Page last updated: 2024-10-25

citalopram and Pregnancy

citalopram has been researched along with Pregnancy in 86 studies

Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Even though the sample size was limited, results from this prospective clinical trial suggest uncomplicated pregnancy outcome in mothers using citalopram during pregnancy and minimal exposure of the infants to citalopram during lactation."9.10Citalopram in pregnancy and lactation. ( Ekblad, S; Ekblad, U; Heikkinen, T; Kero, P; Laine, K, 2002)
"MEDLINE and PubMed databases were searched for English language articles by using the following keywords: escitalopram, selective serotonin reuptake inhibitors, major malformations, perinatal complications, pregnancy, and breastfeeding."8.88The safety of escitalopram during pregnancy and breastfeeding: a comprehensive review. ( Bellantuono, C; Bozzi, F; Catena-Dell'Osso, M; Orsolini, L, 2012)
"Treatment of major depression disorder with Selective serotonin reuptake inhibitors (SSRIs), such as citalopram (CTM), during pregnancy effects on the neurological trajectory of the offspring and induces enduring consequences, notably emotional and cognitive impairment."8.12Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. ( Butt, MU; Du, L; Jia, M; Wang, Q; Wang, Y; Wu, J; Zahra, A, 2022)
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels."7.91Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019)
"Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure."7.85Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017)
" Using maternal separation (MS), a paradigm of early adversity, we investigated the effects of adolescent (PND 33-54) escitalopram (ES; 10mg/kg) exposure on depression- and anxiety-like behaviours and the levels of inflammatory cytokines (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, and IL-10) in the ventral hippocampus (HPV), prefrontal cortex (PFC), and serum in adult (PND 61) male offspring mice."7.85Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice. ( Dong, X; Geng, Z; Jin, Y; Li, N; Li, X; Lin, Y; Liu, M; Sun, A; Wang, Q; Wang, Y, 2017)
" The current study investigated whether administration of citalopram to pregnant rats could prevent anxiety and depressive-like behaviour induced by gestational stress in their offspring, and restore the expression of serotonin 1A autoreceptors in GABAergic interneurons in the medial prefrontal cortex and dorsal raphe nuclei in males, and of corticotropin-releasing factor type 2 receptors in GABAergic interneurons in the dorsal raphe nuclei in females."7.83Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring. ( Shoham, S; Weinstock, M; Zohar, I, 2016)
"These data indicate that: (1) clinically relevant antidepressant treatment during human pregnancy can be modeled in rats using escitalopram; (2) chronic mild stress can be delivered in a manner that does not compromise fetal viability; and (3) neither of these prenatal treatments substantially altered maternal care post parturition."7.79Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013)
"A woman treated with citalopram during the entirety of her pregnancy bore a child with Hirschsprung's disease."7.79[Citalopram taken during pregnancy and the child born with Hirschsprung's disease]. ( Nielsen, SW; Qvist, N, 2013)
"We describe the case of a pregnancy healthy outcome after in utero consecutive exposure to lamotrigine and citalopram."7.74Consecutive exposure to lamotrigine and citalopram during pregnancy. ( Gentile, S; Vozzi, F, 2007)
"A term neonate presenting with necrotizing enterocolitis following in utero and breast milk exposure to the newest serotonin selective reuptake inhibitor, escitalopram, is described."7.74Necrotizing enterocolitis associated with in utero and breast milk exposure to the selective serotonin reuptake inhibitor, escitalopram. ( Carter, BS; Potts, AL; Shenai, JP; Young, KL, 2007)
"Citalopram use during the period of embryogenesis in pregnancy is not associated with an apparent major teratogenic risk."7.73Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome. ( Einarson, A; Koren, G; Sarkissian, L; Shuhaiber, S; Sivojelezova, A, 2005)
"The median daily dosage of citalopram was 20mg (Q1: 10mg, Q3: 20mg; range 10-40mg)."5.46Pregnancy exposure to citalopram - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. ( Goecke, TW; Gründer, G; Janssen, G; Paulzen, M; Schoretsanitis, G; Stickeler, E; Stingl, JC, 2017)
"Escitalopram is a serotonin reuptake inhibitor prescribed for depression and anxiety."5.38Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study. ( Einarson, A; Einarson, T; Klieger-Grossmann, C; Koren, G; Panchaud, A; Pistelli, A; Weitzner, B, 2012)
"Bupropion's efficacy for smoking cessation in pregnant women is unknown."5.14The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse. ( Brigham, EP; Chisolm, MS; Jones, HE; Strain, EC; Tuten, M, 2010)
" Across pregnancy and postpartum, the mean dose-corrected plasma concentrations (L/D ratios) of S- and R-citalopram and S-sertraline, and the corresponding primary chiral metabolites S- and R-desmethylcitalopram and N-desmethylsertra-line were assessed."5.13Changes in antidepressant metabolism and dosing across pregnancy and early postpartum. ( Helsel, JC; Perel, JM; Sit, DK; Wisner, KL, 2008)
"Even though the sample size was limited, results from this prospective clinical trial suggest uncomplicated pregnancy outcome in mothers using citalopram during pregnancy and minimal exposure of the infants to citalopram during lactation."5.10Citalopram in pregnancy and lactation. ( Ekblad, S; Ekblad, U; Heikkinen, T; Kero, P; Laine, K, 2002)
