citric acid, anhydrous has been researched along with Neoplasms in 94 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Evaluation of (1) age-related dietary trends over time and (2) factors involved in iron absorption leads to the hypothesis that the combination of citric acid and ascorbic acid (a synergistic pair of strong enhancers) is instrumental in causing a deleterious increase in iron load in aging populations." | 8.79 | Proposed role for a combination of citric acid and ascorbic acid in the production of dietary iron overload: a fundamental cause of disease. ( Crawford, RD, 1995) |
| " Evaluation of (1) age-related dietary trends over time and (2) factors involved in iron absorption leads to the hypothesis that the combination of citric acid and ascorbic acid (a synergistic pair of strong enhancers) is instrumental in causing a deleterious increase in iron load in aging populations." | 4.79 | Proposed role for a combination of citric acid and ascorbic acid in the production of dietary iron overload: a fundamental cause of disease. ( Crawford, RD, 1995) |
| " calcium gluconate for treatment of hypocalcemia." | 3.76 | Increased risk of citrate reactions in patients with multiple myeloma during peripheral blood stem cell leukapheresis. ( Adamski, J; Eisenmann, C; Griffin, AC; Milone, MC; Sachais, BS, 2010) |
| "The culmination of 80+ years of cancer research implicates the aberrant metabolism in tumor cells as a root cause of pathogenesis." | 2.82 | Citrate transporter inhibitors: possible new anticancer agents. ( Kaplan, RS; Mayor, JA; Patil, SA, 2022) |
| "It is well established that cancer cells acquire energy via the Warburg effect and oxidative phosphorylation." | 2.72 | Extracellular citrate and metabolic adaptations of cancer cells. ( Adamski, J; Flores-Borja, F; Gaumann, A; Mycielska, ME; Parkinson, EK; Zahn, G; Ziegler, C, 2021) |
| "Citrate plays a central role in cancer cells' metabolism and regulation." | 2.72 | Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update. ( Coquerel, A; Fournel, L; Fuks, D; Gligorov, J; Icard, P; Lincet, H; Simula, L; Wu, Z, 2021) |
| "An important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation." | 2.66 | Targeting citrate as a novel therapeutic strategy in cancer treatment. ( Huang, L; Peng, G; Wang, C; Xu, H, 2020) |
| "Metabolic reprogramming in cancer cells entails activities that involve several enzymes and metabolites to convert nutrient into building blocks that alter energy metabolism to fuel rapid cell division." | 2.66 | Cancer Cell Metabolites: Updates on Current Tracing Methods. ( Maniam, S, 2020) |
| "This cycle allows cancer cells to burn their host's lipid and protein reserves in order to sustain their own biosynthesis pathways." | 2.48 | Understanding the central role of citrate in the metabolism of cancer cells. ( Icard, P; Lincet, H; Poulain, L, 2012) |
| "Understanding the metabolism of cancer cells may help to develop new anti-cancer treatments." | 2.48 | A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells. ( Icard, P; Lincet, H, 2012) |
| "To restore effective apoptosis in tumors, we propose that the administration of citrate could inhibit ATP production, activate caspase-8 (a key necroptosis inhibitor), and downregulate key anti-apoptotic proteins (Bcl-xL and MCL1)." | 1.91 | The potential for citrate to reinforce epigenetic therapy by promoting apoptosis. ( Alifano, M; Icard, P; Simula, L, 2023) |
| "Berberine is an isoquinoline alkaloid extracted from the root, rhizome and stem bark of Coptidis Rhizoma." | 1.56 | Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles. ( Gu, S; Huang, D; Li, Q; Liang, B; Ouyang, C; Song, X; Su, T; Xie, L; Xie, R; Xu, M; Xu, T, 2020) |
| "Immune surveillance of cancer cells is facilitated by the Natural Killer Group 2D (NKG2D) receptor expressed by different lymphocyte subsets." | 1.56 | Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. ( Aldana, BI; Andresen, L; Bermejo, AV; Daskalaki, E; Desler, C; Gerhart-Hines, Z; Hansen, MH; Hiron, TK; Høgh, RI; Jepsen, SD; Lin, D; Madsen, M; Mellergaard, M; Møller, SH; O'Callaghan, CA; Rasmussen, LJ; Skov, S; Sustarsic, EG; Wandall, HH; Wheelock, CE, 2020) |
