citric acid, anhydrous has been researched along with Cough in 248 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Cough: A sudden, audible expulsion of air from the lungs through a partially closed glottis, preceded by inhalation. It is a protective response that serves to clear the trachea, bronchi, and/or lungs of irritants and secretions, or to prevent aspiration of foreign materials into the lungs.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To quantify the effect of codeine on objective cough frequency (quantified as time spent coughing: cough seconds, cs/h), citric acid cough threshold, and subjective measures in a double-blind, placebo-controlled crossover study in COPD." | 9.12 | Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease. ( Earis, J; Owen, E; Smith, J; Woodcock, A, 2006) |
| "Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy." | 9.07 | Effect of inhaled menthol on citric acid induced cough in normal subjects. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1994) |
| "We have evaluated the properties of capsaicin as a selective cough-inducing agent in healthy human subjects." | 9.07 | Capsaicin-induced cough in humans. ( Hansson, L; Karlsson, JA; Midgren, B; Persson, CG; Simonsson, BG, 1992) |
| "We studied the effects of angiotensin converting enzyme (ACE) inhibitors on cough responses to bradykinin (BK), substance P (SP) and citric acid in a double blind, random study on 10 hypertensive patients receiving ACE inhibitors." | 9.07 | Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril. ( Katsumata, U; Sasaki, H; Sekizawa, K; Takishima, T; Ujiie, Y, 1991) |
| "This controlled crossover study in twenty healthy volunteer subjects utilized the citric acid aerosol-induced cough response as a means to demonstrate the effectiveness of 25 mg of diphenhydramine as an antitussive." | 9.07 | Antitussive effects of diphenhydramine on the citric acid aerosol-induced cough response in humans. ( Ciccone, PE; Masurat, T; Packman, EW; Wilson, J, 1991) |
| "The antitussive effects of dextromethorphan (30 mg) + salbutamol (2 mg), dextromethorphan (30 mg) alone and placebo on artificial cough induced by citric acid were compared in 19 healthy non-smoking volunteers in a double-blind crossover study." | 9.06 | Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. ( Karttunen, P; Kolonen, S; Silvasti, M; Tukiainen, H, 1987) |
| "To clarify the role of oestrogen signalling and the role of oestrogen receptor alpha (ERα) in the cough pathways we performed a study in which coughing was observed in both sexes animal models after the treatment by selective ERα degrader fulvestrant (ICI 182-780) and inhibitor of oestrogen synthesis danazol." | 8.31 | Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes. ( Brozmanova, M; Buday, T; Kopcova, L; Matloobi, A; Plevkova, J; Sterusky, M, 2023) |
| "Erdosteine as a mucolytic agent that decreases mucus viscosity and facilitates mucus expulsion from the airways by cough or ciliary movement." | 7.88 | Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity. ( Fraňová, S; Jošková, M; Kazimierová, I; Pappová, L; Šutovská, M, 2018) |
| "We have previously shown that cough potentiation induced by intravenous administration of the AT1 receptor antagonist losartan is lower than that induced by the ACE inhibitor lisinopril in anesthetized and awake rabbits." | 7.81 | The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit. ( Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T, 2015) |
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 7.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| "The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice." | 7.74 | Role of cyclin-dependent kinase 5 in capsaicin-induced cough. ( Hayashi, SS; Kamei, J; Nozaki, C; Takahashi, Y, 2007) |
| "In this study we investigated the ability of aerosolized substance P to induce either cough or bronchoconstriction in guinea-pigs." | 7.73 | The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs. ( Amine, SA; El-Hashim, AZ, 2005) |
| "This study indicates that residual sedation after propofol anaesthesia for colonoscopy does not adversely affect the cough reflex." | 7.73 | Assessment of the cough reflex after propofol anaesthesia for colonoscopy. ( Bonay, M; Desmonts, JM; Guglielminotti, J; Mantz, J; Mentre, F; Panhard, X; Rackelboom, T; Tesniere, A, 2005) |
| "Nociceptin/orphanin FQ has been reported to inhibit capsaicin- and mechanically provoked cough in animal models, but the mechanism of this effect has not been elucidated." | 7.73 | Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs. ( Brown, C; Carr, MJ; Lee, MG; Undem, BJ, 2006) |
| "We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes." | 7.73 | Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. ( Kamei, J; Takahashi, Y, 2006) |
| "The anti-tussive effect of the R-(+)- and S-(-)-enantiomers of benproperine was evaluated and compared with that of the racemate on cough induced by 7." | 7.72 | Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. ( Chen, S; Kong, W; Li, W; Li, Y; Min, L; Zhong, D, 2004) |
| "The effect of ammonia on the cough response to citric acid and on substance P release from C-fibers involved in this reflex was assessed." | 7.70 | Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P. ( Beerens, D; Gustin, P; Moreaux, B; Nemmar, A, 2000) |
| "To examine the mechanisms of an angiotensin-converting enzyme (ACE) inhibitor-induced cough in perimenopausal and postmenopausal women, cough responses to aerosols of capsaicin and citric acid were examined in four groups of female guinea pigs treated orally with danazol (D) (an agent decreasing plasma estrogen levels), cilazapril (C) (an inhibitor of ACE), both danazol and cilazapril (C+D), or without either drug (control group) for 4 to 5 wk." | 7.69 | Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs. ( Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K, 1996) |
| "Acidic solutions mimick many of the effects of capsaicin (Cap), including pain, bronchoconstriction, cough, and sensory neuropeptide release." | 7.69 | Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. ( Barnes, PJ; Belvisi, MG; Chung, KF; Fox, AJ; Lalloo, UG, 1995) |
| "The cough response following inhalation challenge with the sensory nerve irritant resiniferatoxin was compared with that of capsaicin and citric acid in guinea-pig and man." | 7.68 | A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man. ( Higgins, KS; Laude, EA; Morice, AH, 1993) |
| "The influence of aerosols of Ruthenium red (RR) on capsaicin- and citric acid-induced cough was investigated in guinea pigs." | 7.68 | Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs. ( Aziz, SM; Bolser, DC; Chapman, RW, 1991) |
| " Increased airway concentration of both prostaglandins and bradykinin has been suggested as the possible cause of the increased cough sensitivity sometimes found in patients with cough associated with taking drugs that inhibit angiotensin-converting enzyme." | 7.67 | Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. ( Choudry, NB; Fuller, RW; Pride, NB, 1989) |
| " The effects of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough have been studied in conscious tracheostomised dogs." | 7.67 | The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs. ( Jackson, DM, 1988) |
| "Menthol has no effect on objective measures of flow but significantly increases the perception of nasal patency." | 6.73 | Does inhaling menthol affect nasal patency or cough? ( Beardsmore, C; Houghton, T; Kenia, P, 2008) |
| "Cough is a common and protective reflex, but persistent coughing is debilitating and impairs quality of life." | 6.71 | Theobromine inhibits sensory nerve activation and cough. ( Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS, 2005) |
| "1." | 6.68 | The effect of inhaled and oral dextromethorphan on citric acid induced cough in man. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1995) |
| "Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme (ACE) inhibitors for the therapy of hypertension and congestive heart failure." | 5.36 | Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2010) |
| "Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inhibitors." | 5.36 | Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits. ( Bongianni, F; Cinelli, E; Evangelista, S; Mutolo, D; Pantaleo, T, 2010) |
| "Altitude-related cough is a troublesome condition of unknown etiology." | 5.35 | Changes in plasma bradykinin concentration and citric acid cough threshold at high altitude. ( Aldashev, A; Kim, EV; Mason, NP; Mélot, C; Mirrakhimov, MM; Naeije, R; Petersen, M; Sarybaev, A, 2009) |
| "Cough was induced by inhalation of citric acid aerosol before and after exposure to oxygen." | 5.34 | Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs. ( Bartos, V; Brozmanova, M; Javorka, M; Masar, J; Plank, L; Plevkova, J; Tatar, M, 2007) |
| "Bradykinin, however, plays a major role in coughing induced by citric acid alone." | 5.31 | Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs. ( Advenier, C; Gustin, P; Moreaux, B, 2001) |
| "Nedocromil sodium has been observed to stimulate bronchial C fibers, and it is suggested that this activity may relate to the antitussive effect of the compound." | 5.28 | Effect of nedocromil sodium on SO2-induced airway hyperresponsiveness and citric acid-induced cough in dogs. ( Eady, RP; Jackson, DM, 1989) |
| " It is suggested that this method of testing the effects of an antitussive on such a dose-response curve may be a useful one." | 5.27 | An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid. ( Apps, MC; Burke, CA; Cox, ID; Empey, DW; Hughes, DT; Osman, RC; Wallis, PJ, 1984) |
| "Challenge tests involving chemical stimulation by inhalation of capsaicin or citric acid are currently used to assess cough sensitivity." | 5.14 | Cough challenge tests involving mechanical stimulation of the cervical trachea in patients with cough as a leading symptom. ( Furihata, K; Hamamoto, Y; Iikura, M; Kamimura, M; Mizutani, T; Mouri, A; Takayama, K, 2010) |
| "To quantify the effect of codeine on objective cough frequency (quantified as time spent coughing: cough seconds, cs/h), citric acid cough threshold, and subjective measures in a double-blind, placebo-controlled crossover study in COPD." | 5.12 | Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease. ( Earis, J; Owen, E; Smith, J; Woodcock, A, 2006) |
| "Characteristics of the response to placebo in a citric acid-induced cough challenge were investigated as part of a randomized, double-blind crossover trial to assess the antitussive effect of dextromethorphan." | 5.09 | The placebo response to citric acid-induced cough: pharmacodynamics and gender differences. ( Abdul-Manap, R; Morice, AH; Rostami-Hodjegan, A; Tucker, GT; Wright, CE, 2001) |
| "Menthol is a commonly used ingredient in many over the counter cough remedies, but there is little objective evidence as to its efficacy." | 5.07 | Effect of inhaled menthol on citric acid induced cough in normal subjects. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1994) |
| "We have evaluated the properties of capsaicin as a selective cough-inducing agent in healthy human subjects." | 5.07 | Capsaicin-induced cough in humans. ( Hansson, L; Karlsson, JA; Midgren, B; Persson, CG; Simonsson, BG, 1992) |
| "We studied the effects of angiotensin converting enzyme (ACE) inhibitors on cough responses to bradykinin (BK), substance P (SP) and citric acid in a double blind, random study on 10 hypertensive patients receiving ACE inhibitors." | 5.07 | Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril. ( Katsumata, U; Sasaki, H; Sekizawa, K; Takishima, T; Ujiie, Y, 1991) |
| "This controlled crossover study in twenty healthy volunteer subjects utilized the citric acid aerosol-induced cough response as a means to demonstrate the effectiveness of 25 mg of diphenhydramine as an antitussive." | 5.07 | Antitussive effects of diphenhydramine on the citric acid aerosol-induced cough response in humans. ( Ciccone, PE; Masurat, T; Packman, EW; Wilson, J, 1991) |
| "To compare the effects of three different angiotensin converting enzyme (ACE) inhibitors on the cough reflex, capsaicin and citric acid challenge tests were done in normal subjects and hypertensive patients before and after administration of delapril, captopril, or enalapril." | 5.07 | Comparative study of the effects of three angiotensin converting enzyme inhibitors on the cough reflex. ( Katahira, K; Mikami, H; Ogihara, T; Otsuka, A, 1991) |
| "The antitussive effects of dextromethorphan (30 mg) + salbutamol (2 mg), dextromethorphan (30 mg) alone and placebo on artificial cough induced by citric acid were compared in 19 healthy non-smoking volunteers in a double-blind crossover study." | 5.06 | Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough. ( Karttunen, P; Kolonen, S; Silvasti, M; Tukiainen, H, 1987) |