"We performed a search for the English language literature indexed on MEDLINE/PubMed for the period 2012 to 2017, using the following key terms: fluoxetine, prozac, paxil, oxactin, paroxetine, seroxat, sertraline, lustral, citalopram, cipramil, escitalopram, cipralex, fluvoxamine, faverin, with 'pregnant woman', 'pregnant women', pregnancy."4.95What are the risks associated with different Selective Serotonin Re-uptake Inhibitors (SSRIs) to treat depression and anxiety in pregnancy? An evaluation of current evidence. ( Agius, M; Ripullone, K; Womersley, K, 2017)
"MEDLINE and PubMed databases were searched for English language articles by using the following keywords: escitalopram, selective serotonin reuptake inhibitors, major malformations, perinatal complications, pregnancy, and breastfeeding."4.88The safety of escitalopram during pregnancy and breastfeeding: a comprehensive review. ( Bellantuono, C; Bozzi, F; Catena-Dell'Osso, M; Orsolini, L, 2012)
"The recent clinical studies on hypericum extract support the present indications for its use in mild to moderate depression and depressive episodes."4.84[New developments in hypericum extracts: data on efficacy and interactions]. ( Kraft, K, 2007)
"Treatment of major depression disorder with Selective serotonin reuptake inhibitors (SSRIs), such as citalopram (CTM), during pregnancy effects on the neurological trajectory of the offspring and induces enduring consequences, notably emotional and cognitive impairment."4.12Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. ( Butt, MU; Du, L; Jia, M; Wang, Q; Wang, Y; Wu, J; Zahra, A, 2022)
"Plasma levels of Sertraline, Citalopram and Escitalopram were more frequently in range in late pregnancy when compared to other drugs."4.02Correlation between pharmacokinetics and pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Selective Serotonin and Noradrenaline Reuptake Inhibitors and maternal and neonatal outcomes: Results from a naturalistic study in patients with affec ( Bosi, MF; Cafaro, R; Cetin, I; Clementi, E; Colombo, A; Dell'Osso, B; Di Bernardo, I; Giordano, F; Giorgetti, F; Pileri, P; Varinelli, A; Viganò, CA, 2021)
"Urinary SSRIs (fluoxetine, sertraline, escitalopram/citalopram) were measured while trying to conceive and, for women who became pregnant, at weeks 0, 4, and 8 of pregnancy."3.96Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss. ( Flannagan, KS; Kim, K; Mumford, SL; Perkins, NJ; Radoc, JG; Schisterman, EF; Silver, RM; Sjaarda, LA, 2020)
" A treatment with escitalopram reversed depression-like behavior accompanied by reductions in BDNF levels in serum and the nucleus accumbens, while a treatment with blonanserin ameliorated abnormal social interaction behavior with reductions in serum BDNF levels."3.91Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens. ( Deriha, K; Furuse, K; Hashiguchi, H; Hashimoto, E; Ishii, T; Kawanishi, C; Kigawa, Y; Shiraishi, M; Tayama, M; Ukai, W, 2019)
"Citalopram (CTM), a selective serotonin reuptake inhibitor (SSRI), has been widely used to treat panic disorders, such as depression which is one of the most disabling, yet common, psychiatric disorders."3.91Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice. ( Chen, Y; Jiang, J; Long, C; Yang, L; Zahra, A; Zheng, Y, 2019)
"For paroxetine and fluvoxamine the pronounced decline in maternal drug serum concentrations in pregnancy may necessitate a dose increase of about 100% during the third trimester in order to maintain stable concentrations."3.85Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition. ( Brekke, M; Molden, E; Skogvoll, E; Spigset, O; Westin, AA, 2017)
" Using maternal separation (MS), a paradigm of early adversity, we investigated the effects of adolescent (PND 33-54) escitalopram (ES; 10mg/kg) exposure on depression- and anxiety-like behaviours and the levels of inflammatory cytokines (interleukin [IL]-1β, tumor necrosis factor [TNF]-α, and IL-10) in the ventral hippocampus (HPV), prefrontal cortex (PFC), and serum in adult (PND 61) male offspring mice."3.85Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice. ( Dong, X; Geng, Z; Jin, Y; Li, N; Li, X; Lin, Y; Liu, M; Sun, A; Wang, Q; Wang, Y, 2017)
"Neonatal abstinence syndrome (NAS) due to prenatally exposure to citalopram can develop during the first days of life even with low dose of drug exposure."3.85Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report. ( Bas, AY; Celik, IH; Demirel, N; Erol, S; Ozcan, B, 2017)
" Despite extended residual persistence of dichlorodiphenyltrichloroethane (DDT) in the environment, the mechanisms of perinatal actions of DDT that could account for adult-onset of depression are largely unknown."3.85Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling. ( Grochowalski, A; Kajta, M; Lason, W; Litwa, E; Nalepa, I; Rogóż, Z; Rzemieniec, J; Wnuk, A; Wojtowicz, AK; Zelek-Molik, A, 2017)
" The current study investigated whether administration of citalopram to pregnant rats could prevent anxiety and depressive-like behaviour induced by gestational stress in their offspring, and restore the expression of serotonin 1A autoreceptors in GABAergic interneurons in the medial prefrontal cortex and dorsal raphe nuclei in males, and of corticotropin-releasing factor type 2 receptors in GABAergic interneurons in the dorsal raphe nuclei in females."3.83Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring. ( Shoham, S; Weinstock, M; Zohar, I, 2016)
"The objective of the current study is to determine whether the increased anxiety of prenatally stressed (PS) rats of both sexes is associated with changes in 5HT1A and CRF type 2 receptors (5HT1AR and CRFR2) in the prefrontal cortex (PFC)-dorsal raphe nuclei (DRN) axis, and how these are affected by chronic treatment with citalopram (10 mg/kg/day)."3.81Sex dependent reduction by prenatal stress of the expression of 5HT1A receptors in the prefrontal cortex and CRF type 2 receptors in the raphe nucleus in rats: reversal by citalopram. ( Dosoretz-Abittan, L; Shoham, S; Weinstock, M; Zohar, I, 2015)