| "Depending on their immune status, solid tumors can be immunologically classified into three groups: "hot" tumors are infiltrated with T lymphocytes, "cold" tumors are not infiltrated and "immune excluded" tumors are only infiltrated in the peripheral tumor tissue." | 1.51 | Functionalization Of T Lymphocytes With Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles For Magnetically Controlled Immune Therapy. ( Alexiou, C; Band, J; Cebulla, N; Dudziak, D; Friedrich, B; Friedrich, RP; Janko, C; Lee, G; Mühlberger, M; Tietze, R; Unterweger, H, 2019) |
| "One hundred twenty two consecutive ICU cancer patients with AKI treated with citrate-based CVVHD were prospectively evaluated in this prospective observational study." | 1.48 | Use of regional citrate anticoagulation for continuous venovenous hemodialysis in critically ill cancer patients with acute kidney injury. ( Bezerra, JS; Burdmann, EA; Caires, RA; Costa E Silva, VT; Costalonga, EC; Fukushima, JT; Hajjar, LA; Oikawa, L; Oliveira Coelho, F; Oliveira, APL; Soares, CM, 2018) |
| " We also analysed the potential of these particles for magnetic fluid hyperthermia by determination of the specific absorption rate at a constant frequency of 215 kHz; the temperature increase of the particles was 30." | 1.39 | Cationic albumin-conjugated magnetite nanoparticles, novel candidate for hyperthermia cancer therapy. ( Cheraghipour, E; Javadpour, S, 2013) |
| "Furthermore, we demonstrate that cancer cells incubated with GNPs are killed when exposed to 13." | 1.37 | A radio-frequency coupling network for heating of citrate-coated gold nanoparticles for cancer therapy: design and analysis. ( Ferrara, KW; Ingham, ES; Kruse, DE; Lindfors, HA; Paoli, EE; Stephens, DN, 2011) |
| "Because AIDS patients frequently present with minimal symptomatology, radionuclide imaging with its ability to survey the entire body, is especially valuable." | 1.29 | The role of gallium and labeled leukocyte scintigraphy in the AIDS patient. ( Goldsmith, SJ; Palestro, CJ, 1995) |
| "Tumors were clearly visualized in 19 out of 32 sites, with 59% of positive rate." | 1.28 | [Tumor imaging using 99mTc-hexamethylpropyleneamine oxime]. ( Fujii, H; Hasegawa, T; Hashimoto, S; Hashimoto, T; Kinoshita, F; Kubo, A; Nakamura, K; Okuyama, Y; Sanmiya, T; Shimizu, S, 1990) |
| "All cases had malignant tumors." | 1.28 | [Study on liver uptake changes in serial 67Ga scintigraphy]. ( Kobayashi, H; Sakuma, S; Tanaka, K, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (25.53) | 18.7374 |
| 1990's | 14 (14.89) | 18.2507 |
| 2000's | 7 (7.45) | 29.6817 |
| 2010's | 34 (36.17) | 24.3611 |
| 2020's | 15 (15.96) | 2.80 |
| Authors | Studies |
|---|---|
| Parkinson, EK | 1 |
| Adamski, J | 2 |
| Zahn, G | 1 |
| Gaumann, A | 1 |
| Flores-Borja, F | 1 |
| Ziegler, C | 1 |
| Mycielska, ME | 2 |
| Patil, SA | 1 |
| Mayor, JA | 1 |
| Kaplan, RS | 1 |
| Xia, Y | 2 |
| Xue, H | 2 |
| Li, J | 8 |
| Yu, Y | 4 |
| Huang, W | 1 |
| Zhou, C | 2 |
| Shi, T | 1 |
| Cheng, Y | 1 |
| Zhang, C | 4 |
| Liu, S | 2 |
| Song, Z | 1 |
| Xu, S | 1 |
| Lou, J | 1 |
| van den Bosch, CH | 1 |
| Loeffen, Y | 1 |
| van der Steeg, AFW | 1 |
| van der Bruggen, JT | 1 |
| Frakking, FNJ | 1 |
| Fiocco, M | 1 |
| van de Ven, CP | 1 |
| Wijnen, MHWA | 1 |
| van de Wetering, MD | 1 |
| Icard, P | 8 |
| Alifano, M | 4 |
| Simula, L | 3 |
| Mühlberger, M | 1 |
| Janko, C | 1 |
| Unterweger, H | 1 |
| Friedrich, RP | 1 |
| Friedrich, B | 1 |
| Band, J | 1 |
| Cebulla, N | 1 |
| Alexiou, C | 1 |
| Dudziak, D | 1 |
| Lee, G | 2 |
| Tietze, R | 1 |
| Huang, L | 3 |
| Wang, C | 3 |
| Xu, H | 3 |
| Peng, G | 1 |
| Ferraz, FS | 1 |
| López, JL | 1 |
| Lacerda, SMSN | 1 |
| Procópio, MS | 1 |
| Figueiredo, AFA | 1 |
| Martins, EMN | 1 |
| Guimarães, PPG | 1 |
| Ladeira, LO | 1 |
| Kitten, GT | 1 |
| Dias, FF | 1 |
| Domingues, RZ | 1 |
| Costa, GMJ | 1 |
| Halim, AA | 1 |
| Alsayed, B | 1 |
| Embarak, S | 1 |
| Yaseen, T | 1 |
| Dabbous, S | 1 |
| Fontaine, O | 1 |
| Dueluzeau, R | 1 |
| Raibaud, P | 1 |
| Chabanet, C | 1 |
| Popoff, MR | 1 |
| Badoual, J | 1 |
| Gabilan, JC | 1 |
| Andremont, A | 1 |
| Gómez, L | 1 |
| Andrés, S | 1 |
| Sánchez, J | 1 |
| Alonso, JM | 1 |
| Rey, J | 1 |
| López, F | 1 |
