citalopram has been researched along with Erectile Dysfunction in 7 studies
Citalopram: A furancarbonitrile that is one of the serotonin uptake inhibitors used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patients who also suffer from TARDIVE DYSKINESIA in preference to tricyclic antidepressants, which aggravate dyskinesia.
citalopram : A racemate comprising equimolar amounts of (R)-citalopram and its enantiomer, escitalopram. It is used as an antidepressant, although only escitalopram is active.
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile : A nitrile that is 1,3-dihydro-2-benzofuran-5-carbonitrile in which one of the hydrogens at position 1 is replaced by a p-fluorophenyl group, while the other is replaced by a 3-(dimethylamino)propyl group.
Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This was a randomized, double-blind, placebo- and active comparator-controlled study, in which patients (> or = 18 years) meeting DSM-IV criteria for Major Depressive Disorder (MDD) received duloxetine 60 mg once daily (QD; N = 273), escitalopram 10 mg QD (N = 274), or placebo (N = 137) for 8 weeks." | 9.12 | Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study. ( Greist, JH; Mallinckrodt, CH; Nierenberg, AA; Prakash, A; Sambunaris, A; Tollefson, GD; Wohlreich, MM, 2007) |
| "To construct a cost-utility model comparing escitalopram with sertraline in the treatment of major depressive disorders." | 7.74 | Cost-utility comparison of escitalopram and sertraline in the treatment of major depressive disorder. ( Armstrong, EP; Haim Erder, M; Skrepnek, GH, 2007) |
| "The inhibitory effects of escitalopram on erectile and vascular function were not accompanied by a change in endothelial nitric oxide synthase, neuronal nitric oxide synthase, inducible nitric oxide synthase expression, or endothelial nitric oxide synthase activity, suggesting that the inhibitory effect is caused by a decrease in nitric oxide bioavailability mediated by increased NADPH oxidase and reactive oxygen species production." | 5.39 | Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability mediated by increased nicotinamide adenine dinucleotide phosphate oxidase activity and reactive oxygen species production. ( Gokce, A; Hellstrom, WJ; Kadowitz, PJ; Kassan, M; Lasker, GF; Mandava, SH; Matrougui, K; Serefoglu, EC; Sikka, SC, 2013) |
| "This was a randomized, double-blind, placebo- and active comparator-controlled study, in which patients (> or = 18 years) meeting DSM-IV criteria for Major Depressive Disorder (MDD) received duloxetine 60 mg once daily (QD; N = 273), escitalopram 10 mg QD (N = 274), or placebo (N = 137) for 8 weeks." | 5.12 | Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study. ( Greist, JH; Mallinckrodt, CH; Nierenberg, AA; Prakash, A; Sambunaris, A; Tollefson, GD; Wohlreich, MM, 2007) |
| "To construct a cost-utility model comparing escitalopram with sertraline in the treatment of major depressive disorders." | 3.74 | Cost-utility comparison of escitalopram and sertraline in the treatment of major depressive disorder. ( Armstrong, EP; Haim Erder, M; Skrepnek, GH, 2007) |
| "Bupropion SR in the treatment of PTSD had no significant effect in the current sample." | 2.73 | A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder. ( Becker, ME; Beckham, JC; Bukenya, DS; Dennis, MF; Hertzberg, MA; Moore, SD, 2007) |
| "The treatment with citalopram or with fluoxetine was confirmed to delay ejaculation, but was significant only for citalopram." | 2.73 | The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. ( Balestrieri, A; Bettica, P; Carani, C; Granata, AR; Madeo, B; Milleri, S; Rochira, V, 2008) |