"Our results provide confirmatory evidence that citalopram exposure is associated with cellular and morphological alterations of the craniofacial complex, which may have important implications for use during pregnancy."3.80Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice. ( Cray, JJ; Elsalanty, M; Howie, RN; Parsons, TE; Weinberg, SM; Yu, JC, 2014)
"A woman treated with citalopram during the entirety of her pregnancy bore a child with Hirschsprung's disease."3.79[Citalopram taken during pregnancy and the child born with Hirschsprung's disease]. ( Nielsen, SW; Qvist, N, 2013)
"These data indicate that: (1) clinically relevant antidepressant treatment during human pregnancy can be modeled in rats using escitalopram; (2) chronic mild stress can be delivered in a manner that does not compromise fetal viability; and (3) neither of these prenatal treatments substantially altered maternal care post parturition."3.79Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment. ( Boss-Williams, KA; Bourke, CH; Capello, CF; Owens, MJ; Rogers, SM; Stowe, ZN; Weiss, JM; Yu, ML, 2013)
" We examined whether treatment with a selective serotonin reuptake inhibitor [escitalopram (ESC)] could downregulate HPA axis activity and restore insulin sensitivity in LBW rats."3.76Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats. ( Buhl, CS; Buhl, ES; Elfving, B; Jensen, TK; Jessen, N; Kristiansen, SB; Lund, S; Petersen, KF; Pold, R; Schmitz, O; Solskov, L; Wegener, G, 2010)
"A term neonate presenting with necrotizing enterocolitis following in utero and breast milk exposure to the newest serotonin selective reuptake inhibitor, escitalopram, is described."3.74Necrotizing enterocolitis associated with in utero and breast milk exposure to the selective serotonin reuptake inhibitor, escitalopram. ( Carter, BS; Potts, AL; Shenai, JP; Young, KL, 2007)
"We describe the case of a pregnancy healthy outcome after in utero consecutive exposure to lamotrigine and citalopram."3.74Consecutive exposure to lamotrigine and citalopram during pregnancy. ( Gentile, S; Vozzi, F, 2007)
"Citalopram use during the period of embryogenesis in pregnancy is not associated with an apparent major teratogenic risk."3.73Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome. ( Einarson, A; Koren, G; Sarkissian, L; Shuhaiber, S; Sivojelezova, A, 2005)
"We describe the first reported case of acute cholestasis due to citalopram (selective serotonin reuptake inhibitor) occurring in a patient who also experienced obstetric cholestasis in association with each of three pregnancies; in a second patient cholestasis developed due to dothiepin (tricyclic antidepressant), and six years later due to paroxetine."3.72Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2). ( Chilton, AP; Elias, E; Hubscher, SG; Milkiewicz, P, 2003)
"Citalopram, fluoxetine and desmethylfluoxetine all cross the human placenta, and may, therefore, affect the perinatal outcome of infants exposed to these drugs during pregnancy."3.71Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta. ( Ekblad, U; Heikkine, T; Laine, K, 2002)
" A population pharmacokinetic model that aimed to better characterize maternal and infant exposure to SCIT and its metabolite was developed."1.56A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk. ( Beaufils, E; Bickle Graz, M; Borradori Tolsa, C; Claris, O; Csajka, C; Eap, CB; Epiney, M; Fischer, CJ; Gaucherand, P; Guidi, M; Hascoët, JM; Kassai-Koupai, B; Morisod Harari, M; Nguyen, KA; Panchaud, A; Rothenburger, S; Rouiller, S; Tolsa, JF; Vial, Y; Weisskopf, E, 2020)
" Serum concentration of citalopram and daily dosage correlated positively while daily dosage and mother milk concentration did not (rho = 0."1.51Antidepressants in breast milk; comparative analysis of excretion ratios. ( Augustin, M; Franz, C; Gründer, G; Paulzen, M; Saßmannshausen, H; Schoretsanitis, G, 2019)
"The median daily dosage of citalopram was 20mg (Q1: 10mg, Q3: 20mg; range 10-40mg)."1.46Pregnancy exposure to citalopram - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood. ( Goecke, TW; Gründer, G; Janssen, G; Paulzen, M; Schoretsanitis, G; Stickeler, E; Stingl, JC, 2017)
"Depression during pregnancy has been linked to in utero stress and is associated with long-lasting symptoms in offspring, including anxiety, helplessness, attentional deficits, and social withdrawal."1.42Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats. ( Bourke, CH; Ehrlich, DE; Hazra, R; Jairam, N; Neigh, GN; Nemeth, CL; Owens, MJ; Rainnie, DG; Rowson, S; Ryan, SJ; Sholar, CA; Stowe, ZN, 2015)
"We suggest the hypothesis that neonatal withdrawal syndrome may follow citalopram serotonin toxicity."1.39Neonatal toxicity following maternal citalopram treatment. ( Bonati, M; Butera, R; Cotti Cottini, F; Eleftheriou, G; Farina, M, 2013)
"Escitalopram is a serotonin reuptake inhibitor prescribed for depression and anxiety."1.38Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study. ( Einarson, A; Einarson, T; Klieger-Grossmann, C; Koren, G; Panchaud, A; Pistelli, A; Weitzner, B, 2012)
"Escitalopram is an antidepressant drug shown to reverse the depressive-like features caused by this stress model."1.38Escitalopram improves memory deficits induced by maternal separation in the rat. ( Batalha, VL; Couto, FS; Data-Franca, J; Lopes, LV; Ribeiro, JA; Valadas, JS, 2012)
"It is important that variations in drug metabolism during pregnancy be considered as these changes may necessitate a dosage adjustment to ensure that therapeutic failure does not occur during pregnancy."1.36Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach. ( Baumer, C; Koren, G; O'Brien, L; Sachs, H; Thieme, D, 2010)
"Citalopram promotes proliferation and differentiation of NPCs from embryonic rat hippocampus."1.34[The effects of citalopram on proliferation and differentiation of neural precursor cells from embryonic rat hippocampus]. ( Chen, BA; Guo, YJ; Teng, GJ; Wang, SH; Zhang, ZJ, 2007)

