Page last updated: 2024-10-17

citric acid, anhydrous and Angor Pectoris

citric acid, anhydrous has been researched along with Angor Pectoris in 5 studies

Citric Acid: A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.
citric acid : A tricarboxylic acid that is propane-1,2,3-tricarboxylic acid bearing a hydroxy substituent at position 2. It is an important metabolite in the pathway of all aerobic organisms.

Research Excerpts

Excerpt	Relevance	Reference
"Ranolazine was given as an intravenous bolus followed by continuous infusion; the mean total dose was 32."	1.30	Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease. ( Bagger, JP; Bøtker, HE; Nielsen, TT; Thomassen, A, 1997)

Research

Studies (5)

Timeframe	Studies, this research(%)	All Research%
pre-1990	3 (60.00)	18.7374
1990's	2 (40.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Thuesen, L	1
Nielsen, TT	3
Thomassen, A	3
Bagger, JP	3
Henningsen, P	3
Herrmann, W	1
Kost, HR	1
Lindhofer, HG	1
Toftegaard Nielsen, T	1
Thomsen, PE	1
Eyjolfsson, K	1
Bøtker, HE	2
Thygesen, K	1

Clinical Trials (1)

Trial Overview

Trial			Phase	Enrollment	Study Type	Start Date	Status
Phase III Study of Intravenous Glutamate Infusion for Metabolic Protection of the Heart in Surgery for Unstable Coronary Artery Disease[NCT00489827]			Phase 3	865 participants (Actual)	Interventional	2005-10-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Atrial Fibrillation

Number of patients with atrial fibrillation recorded postoperatively (NCT00489827)
Timeframe: Hospital stay

Intervention	Participants (Count of Participants)
Intravenous Glutamate	147
Saline Infusion	152

ICU Stay

ICU duration of stay (hours) (NCT00489827)
Timeframe: ICU stay

Intervention	hours (Median)
Intravenous Glutamate	21
Saline Infusion	21

Number of Participants With Perioperative Myocardial Infarction, Postoperative Heart Failure or Postoperative Mortality

(NCT00489827)
Timeframe: 30 days

Intervention	Participants (Count of Participants)
Intravenous Glutamate	31
Saline Infusion	25

Number of Participants With Postoperative Stroke < 24 Hours

Incidence of Postoperative stroke < 24 hours of surgery verifed by CT-scan (NCT00489827)
Timeframe: 24 hours

Intervention	Participants (Count of Participants)
Intravenous Glutamate	4
Saline Infusion	6

Postoperative Hemodynamic State in Patients With Severely Reduced Left Ventricular Ejection Fraction (LVEF<0.40)

Hemodynamic instability despite inotropes or need for IABP at the end of surgery in patients with severely reduced left ventricular ejection fraction (LVEF<0.40) (NCT00489827)
Timeframe: End of surgery

Intervention	Participants (Count of Participants)
Intravenous Glutamate	1
Saline Infusion	5

Postoperative Renal Function

maximum p-creatinine value recorded postoperatively < 30 days (NCT00489827)
Timeframe: 30 days

Intervention	µmol/L (Mean)
Intravenous Glutamate	106
Saline Infusion	106

Severe Circulatory Failure in CCS Class IV Patients

Severe circulatory failure according to prespecified criteria as judged by a blinded endpoints committee in CCS class IV patients (NCT00489827)
Timeframe: 30 days

Intervention	Participants (Count of Participants)
Intravenous Glutamate	3
Saline Infusion	16

Degree of Perioperative Myocardial Injury

p-CK-MB postoperative day 1, p-troponin-T postoperative day 3 (NCT00489827)
Timeframe: perioperative

Intervention	µg/L (Median)
	CK-MB day 1	Troponin-T day 3
Intravenous Glutamate	14	0.27
Saline Infusion	14	0.24

Postoperative Hemodynamic State

Mixed venous oxygen saturation (SvO2) measured at weaning from cardiopulmonary bypass and on arrival to ICU (NCT00489827)
Timeframe: Until arrival to ICU

Intervention	percentage of saturated hemoglobin (Mean)
	SvO2 at weaning from CPB	SvO2 on arrival to ICU
Intravenous Glutamate	72.0	65.0
Saline Infusion	72.2	64.9

Trials

1 trial available for citric acid, anhydrous and Angor Pectoris

Article	Year
[Is cholesterol lowering following UVA blood irradiation an effect of citrate?]. Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1984, Nov-15, Volume: 39, Issue:22 Topics: Angina Pectoris; Blood Transfusion, Autologous; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Cit	1984

Other Studies

4 other studies available for citric acid, anhydrous and Angor Pectoris

Article	Year
Beneficial effect of a low-fat low-calorie diet on myocardial energy metabolism in patients with angina pectoris. Lancet (London, England), 1984, Jul-14, Volume: 2, Issue:8394 Topics: Alanine; Angina Pectoris; Cardiac Pacing, Artificial; Citrates; Citric Acid; Dietary Fats; Energy In	1984
Myocardial release of citrate and lactate during atrial pacing-induced angina pectoris. Scandinavian journal of clinical and laboratory investigation, 1981, Volume: 41, Issue:5 Topics: Adult; Angina Pectoris; Blood Glucose; Cardiac Pacing, Artificial; Citrates; Citric Acid; Fatty Acid	1981
Effects of ranolazine on ischemic threshold, coronary sinus blood flow, and myocardial metabolism in coronary artery disease. Cardiovascular drugs and therapy, 1997, Volume: 11, Issue:3 Topics: Acetanilides; Aged; Alanine; Angina Pectoris; Blood Pressure; Citric Acid; Coronary Circulation; Cor	1997
Effects of glutamate on exercise tolerance and circulating substrate levels in stable angina pectoris. The American journal of cardiology, 1990, Jan-15, Volume: 65, Issue:3 Topics: Alanine; Angina Pectoris; Blood Chemical Analysis; Citrates; Citric Acid; Electrocardiography; Exerc	1990