citalopram has been researched along with Psychotic Disorders in 29 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Psychotic Disorders: Disorders in which there is a loss of ego boundaries or a gross impairment in reality testing with delusions or prominent hallucinations. (From DSM-IV, 1994)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subsyndromal symptoms of depression in middle aged and older patients with schizophrenia responded to treatment with citalopram with lessening of depressive symptoms and improved functioning and quality of life." | 9.14 | Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial. ( Fellows, I; Golshan, S; Jeste, DV; Kasckow, JW; Lehman, D; Mohamed, S; Solorzano, E; Zisook, S, 2009) |
| "To examine the effects of citalopram augmentation of antipsychotics on suicidal ideation in middle-aged and older people with schizophrenia and subthreshold depressive symptoms." | 9.14 | Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial. ( Fellows, I; Golshan, S; Kasckow, JW; Lanouette, NM; Mohamed, S; Rao, S; Vahia, I; Zisook, S, 2010) |
| "To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation." | 9.12 | A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. ( Blakesley, RE; Houck, PR; Huber, KA; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J, 2007) |
| "Subsyndromal symptoms of depression in middle aged and older patients with schizophrenia responded to treatment with citalopram with lessening of depressive symptoms and improved functioning and quality of life." | 5.14 | Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial. ( Fellows, I; Golshan, S; Jeste, DV; Kasckow, JW; Lehman, D; Mohamed, S; Solorzano, E; Zisook, S, 2009) |
| "To examine the effects of citalopram augmentation of antipsychotics on suicidal ideation in middle-aged and older people with schizophrenia and subthreshold depressive symptoms." | 5.14 | Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial. ( Fellows, I; Golshan, S; Kasckow, JW; Lanouette, NM; Mohamed, S; Rao, S; Vahia, I; Zisook, S, 2010) |
| "To compare citalopram and risperidone for the treatment of psychotic symptoms and agitation associated with dementia, with a priori hypotheses that risperidone would be more efficacious for psychosis and citalopram for agitation." | 5.12 | A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia. ( Blakesley, RE; Houck, PR; Huber, KA; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J, 2007) |
| "Randomized, controlled trials of antidepressants (selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, trazodone, and other antidepressants), compared to either placebo or comparator medications (typical or atypical antipsychotics, anticonvulsants, benzodiazepines, cholinesterase inhibitors, memantine or other medications) for treatment of agitation or psychosis in older adults with dementia." | 4.87 | Antidepressants for agitation and psychosis in dementia. ( Adunuri, N; Gill, SS; Gruneir, A; Herrmann, N; Rochon, P; Seitz, DP, 2011) |
| "While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown." | 2.77 | Does antidepressant treatment improve cognition in older people with schizophrenia or schizoaffective disorder and comorbid subsyndromal depression? ( Dawes, SE; Golshan, S; Kasckow, J; Meeks, T; Mohamed, S; Palmer, BW; Zisook, S, 2012) |
| "Escitalopram was investigated since citalopram has demonstrated some effectiveness in AD." | 2.76 | Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer's disease: a randomized double-blind pilot study. ( Barak, Y; Paleacu, D; Plopski, I; Tadger, S, 2011) |
| "Citalopram was found to be more efficacious than placebo in the short-term hospital treatment of psychotic symptoms and behavioral disturbances in nondepressed, demented patients." | 2.70 | Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients. ( Bharucha, A; Chew, ML; Huber, KA; Jacob, NJ; Kastango, KB; Marin, R; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J; Sweet, RA, 2002) |
| "Turner syndrome encompasses several chromosomal abnormalities and includes a typical clinical manifestation." | 2.45 | [Turner-syndrome and psychosis: a case report and brief review of the literature]. ( Preuss, UW; Wustmann, T, 2009) |