| Jiménez, A | 1 |
| Yan, Z | 1 |
| Zhou, L | 1 |
| Zhao, Y | 3 |
| Wang, J | 6 |
| Hu, K | 1 |
| Liu, H | 4 |
| Wang, H | 3 |
| Guo, Z | 1 |
| Song, Y | 1 |
| Huang, H | 4 |
| Yang, R | 1 |
| Owen, TW | 1 |
| Al-Kaysi, RO | 1 |
| Bardeen, CJ | 1 |
| Cheng, Q | 1 |
| Wu, S | 1 |
| Cheng, T | 2 |
| Zhou, X | 1 |
| Wang, B | 4 |
| Zhang, Q | 4 |
| Wu, X | 2 |
| Yao, Y | 3 |
| Ochiai, T | 1 |
| Ishiguro, H | 2 |
| Nakano, R | 2 |
| Kubota, Y | 2 |
| Hara, M | 1 |
| Sunada, K | 1 |
| Hashimoto, K | 1 |
| Kajioka, J | 1 |
| Fujishima, A | 1 |
| Jiao, J | 3 |
| Gai, QY | 3 |
| Wang, W | 2 |
| Zang, YP | 2 |
| Niu, LL | 2 |
| Fu, YJ | 3 |
| Wang, X | 4 |
| Yao, LP | 1 |
| Qin, QP | 1 |
| Wang, ZY | 1 |
| Liu, J | 4 |
| Aleksic Sabo, V | 1 |
| Knezevic, P | 1 |
| Borges-Argáez, R | 1 |
| Chan-Balan, R | 1 |
| Cetina-Montejo, L | 1 |
| Ayora-Talavera, G | 1 |
| Sansores-Peraza, P | 1 |
| Gómez-Carballo, J | 1 |
| Cáceres-Farfán, M | 1 |
| Jang, J | 1 |
| Akin, D | 1 |
| Bashir, R | 1 |
| Yu, Z | 1 |
| Zhu, J | 2 |
| Jiang, H | 1 |
| He, C | 2 |
| Xiao, Z | 1 |
| Xu, J | 2 |
| Sun, Q | 1 |
| Han, D | 1 |
| Lei, H | 1 |
| Zhao, K | 2 |
| Zhu, L | 1 |
| Li, X | 4 |
| Fu, H | 2 |
| Wilson, BK | 1 |
| Step, DL | 1 |
| Maxwell, CL | 1 |
| Gifford, CA | 1 |
| Richards, CJ | 1 |
| Krehbiel, CR | 1 |
| Warner, JM | 1 |
| Doerr, AJ | 1 |
| Erickson, GE | 1 |
| Guretzky, JA | 1 |
| Rasby, RJ | 1 |
| Watson, AK | 1 |
| Klopfenstein, TJ | 1 |
| Sun, Y | 4 |
| Liu, Z | 3 |
| Pham, TD | 1 |
| Lee, BK | 1 |
| Yang, FC | 1 |
| Wu, KH | 1 |
| Lin, WP | 1 |
| Hu, MK | 1 |
| Lin, L | 3 |
| Shao, J | 1 |
| Sun, M | 1 |
| Xu, G | 1 |
| Zhang, X | 6 |
| Xu, N | 1 |
| Wang, R | 1 |
| He, H | 1 |
| Dong, X | 2 |
| Yang, M | 2 |
| Yang, Q | 1 |
| Duan, S | 1 |
| Han, J | 2 |
| Chen, L | 2 |
| Yang, X | 1 |
| Li, W | 3 |
| Wang, T | 2 |
| Campbell, DA | 1 |
| Gao, K | 1 |
| Zager, RA | 1 |
| Johnson, ACM | 1 |
| Guillem, A | 1 |
| Keyser, J | 1 |
| Singh, B | 1 |
| Steubl, D | 1 |
| Schneider, MP | 1 |
| Meiselbach, H | 1 |
| Nadal, J | 1 |
| Schmid, MC | 1 |
| Saritas, T | 1 |
| Krane, V | 1 |
| Sommerer, C | 1 |
| Baid-Agrawal, S | 1 |
| Voelkl, J | 1 |
| Kotsis, F | 1 |
| Köttgen, A | 1 |
| Eckardt, KU | 1 |
| Scherberich, JE | 1 |
| Li, H | 4 |
| Yao, L | 2 |
| Sun, L | 3 |
| Zhu, Z | 1 |
| Naren, N | 1 |
| Zhang, XX | 2 |
| Gentile, GL | 1 |
| Rupert, AS | 1 |
| Carrasco, LI | 1 |
| Garcia, EM | 1 |
| Kumar, NG | 1 |
| Walsh, SW | 1 |
| Jefferson, KK | 1 |
| Guest, RL | 1 |
| Samé Guerra, D | 1 |
| Wissler, M | 1 |
| Grimm, J | 1 |
| Silhavy, TJ | 1 |
| Lee, JH | 2 |
| Yoo, JS | 1 |
| Kim, Y | 1 |
| Kim, JS | 2 |
| Lee, EJ | 1 |
| Roe, JH | 1 |
| Delorme, M | 1 |
| Bouchard, PA | 1 |
| Simon, M | 1 |
| Simard, S | 1 |
| Lellouche, F | 1 |
| D'Urzo, KA | 1 |
| Mok, F | 1 |
| D'Urzo, AD | 1 |
| Koneru, B | 1 |
| Lopez, G | 1 |
| Farooqi, A | 1 |
| Conkrite, KL | 1 |
| Nguyen, TH | 1 |
| Macha, SJ | 1 |
| Modi, A | 1 |
| Rokita, JL | 1 |
| Urias, E | 1 |
| Hindle, A | 1 |
| Davidson, H | 1 |
| Mccoy, K | 1 |
| Nance, J | 1 |
| Yazdani, V | 1 |
| Irwin, MS | 1 |
| Yang, S | 1 |
| Wheeler, DA | 1 |
| Maris, JM | 1 |
| Diskin, SJ | 1 |
| Reynolds, CP | 1 |
| Abhilash, L | 1 |
| Kalliyil, A | 1 |
| Sheeba, V | 1 |
| Hartley, AM | 2 |
| Meunier, B | 2 |
| Pinotsis, N | 1 |
| Maréchal, A | 2 |
| Xu, JY | 1 |
| Genko, N | 1 |
| Haraux, F | 1 |
| Rich, PR | 1 |
| Kamalanathan, M | 1 |
| Doyle, SM | 1 |
| Xu, C | 1 |
| Achberger, AM | 1 |
| Wade, TL | 1 |
| Schwehr, K | 1 |
| Santschi, PH | 1 |
| Sylvan, JB | 1 |
| Quigg, A | 1 |
| Leong, W | 1 |
| Xu, W | 2 |
| Gao, S | 1 |
| Zhai, X | 1 |
| Gilson, E | 1 |
| Ye, J | 1 |
| Lu, Y | 1 |
| Yan, R | 1 |
| Zhang, Y | 6 |
| Hu, Z | 1 |
| You, Q | 1 |
| Cai, Q | 1 |
| Yang, D | 1 |
| Gu, S | 2 |
| Dai, H | 1 |
| Zhao, X | 1 |
| Gui, C | 1 |
| Gui, J | 1 |
| Wu, PK | 1 |
| Hong, SK | 1 |
| Starenki, D | 1 |
| Oshima, K | 1 |
| Shao, H | 1 |
| Gestwicki, JE | 1 |
| Tsai, S | 1 |
| Park, JI | 1 |
| Wang, Y | 7 |
| Zhao, R | 1 |
| Gu, Z | 1 |
| Dong, C | 2 |
| Guo, G | 1 |
| Li, L | 4 |
| Barrett, HE | 1 |
| Meester, EJ | 1 |
| van Gaalen, K | 1 |
| van der Heiden, K | 1 |
| Krenning, BJ | 1 |
| Beekman, FJ | 1 |
| de Blois, E | 1 |
| de Swart, J | 1 |
