citric acid, anhydrous has been researched along with Bronchial Hyperreactivity in 9 studies
Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.
Bronchial Hyperreactivity: Tendency of the smooth muscle of the tracheobronchial tree to contract more intensely in response to a given stimulus than it does in the response seen in normal individuals. This condition is present in virtually all symptomatic patients with asthma. The most prominent manifestation of this smooth muscle contraction is a decrease in airway caliber that can be readily measured in the pulmonary function laboratory.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 7.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| " The aim of the present study was to evaluate the effects of selective PDE4 (rolipram, ROL) and PDE7 inhibitors (BRL50481, BRL) on citric acid-induced cough, in vivo and in vitro airway smooth muscle reactivity in both healthy and ovalbumin sensitized guinea pigs." | 3.79 | Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs. ( Christensen, I; Joskova, M; Mokra, D; Mokry, J; Nosalova, G, 2013) |
| "In this study the effects of non-selective PDE inhibitors (theophylline and theobromine) and selective inhibitors of PDE 1, 3, 4 and 5 on cough, induced by citric acid, were evaluated." | 3.77 | The influence of the PDE inhibitors on cough reflex in guinea pigs. ( Mokry, J; Nosalova, G, 2011) |
| " Pharmacokinetic evaluation in the mouse and rat revealed that oral SB 235375 was well absorbed systemically but did not effectively cross the blood-brain barrier." | 1.31 | Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs. ( Barone, FC; Bush, B; Foley, JJ; Giardina, GA; Griswold, DE; Grugni, M; Hay, DW; Kilian, D; Kotzer, CJ; Legos, JJ; Lundberg, D; Luttmann, MA; Martin, LD; Potts, W; Raveglia, LF; Sandhu, P; Sarau, HM; Schmidt, DB; Underwood, DC, 2002) |
| " Airway hyperresponsiveness was evidenced by significant shifts to the left of dose-response curves for intravenous acetylcholine (ACh) without a change in maximum responses to ACh." | 1.29 | The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs. ( Advenier, C; Emonds-Alt, X; Girard, V; Yavo, JC, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 3 (33.33) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mokry, J | 2 |
| Nosalova, G | 3 |
| Capek, P | 1 |
| Flešková, D | 1 |
| Jureček, L | 1 |
| Hindák, F | 1 |
| Lukavský, J | 1 |
| Cepák, V | 1 |
| Ray, B | 1 |
| Breierová, E | 1 |
| Turjan, J | 1 |
| Joskova, M | 1 |
| Mokra, D | 1 |
| Christensen, I | 1 |
| Brozmanová, M | 1 |
| Hanácek, J | 1 |
| Tatár, M | 1 |
| Strapková, A | 1 |
| Szépe, P | 1 |
| Kamei, J | 1 |
| Takahashi, Y | 1 |
| Itabashi, T | 1 |
| Hayashi, S | 1 |
| Kawai, K | 1 |
| Girard, V | 1 |
| Yavo, JC | 1 |
| Emonds-Alt, X | 2 |
| Advenier, C | 2 |
| Daoui, S | 1 |
| Cognon, C | 1 |
| Naline, E | 1 |
| Hay, DW | 1 |
| Giardina, GA | 1 |
| Griswold, DE | 1 |
| Underwood, DC | 1 |
| Kotzer, CJ | 1 |
| Bush, B | 1 |
| Potts, W | 1 |
| Sandhu, P | 1 |
| Lundberg, D | 1 |
| Foley, JJ | 1 |
| Schmidt, DB | 1 |
| Martin, LD | 1 |
| Kilian, D | 1 |
| Legos, JJ | 1 |
| Barone, FC | 1 |
| Luttmann, MA | 1 |
| Grugni, M | 1 |
| Raveglia, LF | 1 |
| Sarau, HM | 1 |
| Karlsson, JA | 1 |
| Zackrisson, C | 1 |
| Erjefält, J | 1 |
| Forsberg, K | 1 |
9 other studies available for citric acid, anhydrous and Bronchial Hyperreactivity
| Article | Year |
|---|---|
The influence of the PDE inhibitors on cough reflex in guinea pigs.
Topics: Animals; Antitussive Agents; Bronchial Hyperreactivity; Citric Acid; Cough; Guinea Pigs; Male; Ovalb | 2011 |
Influence of viscous Rhodella grisea (Rhodophyceae) proteoglycan on chemically induced cough reflex.
Topics: Administration, Inhalation; Administration, Oral; Airway Resistance; Animals; Antitussive Agents; Bi | 2011 |
Effects of selective inhibition of PDE4 and PDE7 on airway reactivity and cough in healthy and ovalbumin-sensitized guinea pigs.
Topics: Acetylcholine; Airway Resistance; Animals; Bronchial Hyperreactivity; Bronchoconstriction; Citric Ac | 2013 |
Effects of hyperoxia and allergic airway inflammation on cough reflex intensity in guinea pigs.
Topics: Animals; Bronchial Hyperreactivity; Citric Acid; Cough; Female; Guinea Pigs; Hyperoxia; Hypersensiti | 2002 |
Atopic cough-like cough hypersensitivity caused by active sensitization with protein fraction of Aspergillus restrictus strain A-17.
Topics: Administration, Inhalation; Animals; Antigens, Fungal; Antitussive Agents; Aspergillus; Bronchial Hy | 2008 |
The tachykinin NK2 receptor antagonist SR 48968 inhibits citric acid-induced airway hyperresponsiveness in guinea pigs.
Topics: Acetylcholine; Aerosols; Animals; Benzamides; Bronchial Hyperreactivity; Bronchoconstriction; Capsai | 1996 |
Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs.
Topics: Animals; Benzamides; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Citric Acid; Cough; Fe | 1998 |
Nonpeptide tachykinin receptor antagonists. III. SB 235375, a low central nervous system-penetrant, potent and selective neurokinin-3 receptor antagonist, inhibits citric acid-induced cough and airways hyper-reactivity in guinea pigs.
Topics: Acetates; Animals; Antitussive Agents; Behavior, Animal; Bronchial Hyperreactivity; Calcium; Central | 2002 |
Relationship of airway responsiveness to agents causing bronchoconstriction and cough in sensitized guinea-pigs.
Topics: Administration, Inhalation; Animals; Antigens, Helminth; Ascaris suum; Bronchial Hyperreactivity; Br | 1992 |