Compounds > citric acid, anhydrous
Page last updated: 2024-10-17

citric acid, anhydrous and Diarrhea

citric acid, anhydrous has been researched along with Diarrhea in 20 studies

Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.

Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Research Excerpts

ExcerptRelevanceReference
"All three preparations were equally well tolerated with slightly more diarrhea reported among patients receiving magnesium citrate (p = 0."5.08A randomized trial comparing three methods of bowel preparation for flexible sigmoidoscopy. ( Jackson, JL; Osgard, E; Strong, J, 1998)
"Ninety four children aged less than 5 years with diarrhoeal dehydration and acidosis were treated randomly with either World Health Organisation (WHO) oral rehydration solution containing sodium chloride, potassium chloride, sodium bicarbonate and glucose or an oral solution with tripotassium citrate monohydrate replacing the sodium bicarbonate and potassium chloride in the WHO solution."5.05Can potassium citrate replace sodium bicarbonate and potassium chloride of oral rehydration solution? ( Islam, MR, 1985)
"Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients."2.82The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. ( Al-Saber, F; Aldosari, W; Alselaiti, M; Darwish, A; Harb, G; Kaladari, A; Khalfan, H; Khan, G; Koda, A; Kudo, S; Nakajima, M; Rehani, R; Tanaka, T, 2016)
"Split dosage of bowel preparations has been shown to substantially improve bowel cleansing."2.78[Split-dose sodium picosulphate/magnesium citrate for morning colonoscopies performed 2 to 6 hours after fluid intake]. ( Dueñas-Sadornil, C; Fernández-Bermejo, M; González-Santiago, JM; Hernández-Alonso, M; Martín-Noguerol, E; Martínez-Alcalá, C; Mateos-Rodríguez, JM; Molina-Infante, J; Pérez-Gallardo, B; Vinagre-Rodríguez, G, 2013)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19907 (35.00)18.7374
1990's7 (35.00)18.2507
2000's1 (5.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Deng, Q1
Shao, Y1
Wang, Q1
Li, J1
Li, Y1
Ding, X1
Huang, P1
Yin, J1
Yang, H1
Yin, Y1
Yoshioka, S1
Takedatsu, H1
Fukunaga, S1
Kuwaki, K1
Yamasaki, H1
Yamauchi, R1
Mori, A1
Kawano, H1
Yanagi, T1
Mizuochi, T1
Ushijima, K1
Mitsuyama, K1
Tsuruta, O1
Torimura, T1
Martín-Noguerol, E1
González-Santiago, JM1
Martínez-Alcalá, C1
Vinagre-Rodríguez, G1
Hernández-Alonso, M1
Dueñas-Sadornil, C1
Pérez-Gallardo, B1
Mateos-Rodríguez, JM1
Fernández-Bermejo, M1
Molina-Infante, J1
Al-Saber, F1
Aldosari, W1
Alselaiti, M1
Khalfan, H1
Kaladari, A1
Khan, G1
Harb, G1
Rehani, R1
Kudo, S1
Koda, A1
Tanaka, T1
Nakajima, M1
Darwish, A1
Cheng, VC1
Yam, WC1
Tsang, LL1
Yau, MC1
Siu, GK1
Wong, SC1
Chan, JF1
To, KK1
Tse, H1
Hung, IF1
Tai, JW1
Ho, PL1
Yuen, KY1
NISHI, A1
Li, H1
Yang, B1
Islam, MR2
Samadi, AR1
Ahmed, SM1
Bardhan, PK1
Ali, A1
Islam, MA1
Mahalanabis, D1
Majid, N1
Islam, A1
Molla, AM1
Ahmed, MA1
Yameen, A1
Thara, R1
Molla, A1
Issani, Z1
Hendricks, K1
Snyder, JD1
Elliott, EJ1
Watson, AJ1
Walker-Smith, JA1
Farthing, MJ2
Osgard, E1
Jackson, JL1
Strong, J1
Pierce, NF1
Mehta, MN1
Parasuram, R1
Mazumder, RN1
Nath, SK1
Ashraf, H1
Patra, FC1
Alam, AN1
Rolston, DD1
Moriarty, KJ1
Kelly, MJ1
Clark, ML1
Dawson, AM1
Holmberg, C1
Perheentupa, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective, Randomized, Single-Blind, Placebo-Controlled, Dose-Escalation Pilot Study to Evaluate the Safety and Efficacy of 5-ALA-SFC in Subjects With Type II Diabetes[NCT02481141]53 participants (Actual)Interventional2014-07-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change From Baseline in 2 Hour Post Meal Glucose Level

Change from baseline in blood glucose levels 2 hours after breakfast (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline-0.2
5-ALA-SFC Through Week 4 (75 mg 2x/Day) Change From Baseline-12.9
5-ALA-SFC Through Week 12 (100 mg 2x/Day) Change From Baseline-8.5
Placebo Through Week 2 Change From Baseline-26.5
Placebo Through Week 4 Change From Baseline-18.8
Placebo Through Week 12 Change From Baseline-33.0

