorbitol; Toxicology; Transferrin

Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Pernicious; Citric Acid; Drug Combinations; Drug Therapy; Ferric Compounds; Humans; Injections, Intramuscular; Iron; Sorbitol; Toxicology

Topics: Anemia; Anemia, Hypochromic; Anemia, Iron-Deficiency; Citric Acid; Drug Combinations; Drug Therapy; Ferric Compounds; Humans; Iron; Sorbitol

Topics: Anemia, Hypochromic; Citrates; Citric Acid; Drug Combinations; Female; Ferric Compounds; Humans; Iron; Pregnancy; Pregnancy Complications; Sorbitol

Topics: Anemia; Anemia, Hypochromic; Citric Acid; Drug Combinations; Ferric Compounds; Humans; Iron; Sorbitol

Topics: Anemia, Hypochromic; Anemia, Iron-Deficiency; Citrates; Citric Acid; Drug Combinations; Ferric Compounds; Humans; Iron Isotopes; Iron-Dextran Complex; Sorbitol