| "To clarify the role of oestrogen signalling and the role of oestrogen receptor alpha (ERα) in the cough pathways we performed a study in which coughing was observed in both sexes animal models after the treatment by selective ERα degrader fulvestrant (ICI 182-780) and inhibitor of oestrogen synthesis danazol." | 4.31 | Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes. ( Brozmanova, M; Buday, T; Kopcova, L; Matloobi, A; Plevkova, J; Sterusky, M, 2023) |
| "Erdosteine as a mucolytic agent that decreases mucus viscosity and facilitates mucus expulsion from the airways by cough or ciliary movement." | 3.88 | Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity. ( Fraňová, S; Jošková, M; Kazimierová, I; Pappová, L; Šutovská, M, 2018) |
| "The guinea pig sensitized by ovalbumin is the most widely used model to study cough experimentally, as the neurophysiology of the vagus nerve in the guinea pig is closest to humans." | 3.83 | The Guinea Pig Sensitized by House Dust Mite: A Model of Experimental Cough Studies. ( Buday, T; Gavliakova, S; Kavalcikova-Bogdanova, N; Medvedova, I; Mokry, J; Plevkova, J, 2016) |
| " Antitussive evaluations were carried out with cough models in mice and guinea pigs induced by ammonia liquor, capsaicin, and citric acid." | 3.81 | In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn. ( Cheng, X; Gao, Y; Li, S; Liu, W; Ni, J; Qi, S; Wang, C; Wang, G; Wang, J; Wang, Y; Wang, Z; Zheng, T, 2015) |
| "The efficacy of H4R antagonist JNJ7777120 on nasal symptoms, cough, airway resistance (Raw), inflammatory cell count in bronchoalveolar lavage (BAL) and blood in ovalbumin (OVA) induced allergic rhinitis (AR) was studied in guinea pigs." | 3.81 | The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs. ( Buday, T; Gavliakova, S; Kosutova, P; Kovacova-Hanuskova, E; Mokra, D; Mokry, J; Plevkova, J; Urbanova-Fulmekova, A, 2015) |
| "We have previously shown that cough potentiation induced by intravenous administration of the AT1 receptor antagonist losartan is lower than that induced by the ACE inhibitor lisinopril in anesthetized and awake rabbits." | 3.81 | The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit. ( Bongianni, F; Cinelli, E; Mutolo, D; Pantaleo, T, 2015) |
| "The aim of the present study was to analyze differences in cough induction between losartan and lisinopril in both anaesthetized and awake rabbits, i." | 3.79 | Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits. ( Bongianni, F; Cinelli, E; Evangelista, S; Mutolo, D; Pantaleo, T, 2013) |
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 3.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| "We studied the influence of memantine on experimentally induced coughing in response to citric acid and bradykinin inhalation in guinea pigs." | 3.78 | Antitussive effects of memantine in guinea pigs. ( Canning, BJ; Hilton, ECY; Saulsberry, L; Smith, JA, 2012) |
| " The pectic polysaccharides were tested for antitussive activity by studying the effects of citric acid-induced cough reflex in guinea pigs and reactivity of the airway smooth muscle in vivo conditions in comparison to the narcotic drug codeine." | 3.77 | Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs. ( Ebringerová, A; Hromádková, Z; Košťálová, Z; Nosáľová, G; Prisenžňáková, L, 2011) |
| ") decreased the number of cough efforts induced by citric acid in guinea pigs like that of codeine." | 3.77 | In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera. ( Bandyopadhyay, SS; Flešková, D; Nosál'ová, G; Ray, B; Sinha, S, 2011) |
| "In this study the effects of non-selective PDE inhibitors (theophylline and theobromine) and selective inhibitors of PDE 1, 3, 4 and 5 on cough, induced by citric acid, were evaluated." | 3.77 | The influence of the PDE inhibitors on cough reflex in guinea pigs. ( Mokry, J; Nosalova, G, 2011) |
| " Neotuberostemonine, tuberostemonine and stemoninine target on peripheral cough reflex pathway." | 3.76 | Antitussive and central respiratory depressant effects of Stemona tuberosa. ( But, PP; Chan, YM; Hon, PM; Jiang, RW; Shaw, PC; Xu, YT, 2010) |
| "In this study we have evaluated the cough reflex inhibiting potential and modulation of ASM reactivity in vitro, by K+ATP opener-pinacidil in guinea pig and cats." | 3.75 | The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways. ( Franova, S; Sutovska, M; Sutovsky, J, 2009) |
| " Antiasthmatic actions in guinea pigs were observed by histamine and acetylcholine ultrasonic atomization test, involved isolated guinea pig tracheal smoth muscle experiment and anaphylactic shock of guinea pigs." | 3.75 | [Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae]. ( Huang, SC; Lai, P; Liu, LF; Lu, DD; Tang, LH; Wang, Y; Ye, MR; Zhou, TN, 2009) |
| " The allergic inflammation in the nose was induced by repeated intranasal instillations of ovalbumin in the ovalbumin-sensitized guinea pigs." | 3.74 | Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis. ( Brozmanova, M; Kollarik, M; Plevkova, J; Tatar, M, 2008) |
| "The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice." | 3.74 | Role of cyclin-dependent kinase 5 in capsaicin-induced cough. ( Hayashi, SS; Kamei, J; Nozaki, C; Takahashi, Y, 2007) |
| "In this study we investigated whether openers of potassium channels, K+ATP--pinacidil and BK+Ca--NS1619, modulate cough reflex and airway smooth muscle (ASM) reactivity in in vivo and in vitro conditions in guinea pigs." | 3.74 | The role of potassium ion channels in cough and other reflexes of the airways. ( Franova, S; Nosalova, G; Sutovska, M, 2007) |
| "In this study we investigated the ability of aerosolized substance P to induce either cough or bronchoconstriction in guinea-pigs." | 3.73 | The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs. ( Amine, SA; El-Hashim, AZ, 2005) |
| "This study indicates that residual sedation after propofol anaesthesia for colonoscopy does not adversely affect the cough reflex." | 3.73 | Assessment of the cough reflex after propofol anaesthesia for colonoscopy. ( Bonay, M; Desmonts, JM; Guglielminotti, J; Mantz, J; Mentre, F; Panhard, X; Rackelboom, T; Tesniere, A, 2005) |
| "This study was designed to investigate the effect of intraesophageal (IE) administration of capsaicin on cough and specific airway resistance (Saw) in guinea pigs." | 3.73 | The effect of chemical stimulation of esophageal mucosa on citric acid induced cough and specific airway resistance in guinea pig. ( Bartos, V; Brozmanova, M; Kollarik, M; Plank, L; Plevkova, J; Revallo, M; Tatar, M; Varechova, S, 2005) |
| "Cough initiated from the trachea and larynx in anaesthetized guinea-pigs is mediated by capsaicin-insensitive, mechanically sensitive vagal afferent neurones." | 3.73 | Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs. ( Canning, BJ; Mazzone, SB; Mori, N, 2005) |
| "Nociceptin/orphanin FQ has been reported to inhibit capsaicin- and mechanically provoked cough in animal models, but the mechanism of this effect has not been elucidated." | 3.73 | Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs. ( Brown, C; Carr, MJ; Lee, MG; Undem, BJ, 2006) |
| "We examined the effect of inhaled histamine on citric acid-induced coughs and clarified the role of ionotropic purinergic receptors in the resulting changes." | 3.73 | Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs. ( Kamei, J; Takahashi, Y, 2006) |
| " Bronchial asthma model induced by histamine-acetylcholine in guinea pigs was used to observe the antiasthmatic effects." | 3.73 | [Experimental studies on antitussive, expectorant and antiasthmatic effects of extract from Citrus grandis var. tomentosa]. ( Li, PB; Ma, Y; Su, WW; Wang, YG, 2006) |
| "Affinity-purified antibodies to morphine (mixture of homeopathic dilutions C30+C200) produced an antitussive effect on male and female guinea pigs with cough induced by citric acid and capsaicin." | 3.72 | Antitussive activity of Anar. ( Epstein, OI; Kovaleva, VL; Zak, MS, 2003) |
| " Experiments were performed on guinea pigs with cough induced by citric acid and capsaicin." | 3.72 | Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin. ( Dugina, YL; Epstein, OI; Kovaleva, VL; Zak, MS, 2003) |
| "The anti-tussive effect of the R-(+)- and S-(-)-enantiomers of benproperine was evaluated and compared with that of the racemate on cough induced by 7." | 3.72 | Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. ( Chen, S; Kong, W; Li, W; Li, Y; Min, L; Zhong, D, 2004) |
| "To investigate the influence of erdosteine, a new homocysteine-derived expectorant, on airway clearance we studied the effects of the drug on the viscosity of mucin, on the mucociliary transport rate in quails, on airway secretion in rats and on the cough reflex in guinea-pigs." | 3.70 | Mucolytic and antitussive effects of erdosteine. ( Hosoe, H; Isohama, Y; Kai, H; Kaise, T; Miyata, T; Ohmori, K; Takahama, K, 1999) |
| "The effect of ammonia on the cough response to citric acid and on substance P release from C-fibers involved in this reflex was assessed." | 3.70 | Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P. ( Beerens, D; Gustin, P; Moreaux, B; Nemmar, A, 2000) |
| " The antitussive effects of moguisteine have been compared with codeine in several experimental models of cough in guinea-pigs and dogs." | 3.69 | Moguisteine: a novel peripheral non-narcotic antitussive drug. ( Borghi, A; Ceserani, R; Dalla Rosa, C; Gallico, L; Tognella, S, 1994) |
| "To examine the mechanisms of an angiotensin-converting enzyme (ACE) inhibitor-induced cough in perimenopausal and postmenopausal women, cough responses to aerosols of capsaicin and citric acid were examined in four groups of female guinea pigs treated orally with danazol (D) (an agent decreasing plasma estrogen levels), cilazapril (C) (an inhibitor of ACE), both danazol and cilazapril (C+D), or without either drug (control group) for 4 to 5 wk." | 3.69 | Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs. ( Ebihara, T; Nakazawa, H; Ohrui, T; Sasaki, H; Sekizawa, K, 1996) |
| "Acidic solutions mimick many of the effects of capsaicin (Cap), including pain, bronchoconstriction, cough, and sensory neuropeptide release." | 3.69 | Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs. ( Barnes, PJ; Belvisi, MG; Chung, KF; Fox, AJ; Lalloo, UG, 1995) |
| "The antitussive effect of the R-(+)- and S-(-)-enantiomers of moguisteine were evaluated in comparison with the racemate in cough induced by 7." | 3.69 | Antitussive activity of moguisteine enantiomers in guinea-pigs and rats. ( Borghi, A; Cavalletti, E; Ceserani, R; Gallico, L; Tognella, S, 1996) |
| "It has been suggested that bradykinin may play a role in stimulating cough in at least one pathological condition in humans." | 3.69 | Mechanism of irritant-induced cough: studies with a kinin antagonist and a kallikrein inhibitor. ( Church, MK; Evans, DM; Featherstone, RL; Jones, DM; Olsson, H; Parry, JE; Szelke, M, 1996) |
| "All awake guinea-pigs were coughing during the exposure to both citric acid and capsaicin, too." | 3.69 | [Sensitivity of the cough reflex in awake guinea pigs, rats and rabbits]. ( Karcolová, D; Pécová, R; Tatár, M, 1997) |
| "The effects of four angiotensin-converting enzyme (ACE) inhibitors, captopril, enalapril, quinapril and alacepril, on the cough responses caused by citric acid and capsaicin inhalation were studied in normal and bronchitic guinea-pigs." | 3.68 | Differences in the mode of cough augmentation by four angiotensin-converting enzyme inhibitors in guinea-pigs. ( Fuchikami, J; Kai, H; Miyata, T; Suzuki, A; Tabata, T; Takahama, K, 1993) |
| "The antitussive effects of SR 48968, a non-peptide tachykinin NK2 receptor antagonist, were investigated on citric acid-induced cough in the unanesthetized guinea-pig and compared with the effects of codeine." | 3.68 | Antitussive effect of SR 48968, a non-peptide tachykinin NK2 receptor antagonist. ( Advenier, C; Emonds-Alt, X; Girard, V; Naline, E; Vilain, P, 1993) |
| "The cough response following inhalation challenge with the sensory nerve irritant resiniferatoxin was compared with that of capsaicin and citric acid in guinea-pig and man." | 3.68 | A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man. ( Higgins, KS; Laude, EA; Morice, AH, 1993) |
| "The effects of nebulized diuretics on citric acid-induced cough and airway obstruction in guinea pigs and capsaicin-induced cough and increase in airway resistance in humans have been studied." | 3.68 | A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs. ( Choudry, NB; Fuller, RW; Karlsson, JA; Zackrisson, C, 1992) |
| "The influence of aerosols of Ruthenium red (RR) on capsaicin- and citric acid-induced cough was investigated in guinea pigs." | 3.68 | Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs. ( Aziz, SM; Bolser, DC; Chapman, RW, 1991) |
| " Comparisons were made between the doses required of aerosol and intraperitoneally administered morphine, dextromethorphan, codeine and the specific peripherally acting mu-receptor agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) to suppress citric acid-induced coughing in conscious guinea pigs." | 3.68 | Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig. ( Boura, AL; Callaway, JK; King, RG, 1991) |