| "Given this rare manifestation of arsenic poisoning for which there is no clearly defined treatment regimen, this case suggests that the use of a combination of an antipsychotic and an antidepressant may be considered in the rare event of psychosis with obsessive-compulsive features following arsenic poisoning." | 1.46 | An Unusual Case of Acute Psychosis With Obsessive-Compulsive Features Following Arsenic Poisoning. ( Abdel-Gawad, NM; Gharbaoui, Y; Pigott, TA; Teixeira, AL; Wu, HE, 2017) |
| " Escitalopram and aripiprazole were flexibly dosed for 7 weeks, with maximum dosages of 20 and 30 mg/d, respectively." | 1.35 | An open study of aripiprazole and escitalopram for psychotic major depressive disorder. ( Denninger, JW; Dording, C; Fava, M; Hilliker, S; Homberger, C; Matthews, JD; Park, L; Rooney, K; Siefert, C; Sklarsky, K; van Nieuwenhuizen, AO, 2009) |
| "Hyperprolactinemia is a side effect related to antipsychotics that can cause galactorrhea, gynecomastia, amenorrhea, anovulation, impaired spermatogenesis, decreased libido and sexual arousal, impotence, and anorgasmia, consequent to removal of tonic dopaminergic inhibition of prolactin secretion via hypothalamic dopaminergic receptor blockade in the tuberoinfundibolar tract." | 1.31 | Switch to quetiapine in antipsychotic agent-related hyperprolactinemia. ( Keller, R; Mongini, F, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (3.45) | 18.2507 |
| 2000's | 14 (48.28) | 29.6817 |
| 2010's | 12 (41.38) | 24.3611 |
| 2020's | 2 (6.90) | 2.80 |
| Authors | Studies |
|---|---|
| Mattsson, C | 1 |
| Andreasson, T | 1 |
| Waters, N | 1 |
| Sonesson, C | 1 |
| Qi, W | 1 |
| Marx, J | 1 |
| Zingman, M | 1 |
| Li, Y | 1 |
| Petkova, E | 1 |
| Blessing, E | 1 |
| Ardekani, B | 1 |
| Sakalli Kani, A | 1 |
| Cather, C | 1 |
| Freudenreich, O | 1 |
| Holt, D | 1 |
| Zhao, J | 1 |
| Wang, J | 1 |
| Goff, DC | 1 |
| Fischer, CE | 3 |
| Namasivayam, A | 3 |
| Crawford-Holland, L | 3 |
| Hakobyan, N | 3 |
| Schweizer, TA | 3 |
| Munoz, DG | 3 |
| Pollock, BG | 8 |
| Wu, HE | 1 |
| Abdel-Gawad, NM | 1 |
| Gharbaoui, Y | 1 |
| Teixeira, AL | 1 |
| Pigott, TA | 1 |
| Bergman, Y | 1 |
| Barak, Y | 2 |
| Mauritz, MW | 1 |
| van de Sande, R | 1 |
| Goossens, PJ | 1 |
| van Achterberg, T | 1 |
| Draijer, N | 1 |
| Wilkins, JM | 1 |
| Forester, BP | 1 |
| Hollander, E | 1 |
| Hüther, R | 1 |
| Gebhart, C | 1 |
| Mirisch, S | 1 |
| Bäuml, J | 1 |
| Förstl, H | 1 |
| Wustmann, T | 1 |
| Preuss, UW | 1 |
| Matthews, JD | 1 |
| Siefert, C | 1 |
| Dording, C | 1 |
| Denninger, JW | 1 |
| Park, L | 1 |
| van Nieuwenhuizen, AO | 1 |
| Sklarsky, K | 1 |
| Hilliker, S | 1 |
| Homberger, C | 1 |
| Rooney, K | 1 |
| Fava, M | 1 |
| Zisook, S | 4 |
| Kasckow, JW | 2 |
| Golshan, S | 4 |
| Fellows, I | 3 |
| Solorzano, E | 2 |
| Lehman, D | 2 |
| Mohamed, S | 4 |
| Jeste, DV | 2 |
| Dombrovski, AY | 1 |
| Mulsant, BH | 4 |
| Ferrell, RE | 1 |
| Lotrich, FE | 1 |
| Rosen, JI | 1 |
| Wallace, M | 1 |
| Houck, PR | 3 |
| Mazumdar, S | 4 |
| Lanouette, NM | 1 |
| Vahia, I | 1 |
| Rao, S | 1 |
| Seitz, DP | 1 |
| Adunuri, N | 1 |
| Gill, SS | 1 |
| Gruneir, A | 1 |
| Herrmann, N | 1 |
| Rochon, P | 1 |
| Plopski, I | 1 |
| Tadger, S | 1 |
| Paleacu, D | 1 |
| Bou Khalil, R | 1 |
| Dahdah, P | 1 |
| Richa, S | 1 |
| Kahn, DA | 1 |
| Dawes, SE | 1 |
| Palmer, BW | 2 |
| Meeks, T | 1 |
| Kasckow, J | 2 |
| Ismail, Z | 1 |
| Emeremni, CA | 1 |
| Rosen, J | 3 |
| Rajji, TK | 1 |
| Keller, R | 1 |
| Mongini, F | 1 |
| Holzer, L | 1 |
| Paiva, G | 1 |
| Halfon, O | 1 |
| Ose, BL | 1 |
| Pandurangi, AK | 1 |
| Gorman, JM | 1 |
| Goldman, S | 1 |
| Blakesley, RE | 1 |
| Huber, KA | 2 |
| Montross, L | 1 |
| Patterson, TL | 1 |
| Soares, JC | 1 |
| Gershon, S | 1 |
| Borba, CP | 1 |
| Henderson, DC | 1 |
| Schneider, LS | 1 |
| Tariot, PN | 1 |
| Lyketsos, CG | 1 |
| Dagerman, KS | 1 |
| Davis, KL | 1 |
| Davis, S | 1 |
| Hsiao, JK | 1 |
| Katz, IR | 1 |
| Olin, JT | 1 |
| Rabins, PV | 1 |
| Rosenheck, RA | 1 |
| Small, GW | 1 |
| Lebowitz, B | 1 |
| Lieberman, JA | 1 |
| Sweet, RA | 1 |
| Bharucha, A | 1 |
| Marin, R | 1 |
| Jacob, NJ | 1 |
| Kastango, KB | 1 |
