citric acid, anhydrous has been researched along with Hypokalemia in 11 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss." | 9.09 | Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Pak, CY; Ruml, LA, 1999) |
| "The purpose of this study was to compare the efficacy of three dosages of potassium-magnesium citrate in overcoming thiazide-induced hypokalemia and magnesium loss and increasing urinary pH and citrate." | 9.09 | Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Gonzalez, G; Pak, CY; Ruml, LA; Taylor, R; Wuermser, LA, 1999) |
| "The study was performed to ascertain the value of potassium magnesium citrate, magnesium citrate, and potassium citrate in overcoming thiazide-induced hypokalemia and magnesium loss." | 5.09 | Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Pak, CY; Ruml, LA, 1999) |
| "The purpose of this study was to compare the efficacy of three dosages of potassium-magnesium citrate in overcoming thiazide-induced hypokalemia and magnesium loss and increasing urinary pH and citrate." | 5.09 | Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss. ( Gonzalez, G; Pak, CY; Ruml, LA; Taylor, R; Wuermser, LA, 1999) |
| "In an open, randomized study, we investigated the effect of oral potassium chloride (KCl) and of potassium citrate/bicarbonate (K-cit/bic) in 42 patients with hypokalemia (less than or equal to 3." | 5.07 | Potassium substitution via the oral route: does its efficacy depend on the anion of the potassium salt? ( Evers, WM; Krück, F; Meyer-Lehnert, H, 1991) |
| "Ninety four children aged less than 5 years with diarrhoeal dehydration and acidosis were treated randomly with either World Health Organisation (WHO) oral rehydration solution containing sodium chloride, potassium chloride, sodium bicarbonate and glucose or an oral solution with tripotassium citrate monohydrate replacing the sodium bicarbonate and potassium chloride in the WHO solution." | 5.05 | Can potassium citrate replace sodium bicarbonate and potassium chloride of oral rehydration solution? ( Islam, MR, 1985) |
| "Distal renal tubular acidosis (DRTA) is a metabolic disorder that associates urolithiasis and urinary pH > 6." | 1.56 | Prevalence of distal renal tubular acidosis in patients with calcium phosphate stones. ( Bauza, JL; Grases, F; Guimerà, J; Lopez, M; Martínez, A; Pieras, E; Piza, P; Rios, A; Sabate, A; Tubau, V, 2020) |
| "Distal renal tubular acidosis (dRTA) is a hyperchloremic metabolic acidosis disorder characterized by a normal anion gap with abnormal urinary hydrogen (H(+)) excretion." | 1.42 | Clinical evaluation of Chinese patients with primary distal renal tubular acidosis. ( Chen, N; Li, X; Ma, Y; Ren, H; Shen, P; Wang, W; Xu, Y; Zhang, C; Zhang, W, 2015) |
| "Enalapril was given to rats (15 mg/kg/day) for seven days and to humans (10 mg twice daily) for 10 days." | 1.30 | Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia. ( Alpern, RJ; Haynes, S; Melnick, JZ; Pak, CY; Preisig, PA; Sakhaee, K, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Agrawal, SS | 1 |
| Mishra, CK | 1 |
| Agrawal, C | 1 |
| Chakraborty, PP | 1 |
| Guimerà, J | 1 |
| Martínez, A | 1 |
| Tubau, V | 1 |
| Sabate, A | 1 |
| Bauza, JL | 1 |
| Rios, A | 1 |
| Lopez, M | 1 |
| Piza, P | 1 |
| Grases, F | 1 |
| Pieras, E | 1 |
| Zhang, C | 1 |
| Ren, H | 1 |
| Shen, P | 1 |
| Xu, Y | 1 |
| Zhang, W | 1 |
| Wang, W | 1 |
| Li, X | 1 |
| Ma, Y | 1 |
| Chen, N | 1 |
| Contreras, G | 1 |
| Garces, G | 1 |
| Reich, J | 1 |
| Banerjee, D | 1 |
| Young, L | 1 |
| Cely, C | 1 |
| Gadalean, F | 1 |
| Perez, G | 1 |
| Roth, D | 1 |
| DREWES, VM | 1 |
| Melnick, JZ | 1 |
| Preisig, PA | 1 |
| Haynes, S | 1 |
| Pak, CY | 3 |
| Sakhaee, K | 1 |
| Alpern, RJ | 1 |
| Ruml, LA | 2 |
| Gonzalez, G | 1 |
| Taylor, R | 1 |
| Wuermser, LA | 1 |
| Meyer-Lehnert, H | 1 |
| Evers, WM | 1 |
| Krück, F | 1 |
| Sriboonlue, P | 1 |
| Prasongwattana, V | 1 |
| Tungsanga, K | 1 |
| Tosukhowong, P | 1 |
| Phantumvanit, P | 1 |
| Bejraputra, O | 1 |
| Sitprija, V | 1 |