Change From Baseline in Body Weight

Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12

Interventionkg (Mean)
5-ALA-SFC Through Week 6 Change From Baseline-0.1
5-ALA-SFC Through Week 12 Change From Baseline-0.2
Placebo Through Week 6 Change From Baseline-0.3
Placebo Through Week 12 Change From Baseline-0.8

Change From Baseline in Fasting Blood Glucose

The objective of the current study was to investigate the safety and preliminary efficacy of doses up to 200 mg 5-ALA - SFC in a population of patients with type 2 diabetes mellitus living in Bahrain. (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline2.3
5-ALA-SFC Through Week 4 (75 mg 2x/Day) Change From Baseline-0.2
5-ALA-SFC Through Wk 12 (100 mg 2x/Day) Change From Baseline-3.0
Placebo Through Week 2 Change From Baseline-7.3
Placebo Through Week 4 Change From Baseline-0.8
Placebo Through Week 12 Change From Baseline-4.2

Change From Baseline in HbA1c

Change from baseline in HbA1c % (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12

Interventionpercentage of HbA1c (Mean)
5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline-0.2
5-ALA-SFC Through 4 (75 mg 2x/Day) Change From Baseline-0.3
5-ALA-SFC Through 12 (100 mg 2x/Day) Change From Baseline-0.7
Placebo Through Week 2 Change From Baseline-0.5
Placebo Through Week 4 Change From Baseline-0.5
Placebo Through Week 12 Change From Baseline-0.5

Change From Baseline in HDL (Component of Lipid Profile)

Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 6 Change From Baseline-0.8
5-ALA-SFC Through Week 12 Change From Baseline0.5
Placebo Through Week 6 Change From Baseline-1.6
Placebo Through Week 12 Change From Baseline-1.1

Change From Baseline in Total Cholesterol (Component of Lipid Profile)

Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 6 Change From Baseline-5.2
5-ALA-SFC Through Week 12 Change From Baseline6.8
Placebo Through Week 6 Change From Baseline-7.6
Placebo Through Week 12 Change From Baseline-0.1

Change From Baseline in Triglycerides (Component of Lipid Profile)

Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 6 Change From Baseline-1.3
5-ALA-SFC Through Week 12 Change From Baseline3.2
Placebo Through Week 6 Change From Baseline4.5
Placebo Through Week 12 Change From Baseline11.9

Change From Baseline LDL (Component of Lipid Profile)

Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12

Interventionmg/dL (Mean)
5-ALA-SFC Through Week 6 Change From Baseline-2.9
5-ALA-SFC Through Week 12 Change From Baseline7.6
Placebo Through Week 6 Change From Baseline-11.8
Placebo Through Week 12 Change From Baseline-4.0

Subjects With Adverse Events as a Measure of Safety and Tolerability

The objective of the current study was to investigate the safety and preliminary efficacy of doses up to 200 mg 5-ALA - SFC in a population of patients with type 2 diabetes mellitus living in Bahrain. (NCT02481141)
Timeframe: Week 2, Week 4, Week 12

InterventionParticipants (Count of Participants)
5-ALA-SFC Through Week 2 (50 mg 2x/Day)6
5-ALA-SFC Through Week 4 (75 mg 2x/Day)8
5-ALA-SFC Through Week 12 (100 mg 2x/Day)2
Placebo Through Week 23
Placebo Through Week 41
Placebo Through Week 121

Reviews

2 reviews available for citric acid, anhydrous and Diarrhea

ArticleYear
[Studies on processing of Fructus Crataegi].
    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2004, Volume: 29, Issue:6

    Topics: Antidiarrheals; Citric Acid; Crataegus; Diarrhea; Drugs, Chinese Herbal; Flavones; Fruit; Hot Temper

2004
Recent advances in oral rehydration therapy.
    Indian pediatrics, 1991, Volume: 28, Issue:9

    Topics: Administration, Oral; Amino Acids; Citrates; Citric Acid; Diarrhea; Edible Grain; Fluid Therapy; Glu

1991

Trials

7 trials available for citric acid, anhydrous and Diarrhea

ArticleYear
[Split-dose sodium picosulphate/magnesium citrate for morning colonoscopies performed 2 to 6 hours after fluid intake].
    Gastroenterologia y hepatologia, 2013, Volume: 36, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Cathartics; Citrates; Citric Acid; Colonoscopy; Diarrhea; Drinking B

2013
The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain.
    Journal of diabetes research, 2016, Volume: 2016

    Topics: Abdominal Pain; Aminolevulinic Acid; Bahrain; Blood Glucose; Citric Acid; Cough; Diabetes Mellitus,

2016
Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea.
    Gut, 1984, Volume: 25, Issue:8