Research

Studies (86)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (8.14)18.2507
2000's27 (31.40)29.6817
2010's42 (48.84)24.3611
2020's10 (11.63)2.80

Authors

AuthorsStudies
Marks, C1
Silvola, R1
Teal, E1
Quinney, SK1
Haas, DM1
Zahra, A3
Du, L1
Jia, M1
Butt, MU1
Wang, Q2
Wang, Y3
Wu, J1
Olstad, EW1
Nordeng, HME1
Sandve, GK1
Lyle, R1
Gervin, K1
Galbally, M1
Watson, SJ1
Nguyen, T1
Boyce, P1
Hudon Thibeault, AA1
López de Los Santos, Y1
Doucet, N1
Sanderson, JT1
Vaillancourt, C1
Cabrera, RM1
Linda Lin, Y1
Law, E1
Kim, J1
Wlodarczyk, BJ1
Weisskopf, E1
Guidi, M1
Fischer, CJ1
Bickle Graz, M1
Beaufils, E1
Nguyen, KA1
Morisod Harari, M1
Rouiller, S1
Rothenburger, S1
Gaucherand, P1
Kassai-Koupai, B1
Borradori Tolsa, C1
Epiney, M1
Tolsa, JF1
Vial, Y1
Hascoët, JM1
Claris, O1
Eap, CB1
Panchaud, A2
Csajka, C1
Sjaarda, LA1
Radoc, JG1
Flannagan, KS1
Mumford, SL1
Kim, K1
Perkins, NJ1
Silver, RM1
Schisterman, EF1
Colombo, A1
Giordano, F1
Giorgetti, F1
Di Bernardo, I1
Bosi, MF1
Varinelli, A1
Cafaro, R1
Pileri, P1
Cetin, I1
Clementi, E1
Viganò, CA1
Dell'Osso, B1
Burstein, O1
Simon, N1
Simchon-Tenenbaum, Y1
Rehavi, M1
Franko, M1
Shamir, A1
Doron, R1
Liu, K1
Garcia, A1
Park, JJ1
Toliver, AA1
Ramos, L1
Aizenman, CD1
Shea, AK1
Wolfman, W1
Paulzen, M2
Goecke, TW1
Stingl, JC1
Janssen, G1
Stickeler, E1
Gründer, G2
Schoretsanitis, G2
Westin, AA1
Brekke, M1
Molden, E1
Skogvoll, E1
Spigset, O1
Nagano, R1
Nagano, M1
Nakai, A1
Takeshita, T1
Suzuki, H1
Dong, X1
Liu, M1
Sun, A1
Li, N1
Lin, Y1
Geng, Z1
Jin, Y1
Li, X1
Womersley, K1
Ripullone, K1
Agius, M1
Park, SW2
Seo, MK2
Lee, JG2
Hien, LT1
Kim, YH2
Kellner, M1
Porseryd, T1
Porsch-Hällström, I1
Borg, B1
Roufidou, C1
Olsén, KH1
Erol, S1
Ozcan, B1
Celik, IH1
Bas, AY1
Demirel, N1
Jwa, S1
Wada, Y1
Yamamoto, M1
Sumida, Y1
Jiang, J2
Chen, Y2
Long, C2
Yang, L2
Augustin, M1
Saßmannshausen, H1
Franz, C1
Furuse, K1
Ukai, W1
Hashimoto, E1
Hashiguchi, H1
Kigawa, Y1
Ishii, T1
Tayama, M1
Deriha, K1
Shiraishi, M1
Kawanishi, C1
Zheng, Y1
Velasquez, JC3
Zhao, Q1
Chan, Y1
Galindo, LCM1
Simasotchi, C1
Wu, D1
Hou, Z1
Herod, SM2
Oberlander, TF1
Gil, S1
Fournier, T1
Burd, I1
Andrews, AM1
Bonnin, A3
Bourke, CH2
Capello, CF1
Rogers, SM1
Yu, ML1
Boss-Williams, KA1
Weiss, JM1
Stowe, ZN4
Owens, MJ4
Eleftheriou, G1
Butera, R1
Cotti Cottini, F1
Bonati, M1
Farina, M1
Rodgers, AB1
Morgan, CP1
Bronson, SL1
Revello, S1
Bale, TL1
Kouros, N1
Cray, JJ1
Weinberg, SM1
Parsons, TE1
Howie, RN1
Elsalanty, M1
Yu, JC1
Nielsen, SW1
Qvist, N1
Zohar, I2
Dosoretz-Abittan, L1
Shoham, S2
Weinstock, M2
Ehrlich, DE1
Neigh, GN2
Nemeth, CL2
Hazra, R1
Ryan, SJ1
Rowson, S1
Jairam, N1
Sholar, CA1
Rainnie, DG1
Goeden, N1
Ly, NN1
Lee, CH1
Cho, HY1
Choi, CM1
Nhu, LH1
Lee, BJ1
Kim, GM1
Yoon, BJ1
Kelly, SD1
Hardy, EE1
Bourke, C1
Sprowles, JL1
Hufgard, JR1
Gutierrez, A1
Bailey, RA1
Jablonski, SA1
Williams, MT1
Vorhees, CV1
King, JR1
Torii, M1
Kajta, M1
Wnuk, A1
Rzemieniec, J1
Litwa, E1
Lason, W1
Zelek-Molik, A1
Nalepa, I1
Rogóż, Z1
Grochowalski, A1
Wojtowicz, AK1
Frison, G1
Favretto, D1
Vogliardi, S1
Terranova, C1
Ferrara, SD1
Gentile, S3
Tixier, H1
Feyeux, C1
Girod, S1
Thouvenot, S1
Morisse, M1
Douvier, S1
Sagot, P1
Davidson, S1
Prokonov, D1
Taler, M1
Maayan, R1
Harell, D1
Gil-Ad, I1
Weizman, A1
Lanza di Scalea, T1
Wisner, KL2
Werremeyer, A1
O'Brien, L1
Baumer, C1
Thieme, D1
Sachs, H1
Koren, G3
Buhl, ES1
Jensen, TK1
Jessen, N1
Elfving, B1
Buhl, CS1
Kristiansen, SB1
Pold, R1
Solskov, L1
Schmitz, O1
Wegener, G1
Lund, S1
Petersen, KF1
Chisolm, MS1
Brigham, EP1
Tuten, M1
Strain, EC1
Jones, HE1
Tuccori, M1
Montagnani, S1
Testi, A1
Ruggiero, E1
Mantarro, S1
Scollo, C1
Pergola, A1
Fornai, M1
Antonioli, L1
Colucci, R1
Corona, T1
Blandizzi, C1
Weaver, KJ1
Paul, IA4
Lin, RC3
Simpson, KL3
Patel, BN1
Beste, J1
Blackwell, JC1
Klieger-Grossmann, C1
Weitzner, B1
Pistelli, A1
Einarson, T1
Einarson, A2
Darling, RD1
Alzghoul, L1
Zhang, J1
Khatri, N1
Misri, S1
Abizadeh, J1
Albert, G1
Carter, D1
Ryan, D1
Couto, FS1
Batalha, VL1
Valadas, JS1
Data-Franca, J1
Ribeiro, JA1
Lopes, LV1
Bellantuono, C1
Bozzi, F1
Orsolini, L1
Catena-Dell'Osso, M1
Heikkinen, T1
Ekblad, U2
Kero, P1
Ekblad, S1
Laine, K2
Heikkine, T1
Milkiewicz, P1
Chilton, AP1
Hubscher, SG1
Elias, E1
Hendrick, V1
Altshuler, LL1
Hwang, S1
Lee, E1
Haynes, D1
Arborelius, L1
Hawks, BW1
Plotsky, PM1
Nemeroff, CB1
Wu, CC1
Chen, JY1
Tao, PL1
Chen, YA1
Yeh, GC1
Maciag, D2
Coppinger, D2
Lu, Y1
Sivojelezova, A1
Shuhaiber, S1
Sarkissian, L1
Hsiao, SY1
Cherng, CF1
Yang, YK1
Yeh, TL1
Yu, L1
Potts, AL1
Young, KL1
Carter, BS1
Shenai, JP1
Majewski, S1
Donnenfeld, AE1
Kuhlman, K1
Patel, A1
Kraft, K1
Vozzi, F1
Wang, SH1
Zhang, ZJ1
Guo, YJ1
Teng, GJ1
Chen, BA1
Kwon, P1
Lefkowitz, W1
Sit, DK1
Perel, JM1
Helsel, JC1
Blatt, GJ1
Chen, JC1
Rosene, DL1
Volicer, L1
Galler, JR1
Cabrera, TM1
Levy, AD1
Li, Q1
van de Kar, LD1
Battaglia, G1
Seifritz, E1
Holsboer-Trachsler, E1
Haberthur, F1
Hemmeter, U1
Pöldinger, W1
Kim, JA1
Druse, MJ1
Mortensen, OV1
Kristensen, AS1
Rudnick, G1
Wiborg, O1
Snider, RD1
Yan, QS1
Bal, AK1
Bird, MM2
Bal-Klara, A1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Antidepressant Treatments During Pregnancy and Lactation: Prediction of Drug Exposure Through Breastfeeding and Evaluation of Drug Effect on the Neonatal Adaptation and the Development of the Young Child[NCT01796132]Phase 4500 participants (Anticipated)Interventional2012-08-31Recruiting
The Effects of Aspirin in Gestation and Reproduction: A Multi-center, Controlled, Double-blind Randomized Trial.[NCT00467363]1,228 participants (Actual)Interventional2007-06-30Completed
Perinatal Stress and Gene Influences: Pathways to Infant Vulnerability[NCT00525226]1,431 participants (Actual)Observational2007-09-30Completed
Antidepressant Use During Pregnancy[NCT00279370]283 participants (Actual)Observational1999-09-30Completed
A Prospective Study of Pregnant and Postpartum Women With and Without Mood Disorders[NCT03615794]400 participants (Anticipated)Observational2017-10-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Abruption

Partial or complete abruption (ie, premature separation of the placenta) (NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin7
Placebo5