| "The effect of upper abdominal surgery under general anaesthesia on the cough threshold was studied in 26 patients, on the basis of the concentrations of capsaicin and citric acid causing cough." | 3.68 | Cough threshold after upper abdominal surgery. ( Dilworth, JP; Pounsford, JC; White, RJ, 1990) |
| " Increased airway concentration of both prostaglandins and bradykinin has been suggested as the possible cause of the increased cough sensitivity sometimes found in patients with cough associated with taking drugs that inhibit angiotensin-converting enzyme." | 3.67 | Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine. ( Choudry, NB; Fuller, RW; Pride, NB, 1989) |
| " The effects of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough have been studied in conscious tracheostomised dogs." | 3.67 | The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs. ( Jackson, DM, 1988) |
| "Type 2 diabetes mellitus is prevalent especially in Gulf countries and poses serious long-term risks to patients." | 2.82 | The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain. ( Al-Saber, F; Aldosari, W; Alselaiti, M; Darwish, A; Harb, G; Kaladari, A; Khalfan, H; Khan, G; Koda, A; Kudo, S; Nakajima, M; Rehani, R; Tanaka, T, 2016) |
| "Chronic cough is common, and medical treatment can be ineffective." | 2.74 | The effect of mindfulness meditation on cough reflex sensitivity. ( Brammer, C; Brown, N; Calam, R; Johnson, C; Jones, S; Lowe, J; Owen, E; Smith, JA; Woodcock, A; Young, EC, 2009) |
| "Menthol has no effect on objective measures of flow but significantly increases the perception of nasal patency." | 2.73 | Does inhaling menthol affect nasal patency or cough? ( Beardsmore, C; Houghton, T; Kenia, P, 2008) |
| "Cough is a common and protective reflex, but persistent coughing is debilitating and impairs quality of life." | 2.71 | Theobromine inhibits sensory nerve activation and cough. ( Barnes, PJ; Belvisi, MG; Birrell, MA; Crispino, N; Korbonits, D; Korbonits, M; Patel, HJ; Usmani, OS, 2005) |
| "Twenty subjects with GERD, a group of 14 women and 6 men (mean age, 45." | 2.71 | Citric acid cough threshold in patients with gastroesophageal reflux disease rises after laparoscopic fundoplication. ( Ciekalski, J; Dworniczak, S; Dzielicki, J; Jarosz, W; Kozielski, J; Krzywiecki, A; Ziora, D, 2005) |
| "Cough was induced with inhaled citric acid and its magnitude was influenced by changing the setting in 30 adolescents with asthma." | 2.69 | Psychological confounds in medical research: the example of excessive cough in asthma. ( Everaerd, W; Rietveld, S; Van Beest, I, 2000) |
| "1." | 2.68 | The effect of inhaled and oral dextromethorphan on citric acid induced cough in man. ( Grattan, TJ; Higgins, KS; Marshall, AE; Morice, AH, 1995) |
| " The side-effects observed were mild in nature and did not require reduction in dosage or withdrawal of the drug in any of the patients." | 2.66 | A comparative randomized double-blind clinical trial of hexapneumine and clistine as antitussive agents. ( Chakrabarti, A; Jindal, SK; Malik, SK; Pandhi, P; Sharma, PL, 1987) |
| "Cough is initiated by activation of afferent nerve fibers with rapidly adapting receptors (RAR) that conduct action potentials in the Adelta range." | 2.41 | Physiology and plasticity of putative cough fibres in the Guinea pig. ( Carr, MJ; Kollarik, M; Undem, BJ, 2002) |
| "Cough is frequently a symptom in bronchial asthma." | 2.37 | Cough and bronchoconstriction. ( Pounsford, J, 1987) |
| " The dose-response curves in citric acid and capsaicin cough challenge construction shows significantly increased cough threshold in SPF animals compared to wild-type animals of both sexes." | 1.91 | Cough response in specific pathogen-free guinea pig animal model. ( Biringerova, Z; Brozmanova, M; Buday, T; Kopcova, L; Matloobi, A; Plevkova, J, 2023) |
| " The pharmacodynamic study against cough induced by ammonia water in the mouse model and the cough induced by citric acid in the guinea pig model were performed to optimize the extraction process of the sovereign medicinal Indigo Naturalis and the whole prescription of Children's Qingfei Zhisou Syrup." | 1.72 | [Optimization of extraction process of Children's Qingfei Zhisou Syrup based on pharmacodynamics]. ( Fu, JH; Guo, H; Hao, W; Jin, L; Liu, JX; Liu, ZX; Meng, S; Xu, SJ; Zhao, JF, 2022) |
| "Repeated cough may lead to airway remodeling, which was also associated with an increased frequency of cough." | 1.51 | Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model. ( Cui, S; Ito, I; Iwata, T; Izuhara, H; Kanemitsu, Y; Matsumoto, H; Mishima, M; Nagasaki, T; Nakaji, H; Niimi, A; Oguma, T; Tajiri, T, 2019) |
| "Arabinogalactan is a polysaccharide isolated from the roots of the medicinal plant Withania somnifera L." | 1.42 | Antitussive activity of Withania somnifera and opioid receptors. ( Flešková, D; Fraňová, S; Nosálová, G; Ondrejka, I; Ray, B; Sivová, V, 2015) |
| "Cough is a protective reflex action that helps clear the respiratory tract which is continuously exposed to airborne environmental irritants." | 1.40 | Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic. ( Aranake, S; Bhosale, V; Ghosh, I; Karnik, P; Khairatkar-Joshi, N; Kulkarni, A; Mukhopadhyay, I; Shetty, M; Thorat, S; Wale, D, 2014) |
| "Bouts of cough were counted pre and post acute exposure of extract-treated (× 7 d) guinea pigs to 7." | 1.39 | Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species. ( Eze, GI; Okpo, SO; Ozolua, RI; Salami, EO; Uwaya, DO, 2013) |
| "Cough was induced by adding citric acid (CA) to the tracheal perfusion in anaesthetized animals, or by inhaling 0." | 1.39 | The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models. ( Biringerova, Z; Brozmanova, M; Gavliakova, S; Hanuskova, E; Plevkova, J; Poliacek, I; Tatar, M, 2013) |
| "The risk of aspiration pneumonia in Parkinson's disease (PD) may be increased by sensory loss in the laryngopharynx and a reduced cough reflex." | 1.38 | Changes in chemosensitivity and mechanosensitivity in aging and Parkinson's disease. ( Anderson, T; Beckert, L; Huckabee, ML; Leow, LP, 2012) |
| "Urge-to-cough was induced by citric acid challenge and dyspnea was induced by external inspiratory resistive loads." | 1.38 | Urge-to-cough and dyspnea conceal perception of pain in healthy adults. ( Ebihara, S; Ebihara, T; Gui, P; Ito, K; Kanezaki, M; Kashiwazaki, N; Kohzuki, M, 2012) |
| "Dry and persistent cough is one of the commonest side effects experienced by patients treated with angiotensin-converting enzyme (ACE) inhibitors for the therapy of hypertension and congestive heart failure." | 1.36 | Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2. ( Cialdai, C; Giuliani, S; Maggi, CA; Tramontana, M; Valenti, C, 2010) |
| "Cough is the most common symptom reported by patients in a primary care setting and is one of the most frequent secondary effects recorded during treatment with angiotensin-converting enzyme (ACE) inhibitors." | 1.36 | Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits. ( Bongianni, F; Cinelli, E; Evangelista, S; Mutolo, D; Pantaleo, T, 2010) |
| "Cough is widely recognized as a key symptom in the diagnosis and the monitoring of asthma, but little is known about how best to assess cough in asthma." | 1.35 | A comparison of objective and subjective measures of cough in asthma. ( Alam, U; Kelsall, AA; Marsden, PA; McGuinness, K; Naylor, JR; Owen, E; Smith, JA; Sumner, H; Webster, D; Woodcock, AA, 2008) |
| "Cough was assessed visually, acoustically and by analysis of the airflow signal." | 1.35 | Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms. ( El-Hashim, AZ; Jaffal, SM, 2009) |
| "Altitude-related cough is a troublesome condition of unknown etiology." | 1.35 | Changes in plasma bradykinin concentration and citric acid cough threshold at high altitude. ( Aldashev, A; Kim, EV; Mason, NP; Mélot, C; Mirrakhimov, MM; Naeije, R; Petersen, M; Sarybaev, A, 2009) |
| "Cough was elicited by inhalation of citric acid aerosols and evaluated at 30 min (early phase) or 24 h (late phase) after the 1st or 6th nasal challenge (NC) in the sensitized animals." | 1.34 | Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs. ( Bartos, V; Brozmanova, M; Plank, L; Tatar, M, 2007) |
| "Cough was provoked by exposure of animals to citric acid aerosol (CA) in gradually increasing concentrations (0." | 1.34 | Influence of chest gamma-irradiation on cough response in awake guinea pigs. ( Brozmanova, M; Hajtmanova, E; Hanacek, J; Javorka, M; Javorkova, N; Tatar, M; Zamecnik, L, 2007) |
| "Cough was induced by inhalation of citric acid aerosol before and after exposure to oxygen." | 1.34 | Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs. ( Bartos, V; Brozmanova, M; Javorka, M; Masar, J; Plank, L; Plevkova, J; Tatar, M, 2007) |
| "Cough was induced by inhalation of citric acid aerosol at time before and after exposure to hyperoxia." | 1.34 | Dietary intake of flavonoids and hyperoxia-induced oxidative stress related cough in guinea pigs. ( Bartos, V; Brozmanova, M; Plank, L; Plevkova, J; Tatar, M, 2007) |
| "Then, cough was recorded for 12 min using a barometric body plethysmograph." | 1.33 | Mast cells in citric acid-induced cough of guinea pigs. ( Lai, YL; Lin, TY, 2005) |
| "Cough was induced by citric acid aerosol inhalation in gradually increasing concentration (0." | 1.33 | Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs. ( Bartos, V; Brozmanova, M; Plank, L; Plevkova, J; Tatar, M, 2005) |
| "Cough is a common and important symptom of asthma and allergic rhinitis." | 1.33 | Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis. ( Bartos, V; Brozmanová, M; Calkovský, V; Plank, L; Plevková, J; Tatár, M, 2006) |
| "Cough was induced by inhalation of citric acid aerosol in gradually increased concentration (0." | 1.33 | The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy. ( Bartos, V; Brozmanova, M; Javorka, M; Plank, L; Plevkova, J; Tatar, M, 2006) |
| "Cough was induced by citric acid aerosol inhalation in gradually increasing concentrations (0." | 1.33 | Effects of thorax irradiation on citric acid-induced cough in guinea pigs. ( Bartos, V; Brozmanova, M; Hajtmanova, E; Hanacek, J; Javorka, M; Javorkova, N; Plank, L; Tatar, M; Zamecnik, L, 2006) |
| "Cough was evoked by electrical or mechanical stimulation of the tracheal or laryngeal mucosa, or by citric acid applied topically to the trachea or larynx." | 1.32 | Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs. ( Canning, BJ; Mazzone, SB; Meeker, SN; Mori, N; Reynolds, SM; Undem, BJ, 2004) |
| "Cough was provoked in conscious animals placed in bodyplethysmograph box by inhalation of citric acid aerosol (0." | 1.32 | The influence of hyperoxia on cough reflex intensity in guinea pigs treated with bleomycin. ( Brozmanova, M; Hanacek, J; Szepe, P; Tatar, M, 2004) |
| "Cough was induced by inhalation of citric acid aerosols in gradually increasing concentrations for 30 s and was evaluated 1 h after the 8(th) nasal challenge (NCH) and 17 h after the 9(th) NCH." | 1.32 | Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis--the first experience. ( Brozmanova, M; Calkovsky, V; Plevkova, J; Tatar, M, 2004) |
| "Bradykinin, however, plays a major role in coughing induced by citric acid alone." | 1.31 | Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs. ( Advenier, C; Gustin, P; Moreaux, B, 2001) |
| " Pharmacokinetic evaluation in the mouse and rat revealed that oral SB 235375 was well absorbed systemically but did not effectively cross the blood-brain barrier." | 1.31 | Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. ( Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Grugni, M; Hay, DW; Kilian, D; Kotzer, CJ; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Potts, W; Raveglia, LF; Sandhu, P; Sarau, HM; Schmidt, DB; Underwood, DC, 2002) |
| " Intravenous histamine increased intratracheal pressure (ITP) in anaesthetized guinea-pigs and the dose-response curve was significantly (P less than 0." | 1.28 | Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid. ( Forsberg, K; Karlsson, JA; Sjölin, C; Zackrisson, C, 1991) |
| "Nedocromil sodium has been observed to stimulate bronchial C fibers, and it is suggested that this activity may relate to the antitussive effect of the compound." | 1.28 | Effect of nedocromil sodium on SO2-induced airway hyperresponsiveness and citric acid-induced cough in dogs. ( Eady, RP; Jackson, DM, 1989) |
| " It is suggested that this method of testing the effects of an antitussive on such a dose-response curve may be a useful one." | 1.27 | An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid. ( Apps, MC; Burke, CA; Cox, ID; Empey, DW; Hughes, DT; Osman, RC; Wallis, PJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (10.08) | 18.7374 |
| 1990's | 59 (23.79) | 18.2507 |
| 2000's | 86 (34.68) | 29.6817 |
| 2010's | 69 (27.82) | 24.3611 |
| 2020's | 9 (3.63) | 2.80 |
| Authors | Studies |
|---|---|
| Koskela, HO | 1 |
| Nurmi, HM | 1 |
| Song, WJ | 1 |
| Xu, SJ | 1 |
| Guo, H | 1 |
| Zhao, JF | 1 |
| Jin, L | 1 |
| Meng, S | 1 |
| Liu, ZX | 1 |