| Chew, ML | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Combination of Aripiprazole and Selective Serotonin Reuptake Inhibitor (SSRI) Antidepressants in the Acute Treatment of Psychotic Major Depression: Efficacy and Tolerability[NCT00556140] | Phase 3 | 16 participants (Actual) | Interventional | 2003-06-30 | Completed | ||
| Citalopram Augmentation in Older Patients With Schizophrenia[NCT00047450] | 212 participants (Actual) | Interventional | 2001-09-30 | Completed | |||
| Post Marketing Study of Escitalopram Versus Risperidone for the Treatment of Behavioral and Psychological Symptoms Amongst Alzheimer's Disease Patients[NCT01119638] | Phase 4 | 40 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Comparative Effectiveness of Antipsychotic Medications in Patients With Alzheimer's Disease (CATIE Alzheimer's Disease Trial)[NCT00015548] | 450 participants | Interventional | 2001-03-31 | Completed | |||
| Continuation Pharmacotherapy for Agitation of Dementia[NCT00073658] | Phase 2 | 137 participants | Interventional | 2000-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
This remission rate refers to a Hamilton Depression Rating Scale 17 (HAM-D-17) score of 7 or less and no psychotic symptoms as measured by the Structured Clinical Interview for DMS-IV psychosis module. HAM-D-17 scores range from 0-50 with a score of >23 considered severely depressed and <7 to be mildly to not at all depressed. (NCT00556140)
Timeframe: Baseline and 7 weeks
| Intervention | percent of participants (Number) |
|---|---|
| Major Depression With Psychotic Features | 50 |
This response rate refers to the percentage of patients who experienced a 50 percent or greater reduction in symptoms. Specifically, this refers to a 50 percent reduction in Hamilton Depression Rating Scale 17 (HAM-D-17) scores from baseline and no psychotic symptoms as measured by the Structured Clinical Interview for DMS-IV psychosis module. HAM-D-17 scores range from 0-50 with a score of >23 considered severely depressed and <7 to be mildly to not at all depressed. (NCT00556140)
Timeframe: Baseline and 7 weeks
| Intervention | percent of participants (Number) |
|---|---|
| Major Depression With Psychotic Features | 62.5 |
6 reviews available for citalopram and Psychotic Disorders
| Article | Year |
|---|---|
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Psychotic Disorders in the Elderly: Diagnosis, Epidemiology, and Treatment.
Topics: Aged; Antipsychotic Agents; Citalopram; Dementia; Humans; Psychotic Disorders; Schizophrenia | 2022 |
Update on SSRI Treatment for Neuropsychiatric Symptoms of Dementia.
Topics: Antipsychotic Agents; Caregivers; Citalopram; Dementia; Humans; Psychomotor Agitation; Psychotic Dis | 2016 |
[Turner-syndrome and psychosis: a case report and brief review of the literature].
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Benzodiazepines; Chromosome Aberrati | 2009 |
Antidepressants for agitation and psychosis in dementia.
Topics: Adult; Antidepressive Agents; Citalopram; Dementia; Humans; Psychomotor Agitation; Psychotic Disorde | 2011 |
Lycanthropy as a culture-bound syndrome: a case report and review of the literature.
Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Behavior Control; Citalopram; Cultural Ch | 2012 |
Therapeutic targets in late-life psychoses: review of concepts and critical issues.
Topics: Affective Disorders, Psychotic; Age Factors; Age of Onset; Aged; Antipsychotic Agents; Benzodiazepin | 1997 |
11 trials available for citalopram and Psychotic Disorders
| Article | Year |
|---|---|
Hippocampal Subfield Volumes Predict Disengagement from Maintenance Treatment in First Episode Schizophrenia.
Topics: China; Citalopram; Hippocampus; Humans; Magnetic Resonance Imaging; Psychotic Disorders; Schizophren | 2023 |
Citalopram augmentation for subsyndromal symptoms of depression in middle-aged and older outpatients with schizophrenia and schizoaffective disorder: a randomized controlled trial.
Topics: Adult; Aged; Ambulatory Care; Antipsychotic Agents; Citalopram; Diagnostic and Statistical Manual of | 2009 |
Serotonin transporter triallelic genotype and response to citalopram and risperidone in dementia with behavioral symptoms.
