Page last updated: 2024-10-25

citalopram and Heart Failure

citalopram has been researched along with Heart Failure in 10 studies

Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.

Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"To determine whether 24 months of treatment with escitalopram improves mortality, morbidity, and mood in patients with chronic systolic heart failure and depression."9.22Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial. ( Angermann, CE; Blankenberg, S; Böhm, M; Deckert, J; Edelmann, F; Ertl, G; Faller, H; Gelbrich, G; Gottwik, M; Graf, T; Gunold, H; Haass, M; Kindermann, I; Pankuweit, S; Prettin, C; Schunkert, H; Störk, S; Wachter, R, 2016)
"Citalopram treatment of MDD in older patients with heart failure is well-tolerated with low rates of side effects, but was not significantly more effective than placebo in the treatment of depression."9.14A double-blind, placebo-controlled treatment trial of citalopram for major depressive disorder in older patients with heart failure: the relevance of the placebo effect and psychological symptoms. ( Alves, TC; Andrei, AM; da Silva Telles, RM; Fraguas, R; Iosifescu, DV; Rays, J; Wajngarten, M, 2009)
"To determine whether 24 months of treatment with escitalopram improves mortality, morbidity, and mood in patients with chronic systolic heart failure and depression."5.22Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial. ( Angermann, CE; Blankenberg, S; Böhm, M; Deckert, J; Edelmann, F; Ertl, G; Faller, H; Gelbrich, G; Gottwik, M; Graf, T; Gunold, H; Haass, M; Kindermann, I; Pankuweit, S; Prettin, C; Schunkert, H; Störk, S; Wachter, R, 2016)
"Citalopram treatment of MDD in older patients with heart failure is well-tolerated with low rates of side effects, but was not significantly more effective than placebo in the treatment of depression."5.14A double-blind, placebo-controlled treatment trial of citalopram for major depressive disorder in older patients with heart failure: the relevance of the placebo effect and psychological symptoms. ( Alves, TC; Andrei, AM; da Silva Telles, RM; Fraguas, R; Iosifescu, DV; Rays, J; Wajngarten, M, 2009)
"MOOD-HF is a prospective, randomised, double-blind, placebo-controlled, 2-armed, parallel-group multicenter trial investigating the effects of the serotonin re-uptake inhibitor (SSRI) escitalopram on morbidity and mortality (primary endpoint), severity of depression, anxiety, cognitive function, quality of life and health care expenditure in 700 patients with symptomatic systolic CHF and major depression diagnosed by structured clinical interview."5.12Rationale and design of a randomised, controlled, multicenter trial investigating the effects of selective serotonin re-uptake inhibition on morbidity, mortality and mood in depressed heart failure patients (MOOD-HF). ( Angermann, CE; Deckert, J; Ertl, G; Faller, H; Fallgatter, A; Gelbrich, G; Störk, S, 2007)
" The patient was diagnosed with serotonin syndrome, attributed to the coadministration of 2 commonly prescribed medications (citalopram and omeprazole)."3.88Hyperpyrexia in a patient with a left ventricular assist device: a diagnosis beyond the obvious. ( Charitos, C; Kapelios, CJ; Tsamatsoulis, M, 2018)
" The case presentation illustrates the role of pregabalin in successful medical management of this chronic pain disorder, as well as the management of common psychiatric morbidities associated with this condition."3.74Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia. ( Jerome, L, 2007)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (30.00)29.6817
2010's6 (60.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Kobayashi, M1
Kwak, MJ1
Aguilar, D1
Goyal, P1
Holmes, HM1
Deshmukh, AA1
Aparasu, RR1
Tsamatsoulis, M1
Kapelios, CJ1
Charitos, C1
Angermann, CE3
Gelbrich, G2
Störk, S2
Gunold, H1
Edelmann, F1
Wachter, R1
Schunkert, H1
Graf, T1
Kindermann, I1
Haass, M1
Blankenberg, S1
Pankuweit, S1
Prettin, C1
Gottwik, M1
Böhm, M1
Faller, H2
Deckert, J3
Ertl, G3
Ströhle, A1
Rieckmann, N1
Lekakis, J1
Ikonomidis, I1
Papoutsi, Z1
Moutsatsou, P1
Nikolaou, M1
Parissis, J1
Kremastinos, DT1
Fraguas, R1
da Silva Telles, RM1
Alves, TC1
Andrei, AM1
Rays, J1
Iosifescu, DV1
Wajngarten, M1
Labos, C1
Dasgupta, K1
Nedjar, H1
Turecki, G1
Rahme, E1
Jerome, L1
Fallgatter, A1