| Hao, W | 1 |
| Fu, JH | 1 |
| Liu, JX | 1 |
| Buday, T | 6 |
| Matloobi, A | 2 |
| Kopcova, L | 2 |
| Brozmanova, M | 17 |
| Sterusky, M | 2 |
| Plevkova, J | 15 |
| Biringerova, Z | 2 |
| Terada, S | 1 |
| Matsumoto, H | 2 |
| Nishi, K | 1 |
| Kogo, M | 1 |
| Nomura, N | 1 |
| Tashima, N | 1 |
| Morimoto, C | 1 |
| Sunadome, H | 1 |
| Nagasaki, T | 2 |
| Oguma, T | 2 |
| Nakatsuka, Y | 1 |
| Murase, K | 1 |
| Kawaguchi, T | 1 |
| Tabara, Y | 1 |
| Sonomura, K | 1 |
| Matsuda, F | 1 |
| Chin, K | 1 |
| Hirai, T | 1 |
| Higashi, E | 1 |
| Hirayama, S | 1 |
| Nikaido, J | 1 |
| Shibasaki, M | 1 |
| Kono, T | 1 |
| Honjo, A | 1 |
| Ikeda, H | 1 |
| Kamei, J | 5 |
| Fujii, H | 1 |
| Wallace, E | 2 |
| Guiu Hernandez, E | 2 |
| Ang, A | 2 |
| Macrae, P | 2 |
| Foucaud, L | 1 |
| Demoulin, B | 1 |
| Leblanc, AL | 1 |
| Ioan, I | 1 |
| Schweitzer, C | 1 |
| Demoulin-Alexikova, S | 1 |
| Xiang, J | 1 |
| Liu, X | 1 |
| Zhong, S | 1 |
| Fang, Z | 1 |
| Shen, S | 1 |
| Tang, J | 1 |
| Lai, S | 1 |
| Lai, K | 1 |
| Grendar, M | 1 |
| Gao, X | 2 |
| Zhuang, J | 2 |
| Zhao, L | 2 |
| Wei, W | 1 |
| Xu, F | 2 |
| Kim, SH | 1 |
| Kim, DM | 1 |
| Park, HE | 1 |
| Shin, YB | 1 |
| Lee, BJ | 1 |
| Jang, MH | 1 |
| Yoon, JA | 1 |
| Pappová, L | 1 |
| Kazimierová, I | 1 |
| Jošková, M | 3 |
| Šutovská, M | 6 |
| Fraňová, S | 7 |
| Choi, YM | 1 |
| Park, GY | 2 |
| Yoo, Y | 1 |
| Sohn, D | 2 |
| Jang, Y | 2 |
| Im, S | 2 |
| Chou, YL | 2 |
| Mori, N | 6 |
| Canning, BJ | 8 |
| Mills, C | 1 |
| Jones, R | 1 |
| Huckabee, ML | 6 |
| Svajdova, S | 1 |
| Mazurova, L | 1 |
| Rai, ZL | 1 |
| Fowles, HE | 1 |
| Wright, C | 1 |
| Howard, J | 1 |
| Morice, AH | 12 |
| Shou, JW | 1 |
| Zhang, RR | 1 |
| Wu, HY | 1 |
| Xia, X | 1 |
| Nie, H | 1 |
| Jiang, RW | 2 |
| Shaw, PC | 3 |
| El-Hashim, AZ | 6 |
| Mathews, S | 1 |
| Al-Shamlan, F | 1 |
| Xu, X | 1 |
| Chen, Q | 1 |
| Qiu, Z | 1 |
| Shi, C | 1 |
| Ding, H | 1 |
| Wang, L | 2 |
| Lv, H | 1 |
| Yu, L | 1 |
| Koo, H | 1 |
| Han, Y | 1 |
| Cui, S | 1 |
| Ito, I | 1 |
| Nakaji, H | 1 |
| Iwata, T | 1 |
| Tajiri, T | 1 |
| Kanemitsu, Y | 1 |
| Izuhara, H | 1 |
| Mishima, M | 1 |
| Niimi, A | 1 |
| Mei, B | 1 |
| Cui, F | 1 |
| Wu, C | 1 |
| Wen, Z | 1 |
| Wang, W | 1 |
| Shen, M | 1 |
| Hiew, S | 1 |
| Miles, A | 2 |
| Moore, S | 1 |
| McFarlane, M | 1 |
| Lee, F | 1 |
| Allen, J | 1 |
| Salami, EO | 1 |
| Ozolua, RI | 1 |
| Okpo, SO | 1 |
| Eze, GI | 1 |
| Uwaya, DO | 1 |
| Jaffal, SM | 3 |
| Al-Rashidi, FT | 1 |
| Luqmani, YA | 1 |
| Akhtar, S | 1 |
| Mutolo, D | 5 |
| Cinelli, E | 5 |
| Bongianni, F | 5 |
| Evangelista, S | 2 |
| Pantaleo, T | 5 |
| Gavliakova, S | 3 |
| Tatar, M | 18 |
| Hanuskova, E | 1 |
| Poliacek, I | 1 |
| Mukhopadhyay, I | 1 |
| Kulkarni, A | 1 |
| Aranake, S | 1 |
| Karnik, P | 1 |
| Shetty, M | 1 |
| Thorat, S | 1 |
| Ghosh, I | 1 |
| Wale, D | 1 |
| Bhosale, V | 1 |
| Khairatkar-Joshi, N | 1 |
| Capek, P | 3 |
| Kočmalová, M | 2 |
| Pawlaczyk, I | 2 |
| Zaczyńska, E | 1 |
| Czarny, A | 1 |
| Uhliariková, I | 1 |
| Gancarz, R | 2 |
| Falconer, JR | 1 |
| Wu, Z | 1 |
| Lau, H | 1 |
| Suen, J | 1 |
| Pottinger, S | 1 |
| Lee, E | 1 |
| Alazawi, N | 1 |
| Kallesen, M | 2 |
| Gargiulo, DA | 1 |
| Swift, S | 1 |
| Svirskis, D | 1 |
| Nosálová, G | 9 |
| Sivová, V | 2 |
| Ray, B | 4 |
| Ondrejka, I | 1 |
| Flešková, D | 3 |
| Liu, W | 1 |
| Cheng, X | 1 |
| Wang, Y | 2 |
| Li, S | 1 |
| Zheng, T | 1 |
| Gao, Y | 1 |
| Wang, G | 1 |
| Qi, S | 1 |
| Wang, J | 1 |
| Ni, J | 1 |
| Wang, Z | 1 |
| Wang, C | 1 |
| Janssens, T | 1 |
| Brepoels, S | 1 |
| Dupont, L | 1 |
| Van den Bergh, O | 1 |
| Makwana, R | 1 |
| Venkatasamy, R | 1 |
| Spina, D | 2 |
| Page, C | 2 |
| Wex, E | 1 |
| Bouyssou, T | 1 |
| Guillén-Solà, A | 1 |
| Chiarella, SC | 1 |
| Martínez-Orfila, J | 1 |
| Duarte, E | 1 |
| Alvarado-Panesso, M | 1 |
| Figueres-Cugat, A | 1 |
| Bas, N | 1 |
| Marco, E | 1 |
| Kovacova-Hanuskova, E | 1 |
| Kosutova, P | 1 |
| Mokra, D | 2 |
| Urbanova-Fulmekova, A | 1 |
| Mokry, J | 5 |
| Fernández-Blanco, JA | 1 |
| Aguilera, M | 1 |
| Domènech, A | 1 |
| Tarrasón, G | 1 |
| Prats, N | 1 |
| Miralpeix, M | 1 |
| De Alba, J | 1 |
| Clay, E | 1 |
| Patacchini, R | 1 |
| Trevisani, M | 2 |
| Preti, D | 1 |
| Branà, MP | 1 |
| Kelly, HE | 1 |
| Shaw, GM | 1 |
| Brett, CN | 1 |
| Greenwood, FM | 1 |
| Medvedova, I | 1 |
| Kavalcikova-Bogdanova, N | 1 |
| Psirides, A | 1 |
| Bera, K | 1 |
| Nosáľ, S | 1 |
| Al-Saber, F | 1 |
| Aldosari, W | 1 |
| Alselaiti, M | 1 |
| Khalfan, H | 1 |
| Kaladari, A | 1 |
| Khan, G | 1 |
| Harb, G | 1 |
| Rehani, R | 1 |
| Kudo, S | 1 |
| Koda, A | 1 |
| Tanaka, T | 1 |
| Nakajima, M | 1 |
| Darwish, A | 1 |
| Kovacikova, L | 1 |
| Ruzinak, R | 1 |
| Belvisi, MG | 5 |
| Patel, HJ | 2 |
| Freund-Michel, V | 1 |
| Hele, DJ | 1 |
| Crispino, N | 2 |
| Birrell, MA | 2 |
| Scarupa, MD | 1 |
| Marsden, PA | 1 |
| Smith, JA | 6 |
| Kelsall, AA | 1 |
| Owen, E | 3 |
| Naylor, JR | 1 |
| Webster, D | 1 |
| Sumner, H | 1 |
| Alam, U | 1 |
| McGuinness, K | 3 |
| Woodcock, AA | 1 |
| Nishino, T | 2 |
| Yang, XZ | 1 |
| Zhu, JY | 1 |
| Tang, CP | 2 |
| Ke, CQ | 2 |
| Lin, G | 4 |
| Cheng, TY | 1 |
| Rudd, JA | 1 |
| Ye, Y | 3 |
| Zhou, X | 1 |
| Leung, PH | 1 |
| Li, N | 1 |
| Zhang, L | 1 |
| Zuo, Z | 1 |
| Kollarik, M | 4 |
| Thompson, AA | 1 |
| Baillie, JK | 1 |
| Bates, MG | 1 |
| Schnopp, MF | 1 |
| Simpson, A | 1 |
| Partridge, RW | 1 |
| Drummond, GB | 1 |
| Mason, NP | 4 |
| Sutovsky, J | 1 |
| Zhou, TN | 1 |
| Tang, LH | 1 |
| Huang, SC | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Cross Sectional Evaluation of Coughing Force in Stroke Patients With Severe Aspiration[NCT02080988] | 20 participants (Actual) | Observational | 2013-10-31 | Completed | |||
| Prospective, Randomized, Single-Blind, Placebo-Controlled, Dose-Escalation Pilot Study to Evaluate the Safety and Efficacy of 5-ALA-SFC in Subjects With Type II Diabetes[NCT02481141] | 53 participants (Actual) | Interventional | 2014-07-31 | Completed | |||
| Chronic Cough and Small Fiber Neuropathy[NCT03787511] | 60 participants (Anticipated) | Interventional | 2019-03-05 | Recruiting | |||
| EFfect of FIxed Triple Beclometasone/Formoterol/Glycopyrronium Therapy on Cough effiCAcy in Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) patiEnts: EFFICACE[NCT05114434] | 40 participants (Anticipated) | Observational | 2021-11-30 | Not yet recruiting | |||
| Respiratory Kinematics of Reflex and Voluntary Cough in Healthy Older Adults and Parkinson's Disease[NCT02183519] | Phase 1/Phase 2 | 44 participants (Actual) | Interventional | 2014-10-31 | Completed | ||
| Pilot Observational Study, Assessing PCEF of the Voluntary and Reflex Cough in Patients With ALS[NCT02495571] | 60 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Pilot Study of the Cough Reflex Assessment in Patients With Tracheostomy Cannula Following Severe Acquired Brain Injury[NCT02495558] | 30 participants (Anticipated) | Interventional | 2015-10-31 | Recruiting | |||
| Speech Therapy in the Management of Difficult-to-treat Chronic Cough[NCT03457610] | 30 participants (Actual) | Interventional | 2016-01-01 | Completed | |||
| The Effect of Neck Stabilization Exercise Plus Cardiopulmonary Rehabilitation on Pulmonary Function of SCI[NCT04500223] | 13 participants (Actual) | Interventional | 2020-04-01 | Completed | |||
| An 8 Week Non-selected Cohort Study to Investigate Whether the Treatment of Reflux Induced Cough Alters Associated Bronchial Hyper-responsiveness[NCT00668317] | Phase 3 | 5 participants (Actual) | Interventional | 2006-09-30 | Terminated (stopped due to Primary care physicians began prescribing antacid therapy for chronic cough) | ||
| The Effects of Tiotropium on the Cough Reflex in Patients With COPD[NCT00870896] | Early Phase 1 | 5 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change from baseline in blood glucose levels 2 hours after breakfast (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline | -0.2 |
| 5-ALA-SFC Through Week 4 (75 mg 2x/Day) Change From Baseline | -12.9 |
| 5-ALA-SFC Through Week 12 (100 mg 2x/Day) Change From Baseline | -8.5 |
| Placebo Through Week 2 Change From Baseline | -26.5 |
| Placebo Through Week 4 Change From Baseline | -18.8 |
| Placebo Through Week 12 Change From Baseline | -33.0 |
Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12
| Intervention | kg (Mean) |
|---|---|
| 5-ALA-SFC Through Week 6 Change From Baseline | -0.1 |
| 5-ALA-SFC Through Week 12 Change From Baseline | -0.2 |
| Placebo Through Week 6 Change From Baseline | -0.3 |
| Placebo Through Week 12 Change From Baseline | -0.8 |
The objective of the current study was to investigate the safety and preliminary efficacy of doses up to 200 mg 5-ALA - SFC in a population of patients with type 2 diabetes mellitus living in Bahrain. (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline | 2.3 |
| 5-ALA-SFC Through Week 4 (75 mg 2x/Day) Change From Baseline | -0.2 |
| 5-ALA-SFC Through Wk 12 (100 mg 2x/Day) Change From Baseline | -3.0 |
| Placebo Through Week 2 Change From Baseline | -7.3 |
| Placebo Through Week 4 Change From Baseline | -0.8 |
| Placebo Through Week 12 Change From Baseline | -4.2 |
Change from baseline in HbA1c % (NCT02481141)
Timeframe: Baseline, Week 2, Week 4, Week 12
| Intervention | percentage of HbA1c (Mean) |
|---|---|
| 5-ALA-SFC Through Week 2 (50 mg 2x/Day) Change From Baseline | -0.2 |
| 5-ALA-SFC Through 4 (75 mg 2x/Day) Change From Baseline | -0.3 |
| 5-ALA-SFC Through 12 (100 mg 2x/Day) Change From Baseline | -0.7 |
| Placebo Through Week 2 Change From Baseline | -0.5 |
| Placebo Through Week 4 Change From Baseline | -0.5 |
| Placebo Through Week 12 Change From Baseline | -0.5 |
Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 6 Change From Baseline | -0.8 |
| 5-ALA-SFC Through Week 12 Change From Baseline | 0.5 |
| Placebo Through Week 6 Change From Baseline | -1.6 |
| Placebo Through Week 12 Change From Baseline | -1.1 |
Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 6 Change From Baseline | -5.2 |
| 5-ALA-SFC Through Week 12 Change From Baseline | 6.8 |
| Placebo Through Week 6 Change From Baseline | -7.6 |
| Placebo Through Week 12 Change From Baseline | -0.1 |
Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 6 Change From Baseline | -1.3 |
| 5-ALA-SFC Through Week 12 Change From Baseline | 3.2 |
| Placebo Through Week 6 Change From Baseline | 4.5 |
| Placebo Through Week 12 Change From Baseline | 11.9 |
Change from baseline measured at week 6 and week 12 only (NCT02481141)
Timeframe: Baseline, Week 6, Week 12
| Intervention | mg/dL (Mean) |
|---|---|
| 5-ALA-SFC Through Week 6 Change From Baseline | -2.9 |
| 5-ALA-SFC Through Week 12 Change From Baseline | 7.6 |
| Placebo Through Week 6 Change From Baseline | -11.8 |
| Placebo Through Week 12 Change From Baseline | -4.0 |
The objective of the current study was to investigate the safety and preliminary efficacy of doses up to 200 mg 5-ALA - SFC in a population of patients with type 2 diabetes mellitus living in Bahrain. (NCT02481141)
Timeframe: Week 2, Week 4, Week 12
| Intervention | Participants (Count of Participants) |
|---|---|
| 5-ALA-SFC Through Week 2 (50 mg 2x/Day) | 6 |
| 5-ALA-SFC Through Week 4 (75 mg 2x/Day) | 8 |
| 5-ALA-SFC Through Week 12 (100 mg 2x/Day) | 2 |
| Placebo Through Week 2 | 3 |
| Placebo Through Week 4 | 1 |
| Placebo Through Week 12 | 1 |
Peak expiratory flow rate is the maximum volume of air that is expelled per unit time for each cough in a cough epoch. Measured in liters/second. (NCT02183519)
Timeframe: 1-2 hours
| Intervention | Liters of air/second (Mean) |
|---|---|
| Healthy Older Adults | 4.34 |
| Parkinson's Disease | 3.92 |
"Concentration of methacholine (mg/ml) at which participants forced expired volume in 1 sec (FEV1) is reduced by 20% (the provocation concentration of methacholine causing a 20% fall in FEV1-PC20).~To measure if there is a significant difference in PC20 recorded at baseline to that recorded following 8 weeks treatment with omeprazole and ranitidine" (NCT00668317)
Timeframe: baseline and 8 weeks
| Intervention | mg/ml (Mean) |
|---|---|
| Omeprazole and Ranitidine | 0.598 |
Change in FEV1 ( in liters) at baseline and following 30 days of treatment with Spiriva (NCT00870896)
Timeframe: 30 days
| Intervention | liters (Mean) |
|---|---|
| Spirometry | .315 |
We measured the change in FEV1/FVC ratio at baseline and following 30 days of treatment with Spiriva.Change in ratio reflects the percentage value (ratio) at 30 days minus the percentage value (ratio) at baseline x 100 (NCT00870896)
Timeframe: 30 days
| Intervention | percentage change (Mean) |
|---|---|
| Change in FEV1/FVC | 3 |
We measured the change in the number of coughs following capsaicin inhalation challenge from baseline followed by 30 days of treatment with spiriva (NCT00870896)
Timeframe: 30 days
| Intervention | coughs per dose of capsaicin (Mean) |
|---|---|
| Group 1 | 2.5 |
6 reviews available for citric acid, anhydrous and Cough
| Article | Year |
|---|---|
A systematic review of methods of citric acid cough reflex testing.
