citric acid, anhydrous has been researched along with Chemical and Drug Induced Liver Injury in 9 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, these particles tend to migrate in vivo, thereby entering the blood circulatory system in granular form and accumulating in the liver, causing toxic reactions." | 1.48 | Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics. ( Dong, W; Li, Y; Liu, R; Wang, Y; Xie, J, 2018) |
| " Relevant toxic effects (midzonal hepatocellular necrosis, gall bladder hemorrhage) were found in mice treated with 10 nm AgNPs, while in mice treated with 40 nm and 100 nm AgNPs lesions were milder or negligible, respectively." | 1.43 | Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects. ( Argentiere, S; Aureli, F; Bianchessi, S; Cella, C; Cubadda, F; D'Amato, M; De Maglie, M; Lenardi, C; Mattiello, S; Milani, P; Raggi, A; Recordati, C; Scanziani, E, 2016) |
| "In a number of adverse drug reactions leading to hepatotoxicity, drug metabolism is thought to be involved by the generation of reactive metabolites from non-toxic drugs." | 1.38 | Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment. ( Castell, JV; Donato, MT; Gómez-Lechón, MJ; Pérez-Cataldo, G; Tolosa, L, 2012) |
| "Hepatotoxicity was revealed by traditional toxicity evaluation in rats treated with higher dosage and longer treatment of INH." | 1.34 | [Metabonomics profile of urine from rats administrated with different treatment period of isoniazid]. ( Liao, Y; Peng, SQ; Yan, XZ; Zhang, LS, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 6 (66.67) | 24.3611 |
| 2020's | 2 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Moreno-Torres, M | 1 |
| García-Llorens, G | 1 |
| Moro, E | 1 |
| Méndez, R | 1 |
| Quintás, G | 1 |
| Castell, JV | 2 |
| Tao, J | 1 |
| Deng, P | 1 |
| Lin, M | 1 |
| Chen, C | 1 |
| Ma, Q | 1 |
| Yang, L | 1 |
| Zhang, W | 1 |
| Luo, Y | 1 |
| Chen, S | 1 |
| Pi, H | 1 |
| Zhou, Z | 1 |
| Yu, Z | 1 |
| Xie, J | 1 |
| Dong, W | 1 |
| Liu, R | 1 |
| Wang, Y | 1 |
| Li, Y | 1 |
| Recordati, C | 1 |
| De Maglie, M | 1 |
| Bianchessi, S | 1 |
| Argentiere, S | 1 |
| Cella, C | 1 |
| Mattiello, S | 1 |
| Cubadda, F | 1 |
| Aureli, F | 1 |
| D'Amato, M | 1 |
| Raggi, A | 1 |
| Lenardi, C | 1 |
| Milani, P | 1 |
| Scanziani, E | 1 |
| Liao, Y | 1 |
| Peng, SQ | 1 |
| Yan, XZ | 1 |
| Zhang, LS | 1 |
| Akachi, T | 1 |
| Shiina, Y | 1 |
| Kawaguchi, T | 1 |
| Kawagishi, H | 1 |
| Morita, T | 1 |
| Sugiyama, K | 1 |
| Tolosa, L | 1 |
| Donato, MT | 1 |
| Pérez-Cataldo, G | 1 |
| Gómez-Lechón, MJ | 1 |
| Popov, SS | 1 |
| Shul'gin, KK | 1 |
| Pashkov, AN | 1 |
| Zoloedov, VI | 1 |
| Shvedov, GI | 1 |
9 other studies available for citric acid, anhydrous and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Factors that influence the quality of metabolomics data in in vitro cell toxicity studies: a systematic survey.
Topics: Acetaminophen; Cell Line, Tumor; Chemical and Drug Induced Liver Injury; Citric Acid; Hep G2 Cells; | 2021 |
Long-term exposure to polystyrene microplastics induces hepatotoxicity by altering lipid signatures in C57BL/6J mice.
Topics: Animals; Chemical and Drug Induced Liver Injury; Citrates; Citric Acid; Lipids; Mice; Mice, Inbred C | 2024 |
Research on the hepatotoxicity mechanism of citrate-modified silver nanoparticles based on metabolomics and proteomics.
Topics: Animals; Chemical and Drug Induced Liver Injury; Citric Acid; Male; Metabolome; Metabolomics; Metal | 2018 |
Tissue distribution and acute toxicity of silver after single intravenous administration in mice: nano-specific and size-dependent effects.
Topics: Acetates; Animals; Brain; Chemical and Drug Induced Liver Injury; Citric Acid; Gallbladder Diseases; | 2016 |
[Metabonomics profile of urine from rats administrated with different treatment period of isoniazid].
Topics: Animals; Antitubercular Agents; Biomarkers; Chemical and Drug Induced Liver Injury; Citric Acid; Cit | 2007 |
1-methylmalate from camu-camu (Myrciaria dubia) suppressed D-galactosamine-induced liver injury in rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Beverages; Chemical and Drug Induced Liv | 2010 |
Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment.
Topics: Adenoviridae; Aflatoxin B1; Aryl Hydrocarbon Hydroxylases; Calcium; Cell Survival; Chemical and Drug | 2012 |
[Effect of combined therapy with melaxen on lipid peroxidation rate and citrate content in blood serum of patients with drug-induced hepatitis diagnosis].
Topics: Aconitate Hydratase; Adult; Aged; Antibiotics, Antitubercular; Antioxidants; Chemical and Drug Induc | 2012 |