Trials

4 trials available for citalopram and Heart Failure

ArticleYear
Effect of Escitalopram on All-Cause Mortality and Hospitalization in Patients With Heart Failure and Depression: The MOOD-HF Randomized Clinical Trial.
    JAMA, 2016, Jun-28, Volume: 315, Issue:24

    Topics: Affect; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; Citalopram; Depression; Dru

2016
Selective serotonin re-uptake inhibitors decrease the cytokine-induced endothelial adhesion molecule expression, the endothelial adhesiveness to monocytes and the circulating levels of vascular adhesion molecules.
    International journal of cardiology, 2010, Mar-04, Volume: 139, Issue:2

    Topics: Adult; Aged; Aorta; Cell Adhesion; Cell Survival; Chronic Disease; Citalopram; Depression; Endotheli

2010
A double-blind, placebo-controlled treatment trial of citalopram for major depressive disorder in older patients with heart failure: the relevance of the placebo effect and psychological symptoms.
    Contemporary clinical trials, 2009, Volume: 30, Issue:3

    Topics: Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Blood Pressure; Citalopram; Depre

2009
Rationale and design of a randomised, controlled, multicenter trial investigating the effects of selective serotonin re-uptake inhibition on morbidity, mortality and mood in depressed heart failure patients (MOOD-HF).
    European journal of heart failure, 2007, Volume: 9, Issue:12

    Topics: Affect; Citalopram; Cognition; Depression; Double-Blind Method; Follow-Up Studies; Heart Failure; Hu

2007

Other Studies

6 other studies available for citalopram and Heart Failure

ArticleYear
Prescribing Trend of Inappropriate Medications in Outpatient Clinics for Older Adults With Heart Failure in the United States: NAMCS 2012 to 2016.
    The American journal of cardiology, 2021, 08-01, Volume: 152

    Topics: Aged; Ambulatory Care; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-Steroidal; Antidepressi

2021
Hyperpyrexia in a patient with a left ventricular assist device: a diagnosis beyond the obvious.
    Interactive cardiovascular and thoracic surgery, 2018, 05-01, Volume: 26, Issue:5

    Topics: Aged; Citalopram; Fever; Heart Failure; Heart-Assist Devices; Humans; Male; Omeprazole; Proton Pump

2018
Escitalopram and Outcomes Among Patients With Depression and Heart Failure.
    JAMA, 2016, Oct-11, Volume: 316, Issue:14

    Topics: Citalopram; Depression; Depressive Disorder; Depressive Disorder, Major; Double-Blind Method; Heart

2016
Escitalopram and Outcomes Among Patients With Depression and Heart Failure-Reply.
    JAMA, 2016, Oct-11, Volume: 316, Issue:14

    Topics: Citalopram; Depression; Depressive Disorder; Depressive Disorder, Major; Double-Blind Method; Heart

2016
Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2011, Nov-08, Volume: 183, Issue:16

    Topics: Adrenal Cortex Hormones; Age Factors; Aged; Anemia; Angioplasty; Anticoagulants; Antihypertensive Ag

2011
Pregabalin-induced remission in a 62-year-old woman with a 20-year history of vulvodynia.
    Pain research & management, 2007,Autumn, Volume: 12, Issue:3

    Topics: Amitriptyline; Analgesics; Anti-Ulcer Agents; Anticoagulants; Antidepressive Agents; Anxiety; Cardio

2007