Topics: Citric Acid; Cough; Humans; Reflex | 2019 |
The role of mast cells in citric acid-induced airway constriction and cough.
Topics: Animals; Bronchoconstriction; Citric Acid; Constriction, Pathologic; Cough; Guinea Pigs; Leukotriene | 2009 |
Experimentally induced cough.
Topics: Antitussive Agents; Capsaicin; Citric Acid; Cough; Humans; Patient Selection; Reflex; Reproducibilit | 2007 |
Cough challenge in the assessment of cough reflex.
Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Clinical Trials as Topic; Cough; Humans; Nebuli | 2001 |
Physiology and plasticity of putative cough fibres in the Guinea pig.
Topics: Animals; Bradykinin; Capsaicin; Citric Acid; Cough; Guinea Pigs; Neuronal Plasticity; Neurons, Affer | 2002 |
Cough and bronchoconstriction.
Topics: Animals; Asthma; Bronchi; Citrates; Citric Acid; Cough; Humans; Sensory Receptor Cells; Trachea | 1987 |
40 trials available for citric acid, anhydrous and Cough
| Article | Year |
|---|---|
The effect of pH on citric acid cough challenge: A randomised control trial in chronic cough and healthy volunteers.
Topics: Adult; Aged; Aged, 80 and over; Chronic Disease; Citric Acid; Cough; Double-Blind Method; Female; Hu | 2018 |
The impact of harmfulness information on citric acid induced cough and urge-to-cough.
Topics: Administration, Inhalation; Citric Acid; Cough; Dose-Response Relationship, Drug; Female; Humans; Kn | 2015 |
The Safety and Tolerability of 5-Aminolevulinic Acid Phosphate with Sodium Ferrous Citrate in Patients with Type 2 Diabetes Mellitus in Bahrain.
Topics: Abdominal Pain; Aminolevulinic Acid; Bahrain; Blood Glucose; Citric Acid; Cough; Diabetes Mellitus, | 2016 |
The effect of mindfulness meditation on cough reflex sensitivity.
Topics: Bronchial Provocation Tests; Chronic Disease; Citric Acid; Cough; Female; Humans; Male; Meditation; | 2009 |
Cough challenge tests involving mechanical stimulation of the cervical trachea in patients with cough as a leading symptom.
Topics: Acute Disease; Adult; Aged; Asthma; Bronchial Provocation Tests; Bronchitis; Capsaicin; Chronic Dise | 2010 |
Chest wall dynamics during voluntary and induced cough in healthy volunteers.
Topics: Adult; Citric Acid; Cough; Esophagus; Female; Humans; Lung Volume Measurements; Male; Plethysmograph | 2012 |
Chest wall dynamics during voluntary and induced cough in healthy volunteers.
Topics: Adult; Citric Acid; Cough; Esophagus; Female; Humans; Lung Volume Measurements; Male; Plethysmograph | 2012 |
Chest wall dynamics during voluntary and induced cough in healthy volunteers.
Topics: Adult; Citric Acid; Cough; Esophagus; Female; Humans; Lung Volume Measurements; Male; Plethysmograph | 2012 |
Chest wall dynamics during voluntary and induced cough in healthy volunteers.
Topics: Adult; Citric Acid; Cough; Esophagus; Female; Humans; Lung Volume Measurements; Male; Plethysmograph | 2012 |
Failure of nebulized irritant, acidic, or hypotonic solutions or external mechanical stimulation of the trachea to consistently induce coughing in healthy, awake dogs.
Topics: Administration, Inhalation; Animals; Capsaicin; Citric Acid; Cough; Dogs; Female; Hypotonic Solution | 2011 |
Simplified cough test for screening silent aspiration.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cough; Female; Hospitals, University; Humans; Male; Mid | 2012 |
Theobromine inhibits sensory nerve activation and cough.
Topics: Adult; Animals; Antitussive Agents; Capsaicin; Citric Acid; Codeine; Cough; Cross-Over Studies; Dise | 2005 |
Reproducibility and validity of a Yan-style portable citric acid cough challenge.
Topics: Anticoagulants; Citric Acid; Cough; Female; Humans; Male; Nebulizers and Vaporizers; Reflex; Reprodu | 2005 |
Citric acid cough threshold in patients with gastroesophageal reflux disease rises after laparoscopic fundoplication.
Topics: Adult; Chronic Disease; Citric Acid; Cough; Female; Fundoplication; Gastroesophageal Reflux; Humans; | 2005 |
Effect of codeine on objective measurement of cough in chronic obstructive pulmonary disease.
Topics: Aged; Antitussive Agents; Citric Acid; Codeine; Cough; Cross-Over Studies; Double-Blind Method; Fema | 2006 |
Contribution of gastric acid in elderly nursing home patients with cough reflex hypersensitivity.
Topics: Aged, 80 and over; Citric Acid; Cough; Cross-Sectional Studies; Drug Hypersensitivity; Female; Gastr | 2007 |
Coughing induced by airway irritation modulates the sensation of air hunger.
Topics: Adult; Anesthetics, Local; Citric Acid; Cough; Female; Humans; Lidocaine; Male; Pain Measurement; Re | 2008 |
Does inhaling menthol affect nasal patency or cough?
Topics: Administration, Inhalation; Antitussive Agents; Bronchial Provocation Tests; Child; Citric Acid; Cou | 2008 |
Assessment of antitussive effects by citric acid threshold.
Topics: Adult; Antitussive Agents; Aporphines; Bronchial Provocation Tests; Citrates; Citric Acid; Clinical | 1983 |
The effect of inhaled and oral dextromethorphan on citric acid induced cough in man.
Topics: Administration, Inhalation; Administration, Oral; Adult; Citrates; Citric Acid; Cough; Dextromethorp | 1995 |
Effect of inhaled menthol on citric acid induced cough in normal subjects.
Topics: Administration, Inhalation; Adult; Antitussive Agents; Bronchial Provocation Tests; Citrates; Citric | 1994 |
Cough frequency and cough receptor sensitivity to citric acid challenge during a simulated ascent to extreme altitude.
Topics: Adult; Altitude; Analysis of Variance; Atmosphere Exposure Chambers; Bronchial Provocation Tests; Ci | 1999 |
Cough induced by low pH.
Topics: Acetic Acid; Acids; Administration, Inhalation; Adult; Capsaicin; Citric Acid; Cough; Dose-Response | 1999 |
Cough threshold in people with spinal cord injuries.
Topics: Adult; Analysis of Variance; Citric Acid; Cough; Forced Expiratory Volume; Humans; Irritants; Male; | 1999 |
Psychological confounds in medical research: the example of excessive cough in asthma.
Topics: Adolescent; Analysis of Variance; Anxiety; Asthma; Attitude to Health; Bronchial Provocation Tests; | 2000 |
Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma.
Topics: Administration, Inhalation; Adult; Anti-Asthmatic Agents; Asthma; Beclomethasone; Capsaicin; Citric | 2001 |
The placebo response to citric acid-induced cough: pharmacodynamics and gender differences.
Topics: Administration, Inhalation; Adolescent; Adult; Antitussive Agents; Citric Acid; Confounding Factors, | 2001 |
A comparative study of the antitussive activity of levodropropizine and dropropizine in the citric acid-induced cough model in normal subjects.
Topics: Adult; Antitussive Agents; Citrates; Citric Acid; Cough; Double-Blind Method; Female; Humans; Lung; | 1992 |
Contrasting effects of prostaglandins E2 and F2 alpha on sensitivity of the human cough reflex.
Topics: Adolescent; Adult; Capsaicin; Chlorides; Citrates; Citric Acid; Cough; Dinoprost; Dinoprostone; Doub | 1992 |
Capsaicin-induced cough in humans.
Topics: Administration, Inhalation; Adolescent; Adult; Capsaicin; Citrates; Citric Acid; Cough; Dose-Respons | 1992 |
Adaptation of cough reflex with different types of stimulation.
Topics: Adaptation, Physiological; Adult; Bronchial Provocation Tests; Capsaicin; Citrates; Citric Acid; Cou | 1992 |
Effect of changes in inspiratory flow rate on cough responses to inhaled capsaicin.
Topics: Adult; Bronchial Provocation Tests; Capsaicin; Citrates; Citric Acid; Cough; Female; Humans; Male; P | 1991 |
Bradykinin-induced cough reflex markedly increases in patients with cough associated with captopril and enalapril.
Topics: Adult; Aerosols; Aged; Bradykinin; Captopril; Citrates; Citric Acid; Cough; Double-Blind Method; Ena | 1991 |
Antitussive effects of diphenhydramine on the citric acid aerosol-induced cough response in humans.
Topics: Administration, Inhalation; Adolescent; Adult; Citrates; Citric Acid; Cough; Diphenhydramine; Double | 1991 |
Comparative study of the effects of three angiotensin converting enzyme inhibitors on the cough reflex.
Topics: Administration, Inhalation; Adult; Angiotensin-Converting Enzyme Inhibitors; Capsaicin; Captopril; C | 1991 |
Importance of inspiratory flow rate in the cough response to citric acid inhalation in normal subjects.
Topics: Adult; Citrates; Citric Acid; Cough; Dose-Response Relationship, Drug; Female; Forced Expiratory Vol | 1990 |
Effect of bronchodilators on the cough response to inhaled citric acid in normal and asthmatic subjects.
Topics: Aerosols; Airway Resistance; Albuterol; Asthma; Bronchodilator Agents; Citrates; Citric Acid; Cough; | 1985 |
A comparative randomized double-blind clinical trial of hexapneumine and clistine as antitussive agents.
Topics: Adolescent; Adult; Aged; Antitussive Agents; Citrates; Citric Acid; Clinical Trials as Topic; Cough; | 1987 |
Effects of pH and osmolarity on aerosol-induced cough in normal volunteers.
Topics: Adult; Aerosols; Citrates; Citric Acid; Cough; Female; Glucose; Glucose Solution, Hypertonic; Humans | 1988 |
Assessment of the antitussive effect of vadocaine hydrochloride using citric acid-induced cough in healthy volunteers.
Topics: Adult; Antitussive Agents; Citrates; Citric Acid; Cough; Double-Blind Method; Humans; Male; Piperidi | 1988 |
Effects of pholcodine and salbutamol on citric acid induced cough in normal subjects.
Topics: Albuterol; Citrates; Citric Acid; Clinical Trials as Topic; Codeine; Cough; Double-Blind Method; Hum | 1986 |
Antitussive effect of dextromethorphan and dextromethorphan-salbutamol combination in healthy volunteers with artificially induced cough.
Topics: Adult; Albuterol; Antitussive Agents; Citrates; Citric Acid; Cough; Dextromethorphan; Double-Blind M | 1987 |
Characteristics of prostaglandin induced cough in man.
Topics: Acetylcholine; Aerosols; Citrates; Citric Acid; Cough; Dinoprost; Dinoprostone; Humans; Prostaglandi | 1985 |
202 other studies available for citric acid, anhydrous and Cough
| Article | Year |
|---|---|
Deep Inspiration-Provoked Cough: A Sign of Cough Reflex Arc Hypersensitivity.
Topics: Chronic Disease; Citric Acid; Cough; Humans; Reflex | 2021 |
[Optimization of extraction process of Children's Qingfei Zhisou Syrup based on pharmacodynamics].
Topics: Animals; Antitussive Agents; Calcium Sulfate; Citric Acid; Cough; Ethanol; Guinea Pigs; Humans; Indi | 2022 |
Modification of oestrogen signalling pathways influences cough induced by citric acid but not capsaicin in the animal model of both sexes.
Topics: Animals; Capsaicin; Citric Acid; Cough; Danazol; Estrogen Receptor alpha; Estrogens; Female; Fulvest | 2023 |
Cough response in specific pathogen-free guinea pig animal model.
Topics: Animals; Animals, Wild; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Male; Models, Animal; Re | 2023 |
Association of lower plasma citric acid with prolonged cough: the Nagahama study.
Topics: Citric Acid; Cough; Gastroesophageal Reflux; Humans; Plasma; Prospective Studies | 2023 |
Development of Novel δ Opioid Receptor Inverse Agonists without a Basic Nitrogen Atom and Their Antitussive Effects in Mice.
Topics: Analgesics, Opioid; Animals; Antitussive Agents; Citric Acid; Cough; Dose-Response Relationship, Dru | 2019 |
Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings.
Topics: Administration, Inhalation; Adult; Antitussive Agents; Citric Acid; Cough; Female; Humans; Male; Mid | 2019 |
Modulation of protective reflex cough by acute immune driven inflammation of lower airways in anesthetized rabbits.
Topics: Administration, Inhalation; Anesthesia; Animals; Bronchoalveolar Lavage Fluid; Citric Acid; Cough; D | 2019 |
Topics: Animals; Bronchoalveolar Lavage Fluid; Chronic Disease; Citric Acid; Cough; Drugs, Chinese Herbal; F | 2020 |
Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances.
Topics: Acrolein; Animals; Capsaicin; Citric Acid; Cough; Disease Models, Animal; Female; Guinea Pigs; Male; | 2020 |
Cross-effect of TRPV1 and EP3 receptor on coughs and bronchopulmonary C-neural activities.