Clinically Recognized Pregnancy

(NCT00467363)
Timeframe: 8-weeks

Interventionpregnancy (Number)
Aspirin374
Placebo346

Early Pregnancy Loss (EPL)

Implantation failures (NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin28
Placebo27

Ectopic Pregnancy

(NCT00467363)
Timeframe: within 6 weeks

Interventionpregnancy (Number)
Aspirin3
Placebo3

Fetal Pregnancy Loss

(NCT00467363)
Timeframe: until 40 weeks

Interventionpregnancy (Number)
Aspirin4
Placebo6

hCG Recognized Pregnancy

(NCT00467363)
Timeframe: within 8-weeks of gestation

Interventionpregnancy (Number)
Aspirin394
Placebo363

Live Birth

Live birth was obtained prospectively by maternal report and abstraction from medical records by trained staff . (NCT00467363)
Timeframe: after delivery

Interventionlivebirths (Number)
Aspirin309
Placebo286

Molar Pregnancy

(NCT00467363)
Timeframe: 8 weeks

Interventionpregnancy (Number)
Aspirin0
Placebo0

Preeclampsia

(NCT00467363)
Timeframe: until delivery

Interventionparticipants (Number)
Aspirin32
Placebo30

Pregnancy Losses Occurring Less Than 10 Weeks

Includes preembryonic and embryonic losses (exclusive of implantation failures) (NCT00467363)
Timeframe: less than 10-weeks

Interventionpregnancy (Number)
Aspirin56
Placebo53

Preterm Birth

(NCT00467363)
Timeframe: until delivery

Interventioninfants (Number)
Aspirin22
Placebo31

Small for Gestational Age Infant

birthweight (NCT00467363)
Timeframe: until delivery

Interventiongrams (Mean)
Aspirin3327
Placebo3315

Stillbirth

(NCT00467363)
Timeframe: 40 weeks

Interventionparticipants (Number)
Aspirin2
Placebo2

Reviews

5 reviews available for citalopram and Pregnancy

ArticleYear
What are the risks associated with different Selective Serotonin Re-uptake Inhibitors (SSRIs) to treat depression and anxiety in pregnancy? An evaluation of current evidence.
    Psychiatria Danubina, 2017, Volume: 29, Issue:Suppl 3

    Topics: Adult; Anxiety; Citalopram; Depression; Female; Humans; Paroxetine; Pregnancy; Pregnancy Complicatio

2017
Antidepressant medication use during breastfeeding.
    Clinical obstetrics and gynecology, 2009, Volume: 52, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Breast Feeding; Citalopram; Depression, Postpartum; Female

2009
Use of selective serotonin reuptake inhibitors during pregnancy and risk of major and cardiovascular malformations: an update.
    Postgraduate medicine, 2010, Volume: 122, Issue:4

    Topics: Abnormalities, Drug-Induced; Cardiovascular Abnormalities; Citalopram; Depression; Female; Fluoxetin

2010
The safety of escitalopram during pregnancy and breastfeeding: a comprehensive review.
    Human psychopharmacology, 2012, Volume: 27, Issue:6

    Topics: Abnormalities, Drug-Induced; Antidepressive Agents, Second-Generation; Breast Feeding; Citalopram; E

2012
[New developments in hypericum extracts: data on efficacy and interactions].
    Wiener medizinische Wochenschrift (1946), 2007, Volume: 157, Issue:13-14

    Topics: Adolescent; Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Bridg

2007

Trials

5 trials available for citalopram and Pregnancy

ArticleYear
Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013, May-22, Volume: 33, Issue:21

    Topics: Acoustic Stimulation; Adaptation, Ocular; Analysis of Variance; Animals; Animals, Newborn; Citalopra

2013
The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.
    The American journal of drug and alcohol abuse, 2010, Volume: 36, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Citalopram; Depressive Disorder, Major;

2010
Restoration of functionality in postpartum depressed mothers: an open-label study with escitalopram.
    Journal of clinical psychopharmacology, 2012, Volume: 32, Issue:5

    Topics: Adult; Citalopram; Depression, Postpartum; Female; Humans; Pregnancy; Prospective Studies; Quality o

2012
Citalopram in pregnancy and lactation.
    Clinical pharmacology and therapeutics, 2002, Volume: 72, Issue:2

    Topics: Adult; Analysis of Variance; Antidepressive Agents, Second-Generation; Child Development; Citalopram

2002
Changes in antidepressant metabolism and dosing across pregnancy and early postpartum.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Depression, Postpartum; Depressive Diso

2008
Changes in antidepressant metabolism and dosing across pregnancy and early postpartum.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Depression, Postpartum; Depressive Diso

2008
Changes in antidepressant metabolism and dosing across pregnancy and early postpartum.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Depression, Postpartum; Depressive Diso

2008
Changes in antidepressant metabolism and dosing across pregnancy and early postpartum.
    The Journal of clinical psychiatry, 2008, Volume: 69, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Depression, Postpartum; Depressive Diso

2008

Other Studies

76 other studies available for citalopram and Pregnancy

ArticleYear
Comparing newborn outcomes after prenatal exposure to individual antidepressants: A retrospective cohort study.
    Pharmacotherapy, 2021, Volume: 41, Issue:11

    Topics: Antidepressive Agents; Bupropion; Citalopram; Duloxetine Hydrochloride; Escitalopram; Female; Fluoxe

2021
Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice.
    Journal of integrative neuroscience, 2022, Mar-23, Volume: 21, Issue:2

    Topics: Animals; Anxiety; Citalopram; Depression; Depressive Disorder, Major; Female; Male; Mice; Mice, Inbr

2022
Effects of prenatal exposure to (es)citalopram and maternal depression during pregnancy on DNA methylation and child neurodevelopment.
    Translational psychiatry, 2023, 05-05, Volume: 13, Issue:1

    Topics: Child; Citalopram; Cohort Studies; Depression; DNA Methylation; Female; Humans; Infant, Newborn; Pre

2023
Fetal SSRI antidepressant exposure and infant sleep: Findings from the MPEWS pregnancy cohort study.
    Infant behavior & development, 2023, Volume: 72

    Topics: Antidepressive Agents; Citalopram; Cohort Studies; Escitalopram; Female; Humans; Infant; Longitudina

2023
Serotonin and serotonin reuptake inhibitors alter placental aromatase.
    The Journal of steroid biochemistry and molecular biology, 2019, Volume: 195

    Topics: Aromatase; Cells, Cultured; Citalopram; Female; Fluoxetine; Humans; Molecular Docking Simulation; Pa

2019
The teratogenic effects of sertraline in mice.
    Birth defects research, 2020, Volume: 112, Issue:13

    Topics: Animals; Citalopram; Female; Humans; Mice; Mice, Inbred ICR; Paroxetine; Pregnancy; Selective Seroto

2020
A population pharmacokinetic model for escitalopram and its major metabolite in depressive patients during the perinatal period: Prediction of infant drug exposure through breast milk.
    British journal of clinical pharmacology, 2020, Volume: 86, Issue:8