| "The inhibitory effects of escitalopram on erectile and vascular function were not accompanied by a change in endothelial nitric oxide synthase, neuronal nitric oxide synthase, inducible nitric oxide synthase expression, or endothelial nitric oxide synthase activity, suggesting that the inhibitory effect is caused by a decrease in nitric oxide bioavailability mediated by increased NADPH oxidase and reactive oxygen species production." | 1.39 | Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability mediated by increased nicotinamide adenine dinucleotide phosphate oxidase activity and reactive oxygen species production. ( Gokce, A; Hellstrom, WJ; Kadowitz, PJ; Kassan, M; Lasker, GF; Mandava, SH; Matrougui, K; Serefoglu, EC; Sikka, SC, 2013) |
| "Increased incidence of impotence is associated with some selective serotonin-reuptake-inhibitors (SSRIs), but the pathophysiological mechanism is unknown." | 1.31 | Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue. ( Angulo, J; Cuevas, P; Gabancho, S; Gupta, S; Peiró, C; Sáenz de Tejada, I; Sanchez-Ferrer, CF, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (71.43) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kassan, M | 1 |
| Lasker, GF | 1 |
| Sikka, SC | 1 |
| Mandava, SH | 1 |
| Gokce, A | 1 |
| Matrougui, K | 1 |
| Hellstrom, WJ | 1 |
| Kadowitz, PJ | 1 |
| Serefoglu, EC | 1 |
| Belli, H | 1 |
| Aslaner, D | 1 |
| Ural, C | 1 |
| Vardar, MK | 1 |
| Yesilyurt, S | 1 |
| Gul, ES | 1 |
| Armstrong, EP | 1 |
| Skrepnek, GH | 1 |
| Haim Erder, M | 1 |
| Nierenberg, AA | 1 |
| Greist, JH | 1 |
| Mallinckrodt, CH | 1 |
| Prakash, A | 1 |
| Sambunaris, A | 1 |
| Tollefson, GD | 1 |
| Wohlreich, MM | 1 |
| Becker, ME | 1 |
| Hertzberg, MA | 1 |
| Moore, SD | 1 |
| Dennis, MF | 1 |
| Bukenya, DS | 1 |
| Beckham, JC | 1 |
| Madeo, B | 1 |
| Bettica, P | 1 |
| Milleri, S | 1 |
| Balestrieri, A | 1 |
| Granata, AR | 1 |
| Carani, C | 1 |
| Rochira, V | 1 |
| Angulo, J | 1 |
| Peiró, C | 1 |
| Sanchez-Ferrer, CF | 1 |
| Gabancho, S | 1 |
| Cuevas, P | 1 |
| Gupta, S | 1 |
| Sáenz de Tejada, I | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Duloxetine Versus Escitalopram and Placebo in the Treatment of Patients With Major Depression[NCT00073411] | Phase 3 | 675 participants | Interventional | 2003-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for citalopram and Erectile Dysfunction
| Article | Year |
|---|---|
Duloxetine versus escitalopram and placebo in the treatment of patients with major depressive disorder: onset of antidepressant action, a non-inferiority study.
Topics: Adult; Antidepressive Agents; Arrhythmias, Cardiac; Citalopram; Depressive Disorder; Double-Blind Me | 2007 |
A placebo-controlled trial of bupropion SR in the treatment of chronic posttraumatic stress disorder.
Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Attention; Bupropion; Chronic | 2007 |
The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study.
Topics: Adolescent; Adult; Citalopram; Double-Blind Method; Ejaculation; Erectile Dysfunction; Fluoxetine; H | 2008 |
4 other studies available for citalopram and Erectile Dysfunction
| Article | Year |
|---|---|
Chronic escitalopram treatment induces erectile dysfunction by decreasing nitric oxide bioavailability mediated by increased nicotinamide adenine dinucleotide phosphate oxidase activity and reactive oxygen species production.
Topics: Acetophenones; Acetylcholine; Animals; Citalopram; Dose-Response Relationship, Drug; Endothelium, Va | 2013 |
Escitalopram related erectile dysfunction and spontaneous ejaculation during micturition.
Topics: Adult; Citalopram; Depression; Ejaculation; Erectile Dysfunction; Humans; Male; Selective Serotonin | 2010 |
Cost-utility comparison of escitalopram and sertraline in the treatment of major depressive disorder.
Topics: Adult; Antidepressive Agents; Citalopram; Cost-Benefit Analysis; Decision Support Techniques; Depres | 2007 |
Differential effects of serotonin reuptake inhibitors on erectile responses, NO-production, and neuronal NO synthase expression in rat corpus cavernosum tissue.
Topics: Animals; Citalopram; Electric Stimulation; Erectile Dysfunction; Male; Neurons; Nitric Oxide; Nitric | 2001 |