citric acid, anhydrous has been researched along with Insulin Sensitivity in 17 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " UPF are encountered in Western diets (rich in saturated fat and sucrose), where consumption is directly associated with many conditions, such as obesity and diabetes, among others." | 4.12 | Citrate enrichment in a Western diet reduces weight gain ( Branco, JR; Demaria, TM; Esteves, AM; Imbroisi Filho, R; Lisboa, PC; Lopes, BP; Moura, EG; Sola-Penna, M; Zancan, P, 2022) |
| "Hypocitraturia and hypercalciuria are risk factors for calcium stone disease." | 2.47 | Diet-induced metabolic acidosis. ( Adeva, MM; Souto, G, 2011) |
| "Nonalcoholic fatty liver disease (NAFLD) and its evolution to inflammatory steatohepatitis (NASH) are the most common causes of chronic liver damage and transplantation that are reaching epidemic proportions due to the upraising incidence of metabolic syndrome, obesity, and diabetes." | 1.56 | Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. ( Albanese, C; Avantaggiati, ML; Catalina-Rodriguez, O; Cheema, A; Foley, P; Gadre, S; Giaccone, G; Graham, GT; Kallakury, B; Kasprzyk-Pawelec, A; Mosaoa, R; Parasido, E; Tan, M; Yi, C, 2020) |
| "Insulin resistance was defined as a homeostasis model assessment of insulin resistance value > 5 (HOMA-IR = (glucose×insulin)/405)." | 1.43 | Calculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients. ( Flynn, M; O'Bell, J; Pareek, G; Tran, TY, 2016) |
| "Obesity is associated with tissue inflammation which is a crucial etiology of insulin resistance." | 1.43 | An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome. ( Buffington, DA; Humes, HD; Johnston, KA; Westover, AJ, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.88) | 18.2507 |
| 2000's | 5 (29.41) | 29.6817 |
| 2010's | 7 (41.18) | 24.3611 |
| 2020's | 4 (23.53) | 2.80 |
| Authors | Studies |
|---|---|
| Branco, JR | 2 |
| Esteves, AM | 2 |
| Imbroisi Filho, R | 1 |
| Demaria, TM | 3 |
| Lisboa, PC | 1 |
| Lopes, BP | 1 |
| Moura, EG | 1 |
| Zancan, P | 3 |
| Sola-Penna, M | 3 |
| Kitamura, N | 1 |
| Zhang, S | 1 |
| Morel, JD | 1 |
| Nagano, U | 1 |
| Taworntawat, T | 1 |
| Hosoda, S | 1 |
| Nakamura, A | 1 |
| Ogawa, Y | 1 |
| Benegiamo, G | 1 |
| Auwerx, J | 1 |
| Tsubota, K | 1 |
| Yokoyama, Y | 1 |
| Watanabe, M | 1 |
| Tan, M | 1 |
| Mosaoa, R | 1 |
| Graham, GT | 1 |
| Kasprzyk-Pawelec, A | 1 |
| Gadre, S | 1 |
| Parasido, E | 1 |
| Catalina-Rodriguez, O | 1 |
| Foley, P | 1 |
| Giaccone, G | 1 |
| Cheema, A | 1 |
| Kallakury, B | 1 |
| Albanese, C | 1 |
| Yi, C | 1 |
| Avantaggiati, ML | 1 |
| Leandro, JGB | 1 |
| Godoi, V | 1 |
| Marette, A | 1 |
| Valença, HDM | 1 |
| Lanzetti, M | 1 |
| Peyot, ML | 1 |
| Farfari, S | 1 |
| Prentki, M | 1 |
| Deng, T | 1 |
| Mai, Z | 1 |
| Cai, C | 1 |
| Duan, X | 1 |
| Zhu, W | 1 |
| Zhang, T | 1 |
| Wu, W | 1 |
| Zeng, G | 1 |
| Leandro, JG | 1 |
| Espindola-Netto, JM | 1 |
| Vianna, MC | 1 |
| Gomez, LS | 1 |
| Marinho-Carvalho, MM | 1 |
| Paula Neto, HA | 1 |
| Tran, TY | 1 |
| Flynn, M | 1 |
| O'Bell, J | 1 |
| Pareek, G | 1 |
| Brachs, S | 1 |
| Winkel, AF | 1 |
| Tang, H | 1 |
| Birkenfeld, AL | 1 |
| Brunner, B | 1 |
| Jahn-Hofmann, K | 1 |
| Margerie, D | 1 |
| Ruetten, H | 1 |
| Schmoll, D | 1 |
| Spranger, J | 1 |
| Westover, AJ | 1 |
| Johnston, KA | 1 |
| Buffington, DA | 1 |
| Humes, HD | 1 |
| Adeva, MM | 1 |
| Souto, G | 1 |
| Liu, HC | 1 |
| Zhou, YB | 1 |
| Chen, D | 1 |
| Niu, ZJ | 1 |
| Yu, Y | 1 |
| Liu, YQ | 1 |
| Jetton, TL | 1 |
| Leahy, JL | 1 |
| Cloarec, O | 1 |
| Dumas, ME | 1 |
| Craig, A | 1 |
| Barton, RH | 1 |
| Trygg, J | 1 |
| Hudson, J | 1 |
| Blancher, C | 1 |
| Gauguier, D | 1 |
| Lindon, JC | 1 |
| Holmes, E | 1 |
| Nicholson, J | 1 |
| Monti, LD | 1 |
| Setola, E | 1 |
| Fragasso, G | 1 |
| Camisasca, RP | 1 |
| Lucotti, P | 1 |
| Galluccio, E | 1 |
| Origgi, A | 1 |
| Margonato, A | 1 |
| Piatti, P | 1 |
| Isken, F | 1 |
| Schulz, TJ | 1 |
| Möhlig, M | 1 |
| Pfeiffer, AF | 1 |
| Ristow, M | 1 |
| Singh, SP | 1 |
| Niemczyk, M | 1 |
| Saini, D | 1 |
| Awasthi, YC | 1 |
| Zimniak, L | 1 |
| Zimniak, P | 1 |
| Durante, P | 1 |
| Raleigh, X | 1 |
| Gómez, ME | 1 |
| Campos, G | 1 |
| Ryder, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Alkaline Diet for Insulin Sensitivity[NCT02501343] | 32 participants (Actual) | Interventional | 2015-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for citric acid, anhydrous and Insulin Sensitivity
| Article | Year |
|---|---|
Diet-induced metabolic acidosis.