    Topics: Animals; Breast Feeding; Citalopram; Female; Humans; Infant; Milk, Human; Pharmaceutical Preparation

2020
Urinary selective serotonin reuptake inhibitors across critical windows of pregnancy establishment: a prospective cohort study of fecundability and pregnancy loss.
    Fertility and sterility, 2020, Volume: 114, Issue:6

    Topics: Abortion, Spontaneous; Adult; Citalopram; Female; Fertility; Fluoxetine; Humans; Live Birth; Pregnan

2020
Correlation between pharmacokinetics and pharmacogenetics of Selective Serotonin Reuptake Inhibitors and Selective Serotonin and Noradrenaline Reuptake Inhibitors and maternal and neonatal outcomes: Results from a naturalistic study in patients with affec
    Human psychopharmacology, 2021, Volume: 36, Issue:3

    Topics: Citalopram; Escitalopram; Female; Humans; Mood Disorders; Pharmacogenetics; Pregnancy; Selective Ser

2021
Moderation of the transgenerational transference of antenatal stress-induced anxiety.
    Translational psychiatry, 2021, 05-04, Volume: 11, Issue:1

    Topics: Animals; Anxiety; Citalopram; COVID-19; Crataegus; Disease Models, Animal; Drugs, Chinese Herbal; Fe

2021
Early Developmental Exposure to Fluoxetine and Citalopram Results in Different Neurodevelopmental Outcomes.
    Neuroscience, 2021, 07-15, Volume: 467

    Topics: Anxiety; Citalopram; Female; Fluoxetine; Humans; Patch-Clamp Techniques; Pregnancy; Selective Seroto

2021
The role of hormone therapy in the management of severe postpartum depression in patients with Turner syndrome.
    Menopause (New York, N.Y.), 2017, Volume: 24, Issue:11

    Topics: Adult; Citalopram; Depression, Postpartum; Diagnosis, Differential; Estrogen Replacement Therapy; Fe

2017
Pregnancy exposure to citalopram - Therapeutic drug monitoring in maternal blood, amniotic fluid and cord blood.
    Progress in neuro-psychopharmacology & biological psychiatry, 2017, 10-03, Volume: 79, Issue:Pt B

    Topics: Adult; Amniotic Fluid; Citalopram; Cordocentesis; Dose-Response Relationship, Drug; Drug Monitoring;

2017
Selective serotonin reuptake inhibitors and venlafaxine in pregnancy: Changes in drug disposition.
    PloS one, 2017, Volume: 12, Issue:7

    Topics: Adult; Antidepressive Agents; Citalopram; Databases, Factual; Depressive Disorder; Drug Monitoring;

2017
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring.
    Neuroscience, 2017, Sep-30, Volume: 360

    Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Disease Models, Animal; Female; Fluoxetine;

2017
Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2017, Volume: 62

    Topics: Age Factors; Animals; Animals, Newborn; Anxiety, Separation; Brain; Citalopram; Cytokines; Depressio

2017
Effects of maternal separation and antidepressant drug on epigenetic regulation of the brain-derived neurotrophic factor exon I promoter in the adult rat hippocampus.
    Psychiatry and clinical neurosciences, 2018, Volume: 72, Issue:4

    Topics: Acetylation; Animals; Antidepressive Agents, Second-Generation; Brain-Derived Neurotrophic Factor; C

2018
Developmental exposure to the SSRI citalopram causes long-lasting behavioural effects in the three-spined stickleback (Gasterosteus aculeatus).
    Ecotoxicology (London, England), 2018, Volume: 27, Issue:1

    Topics: Animals; Behavior, Animal; Citalopram; Female; Pregnancy; Selective Serotonin Reuptake Inhibitors; S

2018
Neonatal abstinence syndrome due to prenatally citalopram exposure: A case report.
    Archivos argentinos de pediatria, 2017, Dec-01, Volume: 115, Issue:6

    Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; F

2017
Neonatal morbidity due to maternal use of two antidepressant drugs.
    Pediatrics international : official journal of the Japan Pediatric Society, 2018, Volume: 60, Issue:1

    Topics: Anti-Anxiety Agents; Antidepressive Agents; Benzodiazepines; Citalopram; Drug Therapy, Combination;

2018
Memantine rescues prenatal citalopram exposure-induced striatal and social abnormalities in mice.
    Experimental neurology, 2018, Volume: 307

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Citalopram; Corpus Striatum; Excitatory

2018
Antidepressants in breast milk; comparative analysis of excretion ratios.
    Archives of women's mental health, 2019, Volume: 22, Issue:3

    Topics: Adult; Antidepressive Agents; Breast Feeding; Child Development; Citalopram; Depression; Female; Hum

2019
Antidepressant activities of escitalopram and blonanserin on prenatal and adolescent combined stress-induced depression model: Possible role of neurotrophic mechanism change in serum and nucleus accumbens.
    Journal of affective disorders, 2019, 03-15, Volume: 247

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Citalopram; Cor

2019
Exposure to prenatal antidepressant alters medial prefrontal-striatal synchronization in mice.
    Brain research, 2019, 08-15, Volume: 1717

    Topics: Animals; Antidepressive Agents; Anxiety; Brain; Citalopram; Corpus Striatum; Dendrites; Depression;

2019
    ACS chemical neuroscience, 2019, 07-17, Volume: 10, Issue:7

    Topics: Animals; Brain; Citalopram; Disease Models, Animal; Female; Fetal Development; Magnetic Resonance Im

2019
Prenatal exposure to escitalopram and/or stress in rats: a prenatal stress model of maternal depression and its treatment.
    Psychopharmacology, 2013, Volume: 228, Issue:2

    Topics: Animals; Citalopram; Corticosterone; Darkness; Depression; Disease Models, Animal; Female; Infusion

2013
Neonatal toxicity following maternal citalopram treatment.
    Fetal and pediatric pathology, 2013, Volume: 32, Issue:5

    Topics: Citalopram; Depressive Disorder, Major; Diagnosis, Differential; Female; Half-Life; Humans; Infant,

2013
Warning of risk to foetus for mothers using SSRIs.
    Monash bioethics review, 2013, Volume: 31, Issue:2

    Topics: Abnormalities, Drug-Induced; Citalopram; Depressive Disorder; Female; Humans; Pregnancy; Pregnancy C

2013
Selective serotonin reuptake inhibitor exposure alters osteoblast gene expression and craniofacial development in mice.
    Birth defects research. Part A, Clinical and molecular teratology, 2014, Volume: 100, Issue:12

    Topics: Animals; Biomarkers; Cells, Cultured; Citalopram; Craniofacial Abnormalities; Female; Gene Expressio

2014
[Citalopram taken during pregnancy and the child born with Hirschsprung's disease].
    Ugeskrift for laeger, 2013, Dec-09, Volume: 175, Issue:50A

    Topics: Abnormalities, Drug-Induced; Citalopram; Female; Hirschsprung Disease; Humans; Infant, Newborn; Preg