Topics: Aminopyridines; Animals; Bronchi; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinase | 2021 |
Gold Standard? Method of Citric Acid Solution Swallowing Test as a Screening Test for Patients with Tracheostomy.
Topics: Citric Acid; Cough; Deglutition; Humans; Reflex; Tracheostomy | 2022 |
Acute and Chronic Effects of Oral Erdosteine on Ciliary Beat Frequency, Cough Sensitivity and Airway Reactivity.
Topics: Administration, Oral; Animals; Cilia; Citric Acid; Cough; Dose-Response Relationship, Drug; Guinea P | 2018 |
Reduced Diaphragm Excursion During Reflexive Citric Acid Cough Test in Subjects With Subacute Stroke.
Topics: Administration, Inhalation; Aged; Case-Control Studies; Citric Acid; Cough; Deglutition Disorders; D | 2017 |
Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.
Topics: Action Potentials; Adenosine; Animals; Bradykinin; Citric Acid; Cough; Disease Models, Animal; Guine | 2018 |
Measuring voluntary and reflexive cough strength in healthy individuals.
Topics: Aged; Aged, 80 and over; Area Under Curve; Citric Acid; Cough; Female; Healthy Volunteers; Humans; M | 2017 |
The inflammatory molecule sphingosine-1-phosphate is not effective to evoke or sensitize cough in naïve guinea pigs.
Topics: Animals; Citric Acid; Cough; Guinea Pigs; Inflammation; Lysophospholipids; Male; Receptors, Lysosphi | 2018 |
Isolation of novel biflavonoids from Cardiocrinum giganteum seeds and characterization of their antitussive activities.
Topics: Animals; Antitussive Agents; Biflavonoids; Citric Acid; Cough; Electric Stimulation; Female; Guinea | 2018 |
Central adenosine A
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; Administration, Inhala | 2018 |
Association of cough hypersensitivity with tracheal TRPV1 activation and neurogenic inflammation in a novel guinea pig model of citric acid-induced chronic cough.
Topics: Administration, Inhalation; Animals; Bronchi; Chronic Disease; Citric Acid; Cough; Disease Models, A | 2018 |
Determining Peak Cough Flow Cutoff Values to Predict Aspiration Pneumonia Among Patients With Dysphagia Using the Citric Acid Reflexive Cough Test.
Topics: Aged; Area Under Curve; Citric Acid; Cough; Databases, Factual; Deglutition Disorders; Female; Human | 2018 |
Induction of airway remodeling and persistent cough by repeated citric acid exposure in a guinea pig cough model.
Topics: Administration, Inhalation; Airway Remodeling; Animals; Antitussive Agents; Basement Membrane; Citri | 2019 |
Roles of citric acid in conjunction with saline nebulization in experimental tracheostomy in guinea pigs.
Topics: Administration, Inhalation; Animals; Citric Acid; Cough; Guinea Pigs; Interleukin-6; Male; Nebulizer | 2018 |
An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time.
Topics: Acoustics; Aerosols; Animals; Citric Acid; Cough; Dinoprostone; Disease Models, Animal; Guinea Pigs; | 2019 |
Comparison of cough reflex test against instrumental assessment of aspiration.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cohort Studies; Cough; Data Interpretation, Statistical | 2013 |
Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species.
Topics: Analysis of Variance; Animals; Anti-Asthmatic Agents; Antitussive Agents; Bronchial Spasm; Citric Ac | 2013 |
Nerve growth factor enhances cough via a central mechanism of action.
Topics: Airway Obstruction; Animals; Citric Acid; Cough; Female; Guinea Pigs; Male; Nerve Growth Factor; Rec | 2013 |
Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits.
Topics: Administration, Inhalation; Administration, Intravenous; Anesthesia; Angiotensin II Type 1 Receptor | 2013 |
The effects of nasal irritant induced responses on breathing and cough in anaesthetized and conscious animal models.
Topics: Administration, Intranasal; Anesthesia; Animals; Anticoagulants; Antitussive Agents; Citric Acid; Co | 2013 |
Transient receptor potential ankyrin 1 receptor activation in vitro and in vivo by pro-tussive agents: GRC 17536 as a promising anti-tussive therapeutic.
Topics: Animals; Antitussive Agents; Biological Transport; Calcium; Calcium Channels; Cell Line; Citric Acid | 2014 |
Characterization and pharmacodynamic properties of Arnica montana complex.
Topics: Animals; Antitussive Agents; Arnica; Cell Line; Citric Acid; Cough; Guinea Pigs; Humans; Male; Mice; | 2014 |
An investigation into the stability and sterility of citric acid solutions used for cough reflex testing.
Topics: Bacterial Load; Candida albicans; Chromatography, High Pressure Liquid; Citric Acid; Cold Temperatur | 2014 |
Antitussive activity of Withania somnifera and opioid receptors.
Topics: Animals; Antitussive Agents; Citric Acid; Codeine; Cough; Galactans; Guinea Pigs; Male; Naloxone; Na | 2015 |
Inhibitory control of the cough reflex by galanin receptors in the caudal nucleus tractus solitarii of the rabbit.
Topics: Animals; Citric Acid; Cough; Coumarins; Galanin; Male; Physical Stimulation; Rabbits; Receptors, Gal | 2014 |
In vivo evaluation of the antitussive, expectorant and bronchodilating effects of extract and fractions from aerial parts of Peganum harmala linn.
Topics: Acetylcholine; Ammonia; Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Cap | 2015 |
The effect of phytocannabinoids on airway hyper-responsiveness, airway inflammation, and cough.
Topics: Airway Resistance; Animals; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Cannabinoid Receptor | 2015 |
Olodaterol attenuates citric acid-induced cough in naïve and ovalbumin-sensitized and challenged guinea pigs.
Topics: Adrenergic beta-2 Receptor Agonists; Animals; Antitussive Agents; Benzoxazines; Citric Acid; Cough; | 2015 |
Usefulness of citric cough test for screening of silent aspiration in subacute stroke patients: a prospective study.
Topics: Aged; Citric Acid; Cough; Deglutition Disorders; Female; Fluoroscopy; Hospitals, University; Humans; | 2015 |
Chemical and pharmacological profiles of Echinacea complex.
Topics: Albuterol; Animals; Antitussive Agents; Bronchodilator Agents; Chromatography, High Pressure Liquid; | 2015 |
The effect of selective antagonist of H4 receptor JNJ7777120 on nasal symptoms, cough, airway reactivity and inflammation in guinea pigs.
Topics: Airway Resistance; Aluminum Hydroxide; Animals; Bronchoalveolar Lavage Fluid; Citric Acid; Cough; Di | 2015 |
The cough reflex is upregulated by lisinopril microinjected into the caudal nucleus tractus solitarii of the rabbit.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; C | 2015 |
Enhanced cough reflex in a model of bleomycin-induced lung fibrosis in guinea pigs.
Topics: Animals; Bleomycin; Brain-Derived Neurotrophic Factor; Bronchoalveolar Lavage Fluid; Capsaicin; Citr | 2015 |
Ozone-Induced Hypertussive Responses in Rabbits and Guinea Pigs.
Topics: Aminopyridines; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antitussive Agents; Benzamides; Br | 2016 |
The effect of titrated fentanyl on suppressed cough reflex in healthy adult volunteers.
Topics: Adolescent; Adult; Aged; Analgesics, Opioid; Citric Acid; Cough; Dose-Response Relationship, Drug; F | 2016 |
The Guinea Pig Sensitized by House Dust Mite: A Model of Experimental Cough Studies.
Topics: Airway Resistance; Animals; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Immunization; M | 2016 |
Comparison of cough reflex testing with videoendoscopy in recently extubated intensive care unit patients.
Topics: Aged; Airway Extubation; Bronchoscopy; Citric Acid; Cough; Critical Care; Female; Humans; Intensive | 2016 |
Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna.
Topics: Administration, Oral; Airway Resistance; Animals; Antitussive Agents; Citric Acid; Cough; Galactans; | 2016 |
TRPV4 antagonist GSK2193874 does not modulate cough response to osmotic stimuli.
Topics: Animals; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; | 2017 |
Inhibitory activity of the novel CB2 receptor agonist, GW833972A, on guinea-pig and human sensory nerve function in the airways.
Topics: Adult; Animals; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Humans; Male; Middle Aged; Neuro | 2008 |
Differential effects of airway afferent nerve subtypes on cough and respiration in anesthetized guinea pigs.
Topics: Administration, Inhalation; Anesthesia; Animals; Capsaicin; Citric Acid; Cough; Guinea Pigs; Histami | 2008 |
A comparison of objective and subjective measures of cough in asthma.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Citric Acid; Cough; Female; Humans; Irritants; Mal | 2008 |
Aggravation of dyspnoea by coughing: vagal mechanisms.
Topics: Administration, Inhalation; Anesthetics, Local; Citric Acid; Cough; Dyspnea; Humans; Lidocaine; Resp | 2009 |
Alkaloids from roots of Stemona sessilifolia and their antitussive activities.
Topics: 4-Butyrolactone; Alkaloids; Animals; Antitussive Agents; Azepines; Citric Acid; Cough; Disease Model | 2009 |
Oral absorption and antitussive activity of tuberostemonine alkaloids from the roots of Stemona tuberosa.
Topics: Absorption; Alkaloids; Animals; Caco-2 Cells; Citric Acid; Cough; Dose-Response Relationship, Drug; | 2009 |
Cough reflex sensitivity is increased in the guinea pig model of allergic rhinitis.
Topics: Acetates; Allergens; Animals; Anti-Asthmatic Agents; Citric Acid; Cough; Cyclopropanes; Guinea Pigs; | 2008 |
The citric acid cough threshold and the ventilatory response to carbon dioxide on ascent to high altitude.
Topics: Adolescent; Adult; Altitude; Altitude Sickness; Carbon Dioxide; Citric Acid; Cold Temperature; Cough | 2009 |
Nerve growth factor enhances cough and airway obstruction via TrkA receptor- and TRPV1-dependent mechanisms.
Topics: Airway Obstruction; Animals; Carbazoles; Citric Acid; Cough; Diterpenes; Enzyme Inhibitors; Female; | 2009 |
The influence of animal species on the relationship between ATP-sensitive potassium ion channels and defense reflexes of the airways.
Topics: Animals; Antitussive Agents; Cats; Citric Acid; Cough; Female; Glyburide; Guinea Pigs; KATP Channels | 2009 |
Role of excitatory amino acids in the mediation of tracheobronchial cough induced by citric acid inhalation in the rabbit.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Administration, Inhalation; Animals; Citric Acid; Cough; Elect | 2009 |
[Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae].
Topics: Acetylcholine; Anaphylaxis; Animals; Antitussive Agents; Asthma; Astragalus propinquus; Citric Acid; | 2009 |
Changes in plasma bradykinin concentration and citric acid cough threshold at high altitude.
Topics: Adolescent; Adult; Angiotensin-Converting Enzyme Inhibitors; Bradykinin; Citric Acid; Cough; Heart R | 2009 |
Antitussive and central respiratory depressant effects of Stemona tuberosa.
Topics: Alkaloids; Animals; Antitussive Agents; Central Nervous System Agents; Citric Acid; Cough; Guinea Pi | 2010 |
Cardiocrinum seeds as a replacement for Aristolochia fruits in treating cough.
Topics: Animals; Antitussive Agents; Aristolochia; Base Sequence; Citric Acid; Cough; Disease Models, Animal | 2010 |
Acoustic cough-reflux associations in chronic cough: potential triggers and mechanisms.
Topics: Adult; Aged; Chronic Disease; Citric Acid; Cough; Electric Impedance; Esophageal pH Monitoring; Fema | 2010 |
The pharmacological activity of wheat bran polysaccharides.
Topics: Animals; Antitussive Agents; Citric Acid; Cough; Dietary Fiber; Guinea Pigs; Male; Plant Extracts; P | 2010 |
Gender differences in perceptions of urge to cough and dyspnea induced by citric acid in healthy never smokers.
Topics: Administration, Inhalation; Adult; Chelating Agents; Citric Acid; Cough; Dyspnea; Female; Follow-Up | 2010 |
Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; B | 2010 |
Effects of zofenopril and ramipril on cough reflex responses in anesthetized and awake rabbits.
Topics: Anesthesia, Intravenous; Angiotensin-Converting Enzyme Inhibitors; Animals; Bradykinin; Captopril; C | 2010 |
Encoding of the cough reflex in anesthetized guinea pigs.
Topics: 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Anesthesia; Animals; Biphenyl Compounds; Citr | 2011 |
Suppressive effect of pectic polysaccharides from Cucurbita pepo L. var. Styriaca on citric acid-induced cough reflex in guinea pigs.
Topics: Animals; Antitussive Agents; Citric Acid; Codeine; Cough; Cucurbita; Drug Synergism; Fruit; Guinea P | 2011 |
Antitussive indole alkaloids from Kopsia hainanensis.
Topics: Animals; Antitussive Agents; Apocynaceae; Citric Acid; Cough; Guinea Pigs; Indole Alkaloids; Molecul | 2011 |
In vivo anti-tussive activity and structural features of a polysaccharide fraction from water extracted Withania somnifera.
Topics: Animals; Antitussive Agents; Behavior, Animal; Citric Acid; Codeine; Cough; Galactans; Guinea Pigs; | 2011 |
Chronic 'cough hypersensitivity syndrome': a more precise label for chronic cough.
Topics: Animals; Antitussive Agents; Capsaicin; Chronic Disease; Citric Acid; Cough; Humans; Quality of Life | 2011 |
The influence of the PDE inhibitors on cough reflex in guinea pigs.
Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Citric Acid; Cough; Guinea Pigs; Male; Ovalb | 2011 |
Changes in chemosensitivity and mechanosensitivity in aging and Parkinson's disease.
Topics: Adult; Aged; Aged, 80 and over; Aging; Citric Acid; Cough; Endoscopy; Female; Humans; Irritants; Mal | 2012 |
Anti-tussive and bronchodilator mechanisms of action for the enaminone E121.
Topics: Administration, Inhalation; Adrenergic beta-Antagonists; Airway Obstruction; Aniline Compounds; Anim | 2011 |
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Animals; Antitussive Agents; Bi | 2011 |
Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons.