| Verhagen, HJ | 1 |
| Maina, T | 1 |
| Nock, BA | 1 |
| Norenberg, JP | 1 |
| de Jong, M | 1 |
| Gijsen, FJH | 1 |
| Bernsen, MR | 1 |
| Martínez-Milla, J | 1 |
| Galán-Arriola, C | 1 |
| Carnero, M | 1 |
| Cobiella, J | 1 |
| Pérez-Camargo, D | 1 |
| Bautista-Hernández, V | 1 |
| Rigol, M | 1 |
| Solanes, N | 1 |
| Villena-Gutierrez, R | 1 |
| Lobo, M | 1 |
| Mateo, J | 1 |
| Vilchez-Tschischke, JP | 1 |
| Salinas, B | 1 |
| Cussó, L | 1 |
| López, GJ | 1 |
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| Sanchez-González, J | 1 |
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| van den Berg, P | 1 |
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| van Haard, PMM | 1 |
| Geusens, PP | 1 |
| van den Bergh, JP | 1 |
| Zhu, X | 1 |
| Huang, X | 2 |
| Yang, G | 2 |
| Lin, Z | 1 |
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| Abd El-Ghafar, OA | 1 |
| Farouk, HO | 1 |
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| de Carvalho, PA | 1 |
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| de Souza, LB | 1 |
| Chalfun-Júnior, A | 1 |
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| Lu, M | 2 |
| An, Z | 1 |
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| Du, S | 1 |
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| Cui, J | 1 |
| Wu, W | 1 |
| Liu, Y | 7 |
| Song, J | 1 |
| Lian, Q | 1 |
| Uddin Ahmad, Z | 1 |
| Gang, DD | 1 |
| Konggidinata, MI | 1 |
| Gallo, AA | 1 |
| Zappi, ME | 1 |
| Yang, TWW | 1 |
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| Capoluongo, E | 1 |
| Pocino, K | 1 |
| Ianiro, G | 1 |
| Cammarota, G | 1 |
| Gasbarrini, A | 1 |
| Montalto, M | 1 |
| Somasundar, Y | 1 |
| Lu, IC | 1 |
| Mills, MR | 1 |
| Qian, LY | 1 |
| Olivares, X | 1 |
| Ryabov, AD | 1 |
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| Wáng, YXJ | 1 |
| Sun, J | 2 |
| Chu, S | 1 |
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| Li, D | 2 |
| Zheng, S | 2 |
| Ma, L | 1 |
| Wang, L | 3 |
| Hu, T | 1 |
| Wang, F | 1 |
| Han, Z | 1 |
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| Lei, P | 1 |
| Dias-Santagata, D | 1 |
| Lennerz, JK | 1 |
| Sadow, PM | 1 |
| Frazier, RP | 1 |
| Govinda Raju, S | 1 |
| Henry, D | 1 |
| Chung, T | 1 |
| Kherani, J | 1 |
| Rothenberg, SM | 1 |
| Wirth, LJ | 1 |
| Marti, CN | 1 |
| Choi, NG | 1 |
| Bae, SJ | 1 |
| Ni, L | 1 |
| Luo, X | 1 |
| Dai, T | 1 |
| Yang, Y | 4 |
| Lee, R | 1 |
| Fleischer, AS | 1 |
| Wemhoff, AP | 1 |
| Ford, CR | 1 |
| Kleppinger, EL | 1 |
| Helms, K | 1 |
| Bush, AA | 1 |
| Luna-Abanto, J | 1 |
| García Ruiz, L | 1 |
| Laura Martinez, J | 1 |
| Álvarez Larraondo, M | 1 |
| Villoslada Terrones, V | 1 |
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| Maric, N | 1 |
| Simundic, AM | 1 |
| Chogtu, B | 1 |
| Ommurugan, B | 1 |
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| Kalthur, SG | 1 |
| Benidir, M | 1 |
| El Massoudi, S | 1 |
| El Ghadraoui, L | 1 |
| Lazraq, A | 1 |
| Benjelloun, M | 1 |
| Errachidi, F | 1 |
| Cassar, M | 1 |
| Law, AD | 1 |
| Chow, ES | 1 |
| Giebultowicz, JM | 1 |
| Kretzschmar, D | 1 |
| Salonurmi, T | 1 |
| Nabil, H | 1 |
| Ronkainen, J | 1 |
| Hyötyläinen, T | 1 |
| Hautajärvi, H | 1 |
| Savolainen, MJ | 1 |
| Tolonen, A | 1 |
| Orešič, M | 1 |
| Känsäkoski, P | 1 |
| Rysä, J | 1 |
| Hakkola, J | 1 |
| Hukkanen, J | 1 |
| Zhu, N | 1 |
| Li, Y | 4 |
| Du, Q | 1 |
| Hao, P | 1 |
| Cao, X | 1 |
| Li, CX | 1 |
| Zhao, S | 1 |
| Luo, XM | 1 |
| Feng, JX | 1 |
| Gonzalez-Cotto, M | 1 |
| Guo, L | 1 |
| Karwan, M | 1 |
| Sen, SK | 1 |
| Barb, J | 1 |
| Collado, CJ | 1 |
| Elloumi, F | 1 |
| Palmieri, EM | 1 |
| Boelte, K | 1 |
| Kolodgie, FD | 1 |
| Finn, AV | 1 |
| Biesecker, LG | 1 |
| McVicar, DW | 1 |
| Qu, F | 1 |
| Deng, Z | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Single-arm Phase II Clinical Trial to Evaluate the Initial Efficacy and Safety of Sintilimab Injection Combined With Inlyta in Fumarate Hydratase- Deficient Renal Cell Carcinoma[NCT04387500] | Phase 2 | 41 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
23 reviews available for citric acid, anhydrous and Neoplasms
| Article | Year |
|---|---|
Extracellular citrate and metabolic adaptations of cancer cells.