2013
Sex dependent reduction by prenatal stress of the expression of 5HT1A receptors in the prefrontal cortex and CRF type 2 receptors in the raphe nucleus in rats: reversal by citalopram.
    Psychopharmacology, 2015, Volume: 232, Issue:9

    Topics: Animals; Anxiety; Citalopram; Corticotropin-Releasing Hormone; Dorsal Raphe Nucleus; Female; GABAerg

2015
Prenatal stress, regardless of concurrent escitalopram treatment, alters behavior and amygdala gene expression of adolescent female rats.
    Neuropharmacology, 2015, Volume: 97

    Topics: Amygdala; Animals; Anxiety; Citalopram; Corticosterone; Disease Models, Animal; Estradiol; Female; g

2015
Perinatal citalopram does not prevent the effect of prenatal stress on anxiety, depressive-like behaviour and serotonergic transmission in adult rat offspring.
    The European journal of neuroscience, 2016, Volume: 43, Issue:4

    Topics: Animals; Anxiety; Autoreceptors; Behavior, Animal; Citalopram; Corticotropin-Releasing Hormone; Dise

2016
Maternal Pharmacokinetics and Fetal Disposition of (±)-Citalopram during Mouse Pregnancy.
    ACS chemical neuroscience, 2016, Mar-16, Volume: 7, Issue:3

    Topics: Animals; Chromatography, High Pressure Liquid; Citalopram; Female; Fetus; Mice; Pregnancy; Prenatal

2016
Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus.
    Neuropharmacology, 2016, Volume: 105

    Topics: Adult; Animals; Antidepressive Agents, Second-Generation; Anxiety, Separation; Brain-Derived Neurotr

2016
Prenatal stress-induced increases in hippocampal von Willebrand factor expression are prevented by concurrent prenatal escitalopram.
    Physiology & behavior, 2017, 04-01, Volume: 172

    Topics: Age Factors; Amygdala; Angiogenic Proteins; Animals; Citalopram; Female; Hippocampus; Male; Prefront

2017
Perinatal exposure to the selective serotonin reuptake inhibitor citalopram alters spatial learning and memory, anxiety, depression, and startle in Sprague-Dawley rats.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2016, Volume: 54

    Topics: Age Factors; Amphetamines; Animals; Animals, Newborn; Anxiety; Body Weight; Citalopram; Depression;

2016
Effect of Maternal ±Citalopram Exposure on P11 Expression and Neurogenesis in the Mouse Fetal Brain.
    ACS chemical neuroscience, 2017, 05-17, Volume: 8, Issue:5

    Topics: Animals; Axons; Citalopram; Female; Maternal Exposure; Mice; Neurogenesis; Neurons; Pregnancy; Selec

2017
Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.
    The Journal of steroid biochemistry and molecular biology, 2017, Volume: 171

    Topics: Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Brain; Citalopram; DDT; Depress

2017
Quantification of citalopram or escitalopram and their demethylated metabolites in neonatal hair samples by liquid chromatography-tandem mass spectrometry.
    Therapeutic drug monitoring, 2008, Volume: 30, Issue:4

    Topics: Adult; Calibration; Chromatography, High Pressure Liquid; Citalopram; Female; Hair; Humans; Infant,

2008
Use of escitalopram during pregnancy: navigating towards international guidelines and the real world.
    Clinical drug investigation, 2008, Volume: 28, Issue:11

    Topics: Adult; Citalopram; Female; Fetus; Humans; Infant, Newborn; International Cooperation; Lactation; Liv

2008
Acute voluntary intoxication with selective serotonin reuptake inhibitors during the third trimester of pregnancy: therapeutic management of mother and fetus.
    American journal of obstetrics and gynecology, 2008, Volume: 199, Issue:5

    Topics: Adrenal Cortex Hormones; Adult; Antidotes; Calcium Channel Blockers; Charcoal; Citalopram; Depressio

2008
Effect of exposure to selective serotonin reuptake inhibitors in utero on fetal growth: potential role for the IGF-I and HPA axes.
    Pediatric research, 2009, Volume: 65, Issue:2

    Topics: Adult; Birth Weight; Case-Control Studies; Citalopram; Female; Fetal Blood; Fetal Development; Fetal

2009
Ziprasidone and citalopram use in pregnancy and lactation in a woman with psychotic depression.
    The American journal of psychiatry, 2009, Volume: 166, Issue:11

    Topics: Adult; Affective Disorders, Psychotic; Antipsychotic Agents; Citalopram; Drug Therapy, Combination;

2009
Changes in antidepressant metabolism in pregnancy evidenced by metabolic ratios in hair: a novel approach.
    Forensic science international, 2010, Mar-20, Volume: 196, Issue:1-3

    Topics: Adult; Antidepressive Agents; Citalopram; Cyclohexanols; Female; Fluoxetine; Gas Chromatography-Mass

2010
Treatment with an SSRI antidepressant restores hippocampo-hypothalamic corticosteroid feedback and reverses insulin resistance in low-birth-weight rats.
    American journal of physiology. Endocrinology and metabolism, 2010, Volume: 298, Issue:5

    Topics: Adrenocorticotropic Hormone; Analysis of Variance; Animals; Area Under Curve; Blood Glucose; Body We

2010
Neonatal exposure to citalopram selectively alters the expression of the serotonin transporter in the hippocampus: dose-dependent effects.
    Anatomical record (Hoboken, N.J. : 2007), 2010, Volume: 293, Issue:11

    Topics: Animals; Animals, Newborn; Caudate Nucleus; Cerebral Cortex; Citalopram; Cognition; Dose-Response Re

2010
Antidepressant use during pregnancy. FPIN’s clinical inquiries.
    American family physician, 2011, May-15, Volume: 83, Issue:10

    Topics: Adult; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Citalopram; Cyclo

2011
Pregnancy outcomes following use of escitalopram: a prospective comparative cohort study.
    Journal of clinical pharmacology, 2012, Volume: 52, Issue:5

    Topics: Abnormalities, Drug-Induced; Abortion, Spontaneous; Abortion, Therapeutic; Analysis of Variance; Ant

2012
Perinatal citalopram exposure selectively increases locus ceruleus circuit function in male rats.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Nov-16, Volume: 31, Issue:46

    Topics: Action Potentials; Animals; Animals, Newborn; Citalopram; Dopamine beta-Hydroxylase; Female; Locus C

2011
Escitalopram improves memory deficits induced by maternal separation in the rat.
    European journal of pharmacology, 2012, Nov-15, Volume: 695, Issue:1-3

    Topics: Animals; Antidepressive Agents; Anxiety, Separation; Behavior, Animal; Citalopram; Cognition; Female

2012
Transplacental transfer of citalopram, fluoxetine and their primary demethylated metabolites in isolated perfused human placenta.
    BJOG : an international journal of obstetrics and gynaecology, 2002, Volume: 109, Issue:9