Topics: Action Potentials; Animals; Citric Acid; Cough; Dependovirus; Green Fluorescent Proteins; Guinea Pig | 2011 |
Antitussive effects of memantine in guinea pigs.
Topics: Animals; Antitussive Agents; Baclofen; Bradykinin; Citric Acid; Cough; Dextromethorphan; Guinea Pigs | 2012 |
Urge-to-cough and dyspnea conceal perception of pain in healthy adults.
Topics: Adult; Citric Acid; Cough; Dyspnea; Female; Humans; Male; Middle Aged; Pain Perception; Pain Thresho | 2012 |
Experimental model of allergic asthma.
Topics: Airway Resistance; Animals; Asthma; Bronchoalveolar Lavage Fluid; Bronchoconstriction; Citric Acid; | 2013 |
Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Citric Ac | 2013 |
Intra- and inter-rater reliability for judgement of cough following citric acid inhalation.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cough; Female; Humans; Inhalation Exposure; Judgment; M | 2013 |
Intra- and inter-rater reliability for judgement of cough following citric acid inhalation.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cough; Female; Humans; Inhalation Exposure; Judgment; M | 2013 |
Intra- and inter-rater reliability for judgement of cough following citric acid inhalation.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cough; Female; Humans; Inhalation Exposure; Judgment; M | 2013 |
Intra- and inter-rater reliability for judgement of cough following citric acid inhalation.
Topics: Adult; Aged; Aged, 80 and over; Citric Acid; Cough; Female; Humans; Inhalation Exposure; Judgment; M | 2013 |
Sex-related differences in cough reflex sensitivity in patients with chronic cough.
Topics: Adult; Aged; Asthma; Bronchial Provocation Tests; Capsaicin; Chronic Disease; Citric Acid; Cough; Fe | 2002 |
[Coughing model by microinjection of citric acid into the larynx in guinea pig].
Topics: Animals; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Larynx; Male; Microinjections; Rat | 2002 |
Effects of hyperoxia and allergic airway inflammation on cough reflex intensity in guinea pigs.
Topics: Animals; Bronchial Hyperreactivity; Citric Acid; Cough; Female; Guinea Pigs; Hyperoxia; Hypersensiti | 2002 |
RSD931, a novel anti-tussive agent acting on airway sensory nerves.
Topics: Administration, Inhalation; Aerosols; Animals; Antitussive Agents; Bronchi; Bronchoconstriction; Cap | 2003 |
Antitussive activity of Anar.
Topics: Animals; Antibodies; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; Lung; M | 2003 |
Ultralow doses of antibodies to inflammatory mediators: antitussive properties of antibodies to bradykinin, histamine, and serotonin.
Topics: Animals; Antibodies; Antitussive Agents; Bradykinin; Capsaicin; Citric Acid; Cough; Dose-Response Re | 2003 |
The experimental production of cough in human subjects induced by citric acid aerosols; preliminary studies on the evaluation of antitussive agents.
Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans | 1954 |
The cough response of normal human subjects stimulated experimentally by citric acid aerosol: alterations produced by antitussive agents. I. Methology.
Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans | 1956 |
The cough response of healthy human subjects stimulated by citric acid aerosol. II. Evaluation of antitussive agents.
Topics: Aerosols; Antitussive Agents; Citrates; Citric Acid; Cough; Humans | 1957 |
[Detection and measurement of the excitability of nerve endings in the lung; comparative study of various cough-inducing agents: acetylcholine, citric acid, acetic acid].
Topics: Acetates; Acetic Acid; Acetylcholine; Citrates; Citric Acid; Cough; Lung; Nerve Endings | 1959 |
[Assessment of cough threshold in patients with gastroesophageal reflux disease].
Topics: Administration, Inhalation; Adult; Aged; Case-Control Studies; Citric Acid; Cough; Female; Forced Ex | 2003 |
Effect of a novel NK1 receptor selective antagonist (NKP608) on citric acid induced cough and airway obstruction.
Topics: Airway Obstruction; Animals; Benzamides; Citric Acid; Cough; Guinea Pigs; Male; Neurokinin-1 Recepto | 2004 |
Passive smoke effects on cough and airways in young guinea pigs: role of brainstem substance P.
Topics: Aerosols; Age Factors; Animals; Brain Stem; Bronchoconstriction; Citric Acid; Cough; Guinea Pigs; Ho | 2004 |
Antitussive activity of Stemona alkaloids from Stemona tuberosa.
Topics: Alkaloids; Animals; Antitussive Agents; Citric Acid; Cough; Dose-Response Relationship, Drug; Guinea | 2003 |
Cough reflex induced by microinjection of citric acid into the larynx of guinea pigs: new coughing model.
Topics: Animals; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Larynx; Male; Microinjections | 2003 |
Objective recognition of cough sound as biomarker for aerial pollutants.
Topics: Air Pollutants; Air Pollution, Indoor; Ammonia; Animals; Biomarkers; Citric Acid; Cough; Dust; Envir | 2004 |
Identification of the tracheal and laryngeal afferent neurones mediating cough in anaesthetized guinea-pigs.
Topics: Anesthesia; Animals; Bradykinin; Capsaicin; Citric Acid; Cough; Electric Stimulation; Electrophysiol | 2004 |
Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs.
Topics: Animals; Antitussive Agents; Benzhydryl Compounds; Citric Acid; Cough; Disease Models, Animal; Dose- | 2004 |
The influence of hyperoxia on cough reflex intensity in guinea pigs treated with bleomycin.
Topics: Animals; Bleomycin; Citric Acid; Cough; Female; Guinea Pigs; Hyperoxia; Lung; Physical Stimulation; | 2004 |
Mast cells in citric acid-induced cough of guinea pigs.
Topics: Aerosols; Animals; Citric Acid; Cough; Guinea Pigs; Histamine; Leukotriene C4; Mast Cells | 2005 |
Effects of inhaled corticosteroids on cough in awake guinea pigs with experimental allergic rhinitis--the first experience.
Topics: Administration, Inhalation; Aerosols; Animals; Anti-Inflammatory Agents; Beclomethasone; Bronchial P | 2004 |
The role of substance P and bradykinin in the cough reflex and bronchoconstriction in guinea-pigs.
Topics: Animals; Bradykinin; Bronchoconstriction; Citric Acid; Cough; Dose-Response Relationship, Drug; Glyc | 2005 |
Assessment of the cough reflex after propofol anaesthesia for colonoscopy.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Intravenous; Citric Acid; Colonoscopy; Cough; Dose-R | 2005 |
The effect of chemical stimulation of esophageal mucosa on citric acid induced cough and specific airway resistance in guinea pig.
Topics: Airway Resistance; Animals; Capsaicin; Citric Acid; Cough; Esophagitis; Esophagus; Guinea Pigs; Hydr | 2005 |
Synergistic interactions between airway afferent nerve subtypes regulating the cough reflex in guinea-pigs.
Topics: Administration, Inhalation; Animals; Bradykinin; Bronchial Spasm; Capsaicin; Citric Acid; Cough; Gui | 2005 |
Mechanisms of capsaicin- and citric-acid-induced cough reflexes in guinea pigs.
Topics: Animals; Capsaicin; Citric Acid; Cough; Disease Models, Animal; Drug Interactions; Guinea Pigs; Irri | 2005 |
Study of anti-tussive activity of Ocimum sanctum Linn in guinea pigs.
Topics: Aerosols; Animals; Citric Acid; Cough; Guinea Pigs; Male; Medicine, Ayurvedic; Medicine, Traditional | 2005 |
Antileukotriene treatment and allergic rhinitis-related cough in guinea pigs.
Topics: Acetates; Administration, Oral; Animals; Citric Acid; Cough; Cyclopropanes; Disease Models, Animal; | 2005 |
Effect of nociceptin in acid-evoked cough and airway sensory nerve activation in guinea pigs.
Topics: Animals; Aortic Bodies; Capsaicin; Citric Acid; Cough; Glomus Jugulare; Guinea Pigs; Male; Neurons, | 2006 |
Identification of some benproperine metabolites in humans and investigation of their antitussive effect.
Topics: Adult; Animals; Antitussive Agents; Benzhydryl Compounds; Chromatography, Liquid; Citric Acid; Cough | 2005 |
Involvement of P2X receptor subtypes in ATP-induced enhancement of the cough reflex sensitivity.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Capsaicin; Citric Acid; Cough; Dose-Res | 2005 |
Early and late allergic phase related cough response in sensitized guinea pigs with experimental allergic rhinitis.
Topics: Allergens; Animals; Citric Acid; Cough; Disease Models, Animal; Guinea Pigs; Immunization; Male; Nas | 2006 |
Modulation of citric acid-induced cough following lipopolysaccharide-mediated neutrophilia in the guinea pig.
Topics: Administration, Inhalation; Aerosols; Amidines; Animals; Anti-Inflammatory Agents; Benzylamines; Bro | 2007 |
Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs.
Topics: Animals; Capsaicin; Citric Acid; Cough; Cyclic AMP-Dependent Protein Kinases; Cyclooxygenase Inhibit | 2006 |
Na+-K+-2Cl- cotransporters and Cl- channels regulate citric acid cough in guinea pigs.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Animals; Chloride Channels; Chlorides; Citric Acid | 2006 |
Effects of eppikahangeto, a Kampo formula, and Ephedrae herba against citric acid-induced laryngeal cough in guinea pigs.
Topics: Animals; Antitussive Agents; Citric Acid; Cough; Disease Models, Animal; Dose-Response Relationship, | 2006 |
Evaluation of the antitussive effect of stigma and petals of saffron (Crocus sativus) and its components, safranal and crocin in guinea pigs.
Topics: Animals; Antitussive Agents; Carotenoids; Citric Acid; Cough; Crocus; Cyclohexenes; Female; Flowers; | 2006 |
Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs.
Topics: Anesthesia; Animals; Autacoids; Citric Acid; Cough; Dose-Response Relationship, Drug; Epithelium; Ev | 2006 |
Involvement of ionotropic purinergic receptors in the histamine-induced enhancement of the cough reflex sensitivity in guinea pigs.
Topics: Adenosine Triphosphate; Administration, Inhalation; Animals; Citric Acid; Cough; Dose-Response Relat | 2006 |
Effect of d-pseudoephedrine on cough reflex and its mode of action in guinea pigs.
Topics: Animals; Antitussive Agents; Bronchodilator Agents; Citric Acid; Cough; Dose-Response Relationship, | 2006 |
[Experimental studies on antitussive, expectorant and antiasthmatic effects of extract from Citrus grandis var. tomentosa].
Topics: Acetylcholine; Ammonia; Animals; Anti-Asthmatic Agents; Antitussive Agents; Asthma; Citric Acid; Cit | 2006 |
The interaction of dietary antioxidant vitamins and oxidative stress on cough reflex in guinea-pigs after long term oxygen therapy.
Topics: Animals; Antioxidants; Ascorbic Acid; Citric Acid; Cough; Guinea Pigs; Lung; Male; Oxidative Stress; | 2006 |
Effects of thorax irradiation on citric acid-induced cough in guinea pigs.
Topics: Animals; Citric Acid; Cough; Female; Gamma Rays; Guinea Pigs; Male; Radiotherapy; Respiratory System | 2006 |
Animal models of cough: literature review and presentation of a novel cigarette smoke-enhanced cough model in the guinea-pig.
Topics: Animals; Antitussive Agents; Area Under Curve; Atropine; Capsaicin; Citric Acid; Codeine; Cough; Dis | 2007 |
Role of cyclin-dependent kinase 5 in capsaicin-induced cough.
Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Cough; Cyclin-Dependent Kinase 5; Male; Mice; M | 2007 |
ERS guidelines on the assessment of cough.
Topics: Aerosols; Animals; Antitussive Agents; Capsaicin; Citric Acid; Clinical Trials as Topic; Cough; Dise | 2007 |
Cough reflex sensitivity after elective Caesarean section under spinal anaesthesia and after vaginal delivery.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Anesthesia, Obstetrical; Anesthesia, Spinal; Cesarean | 2007 |
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hy | 2008 |
Experimental allergic rhinitis-related cough and airway eosinophilia in sensitized guinea pigs.
Topics: Aerosols; Animals; Bronchi; Citric Acid; Cough; Disease Models, Animal; Eosinophilia; Guinea Pigs; L | 2007 |
Influence of chest gamma-irradiation on cough response in awake guinea pigs.
Topics: Animals; Citric Acid; Cough; Female; Gamma Rays; Guinea Pigs; Male; Radiation Injuries, Experimental | 2007 |
Oral N-acetylcysteine reverses hyperoxia-related cough suppression in guinea pigs.
Topics: Acetylcysteine; Administration, Oral; Animals; Antioxidants; Citric Acid; Cough; Disease Models, Ani | 2007 |
Evaluation of the cough reflex and airway reactivity in toluene- and ovalbumin-induced airway hyperresponsiveness.
Topics: Airway Resistance; Animals; Bronchial Provocation Tests; Bronchoconstriction; Bronchoconstrictor Age | 2007 |
Tussigenic agents in the measurement of cough reflex sensitivity.
Topics: Adult; Capsaicin; Citric Acid; Cough; Female; Humans; Male; Maximal Expiratory Flow Rate; Reflex; Re | 2007 |
The role of potassium ion channels in cough and other reflexes of the airways.
Topics: Acetylcholine; Aerosols; Airway Resistance; Animals; Benzimidazoles; Citric Acid; Cough; Glyburide; | 2007 |
Dietary intake of flavonoids and hyperoxia-induced oxidative stress related cough in guinea pigs.
Topics: Animals; Antioxidants; Citric Acid; Cough; Flavonoids; Guinea Pigs; Hyperoxia; Male; Oxidative Stres | 2007 |
Novel triple neurokinin receptor antagonist CS-003 strongly inhibits neurokinin related responses.
Topics: Animals; Bronchi; Capillary Permeability; Capsaicin; Chlorocebus aethiops; Citric Acid; COS Cells; C | 2008 |
An electromyographic method of objectively assessing cough intensity and use of the method to assess effects of codeine on the dose-response curve to citric acid.