| Islam, MR | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Preventing Metabolic Side Effects of Thiazide Diuretics With KMgCitrate[NCT02665117] | 61 participants (Actual) | Interventional | 2015-01-31 | Completed | |||
| A Multi-Site Placebo-Controlled Randomized Double-Blind Study to Evaluate the Efficacy and Safety of Using MPC-5971 as Adjuvant Therapy in Subjects Undergoing Shock Wave Lithotripsy[NCT00860093] | Phase 2 | 135 participants (Actual) | Interventional | 2010-04-30 | Terminated (stopped due to Sponsor Corporate Business Decision) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Will be measured using hepatic magnetic resonance imaging at baseline and at week 16 (NCT02665117)
Timeframe: baseline to week 16
| Intervention | percent (Mean) |
|---|---|
| KMgCit + Chlorthalidone | 0.31 |
| KCl + Chlorthalidone | 1.59 |
Fasting plasma glucose was measured from venous blood sample at week 4 and week 16 (NCT02665117)
Timeframe: week 4 and week 16
| Intervention | mg/dL (Mean) |
|---|---|
| KMgCit + Chlorthalidone | -5.6 |
| KCl + Chlorthalidone | 2.3 |
Will be measured from venous blood sample from week 4 to week 16 (NCT02665117)
Timeframe: week 4 to week 16
| Intervention | pg/ml (Mean) |
|---|---|
| KMgCit + Chlorthalidone | 38.1 |
| KCl + Chlorthalidone | 13.6 |
Will be measured using magnetic resonance imaging at baseline and at week 16 (NCT02665117)
Timeframe: baseline to week 16
| Intervention | mM (Mean) |
|---|---|
| KMgCit + Chlorthalidone | -0.01 |
| KCl + Chlorthalidone | 0.02 |
4 trials available for citric acid, anhydrous and Hypokalemia
| Article | Year |
|---|---|
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of potassium magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Citrates; Citric Acid; Diuretics; Drug Combinations; Female; Humans; Hydrochlorothiazide; Hyp | 1999 |
Effect of varying doses of potassium-magnesium citrate on thiazide-induced hypokalemia and magnesium loss.
Topics: Adult; Benzothiadiazines; Citrates; Citric Acid; Diuretics; Dose-Response Relationship, Drug; Drug C | 1999 |
Potassium substitution via the oral route: does its efficacy depend on the anion of the potassium salt?
Topics: Acid-Base Equilibrium; Administration, Oral; Adult; Aged; Aged, 80 and over; Bicarbonates; Chlorides | 1991 |
Can potassium citrate replace sodium bicarbonate and potassium chloride of oral rehydration solution?
Topics: Acidosis; Bicarbonates; Child, Preschool; Citrates; Citric Acid; Clinical Trials as Topic; Diarrhea; | 1985 |
7 other studies available for citric acid, anhydrous and Hypokalemia
| Article | Year |
|---|---|
Rickets with hypophosphatemia, hypokalemia and normal anion gap metabolic acidosis: not always an easy diagnosis.
Topics: Calcium; Child; Citric Acid; Diagnosis, Differential; Female; Humans; Hypokalemia; Hypophosphatemia; | 2020 |
Prevalence of distal renal tubular acidosis in patients with calcium phosphate stones.
Topics: Acidosis, Renal Tubular; Adult; Age Distribution; Calcium Phosphates; Citric Acid; Diagnostic Techni | 2020 |
Clinical evaluation of Chinese patients with primary distal renal tubular acidosis.
Topics: Acidosis, Renal Tubular; Adolescent; Adult; Aged; Aged, 80 and over; Asian People; Calcium; Child; C | 2015 |
Predictors of alkalosis after liver transplantation.
Topics: Alkalosis; Bicarbonates; Carbon Dioxide; Citric Acid; Databases as Topic; Female; Humans; Hypokalemi | 2002 |
[Renal tubule acidosis. A case with symptom-producing hypokalemia and normal citrate excretion].
Topics: Acid-Base Equilibrium; Acidosis; Citrates; Citric Acid; Humans; Hypokalemia; Kidney Diseases; Medica | 1962 |
Converting enzyme inhibition causes hypocitraturia independent of acidosis or hypokalemia.
Topics: Acidosis; Adult; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Citric Acid; Ena | 1998 |
Blood and urinary aggregator and inhibitor composition in controls and renal-stone patients from northeastern Thailand.
Topics: Adult; Citrates; Citric Acid; Humans; Hypokalemia; Kidney Calculi; Male; Middle Aged; Potassium; Pot | 1991 |