    Topics: Citalopram; Female; Fluoxetine; Humans; Maternal-Fetal Exchange; Placenta; Pregnancy; Prospective St

2002
Antidepressant induced cholestasis: hepatocellular redistribution of multidrug resistant protein (MRP2).
    Gut, 2003, Volume: 52, Issue:2

    Topics: Acute Disease; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressiv

2003
Placental passage of antidepressant medications.
    The American journal of psychiatry, 2003, Volume: 160, Issue:5

    Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder; Dose-Response Relationship, Drug; Fem

2003
Increased responsiveness of presumed 5-HT cells to citalopram in adult rats subjected to prolonged maternal separation relative to brief separation.
    Psychopharmacology, 2004, Volume: 176, Issue:3-4

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Binding Sites; Citalopram; Dose-Re

2004
Neonatal complications after intrauterine exposure to SSRI antidepressants.
    Prescrire international, 2004, Volume: 13, Issue:71

    Topics: Antidepressive Agents; Citalopram; Depression; Female; Fluoxetine; Fluvoxamine; Follow-Up Studies; F

2004
Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine.
    European journal of pharmacology, 2005, Apr-04, Volume: 512, Issue:1

    Topics: Animals; Animals, Newborn; Behavior, Animal; Citalopram; Clomipramine; Female; Fluoxetine; Maternal-

2005
Neonatal antidepressant exposure has lasting effects on behavior and serotonin circuitry.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2006, Volume: 31, Issue:1

    Topics: Animals; Animals, Newborn; Antidepressive Agents; Antidepressive Agents, Tricyclic; Antigens, Nuclea

2006
Citalopram use in pregnancy: prospective comparative evaluation of pregnancy and fetal outcome.
    American journal of obstetrics and gynecology, 2005, Volume: 193, Issue:6

    Topics: Antidepressive Agents, Second-Generation; Birth Weight; Citalopram; Female; Gestational Age; Humans;

2005
Prenatal bupropion exposure enhances the cocaine reward and stress susceptibility in adult mice.
    The Chinese journal of physiology, 2005, Dec-31, Volume: 48, Issue:4

    Topics: Animals; Antidepressive Agents, Second-Generation; Anxiety; Bupropion; Citalopram; Cocaine; Conditio

2005
Escitalopram late in pregnancy and while breast-feeding.
    The Annals of pharmacotherapy, 2006, Volume: 40, Issue:9

    Topics: Adult; Breast Feeding; Citalopram; Depressive Disorder, Major; Female; Humans; Infant, Newborn; Male

2006
Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.
    Brain research, 2006, Dec-13, Volume: 1125, Issue:1

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Age Factors; Analysis of Variance; Animals; Animals, Newborn

2006
Necrotizing enterocolitis associated with in utero and breast milk exposure to the selective serotonin reuptake inhibitor, escitalopram.
    Journal of perinatology : official journal of the California Perinatal Association, 2007, Volume: 27, Issue:2

    Topics: Citalopram; Enterocolitis, Necrotizing; Female; Humans; Infant, Newborn; Milk, Human; Pregnancy; Pre

2007
Second-trimester prenatal diagnosis of total arhinia.
    Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2007, Volume: 26, Issue:3

    Topics: Abortion, Eugenic; Adolescent; Antidepressive Agents, Second-Generation; Citalopram; Craniofacial Ab

2007
Consecutive exposure to lamotrigine and citalopram during pregnancy.
    Archives of women's mental health, 2007, Volume: 10, Issue:6

    Topics: Antidepressive Agents, Second-Generation; Anxiety; Citalopram; Depression; Drug Administration Sched

2007
[The effects of citalopram on proliferation and differentiation of neural precursor cells from embryonic rat hippocampus].
    Zhonghua yi xue za zhi, 2007, Oct-23, Volume: 87, Issue:39

    Topics: Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Citalopram; Dose-

2007
Neonatal extrapyramidal movements. Neonatal withdrawal due to maternal citalopram and ondansetron use.
    Pediatric annals, 2008, Volume: 37, Issue:3

    Topics: Adult; Anti-Anxiety Agents; Basal Ganglia Diseases; Citalopram; Female; Humans; Infant, Newborn; Lor

2008
Prenatal protein malnutrition effects on the serotonergic system in the hippocampal formation: an immunocytochemical, ligand binding, and neurochemical study.
    Brain research bulletin, 1994, Volume: 34, Issue:5

    Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Chromatography, High Pressure Liquid; Citalopram; F

1994
Prenatal methamphetamine attenuates serotonin mediated renin secretion in male and female rat progeny: evidence for selective long-term dysfunction of serotonin pathways in brain.
    Synapse (New York, N.Y.), 1993, Volume: 15, Issue:3

    Topics: Analysis of Variance; Animals; Body Weight; Brain; Cerebral Cortex; Citalopram; Female; Hypothalamus

1993
Unrecognized pregnancy during citalopram treatment.
    The American journal of psychiatry, 1993, Volume: 150, Issue:9

    Topics: Abortion, Induced; Adult; Citalopram; Depressive Disorder; Female; Fetus; Humans; Maternal-Fetal Exc

1993
Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring.
    Brain research. Developmental brain research, 1996, Apr-30, Volume: 92, Issue:2

    Topics: Animals; Autoradiography; Brain; Brain Chemistry; Buspirone; Central Nervous System Depressants; Cit

1996
Molecular cloning, expression and characterization of a bovine serotonin transporter.
    Brain research. Molecular brain research, 1999, Jul-23, Volume: 71, Issue:1

    Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cattle; Citalopram; Cloning, Molecular; Desipramine;

1999
Case report: left bundle branch block--a rare complication of citalopram overdose.
    Journal of the South Carolina Medical Association (1975), 2001, Volume: 97, Issue:9

    Topics: Adult; Bundle-Branch Block; Citalopram; Drug Overdose; Female; Humans; Pregnancy; Selective Serotoni

2001
Reduced serotonin release and serotonin uptake sites in the rat nucleus accumbens and striatum after prenatal cocaine exposure.
    Brain research, 2002, Mar-01, Volume: 929, Issue:1

    Topics: Animals; Animals, Newborn; Citalopram; Cocaine; Cocaine-Related Disorders; Electric Stimulation; Fem

2002
Changes in the amount and distribution of neuronal alkaline and acid phosphatase after chronic exposure of cultures of cingulate cortex to antidepressant drugs.
    Journal of neural transmission. General section, 1992, Volume: 90, Issue:1

    Topics: Acid Phosphatase; Alkaline Phosphatase; Amitriptyline; Animals; Antidepressive Agents; Cells, Cultur

1992
The effects of various antidepressant drugs on the fine-structure of neurons of the cingulate cortex in culture.
    Neuroscience, 1990, Volume: 37, Issue:3

    Topics: Amitriptyline; Animals; Antidepressive Agents; Citalopram; Cytoskeleton; Desipramine; Female; Gyrus

1990