Topics: Action Potentials; Adult; Citrates; Citric Acid; Codeine; Cough; Dose-Response Relationship, Drug; E | 1984 |
The antitussive effects of menthol, camphor and cineole in conscious guinea-pigs.
Topics: Administration, Inhalation; Animals; Antitussive Agents; Camphor; Citrates; Citric Acid; Cough; Cycl | 1994 |
Differences in the mode of cough augmentation by four angiotensin-converting enzyme inhibitors in guinea-pigs.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Bronchitis; Capsaicin; Citrates; Citric Acid; Cou | 1993 |
Moguisteine: a novel peripheral non-narcotic antitussive drug.
Topics: Aerosols; Animals; Antitussive Agents; Binding, Competitive; Capsaicin; Citrates; Citric Acid; Codei | 1994 |
Laryngeal and tracheobronchial cough in anesthetized dogs.
Topics: Anesthesia; Animals; Blood Pressure; Bronchi; Bronchoscopy; Capsaicin; Citrates; Citric Acid; Cough; | 1994 |
Effect of clonidine on induced cough and bronchoconstriction in guinea pigs and healthy humans.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic alpha-2 Receptor Antagonists; Adult; Ai | 1994 |
Antitussive effect of oxatomide on citric acid-induced cough in conscious guinea pig. Preliminary communication.
Topics: Animals; Antitussive Agents; Citrates; Citric Acid; Cough; Guinea Pigs; Histamine H1 Antagonists; In | 1993 |
Antitussive effect of SR 48968, a non-peptide tachykinin NK2 receptor antagonist.
Topics: Animals; Antitussive Agents; Benzamides; Citrates; Citric Acid; Codeine; Cough; Dose-Response Relati | 1993 |
Relationship between respiratory symptoms and cough receptor sensitivity.
Topics: Bronchi; Child; Child, Preschool; Citrates; Citric Acid; Cohort Studies; Cough; Female; Follow-Up St | 1994 |
A comparative study of the effects of citric acid, capsaicin and resiniferatoxin on the cough challenge in guinea-pig and man.
Topics: Administration, Inhalation; Adult; Animals; Bronchoconstriction; Capsaicin; Citrates; Citric Acid; C | 1993 |
Lack of importance of the superior laryngeal nerves in citric acid cough in humans.
Topics: Administration, Inhalation; Adult; Anesthesia; Citrates; Citric Acid; Cough; Female; Humans; Larynge | 1993 |
Effect of nebulized lidocaine on ventilatory response to CO2 in healthy subjects.
Topics: Administration, Inhalation; Adult; Aerosols; Carbon Dioxide; Citrates; Citric Acid; Cough; Female; H | 1993 |
Cough reflex threshold in diabetes mellitus with and without autonomic neuropathy.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Autonomic Nervous System Diseases; Child; Citra | 1995 |
Angiotensin-converting enzyme inhibitor and danazol increase sensitivity of cough reflex in female guinea pigs.
Topics: Adrenergic beta-Agonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Capsaicin; Cilazapril; | 1996 |
Suppressive effect of clenbuterol on citric acid-induced cough reflex in guinea pigs.
Topics: Airway Resistance; Animals; Bronchodilator Agents; Citrates; Citric Acid; Clenbuterol; Cough; Dose-R | 1995 |
Capsazepine inhibits cough induced by capsaicin and citric acid but not by hypertonic saline in guinea pigs.
Topics: Animals; Antitussive Agents; Bronchodilator Agents; Capsaicin; Citrates; Citric Acid; Cough; Guinea | 1995 |
Antitussive activity of moguisteine enantiomers in guinea-pigs and rats.
Topics: Administration, Oral; Aerosols; Animals; Antacids; Antitussive Agents; Capsaicin; Citric Acid; Cough | 1996 |
Effects of specific tachykinin receptor antagonists on citric acid-induced cough and bronchoconstriction in unanesthetized guinea pigs.
Topics: Animals; Antacids; Benzamides; Bronchoconstriction; Citric Acid; Cough; Dipeptides; Guinea Pigs; Ind | 1996 |
Mechanism of irritant-induced cough: studies with a kinin antagonist and a kallikrein inhibitor.
Topics: Administration, Inhalation; Animals; Bradykinin; Bradykinin Receptor Antagonists; Citric Acid; Codei | 1996 |
Activation of large conductance potassium channels inhibits the afferent and efferent function of airway sensory nerves in the guinea pig.
Topics: Afferent Pathways; Animals; Benzimidazoles; Bradykinin; Bronchi; Bronchial Provocation Tests; Citric | 1997 |
Experimental studies on the antitussive properties of the new xanthine derivative 1H-purine-2,6-dione, 3,7-dihydro-3-methyl-7[(5-methyl-1,2,4-oxadiazol-3-yl)methyl]. 1st communication: in vivo demonstration of the effects on animal models of cough and of
Topics: Animals; Antitussive Agents; Capsaicin; Citric Acid; Cough; Female; Guinea Pigs; In Vitro Techniques | 1997 |
Citric acid-induced cough thresholds in normal subjects, patients with bronchial asthma, and smokers.
Topics: Administration, Inhalation; Adult; Aged; Asthma; Citric Acid; Cough; Female; Forced Expiratory Volum | 1997 |
Cough frequency and cough-receptor sensitivity are increased in man at altitude.
Topics: Altitude; Bronchial Provocation Tests; Citric Acid; Cough; Humans; Nebulizers and Vaporizers; Sensor | 1997 |
[Sensitivity of the cough reflex in awake guinea pigs, rats and rabbits].
Topics: Administration, Inhalation; Animals; Capsaicin; Citric Acid; Cough; Guinea Pigs; Physical Stimulatio | 1997 |
Airway dynamics, oesophageal pressure and cough.
Topics: Administration, Inhalation; Adult; Citric Acid; Cough; Esophagus; Humans; Male; Pressure; Pulmonary | 1998 |
Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs.
Topics: Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Citric Acid; Cough; Fe | 1998 |
An increase in the threshold of citric acid-induced cough during chest wall vibration in healthy humans.
Topics: Administration, Inhalation; Adult; Afferent Pathways; Citric Acid; Cough; Female; Humans; Intercosta | 1998 |
Effects of moguisteine on the cough reflex induced by afferent electrical stimulation of the superior laryngeal nerve in guinea pigs.
Topics: Aerosols; Animals; Anticoagulants; Antitussive Agents; Citric Acid; Codeine; Cough; Dose-Response Re | 1998 |
Mucolytic and antitussive effects of erdosteine.
Topics: Animals; Antitussive Agents; Citric Acid; Cough; Drug Interactions; Expectorants; Female; Male; Muco | 1999 |
Effects of some Malian medicinal plants on the respiratory tract of guinea-pigs.
Topics: Airway Resistance; Animals; Anti-Asthmatic Agents; Antitussive Agents; Bronchial Spasm; Bronchoconst | 1999 |
Development of a cough induction test in pigs: effects of SR 48968 and enalapril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Newborn; Benzamides; Citric Acid; Cough; | 1999 |
Role of substance P and tachykinin receptor antagonists in citric acid-induced cough in pigs.
Topics: Animals; Benzamides; Citric Acid; Cough; Female; Lung; Male; Neurokinin-1 Receptor Antagonists; Pipe | 2000 |
Inhibiting effect of ammonia on citric acid-induced cough in pigs: a possible involvement of substance P.
Topics: Ammonia; Animals; Bronchoalveolar Lavage Fluid; Citric Acid; Cough; Female; Male; Mucous Membrane; N | 2000 |
The applied physiology of cough.
Topics: Acetic Acid; Capsaicin; Citric Acid; Cough; Forced Expiratory Volume; Humans; Infant, Newborn; Pulmo | 2001 |
Role of bradykinin and tachykinins in the potentiation by enalapril of coughing induced by citric acid in pigs.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antitussive Agents; | 2001 |
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central | 2002 |
The difference in citric acid-induced cough in congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs.
Topics: Administration, Inhalation; Aerosols; Animals; Asthma; Citric Acid; Cough; Disease Models, Animal; G | 2001 |
Effects of inhaled alpha 2-adrenoceptor and GABAB receptor agonists on citric acid-induced cough and tidal volume changes in guinea pigs.
Topics: Acetylcholine; Administration, Inhalation; Adrenergic alpha-Agonists; Animals; Atropine; Azepines; B | 1992 |
Relationship of airway responsiveness to agents causing bronchoconstriction and cough in sensitized guinea-pigs.
Topics: Administration, Inhalation; Animals; Antigens, Helminth; Ascaris suum; Bronchial Hyperreactivity; Br | 1992 |
Selective inhibition of cough and bronchoconstriction in conscious guinea pigs.
Topics: Animals; Antitussive Agents; Bronchoconstriction; Bronchodilator Agents; Citrates; Citric Acid; Coug | 1992 |
A comparison of the effect of inhaled diuretics on airway reflexes in humans and guinea pigs.
Topics: Administration, Inhalation; Adult; Airway Obstruction; Airway Resistance; Animals; Capsaicin; Citrat | 1992 |
[Measurement of cough threshold].
Topics: Age Factors; Asthma; Bronchitis; Citrates; Citric Acid; Cough; Differential Threshold; Humans; Refle | 1992 |
Selectivity of ruthenium red in inhibiting bronchoconstriction and CGRP release induced by afferent C-fibre activation in the guinea-pig lung.
Topics: Animals; Bradykinin; Bronchoconstriction; Calcitonin Gene-Related Peptide; Capsaicin; Citrates; Citr | 1991 |
Ruthenium red decreases capsaicin and citric acid-induced cough in guinea pigs.
Topics: Aerosols; Animals; Capsaicin; Citrates; Citric Acid; Cough; Dose-Response Relationship, Drug; Guinea | 1991 |
Evidence for peripheral mechanisms mediating the antitussive actions of opioids in the guinea pig.
Topics: Administration, Inhalation; Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Dext | 1991 |
Cigarette smoke-induced changes in guinea-pig airway responsiveness to histamine and citric acid.
Topics: Animals; Bronchi; Citrates; Citric Acid; Cough; Drug Resistance; Female; Guinea Pigs; Histamine; Mal | 1991 |
[Chronic cough].
Topics: Chronic Disease; Citrates; Citric Acid; Cough; Gallium Radioisotopes; Humans; Radionuclide Imaging; | 1991 |
[Cough and bronchial obstruction induced by citric acid in smokers, occasional smokers and non-smokers].
Topics: Adult; Aerosols; Bronchial Provocation Tests; Bronchoconstriction; Citrates; Citric Acid; Cough; Fem | 1991 |
Citric acid cough threshold and airway responsiveness in asthmatic patients and smokers with chronic airflow obstruction.
Topics: Adult; Asthma; Bronchoconstriction; Citrates; Citric Acid; Cough; Female; Forced Expiratory Volume; | 1991 |
Lack of cough reflex in aspiration pneumonia.
Topics: Aged; Aged, 80 and over; Citrates; Citric Acid; Cough; Humans; Physical Stimulation; Pneumonia, Aspi | 1990 |
Airway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs.
Topics: Animals; Bronchi; Citrates; Citric Acid; Codeine; Cough; Female; Guinea Pigs; Male; Meperidine; Morp | 1990 |
Cough threshold after upper abdominal surgery.
Topics: Abdomen; Bronchial Provocation Tests; Capsaicin; Citrates; Citric Acid; Cough; Female; Humans; Lung; | 1990 |
Effect of nedocromil sodium on SO2-induced airway hyperresponsiveness and citric acid-induced cough in dogs.
Topics: Animals; Antitussive Agents; Bronchi; Bronchial Spasm; Bronchoalveolar Lavage Fluid; Citrates; Citri | 1989 |
The effect of angiotensin converting enzyme inhibitors (ACE-I) and selective beta 1-antagonists on bronchial reactivity and the cough reflex in man.
Topics: Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Bronchi; Citrates; Citric Aci | 1989 |
Sensitivity of the human cough reflex: effect of inflammatory mediators prostaglandin E2, bradykinin, and histamine.
Topics: Adult; Airway Resistance; Bradykinin; Capsaicin; Citrates; Citric Acid; Cough; Dinoprostone; Female; | 1989 |
The effect of nedocromil sodium, sodium cromoglycate and codeine phosphate on citric acid-induced cough in dogs.
Topics: Animals; Antitussive Agents; Citrates; Citric Acid; Codeine; Cough; Cromolyn Sodium; Dogs; Female; M | 1988 |
Cough response to citric acid aerosol in occasional smokers.
Topics: Adult; Citrates; Citric Acid; Cough; Female; Humans; Smoking | 1986 |
Cough threshold to citric acid in diabetic patients with and without autonomic neuropathy.
Topics: Adult; Citrates; Citric Acid; Cough; Diabetes Mellitus, Type 1; Diabetic Neuropathies; Female; Human | 1988 |
Airway response to aerosol inhalations in leprosy.
Topics: Adolescent; Adult; Aerosols; Airway Resistance; Autonomic Fibers, Postganglionic; Bronchi; Citrates; | 1988 |
[Comparison of the absolute concentration method and cumulative dose method for cough threshold determination].
Topics: Administration, Inhalation; Adult; Aerosols; Citrates; Citric Acid; Cough; Female; Humans; Male; Pre | 1987 |
Cough induced by stimulation of capsaicin-sensitive sensory neurons in conscious guinea-pigs.
Topics: Afferent Pathways; Animals; Bronchi; Capsaicin; Citrates; Citric Acid; Cough; Guinea Pigs; Irritants | 1986 |
Irritant induced cough as a model of intrapulmonary airway reactivity.
Topics: Airway Resistance; Animals; Bronchial Provocation Tests; Citrates; Citric Acid; Cough; Guinea Pigs; | 1985 |
Diurnal variation and adaptation of the cough response to citric acid in normal subjects.
Topics: Adaptation, Physiological; Adult; Aerosols; Circadian Rhythm; Citrates; Citric Acid; Cough; Dose-Res | 1985 |