Topics: Citrates; Citric Acid; Citric Acid Cycle; Humans; Neoplasms; Oxidative Phosphorylation; Tumor Microe | 2021 |
Citrate transporter inhibitors: possible new anticancer agents.
Topics: Antineoplastic Agents; Carrier Proteins; Citric Acid; Humans; Neoplasms | 2022 |
Targeting citrate as a novel therapeutic strategy in cancer treatment.
Topics: Apoptosis; Cell Proliferation; Citrate (si)-Synthase; Citric Acid; Energy Metabolism; Humans; Metabo | 2020 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Cancer Cell Metabolites: Updates on Current Tracing Methods.
Topics: Amino Acids; Citric Acid; Glucose; Glycine; Humans; Isotope Labeling; Lactic Acid; Neoplasms; Succin | 2020 |
The Mitochondrial Citrate Carrier SLC25A1/CIC and the Fundamental Role of Citrate in Cancer, Inflammation and Beyond.
Topics: Allosteric Site; Animals; Chromosomes, Human, Pair 22; Citrates; Citric Acid; Cytosol; Diabetes Mell | 2021 |
Consequences of NaCT/SLC13A5/mINDY deficiency: good versus evil, separated only by the blood-brain barrier.
Topics: Animals; Blood-Brain Barrier; Bone and Bones; Citric Acid; Citric Acid Cycle; Dental Enamel; Diabete | 2021 |
Understanding the Central Role of Citrate in the Metabolism of Cancer Cells and Tumors: An Update.
Topics: Animals; Citric Acid; Humans; Neoplasms; Oxidation-Reduction; Tumor Microenvironment; Warburg Effect | 2021 |
[The cancer tumor: a metabolic parasite?].
Topics: Amino Acids; Cell Hypoxia; Cell Proliferation; Citric Acid; Glycolysis; Humans; Lipolysis; NADP; Neo | 2013 |
The Warburg effect then and now: from cancer to inflammatory diseases.
Topics: AMP-Activated Protein Kinases; Animals; Carrier Proteins; Cell Line, Tumor; Cell Proliferation; Citr | 2013 |
Citrate--new functions for an old metabolite.
Topics: Acetylation; Animals; Citric Acid; Histones; Humans; Inflammation; Insulin; Insulin Secretion; Mitoc | 2014 |
MALDI mass spectrometric imaging meets "omics": recent advances in the fruitful marriage.
Topics: Animals; Brain; Calcinosis; Citric Acid; Humans; Metabolomics; Neoplasms; Neuropeptides; Proteomics; | 2015 |
The reduced concentration of citrate in cancer cells: An indicator of cancer aggressiveness and a possible therapeutic target.
Topics: Acetyl Coenzyme A; Apoptosis; ATP Citrate (pro-S)-Lyase; Biomarkers, Tumor; Citric Acid; Citric Acid | 2016 |
Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection.
Topics: Carbon; Cells, Cultured; Citric Acid; Citric Acid Cycle; Cytomegalovirus; Energy Metabolism; Fatty A | 2011 |
Understanding the central role of citrate in the metabolism of cancer cells.
Topics: Cell Proliferation; Citric Acid; Glycolysis; Humans; Neoplasms | 2012 |
ATP citrate lyase inhibitors as novel cancer therapeutic agents.
Topics: Animals; Antineoplastic Agents; ATP Citrate (pro-S)-Lyase; Citric Acid; Drug Design; Enzyme Inhibito | 2012 |
A global view of the biochemical pathways involved in the regulation of the metabolism of cancer cells.
Topics: Adenosine Triphosphate; Animals; Apoptosis; Cell Proliferation; Citric Acid; Citric Acid Cycle; Glyc | 2012 |
In vivo magnetic resonance spectroscopy in cancer.
Topics: Animals; Biopsy; Brain; Choline; Citric Acid; Esters; Female; Humans; Hydrogen; Isotopes; Lipids; Ma | 2005 |
'Why do tumour cells glycolyse?': from glycolysis through citrate to lipogenesis.
Topics: Aerobiosis; Citric Acid; Glucose; Glycolysis; Lipogenesis; Neoplasms | 2005 |
Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation.
Topics: Aconitate Hydratase; Citric Acid; Citric Acid Cycle; Fumarate Hydratase; Genes, Tumor Suppressor; Hu | 2006 |
Proposed role for a combination of citric acid and ascorbic acid in the production of dietary iron overload: a fundamental cause of disease.
Topics: Aging; Ascorbic Acid; Citrates; Citric Acid; Diet; Disease; Free Radicals; Heart Diseases; Humans; I | 1995 |
[Tumor imaging in nuclear medicine].
Topics: Citric Acid; Gallium Radioisotopes; Gamma Cameras; Humans; Indium Radioisotopes; Neoplasms; Octreoti | 1996 |
[The role of modifying factors in the carcinogenic effect of asbestos and asbestos-containing dusts].
Topics: Animals; Asbestos; Citrates; Citric Acid; Dust; Humans; Neoplasms; Zirconium | 1987 |
3 trials available for citric acid, anhydrous and Neoplasms
| Article | Year |
|---|---|
CATERPILLAR-study protocol: an assessor-blinded randomised controlled trial comparing taurolidine-citrate-heparin to heparin-only lock solutions for the prevention of central line-associated bloodstream infections in paediatric oncology patients.