    Topics: Acidosis; Acute Disease; Adolescent; Adult; Antacids; Bicarbonates; Carbon Dioxide; Child; Child, Pr

1984
Is rice based oral rehydration therapy effective in young infants?
    Archives of disease in childhood, 1994, Volume: 71, Issue:1

    Topics: Citrates; Citric Acid; Copper Sulfate; Diarrhea; Drug Combinations; Feces; Fluid Therapy; Humans; Hy

1994
A randomized trial comparing three methods of bowel preparation for flexible sigmoidoscopy.
    The American journal of gastroenterology, 1998, Volume: 93, Issue:7

    Topics: Abdominal Pain; Administration, Oral; Adult; Aged; Ambulatory Care; Cathartics; Citric Acid; Colon;

1998
Oral rehydration solution containing trisodium citrate for treating severe diarrhoea: controlled clinical trial.
    BMJ (Clinical research ed.), 1991, Jan-12, Volume: 302, Issue:6768

    Topics: Adolescent; Adult; Bicarbonates; Child; Cholera; Citrates; Citric Acid; Diarrhea; Double-Blind Metho

1991
Can potassium citrate replace sodium bicarbonate and potassium chloride of oral rehydration solution?
    Archives of disease in childhood, 1985, Volume: 60, Issue:9

    Topics: Acidosis; Bicarbonates; Child, Preschool; Citrates; Citric Acid; Clinical Trials as Topic; Diarrhea;

1985

Other Studies

11 other studies available for citric acid, anhydrous and Diarrhea

ArticleYear
Effects and interaction of dietary electrolyte balance and citric acid on the intestinal function of weaned piglets.
    Journal of animal science, 2020, May-01, Volume: 98, Issue:5

    Topics: Animals; Citric Acid; Cytokines; Diarrhea; Diet; Dietary Supplements; Gastrointestinal Microbiome; I

2020
Study to determine guidelines for pediatric colonoscopy.
    World journal of gastroenterology, 2017, Aug-21, Volume: 23, Issue:31

    Topics: Abdominal Pain; Adolescent; Age Factors; Cathartics; Child; Child, Preschool; Citric Acid; Colon; Co

2017
Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts.
    Journal of clinical microbiology, 2012, Volume: 50, Issue:5

    Topics: Adolescent; Adult; Agar; Aged; Aged, 80 and over; Bacteriological Techniques; Bile Acids and Salts;

2012
[THE CLINICAL AND EXPERIMENTAL STUDIES ON THE CITRIC ACID METABOLISM IN EKIRI-LIKE SYNDROME].
    Kumamoto Igakkai zasshi. The Journal of the Kumamoto Medical Society, 1963, Feb-25, Volume: 37

    Topics: Animals; Blood Chemical Analysis; Child; Citrates; Citric Acid; Diarrhea; Diarrhea, Infantile; Dipht

1963
News from WHO's Diarrhoeal Diseases Control Programme.
    WHO chronicle, 1984, Volume: 38, Issue:5

    Topics: Administration, Oral; Adult; Bicarbonates; Child; Citrates; Citric Acid; Diarrhea; Humans; Infant; S

1984
Use of rice-based oral rehydration solution in a large diarrhoea treatment centre in Bangladesh: in-house production, use and relative cost.
    The Journal of tropical medicine and hygiene, 1994, Volume: 97, Issue:6

    Topics: Bangladesh; Cholera; Citrates; Citric Acid; Costs and Cost Analysis; Diarrhea; Flour; Fluid Therapy;

1994
Bicarbonate and citrate in oral rehydration therapy: studies in a model of secretory diarrhea.
    Journal of pediatric gastroenterology and nutrition, 1993, Volume: 16, Issue:3

    Topics: Animals; Antacids; Bicarbonates; Cholera Toxin; Citrates; Citric Acid; Diarrhea; Disease Models, Ani

1993
Oral rehydration therapy in the management of acute diarrhoea.
    Acta paediatrica Japonica : Overseas edition, 1991, Volume: 33, Issue:3

    Topics: Acute Disease; Administration, Oral; Child, Preschool; Citrates; Citric Acid; Diarrhea; Drug Combina

1991
Acetate and citrate stimulate water and sodium absorption in the human jejunum.
    Digestion, 1986, Volume: 34, Issue:2

    Topics: Acetates; Acetic Acid; Citrates; Citric Acid; Diarrhea; Humans; Intestinal Absorption; Jejunum; Perf

1986
Congenital Na+ diarrhea: a new type of secretory diarrhea.
    The Journal of pediatrics, 1985, Volume: 106, Issue:1

    Topics: Acidosis; Adolescent; Aldosterone; Citrates; Citric Acid; Diarrhea; Electrolytes; Feces; Female; Gas

1985
Citrate in oral rehydration therapy.
    Gut, 1985, Volume: 26, Issue:4

    Topics: Administration, Oral; Citrates; Citric Acid; Diarrhea; Fluid Therapy; Humans

1985