Topics: Aged; Aged, 80 and over; Alleles; Antipsychotic Agents; Behavioral Symptoms; Citalopram; Dementia; F | 2010 |
Augmentation with citalopram for suicidal ideation in middle-aged and older outpatients with schizophrenia and schizoaffective disorder who have subthreshold depressive symptoms: a randomized controlled trial.
Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Citalopram; Depression; | 2010 |
Escitalopram versus risperidone for the treatment of behavioral and psychotic symptoms associated with Alzheimer's disease: a randomized double-blind pilot study.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Citalopram; Double-Blind Method; Female; Humans; Male | 2011 |
Does antidepressant treatment improve cognition in older people with schizophrenia or schizoaffective disorder and comorbid subsyndromal depression?
Topics: Adult; Aging; Antidepressive Agents; Citalopram; Cognition Disorders; Comorbidity; Depression; Doubl | 2012 |
A comparison of the E-BEHAVE-AD, NBRS, and NPI in quantifying clinical improvement in the treatment of agitation and psychosis associated with dementia.
Topics: Aged, 80 and over; Citalopram; Dementia; Double-Blind Method; Female; Humans; Male; Psychiatric Stat | 2013 |
A double-blind comparison of citalopram and risperidone for the treatment of behavioral and psychotic symptoms associated with dementia.
Topics: Aged, 80 and over; Antipsychotic Agents; Citalopram; Dementia; Double-Blind Method; Female; Hospital | 2007 |
Subsyndromal depressive symptoms in middle-aged and older persons with schizophrenia.
Topics: Age Factors; Chronic Disease; Citalopram; Comorbidity; Depression; Depressive Disorder, Major; Doubl | 2007 |
National Institute of Mental Health Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE): Alzheimer disease trial methodology.
Topics: Aged; Algorithms; Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Citalopram; Cost-Benefit | 2001 |
Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Behavioral Symptoms; Citalopram; Dementia; Donepezil; | 2002 |
12 other studies available for citalopram and Psychotic Disorders
| Article | Year |
|---|---|
Systematic in vivo screening of a series of 1-propyl-4-arylpiperidines against dopaminergic and serotonergic properties in rat brain: a scaffold-jumping approach.
Topics: Animals; Behavior, Animal; Brain; Dopamine; Dopamine Agents; Dopamine D2 Receptor Antagonists; Locom | 2012 |
An Unusual Case of Acute Psychosis With Obsessive-Compulsive Features Following Arsenic Poisoning.
Topics: Adult; Antipsychotic Agents; Arsenic Poisoning; Citalopram; Humans; Male; Obsessive-Compulsive Disor | 2017 |
Escitalopram for antipsychotic nonresponsive visual hallucinosis: eight patients suffering from Charles Bonnet syndrome.
Topics: Aged, 80 and over; Citalopram; Eye Diseases; Female; Hallucinations; Humans; Male; Psychotic Disorde | 2013 |
Phase-based treatment of a complex severely mentally ill case involving complex posttraumatic stress disorder and psychosis related to Dandy Walker syndrome.
Topics: Adult Survivors of Child Abuse; Antipsychotic Agents; Citalopram; Comorbidity; Dandy-Walker Syndrome | 2014 |
Differential treatment response, neuroinflammation, and psychosis associated with chromosome deletion.
Topics: Brain; Chromosome Deletion; Citalopram; Depressive Disorder; Humans; Inflammation Mediators; Obsessi | 2008 |
Choreatic symptoms during and after treatment with paliperidone and escitalopram.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Chorea; Citalopram; Depressive Disor | 2008 |
An open study of aripiprazole and escitalopram for psychotic major depressive disorder.
Topics: Adult; Antipsychotic Agents; Aripiprazole; Citalopram; Depressive Disorder, Major; Drug Therapy, Com | 2009 |
Switch to quetiapine in antipsychotic agent-related hyperprolactinemia.
Topics: Adolescent; Adult; Antipsychotic Agents; Citalopram; Dibenzothiazepines; Drug Therapy, Combination; | 2002 |
Quetiapine-induced weight gain and escitalopram.
Topics: Adolescent; Antipsychotic Agents; Citalopram; Depressive Disorder; Dibenzothiazepines; Drug Synergis | 2005 |
Delusional wife: a case of diagnostic ambiguity and treatment challenge.
Topics: Adult; Alcoholism; Antipsychotic Agents; Benzodiazepines; Citalopram; Delusions; Depressive Disorder | 2005 |
Possible antipsychotic effect of fluvoxamine.
Topics: Antipsychotic Agents; Citalopram; Delayed-Action Preparations; Depressive Disorder, Major; Drug Admi | 2005 |
Citalopram and clozapine: potential drug interaction.
Topics: Adult; Citalopram; Clozapine; Confusion; Dose-Response Relationship, Drug; Drug Administration Sched | 2000 |