Topics: Catheter-Related Infections; Central Venous Catheters; Child; Citrates; Citric Acid; Heparin; Humans | 2023 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Topics: A549 Cells; Acetylmuramyl-Alanyl-Isoglutamine; Acinetobacter baumannii; Acute Lung Injury; Adaptor P | 2016 |
Phase I study using desferrioxamine and iron sorbitol citrate in an attempt to modulate the iron status of tumor cells to enhance doxorubicin activity.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Citrates; Citric Acid; Deferoxamine; Do | 1993 |
69 other studies available for citric acid, anhydrous and Neoplasms
| Article | Year |
|---|---|
A nomogram prediction of citrate reaction during mononuclear cell collection in solid tumor patients.
Topics: Citrates; Citric Acid; Humans; Leukocytes, Mononuclear; Neoplasms; Nomograms; Retrospective Studies | 2023 |
The potential for citrate to reinforce epigenetic therapy by promoting apoptosis.
Topics: Adenosine Triphosphate; Apoptosis; bcl-X Protein; Citrates; Citric Acid; Epigenesis, Genetic; Humans | 2023 |
Functionalization Of T Lymphocytes With Citrate-Coated Superparamagnetic Iron Oxide Nanoparticles For Magnetically Controlled Immune Therapy.
Topics: Cell Line, Tumor; Citric Acid; Dextrans; Humans; Immunotherapy; Iron; Magnetics; Magnetite Nanoparti | 2019 |
Biotechnological approach to induce human fibroblast apoptosis using superparamagnetic iron oxide nanoparticles.
Topics: Apoptosis; Cancer-Associated Fibroblasts; Cell Death; Cell Line; Cell Survival; Citric Acid; Endocyt | 2020 |
Berberine inhibits cancer cells growth by suppressing fatty acid synthesis and biogenesis of extracellular vesicles.
Topics: Acetyl-CoA Carboxylase; AMP-Activated Protein Kinases; Antineoplastic Agents; Berberine; Blotting, W | 2020 |
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.
Topics: Cell Line, Tumor; Chromatin Assembly and Disassembly; Citric Acid; Cytoplasm; Female; Gene Editing; | 2020 |
Injectable biodegradation-visual self-healing citrate hydrogel with high tissue penetration for microenvironment-responsive degradation and local tumor therapy.
Topics: Citric Acid; Doxorubicin; Drug Liberation; Humans; Hydrogels; Neoplasms; Tumor Microenvironment | 2020 |
Fructose-1,6-bisphosphate promotes PI3K and glycolysis in T cells?
Topics: Adenosine Triphosphate; Citric Acid; Fructosediphosphates; Glycolysis; Lymphocyte Activation; Mitoch | 2021 |
Size-dependent effect of cystine/citric acid-capped confeito-like gold nanoparticles on cellular uptake and photothermal cancer therapy.
Topics: Cell Line, Tumor; Cell Survival; Citric Acid; Cystine; Endocytosis; Gold; Humans; Metal Nanoparticle | 2018 |
Use of regional citrate anticoagulation for continuous venovenous hemodialysis in critically ill cancer patients with acute kidney injury.
Topics: Acute Kidney Injury; Aged; Anticoagulants; Calcium; Citric Acid; Critical Care; Critical Illness; El | 2018 |
Extracellular Citrate and Cancer Metabolism-Response.
Topics: Citrates; Citric Acid; Humans; Neoplasms | 2018 |
Extracellular Citrate and Cancer Metabolism-Letter.
Topics: Citrates; Citric Acid; Humans; Male; Neoplasms; Prostate | 2018 |
Functionalized nitrogen doped graphene quantum dots and bimetallic Au/Ag core-shell decorated imprinted polymer for electrochemical sensing of anticancerous hydroxyurea.
Topics: Biosensing Techniques; Citric Acid; Electrochemical Techniques; Gold; Graphite; Humans; Hydroxyurea; | 2019 |
Engineering multifunctional bioactive citric acid-based nanovectors for intrinsical targeted tumor imaging and specific siRNA gene delivery in vitro/in vivo.
Topics: Animals; Antineoplastic Agents; Biocompatible Materials; Cell Line, Tumor; Citric Acid; Diagnostic I | 2019 |
Voltammetric immunosensor for E-cadherin promoter DNA methylation using a Fe
Topics: Antigens, CD; Biomarkers, Tumor; Cadherins; Cell-Free Nucleic Acids; Citric Acid; DNA Methylation; E | 2019 |
Spatial-fluxomics provides a subcellular-compartmentalized view of reductive glutamine metabolism in cancer cells.
Topics: Animals; Carbon Isotopes; Cell Compartmentation; Cell Hypoxia; Citrate (si)-Synthase; Citric Acid; C | 2019 |
Gluconeogenesis of Cancer Cells Is Disrupted by Citrate.
Topics: Citrates; Citric Acid; Gluconeogenesis; Glycolysis; Humans; Neoplasms | 2019 |
Sensitivity analysis for studying the relation between biochemical reactions and metabolic phenotypes.
Topics: Animals; Citric Acid; Citric Acid Cycle; Computer Simulation; Humans; Mitochondria; Models, Biologic | 2013 |
A comment to the article published in the APJCP by Choi and co-workers about the treatment of cancer with citric acid.
Topics: Citric Acid; Humans; Neoplasms | 2012 |
Superparamagnetic hollow hybrid nanogels as a potential guidable vehicle system of stimuli-mediated MR imaging and multiple cancer therapeutics.
Topics: Antineoplastic Agents; Cell Proliferation; Citric Acid; Dose-Response Relationship, Drug; Drug Scree | 2013 |
Cationic albumin-conjugated magnetite nanoparticles, novel candidate for hyperthermia cancer therapy.
Topics: Albumins; Citric Acid; Hyperthermia, Induced; Magnetite Nanoparticles; Microscopy, Electron, Scannin | 2013 |
Real-time infrared thermography detection of magnetic nanoparticle hyperthermia in a murine model under a non-uniform field configuration.
