citalopram has been researched along with Nerve Degeneration in 7 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with citalopram was effective in reversing the behavioral deficits induced by bulbectomy, but did not protect against neurodegeneration." | 1.34 | Antidepressant-mediated reversal of abnormal behavior and neurodegeneration in mice following olfactory bulbectomy. ( Jarosik, J; Legutko, B; Unsicker, K; von Bohlen Und Halbach, O, 2007) |
| "Depression is the most common psychiatric complication in Parkinson's disease (PD)." | 1.34 | Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats. ( Juckel, G; Klein, J; Kupsch, A; Lee, T; Morgenstern, R; Mundt, A; Petrus, D; von Rumohr, A; Winter, C, 2007) |
| "Dexfenfluramine treatment decreased the density of 5-HT uptake sites in the cortex, labelled with [3H]-citalopram, but this partially recovered towards control values at 60 days." | 1.29 | Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats. ( Collins, P; Hindmarsh, JG; Hunt, S; Jenner, P; Rose, S, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 2 (28.57) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, IH | 1 |
| Ma, KH | 1 |
| Kao, TJ | 1 |
| Lin, YY | 1 |
| Weng, SJ | 1 |
| Yen, TY | 1 |
| Chen, LC | 1 |
| Huang, YS | 1 |
| Hannestad, J | 1 |
| Jarosik, J | 1 |
| Legutko, B | 1 |
| Unsicker, K | 1 |
| von Bohlen Und Halbach, O | 1 |
| Winter, C | 1 |
| von Rumohr, A | 1 |
| Mundt, A | 1 |
| Petrus, D | 1 |
| Klein, J | 1 |
| Lee, T | 1 |
| Morgenstern, R | 1 |
| Kupsch, A | 1 |
| Juckel, G | 1 |
| Gobbi, M | 1 |
| Regondi, MC | 1 |
| Pompeiano, M | 1 |
| Palacios, JM | 1 |
| Mennini, T | 1 |
| Rose, S | 1 |
| Hunt, S | 1 |
| Collins, P | 1 |
| Hindmarsh, JG | 1 |
| Jenner, P | 1 |
| Le Marec, N | 1 |
| Hébert, C | 1 |
| Amdiss, F | 1 |
| Botez, MI | 1 |
| Reader, TA | 1 |
7 other studies available for citalopram and Nerve Degeneration
| Article | Year |
|---|---|
Involvement of autophagy upregulation in 3,4-methylenedioxymethamphetamine ('ecstasy')-induced serotonergic neurotoxicity.
Topics: Adenine; Animals; Autophagy; Benzylamines; Brain Stem; Cells, Cultured; Citalopram; Dose-Response Re | 2016 |
Comment on "Paroxetine prevents loss of nigrostriatal dopaminergic neurons by inhibiting brain inflammation and oxidative stress in an experimental model of Parkinson's disease".
Topics: Animals; Anti-Inflammatory Agents; Brain; Citalopram; Encephalitis; Humans; Inflammation; Lipopolysa | 2010 |
Antidepressant-mediated reversal of abnormal behavior and neurodegeneration in mice following olfactory bulbectomy.
Topics: Amitriptyline; Amygdala; Animals; Antidepressive Agents; Antidepressive Agents, Second-Generation; A | 2007 |
Lesions of dopaminergic neurons in the substantia nigra pars compacta and in the ventral tegmental area enhance depressive-like behavior in rats.
Topics: Adrenergic Agents; Amphetamine; Analysis of Variance; Animals; Antidepressive Agents; Behavior, Anim | 2007 |
Differential effects of 5,7-dihydroxytryptamine-induced serotoninergic degeneration of 5-HT1A receptors and 5-HT uptake sites in the rat brain.
Topics: 5,7-Dihydroxytryptamine; 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Autoradiography; Brain; Ci | 1994 |
Repeated administration of escalating high doses of dexfenfluramine does not produce morphological evidence for neurotoxicity in the cortex of rats.
Topics: Animals; Appetite Depressants; Binding Sites; Biomarkers; Cerebral Cortex; Citalopram; Fenfluramine; | 1996 |
Regional distribution of 5-HT transporters in the brain of wild type and 'Purkinje cell degeneration' mutant mice: a quantitative autoradiographic study with [3H]citalopram.
Topics: Animals; Autoradiography; Basal Ganglia; Brain Chemistry; Brain Stem; Carrier Proteins; Citalopram; | 1998 |