Topics: Acid-Base Equilibrium; Acidosis; Bicarbonates; Biomarkers; Cardiovascular Diseases; Citric Acid; Die | 2011 |
2 trials available for citric acid, anhydrous and Insulin Sensitivity
| Article | Year |
|---|---|
Effect of intensive vs conventional insulin therapy on perioperative nutritional substrates metabolism in patients undergoing gastrectomy.
Topics: Adult; Aged; Albumins; Blood Glucose; Body Composition; Calcium; Carbohydrate Metabolism; Citric Aci | 2012 |
Metabolic and endothelial effects of trimetazidine on forearm skeletal muscle in patients with type 2 diabetes and ischemic cardiomyopathy.
Topics: 3-Hydroxybutyric Acid; Aged; Blood Glucose; Citric Acid; Cross-Over Studies; Cyclic GMP; Diabetes Me | 2006 |
14 other studies available for citric acid, anhydrous and Insulin Sensitivity
| Article | Year |
|---|---|
Citrate enrichment in a Western diet reduces weight gain
Topics: Animals; Citric Acid; Diet, High-Fat; Diet, Western; Insulin Resistance; Mice; Mice, Inbred C57BL; O | 2022 |
Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health.
Topics: Aminolevulinic Acid; Animals; Citric Acid; Diabetes Mellitus, Type 2; Diet, High-Fat; DNA, Mitochond | 2023 |
Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH.
Topics: Acetyl Coenzyme A; Animals; Blood Glucose; Carrier Proteins; Cell Polarity; Citric Acid; Diet, High- | 2020 |
Dietary citrate acutely induces insulin resistance and markers of liver inflammation in mice.
Topics: Animals; Citric Acid; Diet; Glucose; Glucose Intolerance; Glucose Tolerance Test; Glycogen Synthase | 2021 |
Influence of weight status on 24-hour urine composition in adults without urolithiasis: A nationwide study based on a Chinese Han population.
Topics: Adult; Body Mass Index; Body Weight; Calcium; China; Citric Acid; Humans; Insulin Resistance; Logist | 2017 |
Exogenous citrate impairs glucose tolerance and promotes visceral adipose tissue inflammation in mice.
Topics: Animals; Citric Acid; Cytokines; Diet, Western; Dietary Sucrose; Food Additives; Glucose Intolerance | 2016 |
Calculated insulin resistance correlates with stone-forming urinary metabolic changes and greater stone burden in high-risk stone patients.
Topics: Adolescent; Adult; Aged; Calcium; Citric Acid; Female; Humans; Hydrogen-Ion Concentration; Insulin; | 2016 |
Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice.
Topics: Animals; Citrates; Citric Acid; Dicarboxylic Acid Transporters; Diet; Insulin Resistance; Lipid Meta | 2016 |
An Immunomodulatory Device Improves Insulin Resistance in Obese Porcine Model of Metabolic Syndrome.
Topics: Animals; Citric Acid; Disease Models, Animal; Extracorporeal Circulation; Immunomodulation; Inflamma | 2016 |
beta-Cell adaptation to insulin resistance. Increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats.
Topics: Animals; Body Weight; Citric Acid; Dose-Response Relationship, Drug; Glucose; Glycerol; Insulin Resi | 2002 |
Statistical total correlation spectroscopy: an exploratory approach for latent biomarker identification from metabolic 1H NMR data sets.
Topics: Amines; Animals; Biomarkers; Citric Acid; Creatine; Creatinine; Dietary Carbohydrates; Discriminant | 2005 |
Chemical inhibition of citrate metabolism alters glucose metabolism in mice.
Topics: Aconitate Hydratase; Animals; Citric Acid; Enzyme Inhibitors; Fluoroacetates; Glucose; Insulin Resis | 2006 |
Role of the electrophilic lipid peroxidation product 4-hydroxynonenal in the development and maintenance of obesity in mice.
Topics: Acetyl-CoA Carboxylase; Aconitate Hydratase; Aging; Aldehydes; Animals; Antigens, CD; Antigens, Diff | 2008 |
Isozyme analysis of human polymorphonuclear leukocyte phosphofructokinase from insulin resistant individuals.
Topics: Adenosine Triphosphate; Case-Control Studies; Citrates; Citric Acid; Diabetes Mellitus, Type 2; Enzy | 1996 |