Topics: Animals; Cell Line, Tumor; Citric Acid; Ferric Compounds; Hyperthermia, Induced; Infrared Rays; Magn | 2013 |
Reductive carboxylation supports redox homeostasis during anchorage-independent growth.
Topics: Cell Adhesion; Cell Hypoxia; Cell Line, Tumor; Cell Proliferation; Citric Acid; Contact Inhibition; | 2016 |
The effect of superparamagnetic iron oxide nanoparticles surface engineering on relaxivity of magnetoliposome.
Topics: Citric Acid; Coated Materials, Biocompatible; Contrast Media; Dextrans; Ferrosoferric Oxide; Humans; | 2016 |
Increased risk of citrate reactions in patients with multiple myeloma during peripheral blood stem cell leukapheresis.
Topics: Calcium Gluconate; Citric Acid; Hematologic Neoplasms; Humans; Hypocalcemia; Kidney Function Tests; | 2010 |
A radio-frequency coupling network for heating of citrate-coated gold nanoparticles for cancer therapy: design and analysis.
Topics: Cell Death; Cell Line, Tumor; Citric Acid; Electromagnetic Fields; Equipment Design; Gold; Hot Tempe | 2011 |
Selective photothermal efficiency of citrate capped gold nanoparticles for destruction of cancer cells.
Topics: Antibodies, Monoclonal; Citric Acid; Epithelial Cells; Gold; Humans; Laser Therapy; Lasers; Metal Na | 2011 |
Effectiveness of low-dose oral calcium carbonate for the prevention of citrate-related toxicity in peripheral blood stem cell collection.
Topics: Administration, Oral; Anticoagulants; Calcium Carbonate; Citric Acid; Female; Hematopoietic Stem Cel | 2012 |
Reductive carboxylation supports growth in tumour cells with defective mitochondria.
Topics: Acetyl Coenzyme A; Animals; Carcinoma, Renal Cell; Cell Hypoxia; Cell Line, Tumor; Citric Acid; Elec | 2011 |
Effectiveness of low-dose oral calcium carbonate for the prevention of citrate-related toxicity in peripheral blood stem cell collection.
Topics: Anticoagulants; Calcium Carbonate; Citric Acid; Female; Hematopoietic Stem Cells; Humans; Leukaphere | 2012 |
Analgesic effect of switching from oral opioids to a once-a-day fentanyl citrate transdermal patch in patients with lung cancer.
Topics: Administration, Cutaneous; Analgesics, Opioid; Citric Acid; Fentanyl; Humans; Lung Neoplasms; Neopla | 2013 |
Do mitochondria regulate cellular iron homeostasis through citric acid and haem production? Implications for cancer and other diseases.
Topics: Blood Platelets; Citric Acid; Heme; Homeostasis; Humans; In Vitro Techniques; Iron; Mitochondria; Mo | 2003 |
Protecting action of citrate on the agent of chicken tumor I (Rous sarcoma virus) during roentgen radiation in vitro.
Topics: Animals; Chickens; Citrates; Citric Acid; In Vitro Techniques; Meat; Neoplasms; Protective Agents; R | 1953 |
Citrate accumulation in slices of transplantable tumors of the rat.
Topics: Animals; Citrates; Citric Acid; Neoplasm Transplantation; Neoplasms; Rats | 1957 |
[Citric acid blood levels. II. Behavior in various malignant tumors, malignant blood diseases & Hodgkin's disease].
Topics: Citrates; Citric Acid; Hematologic Diseases; Hodgkin Disease; Humans; Lymphatic Diseases; Neoplasms; | 1957 |
[Studies on citric acid synthesis in vitro in normal and malignant tissue].
Topics: Biochemical Phenomena; Citrates; Citric Acid; In Vitro Techniques; Neoplasms | 1959 |
The effect of zirconium citrate on the latent period of Sr89-induced bone cancer in mice.
Topics: Animals; Bone and Bones; Bone Neoplasms; Citrates; Citric Acid; Mice; Neoplasms; Osteosarcoma; Stron | 1960 |
CITRIC ACID IN METASTASIZING CARCINOMA OF THE PROSTATE GLAND.
Topics: Carcinoma; Citrates; Citric Acid; Humans; Male; Metabolism; Neoplasm Metastasis; Neoplasms; Prostati | 1963 |
ZIRCONIUM CITRATE REDUCES SR-90 BODY BURDEN.
Topics: Acetazolamide; Animals; Body Burden; Citrates; Citric Acid; Metabolism; Mice; Neoplasms; Neoplasms, | 1964 |
[EFFECT OF PERORALLY ADMINISTERED CITRIC ACID ON BUTTER YELLOW CARCINOGENESIS IN RATS].
Topics: Carcinogenesis; Carcinogens; Citrates; Citric Acid; Neoplasms; Neoplasms, Experimental; p-Dimethylam | 1964 |
THE ROLE OF CITRIC ACID IN THE PHYSIOLOGY OF THE PROSTATE. 3. LACTATE/CITRATE RATIOS IN BENIGN AND MALIGNANT PROSTATIC HOMOGENATES AS AN INDEX OF PROSTATIC MALIGNANCY.
Topics: Chromatography; Citrates; Citric Acid; Citric Acid Cycle; Humans; Lactates; Lactic Acid; Male; Metab | 1964 |
REDUCTION OF STRONTIUM-90 BONE CANCER BY ZIRCONIUM CITRATE.
Topics: Acetazolamide; Animals; Bone Neoplasms; Chelating Agents; Citrates; Citric Acid; Metabolism; Mice; N | 1964 |
[The effect of cholin citrate on the leukocyte count during radiotherapy with carcinoma dosage].
Topics: Choline; Citrates; Citric Acid; Genitalia; Genitalia, Female; Leukocyte Count; Neoplasms | 1954 |
Citric acid in human prostatic secretion and metastasizing cancer of prostate gland.
