Page last updated: 2024-10-17

citric acid, anhydrous and Seizures

citric acid, anhydrous has been researched along with Seizures in 8 studies

Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"This metabolic control of the seizure susceptibility was mapped to a pair of glutamatergic neurons, reversible by optogenetic controls of their activity, and further relayed onto fan-shaped body neurons via the ionotropic glutamate receptors."1.62Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. ( Jeong, J; Kim, JH; Lee, J; Lim, C, 2021)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19902 (25.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's2 (25.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Jeong, J1
Lee, J1
Kim, JH1
Lim, C1
Henke, C1
Töllner, K1
van Dijk, RM1
Miljanovic, N1
Cordes, T1
Twele, F1
Bröer, S1
Ziesak, V1
Rohde, M1
Hauck, SM1
Vogel, C1
Welzel, L1
Schumann, T1
Willmes, DM1
Kurzbach, A1
El-Agroudy, NN1
Bornstein, SR1
Schneider, SA1
Jordan, J1
Potschka, H1
Metallo, CM1
Köhling, R1
Birkenfeld, AL1
Löscher, W1
Bainbridge, MN1
Cooney, E1
Miller, M1
Kennedy, AD1
Wulff, JE1
Donti, T1
Jhangiani, SN1
Gibbs, RA1
Elsea, SH1
Porter, BE1
Graham, BH1
PINCUS, JB1
NATELSON, S1
LUGOVOY, JK1
Dillon, CE1
Laher, MS1
Hasan, AG1
Brown, WR1
Frizelle, FA1
Colls, BM1
Marrazzi, MA1
Holliday, JF1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
SLC13A5 Deficiency: A Prospective Natural History Study - United States Only[NCT06144957]17 participants (Anticipated)Observational2021-12-01Recruiting
SLC13A5 Deficiency: A Prospective Natural History Study - Remote Only (International)[NCT04681781]20 participants (Anticipated)Observational2021-03-01Enrolling by invitation
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

8 other studies available for citric acid, anhydrous and Seizures

ArticleYear
Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset.
    PLoS genetics, 2021, Volume: 17, Issue:10

    Topics: Animals; Citric Acid; Citric Acid Cycle; Dicarboxylic Acid Transporters; Drosophila; Drosophila Prot

2021
Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus.
    Neurobiology of disease, 2020, Volume: 143

    Topics: Animals; Brain; Citric Acid; Dicarboxylic Acid Transporters; Drug Resistant Epilepsy; Female; Hippoc

2020
Analyses of SLC13A5-epilepsy patients reveal perturbations of TCA cycle.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:4

    Topics: Child; Citric Acid; Citric Acid Cycle; Exome Sequencing; Female; Humans; Infant, Newborn; Male; Mass

2017
Analyses of SLC13A5-epilepsy patients reveal perturbations of TCA cycle.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:4

    Topics: Child; Citric Acid; Citric Acid Cycle; Exome Sequencing; Female; Humans; Infant, Newborn; Male; Mass

2017
Analyses of SLC13A5-epilepsy patients reveal perturbations of TCA cycle.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:4

    Topics: Child; Citric Acid; Citric Acid Cycle; Exome Sequencing; Female; Humans; Infant, Newborn; Male; Mass

2017
Analyses of SLC13A5-epilepsy patients reveal perturbations of TCA cycle.
    Molecular genetics and metabolism, 2017, Volume: 121, Issue:4

    Topics: Child; Citric Acid; Citric Acid Cycle; Exome Sequencing; Female; Humans; Infant, Newborn; Male; Mass

2017
Response of citric acid levels to oral administration of glucose; abnormalities observed in the diabetic and convulsive state.
    The Journal of clinical investigation, 1948, Volume: 27, Issue:4

    Topics: Administration, Oral; Citric Acid; Diabetes Mellitus; Glucose; Seizures

1948
The rapid development of hyponatraemia and seizures in an elderly patient following sodium picosulfate/magnesium citrate (Picolax).
    Age and ageing, 2009, Volume: 38, Issue:4

    Topics: Aged, 80 and over; Cathartics; Citrates; Citric Acid; Colonoscopy; Female; Humans; Hyponatremia; Org

2009
Colonic cleansing for colonoscopy: a risk to be taken seriously.
    Gastrointestinal endoscopy, 2011, Volume: 73, Issue:3

    Topics: Accidental Falls; Aged; Bradycardia; Cathartics; Chest Pain; Citric Acid; Colonoscopy; Dyspnea; Fata

2011
Hyponatremia and seizures after bowel preparation: report of three cases.
    Diseases of the colon and rectum, 2005, Volume: 48, Issue:2

    Topics: Administration, Oral; Adult; Aged; Cathartics; Citric Acid; Colonoscopy; Female; Humans; Hyponatremi

2005
Comparison of insulin hypoglycemia-induced and fluoroacetate-induced convulsions in gold thioglucose lesioned mice.
    Biochemical pharmacology, 1981, Dec-01, Volume: 30, Issue:23

    Topics: Animals; Aurothioglucose; Blood Glucose; Body Weight; Citrates; Citric Acid; Female; Fluoroacetates;

1981