Topics: Adenocarcinoma; Citrates; Citric Acid; Humans; Male; Neoplasms; Prostatic Neoplasms | 1962 |
Pyruvate metabolism. III. Formation of citrate in ascitic nodules from a strain of Walker rat mammary carcinoma 256.
Topics: Animals; Breast; Citrates; Citric Acid; Neoplasms; Pyruvates; Pyruvic Acid; Rats | 1962 |
A simple and reliable pretreatment protocol facilitates fluorescent in situ hybridisation on tissue microarrays of paraffin wax embedded tumour samples.
Topics: Breast Neoplasms; Buffers; Citric Acid; Clinical Protocols; Female; Humans; In Situ Hybridization; I | 2003 |
Citric acid metabolism in carcinogenesis and its relationships to calcium metabolism.
Topics: Calcium; Calcium, Dietary; Carcinogenesis; Citric Acid; Humans; Neoplasms | 1950 |
Comparative stability of the agent of chicken tumor I in citrate and phosphate buffers at 37 degrees C.
Topics: Animals; Chickens; Citrates; Citric Acid; Humans; Meat; Neoplasms; Phosphates | 1950 |
Biological activity of the agent of chicken tumor I (Rous) in citrate buffers of various molar concentrations.
Topics: Animals; Chickens; Citrates; Citric Acid; Humans; Meat; Molar; Neoplasms; Sarcoma | 1951 |
Heparin based anticoagulation during peripheral blood stem cell collection may increase the CD34+ cell yield.
Topics: Adolescent; Anticoagulants; Antigens, CD34; Calcium; Chelating Agents; Child; Child, Preschool; Citr | 2004 |
Citric acid content of normal and tumor tissues in vivo following injection of fluoroacetate.
Topics: Citric Acid; Fluoroacetates; Humans; Injections; Neoplasms | 1950 |
The citric acid content of tumor tissue and of tumor-bearing rats.
Topics: Animals; Cells; Citrates; Citric Acid; Neoplasms; Rats | 1949 |
The role of gallium and labeled leukocyte scintigraphy in the AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Citrates; Citric Acid; Ga | 1995 |
Cancer or inflammation? A Holy Grail for nuclear medicine.
Topics: Citrates; Citric Acid; Deoxyglucose; Diagnosis, Differential; Fluorine Radioisotopes; Fluorodeoxyglu | 1994 |
Do fruit juices stimulate iron absorption and toxicity?
Topics: Aging; Ascorbic Acid; Beverages; Bone Diseases; Citrates; Citric Acid; Diabetes Mellitus; Drug Syner | 1995 |
Metal ion speciation in blood plasma: gallium-67-citrate and MRI contrast agents.
Topics: Citrates; Citric Acid; Computer Simulation; Contrast Media; Gadolinium; Gallium; Gallium Radioisotop | 1996 |
Hydroxycitrate causes altered pyruvate metabolism by tumorigenic cells.
Topics: Animals; ATP Citrate (pro-S)-Lyase; Carbon Dioxide; Cell Line; Citrates; Citric Acid; Citric Acid Cy | 1996 |
The role of chelators in the catalysis of glutathione-gamma-glutamyl transpeptidase-dependent lipid peroxidation by transition metals.
Topics: Animals; Catalysis; Chelating Agents; Citric Acid; Copper; Ferrous Compounds; gamma-Glutamyltransfer | 1996 |
Shorter turn-around-time and improved patient care in peripheral blood progenitor cell collection procedures.
Topics: Adult; Ambulatory Care; Anticoagulants; Appointments and Schedules; Blood Banks; Case Management; Ch | 1999 |
Failure of ultrasonic vibration as a means of antigen retrieval in routine diagnostic immunocytochemistry.
Topics: Antigens; Antigens, CD; Antigens, Surface; Biomarkers, Tumor; Cadherins; CD79 Antigens; Citric Acid; | 2000 |
An improved technique for peripheral blood stem cell collection in small patients.
Topics: Adolescent; Blood Volume; Body Weight; Catheterization, Central Venous; Child; Child, Preschool; Cit | 1991 |
Bivariate flow karyotyping of human chromosomes: evaluation of variation in Hoechst 33258 fluorescence, chromomycin A3 fluorescence, and relative chromosomal DNA content.
Topics: Bisbenzimidazole; Cells, Cultured; Chromomycin A3; Chromosomes, Human; Citrates; Citric Acid; DNA; F | 1991 |
Pediatric solid tumors: evaluation by gallium-67 SPECT studies.
Topics: Adolescent; Child; Child, Preschool; Citrates; Citric Acid; Female; Gallium Radioisotopes; Hodgkin D | 1990 |
[Tumor imaging using 99mTc-hexamethylpropyleneamine oxime].
Topics: Adult; Aged; Citrates; Citric Acid; Female; Gallium Radioisotopes; Humans; Male; Middle Aged; Neopla | 1990 |
[The evaluation of the bone marrow accumulation of Ga-67 citrate].
Topics: Bone and Bones; Bone Marrow; Citrates; Citric Acid; Female; Gallium Radioisotopes; Hematocrit; Human | 1989 |
[Study on liver uptake changes in serial 67Ga scintigraphy].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Citrates; Citric Acid; Female; Follow-Up Stud | 1989 |
[Tumor imaging in nuclear medicine].
Topics: 3-Iodobenzylguanidine; Amphetamines; Antibodies, Monoclonal; Citrates; Citric Acid; Gallium Radioiso | 1989 |
[Image diagnosis: nuclear medicine].
Topics: 3-Iodobenzylguanidine; Citrates; Citric Acid; Female; Humans; Iodine Radioisotopes; Iodobenzenes; Lu | 1988 |
[Use of 111In-citrin in bone marrow scintigraphy].
Topics: Bone Marrow; Citrates; Citric Acid; Humans; Indium Radioisotopes; Neoplasms; Polycythemia Vera; Radi | 1988 |